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O43914

- TYOBP_HUMAN

UniProt

O43914 - TYOBP_HUMAN

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Protein

TYRO protein tyrosine kinase-binding protein

Gene
TYROBP, DAP12, KARAP
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei54 – 541Important for interaction with transmembrane receptors

GO - Molecular functioni

  1. identical protein binding Source: IntAct
  2. protein binding Source: IntAct
  3. receptor binding Source: UniProtKB
  4. receptor signaling protein activity Source: ProtInc

GO - Biological processi

  1. axon guidance Source: Reactome
  2. cellular defense response Source: ProtInc
  3. innate immune response Source: Reactome
  4. integrin-mediated signaling pathway Source: Ensembl
  5. intracellular signal transduction Source: ProtInc
  6. macrophage activation involved in immune response Source: Ensembl
  7. neutrophil activation involved in immune response Source: Ensembl
  8. regulation of immune response Source: Reactome
  9. regulation of osteoclast development Source: Ensembl
  10. signal transduction Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_147694. DAP12 interactions.
REACT_147814. DAP12 signaling.
REACT_19200. Other semaphorin interactions.
REACT_23916. Signal regulatory protein (SIRP) family interactions.
SignaLinkiO43914.

Names & Taxonomyi

Protein namesi
Recommended name:
TYRO protein tyrosine kinase-binding protein
Alternative name(s):
DNAX-activation protein 12
Killer-activating receptor-associated protein
Short name:
KAR-associated protein
Gene namesi
Name:TYROBP
Synonyms:DAP12, KARAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:12449. TYROBP.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 4019Extracellular Reviewed predictionAdd
BLAST
Transmembranei41 – 6121Helical; Reviewed predictionAdd
BLAST
Topological domaini62 – 11352Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. integral component of plasma membrane Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) [MIM:221770]: Recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns.
Note: The disease is caused by mutations affecting the gene represented in this entry.2 Publications

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi54 – 541T → A: Reduced interaction with KLRC2 and KIR2DS3. 1 Publication

Organism-specific databases

MIMi221770. phenotype.
Orphaneti2770. Nasu-Hakola disease.
PharmGKBiPA37100.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Chaini22 – 11392TYRO protein tyrosine kinase-binding proteinPRO_0000022603Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi35 – 35Interchain1 Publication
Modified residuei91 – 911Phosphotyrosine By similarity
Modified residuei102 – 1021Phosphotyrosine By similarity

Post-translational modificationi

Tyrosine phosphorylated.

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiO43914.
PRIDEiO43914.

PTM databases

PhosphoSiteiO43914.

Expressioni

Tissue specificityi

Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Expressed in hematological cells and tissues such as peripheral blood leukocytes and spleen. Also found in bone marrow, lymph nodes, placenta, lung and liver. Expressed at lower levels in different parts of the brain especially in the basal ganglia and corpus callosum.1 Publication

Gene expression databases

ArrayExpressiO43914.
BgeeiO43914.
CleanExiHS_TYROBP.
GenevestigatoriO43914.

Organism-specific databases

HPAiCAB009493.
HPA041899.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with SIRPB1 and TREM1. Interacts with CLECSF5. Interacts with SIGLEC14. Interacts with CD300LB and CD300E. Interacts with CD300D By similarity. Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK mediating neutrophils and macrophages integrin-mediated activation By similarity. Interacts with KLRC2 and KIR2DS3.7 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-2214794,EBI-2214794
KLRC2P267172EBI-2214794,EBI-3862171
SIRPB1O002414EBI-2214794,EBI-2615458

Protein-protein interaction databases

BioGridi113155. 7 interactions.
IntActiO43914. 8 interactions.
STRINGi9606.ENSP00000262629.

Structurei

Secondary structure

1
113
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi41 – 6424

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2L34NMR-A/B35-67[»]
2L35NMR-A35-67[»]
B35-66[»]
ProteinModelPortaliO43914.
SMRiO43914. Positions 35-67.

Miscellaneous databases

EvolutionaryTraceiO43914.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini80 – 10829ITAMAdd
BLAST

Sequence similaritiesi

Belongs to the TYROBP family.
Contains 1 ITAM domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44707.
HOGENOMiHOG000056440.
HOVERGENiHBG061468.
InParanoidiO43914.
KOiK07992.
PhylomeDBiO43914.
TreeFamiTF336898.

Family and domain databases

InterProiIPR026200. Tyrobp.
[Graphical view]
PANTHERiPTHR17554. PTHR17554. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O43914-1) [UniParc]FASTAAdd to Basket

Also known as: KARAP-a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGGLEPCSRL LLLPLLLAVS GLRPVQAQAQ SDCSCSTVSP GVLAGIVMGD    50
LVLTVLIALA VYFLGRLVPR GRGAAEAATR KQRITETESP YQELQGQRSD 100
VYSDLNTQRP YYK 113
Length:113
Mass (Da):12,179
Last modified:June 1, 1998 - v1
Checksum:i267CB1C1756F89F0
GO
Isoform 2 (identifier: O43914-2) [UniParc]FASTAAdd to Basket

Also known as: KARAP-b

The sequence of this isoform differs from the canonical sequence as follows:
     77-77: Missing.

Show »
Length:112
Mass (Da):12,108
Checksum:iD89003C4B50874D0
GO
Isoform 3 (identifier: O43914-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-30: Missing.

Note: No experimental confirmation available.

Show »
Length:102
Mass (Da):11,043
Checksum:i4DB742FB830E8C48
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti111 – 1111Y → H.
Corresponds to variant rs14714 [ dbSNP | Ensembl ].
VAR_011985

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei20 – 3011Missing in isoform 3. VSP_046066Add
BLAST
Alternative sequencei77 – 771Missing in isoform 2. VSP_012909

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF019562 mRNA. Translation: AAD09436.1.
AF019563 Genomic DNA. Translation: AAD09437.1.
AJ010098 mRNA. Translation: CAB52288.1.
AY074782 mRNA. Translation: AAL74017.1.
BT009851 mRNA. Translation: AAP88853.1.
AK290385 mRNA. Translation: BAF83074.1.
CR450342 mRNA. Translation: CAG29338.1.
CR542202 mRNA. Translation: CAG46999.1.
BP295666 mRNA. No translation available.
AD000833 Genomic DNA. No translation available.
AD000864 Genomic DNA. No translation available.
BC011175 mRNA. Translation: AAH11175.1.
CCDSiCCDS12482.1. [O43914-1]
CCDS46058.1. [O43914-2]
CCDS54255.1. [O43914-3]
RefSeqiNP_001166985.1. NM_001173514.1. [O43914-3]
NP_003323.1. NM_003332.3. [O43914-1]
NP_937758.1. NM_198125.2. [O43914-2]
UniGeneiHs.515369.

Genome annotation databases

EnsembliENST00000262629; ENSP00000262629; ENSG00000011600. [O43914-1]
ENST00000544690; ENSP00000445332; ENSG00000011600. [O43914-3]
ENST00000589517; ENSP00000468447; ENSG00000011600. [O43914-2]
GeneIDi7305.
KEGGihsa:7305.
UCSCiuc002ocm.3. human. [O43914-1]
uc002ocn.3. human. [O43914-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF019562 mRNA. Translation: AAD09436.1 .
AF019563 Genomic DNA. Translation: AAD09437.1 .
AJ010098 mRNA. Translation: CAB52288.1 .
AY074782 mRNA. Translation: AAL74017.1 .
BT009851 mRNA. Translation: AAP88853.1 .
AK290385 mRNA. Translation: BAF83074.1 .
CR450342 mRNA. Translation: CAG29338.1 .
CR542202 mRNA. Translation: CAG46999.1 .
BP295666 mRNA. No translation available.
AD000833 Genomic DNA. No translation available.
AD000864 Genomic DNA. No translation available.
BC011175 mRNA. Translation: AAH11175.1 .
CCDSi CCDS12482.1. [O43914-1 ]
CCDS46058.1. [O43914-2 ]
CCDS54255.1. [O43914-3 ]
RefSeqi NP_001166985.1. NM_001173514.1. [O43914-3 ]
NP_003323.1. NM_003332.3. [O43914-1 ]
NP_937758.1. NM_198125.2. [O43914-2 ]
UniGenei Hs.515369.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2L34 NMR - A/B 35-67 [» ]
2L35 NMR - A 35-67 [» ]
B 35-66 [» ]
ProteinModelPortali O43914.
SMRi O43914. Positions 35-67.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113155. 7 interactions.
IntActi O43914. 8 interactions.
STRINGi 9606.ENSP00000262629.

PTM databases

PhosphoSitei O43914.

Proteomic databases

PaxDbi O43914.
PRIDEi O43914.

Protocols and materials databases

DNASUi 7305.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000262629 ; ENSP00000262629 ; ENSG00000011600 . [O43914-1 ]
ENST00000544690 ; ENSP00000445332 ; ENSG00000011600 . [O43914-3 ]
ENST00000589517 ; ENSP00000468447 ; ENSG00000011600 . [O43914-2 ]
GeneIDi 7305.
KEGGi hsa:7305.
UCSCi uc002ocm.3. human. [O43914-1 ]
uc002ocn.3. human. [O43914-2 ]

Organism-specific databases

CTDi 7305.
GeneCardsi GC19M036395.
GeneReviewsi TYROBP.
HGNCi HGNC:12449. TYROBP.
HPAi CAB009493.
HPA041899.
MIMi 221770. phenotype.
604142. gene.
neXtProti NX_O43914.
Orphaneti 2770. Nasu-Hakola disease.
PharmGKBi PA37100.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44707.
HOGENOMi HOG000056440.
HOVERGENi HBG061468.
InParanoidi O43914.
KOi K07992.
PhylomeDBi O43914.
TreeFami TF336898.

Enzyme and pathway databases

Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_147694. DAP12 interactions.
REACT_147814. DAP12 signaling.
REACT_19200. Other semaphorin interactions.
REACT_23916. Signal regulatory protein (SIRP) family interactions.
SignaLinki O43914.

Miscellaneous databases

ChiTaRSi TYROBP. human.
EvolutionaryTracei O43914.
GeneWikii TYROBP.
GenomeRNAii 7305.
NextBioi 28562.
PROi O43914.
SOURCEi Search...

Gene expression databases

ArrayExpressi O43914.
Bgeei O43914.
CleanExi HS_TYROBP.
Genevestigatori O43914.

Family and domain databases

InterProi IPR026200. Tyrobp.
[Graphical view ]
PANTHERi PTHR17554. PTHR17554. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells."
    Lanier L.L., Corliss B.C., Wu J., Leong C., Phillips J.H.
    Nature 391:703-707(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
  2. "Killer activating receptor associated protein isoform b."
    Cantoni C., Biassoni R.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Lymphoid tissue.
  3. "Dendritic cells express two types of immunoreceptor DAP12 transcripts."
    Begum N.A., Seya T.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Umbilical cord blood.
  6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Macrophage.
  8. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  10. "Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells."
    Bakker A.B.H., Baker E., Sutherland G.R., Phillips J.H., Lanier L.L.
    Proc. Natl. Acad. Sci. U.S.A. 96:9792-9796(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CLECSF5.
  11. Cited for: DISEASE.
  12. "Inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes."
    Bouchon A., Dietrich J., Colonna M.
    J. Immunol. 164:4991-4995(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TREM1.
  13. "Heterogeneity of presenile dementia with bone cysts (Nasu-Hakola disease): three genetic forms."
    Kondo T., Takahashi K., Kohara N., Takahashi Y., Hayashi S., Takahashi H., Matsuo H., Yamazaki M., Inoue K., Miyamoto K., Yamamura T.
    Neurology 59:1105-1107(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISEASE.
  14. "TREM-1, MDL-1, and DAP12 expression is associated with a mature stage of myeloid development."
    Gingras M.-C., Lapillonne H., Margolin J.F.
    Mol. Immunol. 38:817-824(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  15. "Molecular characterization of a novel immune receptor restricted to the monocytic lineage."
    Aguilar H., Alvarez-Errico D., Garcia-Montero A.C., Orfao A., Sayos J., Lopez-Botet M.
    J. Immunol. 173:6703-6711(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CD300E.
  16. "Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates."
    Angata T., Hayakawa T., Yamanaka M., Varki A., Nakamura M.
    FASEB J. 20:1964-1973(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SIGLEC14.
  17. "Molecular and functional characterization of CD300b, a new activating immunoglobulin receptor able to transduce signals through two different pathways."
    Martinez-Barriocanal A., Sayos J.
    J. Immunol. 177:2819-2830(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CD300LB.
  18. "Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells."
    Yamanishi Y., Kitaura J., Izawa K., Matsuoka T., Oki T., Lu Y., Shibata F., Yamazaki S., Kumagai H., Nakajima H., Maeda-Yamamoto M., Tybulewicz V.L.J., Takai T., Kitamura T.
    Blood 111:688-698(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CD300LB.
  19. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  20. "The structural basis for intramembrane assembly of an activating immunoreceptor complex."
    Call M.E., Wucherpfennig K.W., Chou J.J.
    Nat. Immunol. 11:1023-1029(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 35-67 IN COMPLEX WITH KLRC2, SUBUNIT, DISULFIDE BOND, MUTAGENESIS OF THR-54, INTERACTION WITH KLRC2 AND KIR2DS3.

Entry informationi

Entry nameiTYOBP_HUMAN
AccessioniPrimary (citable) accession number: O43914
Secondary accession number(s): A8K2X0
, F5H389, Q6FGA5, Q9UMT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: September 3, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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