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O43915

- VEGFD_HUMAN

UniProt

O43915 - VEGFD_HUMAN

Protein

Vascular endothelial growth factor D

Gene

FIGF

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.1 Publication

    GO - Molecular functioni

    1. chemoattractant activity Source: UniProtKB
    2. platelet-derived growth factor receptor binding Source: ProtInc
    3. vascular endothelial growth factor receptor binding Source: UniProtKB

    GO - Biological processi

    1. angiogenesis Source: UniProtKB-KW
    2. blood coagulation Source: Reactome
    3. cell differentiation Source: UniProtKB-KW
    4. cell proliferation Source: Ensembl
    5. induction of positive chemotaxis Source: UniProtKB
    6. platelet activation Source: Reactome
    7. platelet degranulation Source: Reactome
    8. positive chemotaxis Source: GOC
    9. positive regulation of cell division Source: UniProtKB-KW
    10. positive regulation of cell proliferation Source: ProtInc
    11. positive regulation of mast cell chemotaxis Source: UniProtKB
    12. vascular endothelial growth factor receptor signaling pathway Source: Reactome

    Keywords - Molecular functioni

    Developmental protein, Growth factor, Mitogen

    Keywords - Biological processi

    Angiogenesis, Differentiation

    Enzyme and pathway databases

    ReactomeiREACT_12380. VEGF ligand-receptor interactions.
    REACT_12583. VEGF binds to VEGFR leading to receptor dimerization.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vascular endothelial growth factor D
    Short name:
    VEGF-D
    Alternative name(s):
    c-Fos-induced growth factor
    Short name:
    FIGF
    Gene namesi
    Name:FIGF
    Synonyms:VEGFD
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:3708. FIGF.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: ProtInc
    3. membrane Source: InterPro
    4. platelet alpha granule lumen Source: Reactome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28146.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Propeptidei22 – 8867Or 99 (in a minor form)1 PublicationPRO_0000023408Add
    BLAST
    Chaini89 – 205117Vascular endothelial growth factor DPRO_0000023409Add
    BLAST
    Propeptidei206 – 354149PRO_0000023410Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi111 ↔ 1531 Publication
    Disulfide bondi136 – 136Interchain1 Publication
    Disulfide bondi142 ↔ 1891 Publication
    Disulfide bondi145 – 145Interchain1 Publication
    Disulfide bondi146 ↔ 1911 Publication
    Glycosylationi155 – 1551N-linked (GlcNAc...)1 Publication
    Glycosylationi185 – 1851N-linked (GlcNAc...)1 Publication
    Glycosylationi287 – 2871N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3 and VEGFR-2. VEGF-D first form an antiparallel homodimer linked by disulfide bonds before secretion. The fully processed VEGF-D is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions.1 Publication

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO43915.
    PRIDEiO43915.

    PTM databases

    PhosphoSiteiO43915.

    Expressioni

    Tissue specificityi

    Highly expressed in lung, heart, small intestine and fetal lung, and at lower levels in skeletal muscle, colon, and pancreas.

    Gene expression databases

    BgeeiO43915.
    CleanExiHS_FIGF.
    GenevestigatoriO43915.

    Organism-specific databases

    HPAiHPA027342.

    Interactioni

    Subunit structurei

    Homodimer; non-covalent and antiparallel.1 Publication

    Protein-protein interaction databases

    BioGridi108567. 3 interactions.
    STRINGi9606.ENSP00000297904.

    Structurei

    Secondary structure

    1
    354
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi93 – 10816
    Beta strandi110 – 11910
    Helixi120 – 1234
    Helixi127 – 1293
    Beta strandi133 – 14311
    Beta strandi152 – 16615
    Beta strandi169 – 1713
    Beta strandi178 – 19215

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2XV7X-ray2.90A92-195[»]
    ProteinModelPortaliO43915.
    SMRiO43915. Positions 92-194.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO43915.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati222 – 237161; approximateAdd
    BLAST
    Repeati258 – 273162Add
    BLAST
    Repeati277 – 293173Add
    BLAST
    Repeati301 – 318184Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni222 – 318974 X 16 AA repeats of C-X(10)-C-X-C-X(1,3)-CAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PDGF/VEGF growth factor family.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG77707.
    HOGENOMiHOG000231512.
    HOVERGENiHBG073119.
    InParanoidiO43915.
    KOiK05449.
    OMAiDTCSCED.
    OrthoDBiEOG7J17ZS.
    PhylomeDBiO43915.
    TreeFamiTF319554.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR023581. PD_growth_factor_CS.
    IPR000072. PDGF/VEGF_dom.
    [Graphical view]
    PfamiPF00341. PDGF. 1 hit.
    [Graphical view]
    SMARTiSM00141. PDGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00249. PDGF_1. 1 hit.
    PS50278. PDGF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O43915-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYREWVVVNV FMMLYVQLVQ GSSNEHGPVK RSSQSTLERS EQQIRAASSL    50
    EELLRITHSE DWKLWRCRLR LKSFTSMDSR SASHRSTRFA ATFYDIETLK 100
    VIDEEWQRTQ CSPRETCVEV ASELGKSTNT FFKPPCVNVF RCGGCCNEES 150
    LICMNTSTSY ISKQLFEISV PLTSVPELVP VKVANHTGCK CLPTAPRHPY 200
    SIIRRSIQIP EEDRCSHSKK LCPIDMLWDS NKCKCVLQEE NPLAGTEDHS 250
    HLQEPALCGP HMMFDEDRCE CVCKTPCPKD LIQHPKNCSC FECKESLETC 300
    CQKHKLFHPD TCSCEDRCPF HTRPCASGKT ACAKHCRFPK EKRAAQGPHS 350
    RKNP 354
    Length:354
    Mass (Da):40,444
    Last modified:June 1, 1998 - v1
    Checksum:i2048D769D735173E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D89630 mRNA. Translation: BAA24264.1.
    Y12863 mRNA. Translation: CAA73370.1.
    Y12864
    , Y12865, Y12866, Y12867, Y12868, Y12869, Y12870 Genomic DNA. Translation: CAA73371.1.
    AJ000185 mRNA. Translation: CAA03942.1.
    AK313173 mRNA. Translation: BAG35990.1.
    CH471074 Genomic DNA. Translation: EAW98885.1.
    BC027948 mRNA. Translation: AAH27948.1.
    CCDSiCCDS14166.1.
    RefSeqiNP_004460.1. NM_004469.4.
    UniGeneiHs.11392.

    Genome annotation databases

    EnsembliENST00000297904; ENSP00000297904; ENSG00000165197.
    GeneIDi2277.
    KEGGihsa:2277.
    UCSCiuc004cwt.2. human.

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D89630 mRNA. Translation: BAA24264.1 .
    Y12863 mRNA. Translation: CAA73370.1 .
    Y12864
    , Y12865 , Y12866 , Y12867 , Y12868 , Y12869 , Y12870 Genomic DNA. Translation: CAA73371.1 .
    AJ000185 mRNA. Translation: CAA03942.1 .
    AK313173 mRNA. Translation: BAG35990.1 .
    CH471074 Genomic DNA. Translation: EAW98885.1 .
    BC027948 mRNA. Translation: AAH27948.1 .
    CCDSi CCDS14166.1.
    RefSeqi NP_004460.1. NM_004469.4.
    UniGenei Hs.11392.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2XV7 X-ray 2.90 A 92-195 [» ]
    ProteinModelPortali O43915.
    SMRi O43915. Positions 92-194.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108567. 3 interactions.
    STRINGi 9606.ENSP00000297904.

    PTM databases

    PhosphoSitei O43915.

    Proteomic databases

    PaxDbi O43915.
    PRIDEi O43915.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000297904 ; ENSP00000297904 ; ENSG00000165197 .
    GeneIDi 2277.
    KEGGi hsa:2277.
    UCSCi uc004cwt.2. human.

    Organism-specific databases

    CTDi 2277.
    GeneCardsi GC0XM015363.
    HGNCi HGNC:3708. FIGF.
    HPAi HPA027342.
    MIMi 300091. gene.
    neXtProti NX_O43915.
    PharmGKBi PA28146.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG77707.
    HOGENOMi HOG000231512.
    HOVERGENi HBG073119.
    InParanoidi O43915.
    KOi K05449.
    OMAi DTCSCED.
    OrthoDBi EOG7J17ZS.
    PhylomeDBi O43915.
    TreeFami TF319554.

    Enzyme and pathway databases

    Reactomei REACT_12380. VEGF ligand-receptor interactions.
    REACT_12583. VEGF binds to VEGFR leading to receptor dimerization.

    Miscellaneous databases

    EvolutionaryTracei O43915.
    GeneWikii C-fos_induced_growth_factor.
    GenomeRNAii 2277.
    NextBioi 9261.
    PROi O43915.
    SOURCEi Search...

    Gene expression databases

    Bgeei O43915.
    CleanExi HS_FIGF.
    Genevestigatori O43915.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR023581. PD_growth_factor_CS.
    IPR000072. PDGF/VEGF_dom.
    [Graphical view ]
    Pfami PF00341. PDGF. 1 hit.
    [Graphical view ]
    SMARTi SM00141. PDGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00249. PDGF_1. 1 hit.
    PS50278. PDGF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a novel vascular endothelial growth factor, VEGF-D."
      Yamada Y., Nezu J., Shimane M., Hirata Y.
      Genomics 42:483-488(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.
    2. "Human FIGF: cloning, gene structure, and mapping to chromosome Xp22.1 between the PIGA and the GRPR genes."
      Rocchigiani M., Lestingi M., Luddi A., Orlandini M., Franco B., Rossi E., Ballabio A., Zuffardi O., Oliviero S.
      Genomics 47:207-216(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Tissue: Lung.
    3. "Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)."
      Achen M.G., Jeltsch M., Kukk E., Maekinen T., Vitali A., Wilks A.F., Alitalo K., Stacker S.A.
      Proc. Natl. Acad. Sci. U.S.A. 95:548-553(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    7. "Biosynthesis of vascular endothelial growth factor-D involves proteolytic processing which generates non-covalent homodimers."
      Stacker S.A., Stenvers K.L., Caesar C., Vitali A., Domagala T., Nice E.C., Roufail S., Simpson R.J., Moritz R., Karpanen T., Alitalo K., Achen M.G.
      J. Biol. Chem. 274:32127-32136(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 89-94; 100-105 AND 206-213, PROTEOLYTIC PROCESSING.
    8. "Structural determinants of vascular endothelial growth factor-D - receptor binding and specificity."
      Leppanen V.M., Jeltsch M., Anisimov A., Tvorogov D., Aho K., Kalkkinen N., Toivanen P., Yla-Herttuala S., Ballmer-Hofer K., Alitalo K.
      Blood 117:1507-1515(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 92-195 OF MUTANT ALA-117, FUNCTION, SUBUNIT, GLYCOSYLATION AT ASN-155 AND ASN-185, DISULFIDE BONDS.

    Entry informationi

    Entry nameiVEGFD_HUMAN
    AccessioniPrimary (citable) accession number: O43915
    Secondary accession number(s): B2R7Z3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 16, 2001
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 127 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3