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O43914

- TYOBP_HUMAN

UniProt

O43914 - TYOBP_HUMAN

Protein

TYRO protein tyrosine kinase-binding protein

Gene

TYROBP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei54 – 541Important for interaction with transmembrane receptors

    GO - Molecular functioni

    1. identical protein binding Source: IntAct
    2. protein binding Source: IntAct
    3. receptor binding Source: UniProtKB
    4. receptor signaling protein activity Source: ProtInc

    GO - Biological processi

    1. axon guidance Source: Reactome
    2. cellular defense response Source: ProtInc
    3. innate immune response Source: Reactome
    4. integrin-mediated signaling pathway Source: Ensembl
    5. intracellular signal transduction Source: ProtInc
    6. macrophage activation involved in immune response Source: Ensembl
    7. neutrophil activation involved in immune response Source: Ensembl
    8. regulation of immune response Source: Reactome
    9. regulation of osteoclast development Source: Ensembl
    10. signal transduction Source: ProtInc

    Enzyme and pathway databases

    ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_147694. DAP12 interactions.
    REACT_147814. DAP12 signaling.
    REACT_19200. Other semaphorin interactions.
    REACT_23916. Signal regulatory protein (SIRP) family interactions.
    SignaLinkiO43914.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    TYRO protein tyrosine kinase-binding protein
    Alternative name(s):
    DNAX-activation protein 12
    Killer-activating receptor-associated protein
    Short name:
    KAR-associated protein
    Gene namesi
    Name:TYROBP
    Synonyms:DAP12, KARAP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:12449. TYROBP.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: UniProtKB
    2. integral component of plasma membrane Source: ProtInc
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) [MIM:221770]: Recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns.
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi54 – 541T → A: Reduced interaction with KLRC2 and KIR2DS3. 1 Publication

    Organism-specific databases

    MIMi221770. phenotype.
    Orphaneti2770. Nasu-Hakola disease.
    PharmGKBiPA37100.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 11392TYRO protein tyrosine kinase-binding proteinPRO_0000022603Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi35 – 35Interchain1 Publication
    Modified residuei91 – 911PhosphotyrosineBy similarity
    Modified residuei102 – 1021PhosphotyrosineBy similarity

    Post-translational modificationi

    Tyrosine phosphorylated.

    Keywords - PTMi

    Disulfide bond, Phosphoprotein

    Proteomic databases

    PaxDbiO43914.
    PRIDEiO43914.

    PTM databases

    PhosphoSiteiO43914.

    Expressioni

    Tissue specificityi

    Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Expressed in hematological cells and tissues such as peripheral blood leukocytes and spleen. Also found in bone marrow, lymph nodes, placenta, lung and liver. Expressed at lower levels in different parts of the brain especially in the basal ganglia and corpus callosum.1 Publication

    Gene expression databases

    ArrayExpressiO43914.
    BgeeiO43914.
    CleanExiHS_TYROBP.
    GenevestigatoriO43914.

    Organism-specific databases

    HPAiCAB009493.
    HPA041899.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked. Interacts with SIRPB1 and TREM1. Interacts with CLECSF5. Interacts with SIGLEC14. Interacts with CD300LB and CD300E. Interacts with CD300D By similarity. Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK mediating neutrophils and macrophages integrin-mediated activation By similarity. Interacts with KLRC2 and KIR2DS3.By similarity7 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself2EBI-2214794,EBI-2214794
    KLRC2P267172EBI-2214794,EBI-3862171
    SIRPB1O002414EBI-2214794,EBI-2615458

    Protein-protein interaction databases

    BioGridi113155. 7 interactions.
    IntActiO43914. 8 interactions.
    STRINGi9606.ENSP00000262629.

    Structurei

    Secondary structure

    1
    113
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi41 – 6424

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2L34NMR-A/B35-67[»]
    2L35NMR-A35-67[»]
    B35-66[»]
    ProteinModelPortaliO43914.
    SMRiO43914. Positions 35-67.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO43914.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 4019ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini62 – 11352CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei41 – 6121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini80 – 10829ITAMAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TYROBP family.Curated
    Contains 1 ITAM domain.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG44707.
    HOGENOMiHOG000056440.
    HOVERGENiHBG061468.
    InParanoidiO43914.
    KOiK07992.
    PhylomeDBiO43914.
    TreeFamiTF336898.

    Family and domain databases

    InterProiIPR026200. Tyrobp.
    [Graphical view]
    PANTHERiPTHR17554. PTHR17554. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O43914-1) [UniParc]FASTAAdd to Basket

    Also known as: KARAP-a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGGLEPCSRL LLLPLLLAVS GLRPVQAQAQ SDCSCSTVSP GVLAGIVMGD    50
    LVLTVLIALA VYFLGRLVPR GRGAAEAATR KQRITETESP YQELQGQRSD 100
    VYSDLNTQRP YYK 113
    Length:113
    Mass (Da):12,179
    Last modified:June 1, 1998 - v1
    Checksum:i267CB1C1756F89F0
    GO
    Isoform 2 (identifier: O43914-2) [UniParc]FASTAAdd to Basket

    Also known as: KARAP-b

    The sequence of this isoform differs from the canonical sequence as follows:
         77-77: Missing.

    Show »
    Length:112
    Mass (Da):12,108
    Checksum:iD89003C4B50874D0
    GO
    Isoform 3 (identifier: O43914-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         20-30: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:102
    Mass (Da):11,043
    Checksum:i4DB742FB830E8C48
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti111 – 1111Y → H.
    Corresponds to variant rs14714 [ dbSNP | Ensembl ].
    VAR_011985

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei20 – 3011Missing in isoform 3. 1 PublicationVSP_046066Add
    BLAST
    Alternative sequencei77 – 771Missing in isoform 2. 3 PublicationsVSP_012909

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF019562 mRNA. Translation: AAD09436.1.
    AF019563 Genomic DNA. Translation: AAD09437.1.
    AJ010098 mRNA. Translation: CAB52288.1.
    AY074782 mRNA. Translation: AAL74017.1.
    BT009851 mRNA. Translation: AAP88853.1.
    AK290385 mRNA. Translation: BAF83074.1.
    CR450342 mRNA. Translation: CAG29338.1.
    CR542202 mRNA. Translation: CAG46999.1.
    BP295666 mRNA. No translation available.
    AD000833 Genomic DNA. No translation available.
    AD000864 Genomic DNA. No translation available.
    BC011175 mRNA. Translation: AAH11175.1.
    CCDSiCCDS12482.1. [O43914-1]
    CCDS46058.1. [O43914-2]
    CCDS54255.1. [O43914-3]
    RefSeqiNP_001166985.1. NM_001173514.1. [O43914-3]
    NP_003323.1. NM_003332.3. [O43914-1]
    NP_937758.1. NM_198125.2. [O43914-2]
    UniGeneiHs.515369.

    Genome annotation databases

    EnsembliENST00000262629; ENSP00000262629; ENSG00000011600. [O43914-1]
    ENST00000544690; ENSP00000445332; ENSG00000011600. [O43914-3]
    ENST00000589517; ENSP00000468447; ENSG00000011600. [O43914-2]
    GeneIDi7305.
    KEGGihsa:7305.
    UCSCiuc002ocm.3. human. [O43914-1]
    uc002ocn.3. human. [O43914-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF019562 mRNA. Translation: AAD09436.1 .
    AF019563 Genomic DNA. Translation: AAD09437.1 .
    AJ010098 mRNA. Translation: CAB52288.1 .
    AY074782 mRNA. Translation: AAL74017.1 .
    BT009851 mRNA. Translation: AAP88853.1 .
    AK290385 mRNA. Translation: BAF83074.1 .
    CR450342 mRNA. Translation: CAG29338.1 .
    CR542202 mRNA. Translation: CAG46999.1 .
    BP295666 mRNA. No translation available.
    AD000833 Genomic DNA. No translation available.
    AD000864 Genomic DNA. No translation available.
    BC011175 mRNA. Translation: AAH11175.1 .
    CCDSi CCDS12482.1. [O43914-1 ]
    CCDS46058.1. [O43914-2 ]
    CCDS54255.1. [O43914-3 ]
    RefSeqi NP_001166985.1. NM_001173514.1. [O43914-3 ]
    NP_003323.1. NM_003332.3. [O43914-1 ]
    NP_937758.1. NM_198125.2. [O43914-2 ]
    UniGenei Hs.515369.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2L34 NMR - A/B 35-67 [» ]
    2L35 NMR - A 35-67 [» ]
    B 35-66 [» ]
    ProteinModelPortali O43914.
    SMRi O43914. Positions 35-67.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113155. 7 interactions.
    IntActi O43914. 8 interactions.
    STRINGi 9606.ENSP00000262629.

    PTM databases

    PhosphoSitei O43914.

    Proteomic databases

    PaxDbi O43914.
    PRIDEi O43914.

    Protocols and materials databases

    DNASUi 7305.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000262629 ; ENSP00000262629 ; ENSG00000011600 . [O43914-1 ]
    ENST00000544690 ; ENSP00000445332 ; ENSG00000011600 . [O43914-3 ]
    ENST00000589517 ; ENSP00000468447 ; ENSG00000011600 . [O43914-2 ]
    GeneIDi 7305.
    KEGGi hsa:7305.
    UCSCi uc002ocm.3. human. [O43914-1 ]
    uc002ocn.3. human. [O43914-2 ]

    Organism-specific databases

    CTDi 7305.
    GeneCardsi GC19M036395.
    GeneReviewsi TYROBP.
    HGNCi HGNC:12449. TYROBP.
    HPAi CAB009493.
    HPA041899.
    MIMi 221770. phenotype.
    604142. gene.
    neXtProti NX_O43914.
    Orphaneti 2770. Nasu-Hakola disease.
    PharmGKBi PA37100.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44707.
    HOGENOMi HOG000056440.
    HOVERGENi HBG061468.
    InParanoidi O43914.
    KOi K07992.
    PhylomeDBi O43914.
    TreeFami TF336898.

    Enzyme and pathway databases

    Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_147694. DAP12 interactions.
    REACT_147814. DAP12 signaling.
    REACT_19200. Other semaphorin interactions.
    REACT_23916. Signal regulatory protein (SIRP) family interactions.
    SignaLinki O43914.

    Miscellaneous databases

    ChiTaRSi TYROBP. human.
    EvolutionaryTracei O43914.
    GeneWikii TYROBP.
    GenomeRNAii 7305.
    NextBioi 28562.
    PROi O43914.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O43914.
    Bgeei O43914.
    CleanExi HS_TYROBP.
    Genevestigatori O43914.

    Family and domain databases

    InterProi IPR026200. Tyrobp.
    [Graphical view ]
    PANTHERi PTHR17554. PTHR17554. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells."
      Lanier L.L., Corliss B.C., Wu J., Leong C., Phillips J.H.
      Nature 391:703-707(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
    2. "Killer activating receptor associated protein isoform b."
      Cantoni C., Biassoni R.
      Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Lymphoid tissue.
    3. "Dendritic cells express two types of immunoreceptor DAP12 transcripts."
      Begum N.A., Seya T.
      Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Umbilical cord blood.
    6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Macrophage.
    8. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    10. "Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells."
      Bakker A.B.H., Baker E., Sutherland G.R., Phillips J.H., Lanier L.L.
      Proc. Natl. Acad. Sci. U.S.A. 96:9792-9796(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CLECSF5.
    11. Cited for: DISEASE.
    12. "Inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes."
      Bouchon A., Dietrich J., Colonna M.
      J. Immunol. 164:4991-4995(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TREM1.
    13. "Heterogeneity of presenile dementia with bone cysts (Nasu-Hakola disease): three genetic forms."
      Kondo T., Takahashi K., Kohara N., Takahashi Y., Hayashi S., Takahashi H., Matsuo H., Yamazaki M., Inoue K., Miyamoto K., Yamamura T.
      Neurology 59:1105-1107(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISEASE.
    14. "TREM-1, MDL-1, and DAP12 expression is associated with a mature stage of myeloid development."
      Gingras M.-C., Lapillonne H., Margolin J.F.
      Mol. Immunol. 38:817-824(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    15. "Molecular characterization of a novel immune receptor restricted to the monocytic lineage."
      Aguilar H., Alvarez-Errico D., Garcia-Montero A.C., Orfao A., Sayos J., Lopez-Botet M.
      J. Immunol. 173:6703-6711(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CD300E.
    16. "Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates."
      Angata T., Hayakawa T., Yamanaka M., Varki A., Nakamura M.
      FASEB J. 20:1964-1973(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SIGLEC14.
    17. "Molecular and functional characterization of CD300b, a new activating immunoglobulin receptor able to transduce signals through two different pathways."
      Martinez-Barriocanal A., Sayos J.
      J. Immunol. 177:2819-2830(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CD300LB.
    18. "Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells."
      Yamanishi Y., Kitaura J., Izawa K., Matsuoka T., Oki T., Lu Y., Shibata F., Yamazaki S., Kumagai H., Nakajima H., Maeda-Yamamoto M., Tybulewicz V.L.J., Takai T., Kitamura T.
      Blood 111:688-698(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CD300LB.
    19. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    20. "The structural basis for intramembrane assembly of an activating immunoreceptor complex."
      Call M.E., Wucherpfennig K.W., Chou J.J.
      Nat. Immunol. 11:1023-1029(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 35-67 IN COMPLEX WITH KLRC2, SUBUNIT, DISULFIDE BOND, MUTAGENESIS OF THR-54, INTERACTION WITH KLRC2 AND KIR2DS3.

    Entry informationi

    Entry nameiTYOBP_HUMAN
    AccessioniPrimary (citable) accession number: O43914
    Secondary accession number(s): A8K2X0
    , F5H389, Q6FGA5, Q9UMT3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 125 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3