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O43920

- NDUS5_HUMAN

UniProt

O43920 - NDUS5_HUMAN

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Protein
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
Gene
NDUFS5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. cellular metabolic process Source: Reactome
  2. mitochondrial electron transport, NADH to ubiquinone Source: UniProtKB
  3. mitochondrial respiratory chain complex I assembly Source: UniProtKB
  4. respiratory electron transport chain Source: Reactome
  5. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiREACT_22393. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
Alternative name(s):
Complex I-15 kDa
Short name:
CI-15 kDa
NADH-ubiquinone oxidoreductase 15 kDa subunit
Gene namesi
Name:NDUFS5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:7712. NDUFS5.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: Reactome
  2. mitochondrial intermembrane space Source: UniProtKB-SubCell
  3. mitochondrial respiratory chain complex I Source: UniProtKB
  4. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31522.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 106105NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
PRO_0000118786Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 66 Reviewed prediction
Disulfide bondi43 ↔ 56 Reviewed prediction

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiO43920.
PaxDbiO43920.
PeptideAtlasiO43920.
PRIDEiO43920.

PTM databases

PhosphoSiteiO43920.

Expressioni

Gene expression databases

ArrayExpressiO43920.
BgeeiO43920.
CleanExiHS_NDUFS5.
GenevestigatoriO43920.

Organism-specific databases

HPAiHPA042582.

Interactioni

Subunit structurei

Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.1 Publication

Protein-protein interaction databases

BioGridi110804. 2 interactions.
IntActiO43920. 4 interactions.
MINTiMINT-2796423.
STRINGi9606.ENSP00000362058.

Structurei

3D structure databases

ProteinModelPortaliO43920.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi33 – 4311C-X9-C motif 1
Add
BLAST
Motifi56 – 6611C-X9-C motif 2
Add
BLAST

Domaini

Contains two C-X9-C motifs that are predicted to form a helix-coil-helix structure, permitting the formation of intramolecular disulfide bonds.1 Publication

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG313534.
HOGENOMiHOG000264236.
HOVERGENiHBG001646.
InParanoidiO43920.
KOiK03938.
OMAiLRQKTMK.
OrthoDBiEOG7C8GKB.
PhylomeDBiO43920.
TreeFamiTF332111.

Family and domain databases

InterProiIPR019342. NADH_UbQ_OxRdtase_FeS-su5.
[Graphical view]
PfamiPF10200. Ndufs5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O43920-1 [UniParc]FASTAAdd to Basket

« Hide

MPFLDIQKRF GLNIDRWLTI QSGEQPYKMA GRCHAFEKEW IECAHGIGYT    50
RAEKECKIEY DDFVECLLRQ KTMRRAGTIR KQRDKLIKEG KYTPPPHHIG 100
KGEPRP 106
Length:106
Mass (Da):12,518
Last modified:January 23, 2007 - v3
Checksum:i3D55402837DD99EE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti96 – 961P → S Detected in a patient with mitochondrial complex I deficiency; uncertain pathological significance. 1 Publication
VAR_064569

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF047434 mRNA. Translation: AAC39878.1.
AF020352 mRNA. Translation: AAB87866.1.
BC001884 mRNA. Translation: AAH01884.1.
CCDSiCCDS434.1.
RefSeqiNP_001171908.1. NM_001184979.1.
NP_004543.1. NM_004552.2.
UniGeneiHs.632385.

Genome annotation databases

EnsembliENST00000372967; ENSP00000362058; ENSG00000168653.
ENST00000372969; ENSP00000362060; ENSG00000168653.
GeneIDi4725.
KEGGihsa:4725.
UCSCiuc001ccx.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF047434 mRNA. Translation: AAC39878.1 .
AF020352 mRNA. Translation: AAB87866.1 .
BC001884 mRNA. Translation: AAH01884.1 .
CCDSi CCDS434.1.
RefSeqi NP_001171908.1. NM_001184979.1.
NP_004543.1. NM_004552.2.
UniGenei Hs.632385.

3D structure databases

ProteinModelPortali O43920.
ModBasei Search...

Protein-protein interaction databases

BioGridi 110804. 2 interactions.
IntActi O43920. 4 interactions.
MINTi MINT-2796423.
STRINGi 9606.ENSP00000362058.

Chemistry

ChEMBLi CHEMBL2363065.
DrugBanki DB00157. NADH.

PTM databases

PhosphoSitei O43920.

Proteomic databases

MaxQBi O43920.
PaxDbi O43920.
PeptideAtlasi O43920.
PRIDEi O43920.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000372967 ; ENSP00000362058 ; ENSG00000168653 .
ENST00000372969 ; ENSP00000362060 ; ENSG00000168653 .
GeneIDi 4725.
KEGGi hsa:4725.
UCSCi uc001ccx.3. human.

Organism-specific databases

CTDi 4725.
GeneCardsi GC01P039491.
HGNCi HGNC:7712. NDUFS5.
HPAi HPA042582.
MIMi 603847. gene.
neXtProti NX_O43920.
PharmGKBi PA31522.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG313534.
HOGENOMi HOG000264236.
HOVERGENi HBG001646.
InParanoidi O43920.
KOi K03938.
OMAi LRQKTMK.
OrthoDBi EOG7C8GKB.
PhylomeDBi O43920.
TreeFami TF332111.

Enzyme and pathway databases

Reactomei REACT_22393. Respiratory electron transport.

Miscellaneous databases

ChiTaRSi NDUFS5. human.
GeneWikii NDUFS5.
GenomeRNAii 4725.
NextBioi 18222.
PROi O43920.
SOURCEi Search...

Gene expression databases

ArrayExpressi O43920.
Bgeei O43920.
CleanExi HS_NDUFS5.
Genevestigatori O43920.

Family and domain databases

InterProi IPR019342. NADH_UbQ_OxRdtase_FeS-su5.
[Graphical view ]
Pfami PF10200. Ndufs5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning."
    Mao M., Fu G., Wu J.-S., Zhang Q.-H., Zhou J., Kan L.-X., Huang Q.-H., He K.-L., Gu B.-W., Han Z.-G., Shen Y., Gu J., Yu Y.-P., Xu S.-H., Wang Y.-X., Chen S.-J., Chen Z.
    Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  2. "The human NADH:ubiquinone oxidoreductase NDUFS5 (15 kDa) subunit: cDNA cloning, chromosomal localization, tissue distribution and the absence of mutations in isolated complex I-deficient patients."
    Loeffen J., Smeets R., Smeitink J., Triepels R., Sengers R., Trijbels F., van den Heuvel L.
    J. Inherit. Metab. Dis. 22:19-28(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  4. "The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification."
    Murray J., Zhang B., Taylor S.W., Oglesbee D., Fahy E., Marusich M.F., Ghosh S.S., Capaldi R.A.
    J. Biol. Chem. 278:13619-13622(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE NADH-UBIQUINONE OXIDOREDUCTASE COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "NDUFB7 and NDUFA8 are located at the intermembrane surface of complex I."
    Szklarczyk R., Wanschers B.F., Nabuurs S.B., Nouws J., Nijtmans L.G., Huynen M.A.
    FEBS Lett. 585:737-743(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: DOMAIN, MOTIF.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: VARIANT SER-96.

Entry informationi

Entry nameiNDUS5_HUMAN
AccessioniPrimary (citable) accession number: O43920
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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