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Protein

NKG2-F type II integral membrane protein

Gene

KLRC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells.

GO - Biological processi

  • cellular defense response Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
NKG2-F type II integral membrane protein
Alternative name(s):
NK cell receptor F
NKG2-F-activating NK receptor
Gene namesi
Name:KLRC4
Synonyms:NKG2F
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:6377. KLRC4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7474CytoplasmicSequence analysisAdd
BLAST
Transmembranei75 – 9521Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini96 – 15863ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30166.

Polymorphism and mutation databases

BioMutaiKLRC4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 158158NKG2-F type II integral membrane proteinPRO_0000046673Add
BLAST

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO43908.
PRIDEiO43908.

Expressioni

Tissue specificityi

Natural killer cells.

Gene expression databases

BgeeiO43908.
GenevisibleiO43908. HS.

Interactioni

Subunit structurei

Can form disulfide-bonded heterodimer with CD94.

Protein-protein interaction databases

STRINGi9606.ENSP00000310216.

Structurei

3D structure databases

ProteinModelPortaliO43908.
SMRiO43908. Positions 114-143.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KGBU. Eukaryota.
ENOG4110SFD. LUCA.
GeneTreeiENSGT00730000110282.
HOGENOMiHOG000220925.
HOVERGENiHBG077044.
InParanoidiO43908.
KOiK06541.
OMAiKACDCGH.
OrthoDBiEOG76HQ2G.
PhylomeDBiO43908.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.

Sequencei

Sequence statusi: Complete.

O43908-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKQRGTYSE VSLAQDPKRQ QRKLKGNKIS ISGTKQEIFQ VELNLQNASS
60 70 80 90 100
DHQGNDKTYH CKGLLPPPEK LTAEVLGIIC IVLMATVLKT IVLIPCIGVL
110 120 130 140 150
EQNNFSLNRR MQKARHCGHC PEEWITYSNS CYYIGKERRT WEERVCWPVL

RRTLICFL
Length:158
Mass (Da):18,234
Last modified:January 11, 2011 - v2
Checksum:i1AABC0E5ED26ACCC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti29 – 291I → S in allele NKG2-F*02. 4 Publications
Corresponds to variant rs1841958 [ dbSNP | Ensembl ].
VAR_013406
Natural varianti104 – 1041N → S in allele NKG2-F*02. 4 Publications
Corresponds to variant rs2617170 [ dbSNP | Ensembl ].
VAR_013407

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96846 Genomic DNA. Translation: AAC51910.1.
U96845 mRNA. Translation: AAC51909.1.
AF027164 Genomic DNA. Translation: AAC17491.1.
AJ001683 mRNA. Translation: CAA04921.1.
AJ001686 Genomic DNA. Translation: CAA04924.1.
AF350018 mRNA. Translation: AAK83805.1.
AF350019 mRNA. Translation: AAK83806.1.
AC022075 Genomic DNA. No translation available.
BC017784 mRNA. Translation: AAH17784.1.
CCDSiCCDS8624.1.
RefSeqiNP_038459.1. NM_013431.2.
UniGeneiHs.721094.

Genome annotation databases

EnsembliENST00000309384; ENSP00000310216; ENSG00000183542.
GeneIDi8302.
KEGGihsa:8302.
UCSCiuc001qye.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96846 Genomic DNA. Translation: AAC51910.1.
U96845 mRNA. Translation: AAC51909.1.
AF027164 Genomic DNA. Translation: AAC17491.1.
AJ001683 mRNA. Translation: CAA04921.1.
AJ001686 Genomic DNA. Translation: CAA04924.1.
AF350018 mRNA. Translation: AAK83805.1.
AF350019 mRNA. Translation: AAK83806.1.
AC022075 Genomic DNA. No translation available.
BC017784 mRNA. Translation: AAH17784.1.
CCDSiCCDS8624.1.
RefSeqiNP_038459.1. NM_013431.2.
UniGeneiHs.721094.

3D structure databases

ProteinModelPortaliO43908.
SMRiO43908. Positions 114-143.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000310216.

Polymorphism and mutation databases

BioMutaiKLRC4.

Proteomic databases

PaxDbiO43908.
PRIDEiO43908.

Protocols and materials databases

DNASUi8302.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309384; ENSP00000310216; ENSG00000183542.
GeneIDi8302.
KEGGihsa:8302.
UCSCiuc001qye.4. human.

Organism-specific databases

CTDi8302.
GeneCardsiKLRC4.
HGNCiHGNC:6377. KLRC4.
MIMi602893. gene.
neXtProtiNX_O43908.
PharmGKBiPA30166.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KGBU. Eukaryota.
ENOG4110SFD. LUCA.
GeneTreeiENSGT00730000110282.
HOGENOMiHOG000220925.
HOVERGENiHBG077044.
InParanoidiO43908.
KOiK06541.
OMAiKACDCGH.
OrthoDBiEOG76HQ2G.
PhylomeDBiO43908.

Miscellaneous databases

GeneWikiiKLRC4.
GenomeRNAii8302.
NextBioi31107.
PROiO43908.
SOURCEiSearch...

Gene expression databases

BgeeiO43908.
GenevisibleiO43908. HS.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of NKG2-F, a new member of the NKG2 family of human natural killer cell receptor genes."
    Plougastel B., Trowsdale J.
    Eur. J. Immunol. 27:2835-2839(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANTS SER-29 AND SER-104.
  2. "Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes."
    Plougastel B., Trowsdale J.
    Genomics 49:193-199(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-29 AND SER-104.
  3. "The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex."
    Glienke J., Sobanov Y., Brostjan C., Steffens C., Nguyen C., Lehrach H., Hofer E., Francis F.
    Immunogenetics 48:163-173(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANTS SER-29 AND SER-104.
  4. "Conservation and variation in human and common chimpanzee CD94 and NKG2 genes."
    Shum B.P., Flodin L.R., Muir D.G., Rajalingam R., Khakoo S.I., Cleland S., Guethlein L.A., Uhrberg M., Parham P.
    J. Immunol. 168:240-252(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS SER-29 AND SER-104.
  5. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiNKG2F_HUMAN
AccessioniPrimary (citable) accession number: O43908
Secondary accession number(s): O60851
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: January 11, 2011
Last modified: March 16, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.