Reviewed, UniProtKB/Swiss-Prot O43921 (EFNA2_HUMAN)

Names and origin

Protein names

Recommended name:
    Ephrin-A2
Alternative name(s):
    EPH-related receptor tyrosine kinase ligand 6
      Short name=LERK-6
    HEK7-ligand
      Short name=HEK7-L

Gene names

Name:	EFNA2
Synonyms:	EPLG6, LERK6

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	213 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subunit structure	Binds to the receptor tyrosine kinases EPHA3, EPHA4 and EPHA5.
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor Potential.
Sequence similarities	Belongs to the ephrin family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Signal
PTM	Disulfide bond GPI-anchor Glycoprotein Lipoprotein
Gene Ontology (GO)
Biological process	cell-cell signaling Ref.2 Traceable author statement. Source: ProtInc
Cellular component	anchored to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ephrin receptor binding Ref.2 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 188	164	Ephrin-A2		PRO_0000008361
	Propeptide	189 – 213	25	Removed in mature form Potential		PRO_0000008362
Amino acid modifications
	Lipidation	188	1	GPI-anchor amidated asparagine Potential
	Glycosylation	42	1	N-linked (GlcNAc...) Potential
	Glycosylation	174	1	N-linked (GlcNAc...) Potential
	Glycosylation	188	1	N-linked (GlcNAc...) Potential
	Disulfide bond	73 ↔ 114		By similarity
Experimental info
	Sequence conflict	6	1	R → A in CAA07435. Ref.2
	Sequence conflict	25 – 26	2	RA → PP in CAA07435. Ref.2
	Sequence conflict	29 – 30	2	AA → RR in CAA07435. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	O43921-1 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 33C9FB1A8168B2D0	FASTA	213	23,878
	10 20 30 40 50 60 MAPAQRPLLP LLLLLLPLPP PPFARAEDAA RANSDRYAVY WNRSNPRFHA GAGDDGGGYT 70 80 90 100 110 120 VEVSINDYLD IYCPHYGAPL PPAERMEHYV LYMVNGEGHA SCDHRQRGFK RWECNRPAAP 130 140 150 160 170 180 GGPLKFSEKF QLFTPFSLGF EFRPGHEYYY ISATPPNAVD RPCLRLKVYV RPTNETLYEA 190 200 210 PEPIFTSNNS CSSPGGCRLF LSTIPVLWTL LGS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the genes for mouse LERK-3/Ephrin-A3 (Epl3), mouse LERK-4/Ephrin-A4 (Epl4), and human LERK-6/Ephrin-A2 (EPLG6): conservation of intron/exon structure." Cerretti D.P., Nelson N. Genomics 47:131-135(1998) [PubMed: 9465306] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Cloning, chromosal mapping, and tissue expression of the gene encoding the human Eph-family kinase ligand ephrin-A2." Aasheim H.-C., Pedeutour F., Grosgeorge J., Logtenberg T. Biochem. Biophys. Res. Commun. 252:378-382(1998) [PubMed: 9826538] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[3]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U92896, U92893, U92894 Genomic DNA. Translation: AAC39577.1. AJ007292 mRNA. Translation: CAA07435.1. AC004258 Genomic DNA. Translation: AAC04896.1.
IPI	IPI00015159.
PIR	JE0322.
RefSeq	NP_001396.2.
UniGene	Hs.532655
3D structure databases
HSSP	HSSP built from PDB template 1KGY based on UniProtKB P52800.
ModBase	Search...
Proteomic databases
PRIDE	O43921.
Genome annotation databases
Ensembl	ENSG00000099617. Homo sapiens. [Contig view]
GeneID	1943.
KEGG	hsa:1943.
Organism-specific databases
GeneCards	GC19P001237.
H-InvDB	HIX0040152.
HGNC	HGNC:3222. EFNA2.
HPA	CAB005178.
MIM	602756. gene.
PharmGKB	PA27657.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	O43921.
HOVERGEN	O43921.
OMA	O43921. NNSCSSL.
Enzyme and pathway databases
Pathway_Interaction_DB	epha_fwdpathway. EPHA forward signaling.
Gene expression databases
ArrayExpress	O43921.
Bgee	O43921.
CleanEx	HS_EFNA2.
GermOnline	ENSG00000099617. Homo sapiens.
Family and domain databases
InterPro	IPR008972. Cupredoxin. IPR001799. Ephrin. IPR019765. Ephrin_CS. [Graphical view]
Gene3D	G3DSA:2.60.40.420. Cupredoxin. 1 hit.
PANTHER	PTHR11304. Ephrin. 1 hit.
Pfam	PF00812. Ephrin. 1 hit. [Graphical view]
PRINTS	PR01347. EPHRIN.
ProDom	PD002533. Ephrin. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS01299. EPHRIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	7871.
PMAP-CutDB	O43921.
SOURCE	Search...

Entry information

Entry name

EFNA2_HUMAN

Accession

Primary (citable) accession number: O43921
Secondary accession number(s): O76020

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	June 1, 1998
Last modified:	June 16, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)