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Protein

Origin recognition complex subunit 5

Gene

ORC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi37 – 44ATPSequence analysis8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • DNA replication origin binding Source: ProtInc
  • nucleotide binding Source: ProtInc

GO - Biological processi

  • DNA replication Source: Reactome
  • DNA replication initiation Source: ProtInc
  • G1/S transition of mitotic cell cycle Source: Reactome

Keywordsi

Biological processDNA replication
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-113507 E2F-enabled inhibition of pre-replication complex formation
R-HSA-176187 Activation of ATR in response to replication stress
R-HSA-68616 Assembly of the ORC complex at the origin of replication
R-HSA-68689 CDC6 association with the ORC:origin complex
R-HSA-68827 CDT1 association with the CDC6:ORC:origin complex
R-HSA-68867 Assembly of the pre-replicative complex
R-HSA-68949 Orc1 removal from chromatin
R-HSA-68962 Activation of the pre-replicative complex

Names & Taxonomyi

Protein namesi
Recommended name:
Origin recognition complex subunit 5
Gene namesi
Name:ORC5
Synonyms:ORC5L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000164815.10
HGNCiHGNC:8491 ORC5
MIMi602331 gene
neXtProtiNX_O43913

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5001
OpenTargetsiENSG00000164815
PharmGKBiPA32812

Polymorphism and mutation databases

BioMutaiORC5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001270921 – 435Origin recognition complex subunit 5Add BLAST435

Proteomic databases

EPDiO43913
MaxQBiO43913
PaxDbiO43913
PeptideAtlasiO43913
PRIDEiO43913

PTM databases

iPTMnetiO43913
PhosphoSitePlusiO43913

Expressioni

Tissue specificityi

Abundant in spleen, ovary, prostate, testis, and colon mucosa.1 Publication

Gene expression databases

BgeeiENSG00000164815
CleanExiHS_ORC5L
ExpressionAtlasiO43913 baseline and differential
GenevisibleiO43913 HS

Organism-specific databases

HPAiHPA019730

Interactioni

Subunit structurei

Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi111043, 56 interactors
CORUMiO43913
DIPiDIP-29691N
IntActiO43913, 27 interactors
MINTiO43913
STRINGi9606.ENSP00000297431

Structurei

Secondary structure

1435
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi12 – 22Combined sources11
Beta strandi31 – 36Combined sources6
Helixi39 – 41Combined sources3
Helixi43 – 53Combined sources11
Beta strandi58 – 62Combined sources5
Turni63 – 65Combined sources3
Helixi69 – 78Combined sources10
Helixi100 – 108Combined sources9
Turni113 – 115Combined sources3
Beta strandi116 – 118Combined sources3
Beta strandi120 – 125Combined sources6
Helixi127 – 132Combined sources6
Helixi137 – 142Combined sources6
Helixi144 – 148Combined sources5
Beta strandi152 – 160Combined sources9
Helixi162 – 164Combined sources3
Beta strandi175 – 178Combined sources4
Helixi184 – 191Combined sources8
Turni192 – 194Combined sources3
Helixi201 – 215Combined sources15
Turni216 – 218Combined sources3
Helixi222 – 231Combined sources10
Helixi233 – 241Combined sources9
Helixi254 – 265Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5UJ7X-ray3.39E/F1-284[»]
5UJMelectron microscopy18.00E1-435[»]
ProteinModelPortaliO43913
SMRiO43913
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ORC5 family.Curated

Phylogenomic databases

eggNOGiKOG2543 Eukaryota
ENOG410XSY0 LUCA
GeneTreeiENSGT00390000009380
HOGENOMiHOG000252907
HOVERGENiHBG007875
InParanoidiO43913
KOiK02607
OMAiGEQNIMD
OrthoDBiEOG091G0D0I
PhylomeDBiO43913
TreeFamiTF101095

Family and domain databases

InterProiView protein in InterPro
IPR020796 ORC5
IPR027417 P-loop_NTPase
PANTHERiPTHR12705 PTHR12705, 1 hit
PfamiView protein in Pfam
PF14630 ORC5_C, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O43913-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPHLENVVLC RESQVSILQS LFGERHHFSF PSIFIYGHTA SGKTYVTQTL
60 70 80 90 100
LKTLELPHVF VNCVECFTLR LLLEQILNKL NHLSSSEDGC STEITCETFN
110 120 130 140 150
DFVRLFKQVT TAENLKDQTV YIVLDKAEYL RDMEANLLPG FLRLQELADR
160 170 180 190 200
NVTVLFLSEI VWEKFRPNTG CFEPFVLYFP DYSIGNLQKI LSHDHPPEYS
210 220 230 240 250
ADFYAAYINI LLGVFYTVCR DLKELRHLAV LNFPKYCEPV VKGEASERDT
260 270 280 290 300
RKLWRNIEPH LKKAMQTVYL REISSSQWEK LQKDDTDPGQ LKGLSAHTHV
310 320 330 340 350
ELPYYSKFIL IAAYLASYNP ARTDKRFFLK HHGKIKKTNF LKKHEKTSNH
360 370 380 390 400
LLGPKPFPLD RLLAILYSIV DSRVAPTANI FSQITSLVTL QLLTLVGHDD
410 420 430
QLDGPKYKCT VSLDFIRAIA RTVNFDIIKY LYDFL
Length:435
Mass (Da):50,283
Last modified:June 1, 1998 - v1
Checksum:i0FEB0E829C124745
GO
Isoform 2 (identifier: O43913-2) [UniParc]FASTAAdd to basket
Also known as: ORC5T

The sequence of this isoform differs from the canonical sequence as follows:
     294-435: LSAHTHVELP...DIIKYLYDFL → IRGSIETVTGDTSSANYQDTKVNTKEHSVRK

Note: Does not interact with ORC2.
Show »
Length:324
Mass (Da):37,414
Checksum:i005B2887929C62C8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01180037G → R1 PublicationCorresponds to variant dbSNP:rs1056677Ensembl.1
Natural variantiVAR_01452452K → N. Corresponds to variant dbSNP:rs2307413Ensembl.1
Natural variantiVAR_014525166R → C. Corresponds to variant dbSNP:rs2307402Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042037294 – 435LSAHT…LYDFL → IRGSIETVTGDTSSANYQDT KVNTKEHSVRK in isoform 2. 1 PublicationAdd BLAST142

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047599 mRNA Translation: AAC80283.1
U92538 mRNA Translation: AAC51933.1
AF049127 mRNA Translation: AAC63972.1
AF081459 mRNA Translation: AAC64401.1
AC002067 Genomic DNA No translation available.
AC007393 Genomic DNA No translation available.
CH236947 Genomic DNA Translation: EAL24409.1
CH471070 Genomic DNA Translation: EAW83341.1
BC023652 mRNA Translation: AAH23652.1
CCDSiCCDS47681.1 [O43913-2]
CCDS5734.1 [O43913-1]
RefSeqiNP_002544.1, NM_002553.3 [O43913-1]
NP_859531.1, NM_181747.3 [O43913-2]
UniGeneiHs.432948

Genome annotation databases

EnsembliENST00000297431; ENSP00000297431; ENSG00000164815 [O43913-1]
ENST00000447452; ENSP00000395747; ENSG00000164815 [O43913-2]
GeneIDi5001
KEGGihsa:5001
UCSCiuc003vcb.3 human [O43913-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiORC5_HUMAN
AccessioniPrimary (citable) accession number: O43913
Secondary accession number(s): A4D0P8, O60590, O95268
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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