Reviewed, UniProtKB/Swiss-Prot O43908 (NKG2F_HUMAN)

Names and origin

Protein names

Recommended name:
    NKG2-F type II integral membrane protein
Alternative name(s):
    NKG2-F-activating NK receptor
    NK cell receptor F

Gene names

Name:	KLRC4
Synonyms:	NKG2F

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	158 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells.
Subunit structure	Can form disulfide-bonded heterodimer with CD94.
Subcellular location	Membrane; Single-pass type II membrane protein.
Tissue specificity	Natural killer cells.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Signal-anchor Transmembrane
Molecular function	Receptor
Gene Ontology (GO)
Biological process	cellular defense response Ref.3 Traceable author statement. Source: ProtInc
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 158	158	NKG2-F type II integral membrane protein		PRO_0000046673
Regions
	Topological domain	1 – 74	74	Cytoplasmic Potential
	Transmembrane	75 – 95	21	Signal-anchor for type II membrane protein Potential
	Topological domain	96 – 158	63	Extracellular Potential
Natural variations
	Natural variant	29	1	S → I in allele NKG2-F*02. dbSNP rs1841958.		VAR_013406
	Natural variant	104	1	S → N in allele NKG2-F*02. dbSNP rs2617170.		VAR_013407

Sequences

	Sequence		Length	Mass (Da)
	O43908-1 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 38BFCFF00D26B85F	FASTA	158	18,181
	10 20 30 40 50 60 MNKQRGTYSE VSLAQDPKRQ QRKLKGNKSS ISGTKQEIFQ VELNLQNASS DHQGNDKTYH 70 80 90 100 110 120 CKGLLPPPEK LTAEVLGIIC IVLMATVLKT IVLIPCIGVL EQNSFSLNRR MQKARHCGHC 130 140 150 PEEWITYSNS CYYIGKERRT WEERVCWPVL RRTLICFL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of NKG2-F, a new member of the NKG2 family of human natural killer cell receptor genes." Plougastel B., Trowsdale J. Eur. J. Immunol. 27:2835-2839(1997) [PubMed: 9394807] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]	"Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes." Plougastel B., Trowsdale J. Genomics 49:193-199(1998) [PubMed: 9598306] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex." Glienke J., Sobanov Y., Brostjan C., Steffens C., Nguyen C., Lehrach H., Hofer E., Francis F. Immunogenetics 48:163-173(1998) [PubMed: 9683661] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANTS ILE-29 AND ASN-104.
[4]	"Conservation and variation in human and common chimpanzee CD94 and NKG2 genes." Shum B.P., Flodin L.R., Muir D.G., Rajalingam R., Khakoo S.I., Cleland S., Guethlein L.A., Uhrberg M., Parham P. J. Immunol. 168:240-252(2002) [PubMed: 11751968] [Abstract] Cited for: NUCLEOTIDE SEQUENCE, VARIANTS ILE-29 AND ASN-104.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U96846 Genomic DNA. Translation: AAC51910.1. U96845 mRNA. Translation: AAC51909.1. AF027164 Genomic DNA. Translation: AAC17491.1. AJ001683 mRNA. Translation: CAA04921.1. AJ001686 Genomic DNA. Translation: CAA04924.1. AF350018 mRNA. Translation: AAK83805.1. AF350019 mRNA. Translation: AAK83806.1. BC017784 mRNA. Translation: AAH17784.1.
RefSeq	NP_038459.1.
UniGene	Hs.665704
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000183542. Homo sapiens. [Contig view]
GeneID	8302.
KEGG	hsa:8302.
Organism-specific databases
HGNC	HGNC:6377. KLRC4.
MIM	602893. gene.
PharmGKB	PA30166.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	O43908.
Gene expression databases
ArrayExpress	O43908.
GermOnline	ENSG00000183542. Homo sapiens.
Family and domain databases
InterPro	IPR016186. C-type_lectin-like. [Graphical view]
Gene3D	G3DSA:3.10.100.10. C-type_lectin-like. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	31107.
SOURCE	Search...

Entry information

Entry name

NKG2F_HUMAN

Accession

Primary (citable) accession number: O43908
Secondary accession number(s): O60851

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2002
Last sequence update:	June 1, 1998
Last modified:	November 25, 2008
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)