O43908 (NKG2F_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NKG2-F type II integral membrane protein

Alternative name(s):
NK cell receptor F
NKG2-F-activating NK receptor

Gene names

Name:	KLRC4
Synonyms:	NKG2F

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	158 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells.
Subunit structure	Can form disulfide-bonded heterodimer with CD94.
Subcellular location	Membrane; Single-pass type II membrane protein.
Tissue specificity	Natural killer cells.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Signal-anchor Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular defense response Traceable author statement. Source: ProtInc
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 158	158	NKG2-F type II integral membrane protein		PRO_0000046673
Regions
	Topological domain	1 – 74	74	Cytoplasmic Potential
	Transmembrane	75 – 95	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	96 – 158	63	Extracellular Potential
Natural variations
	Natural variant	29	1	I → S in allele NKG2-F*02. Ref.1 Ref.2 Ref.3 Ref.4 Corresponds to variant rs1841958 [ dbSNP | Ensembl ].		VAR_013406
	Natural variant	104	1	N → S in allele NKG2-F*02. Ref.1 Ref.2 Ref.3 Ref.4 Corresponds to variant rs2617170 [ dbSNP | Ensembl ].		VAR_013407

Sequences

	Sequence		Length	Mass (Da)
	O43908 [UniParc]. Last modified January 11, 2011. Version 2. Checksum: 1AABC0E5ED26ACCC	FASTA	158	18,234
	10 20 30 40 50 60 MNKQRGTYSE VSLAQDPKRQ QRKLKGNKIS ISGTKQEIFQ VELNLQNASS DHQGNDKTYH 70 80 90 100 110 120 CKGLLPPPEK LTAEVLGIIC IVLMATVLKT IVLIPCIGVL EQNNFSLNRR MQKARHCGHC 130 140 150 PEEWITYSNS CYYIGKERRT WEERVCWPVL RRTLICFL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of NKG2-F, a new member of the NKG2 family of human natural killer cell receptor genes." Plougastel B., Trowsdale J. Eur. J. Immunol. 27:2835-2839(1997) [PubMed: 9394807] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANTS SER-29 AND SER-104.
[2]	"Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes." Plougastel B., Trowsdale J. Genomics 49:193-199(1998) [PubMed: 9598306] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-29 AND SER-104.
[3]	"The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex." Glienke J., Sobanov Y., Brostjan C., Steffens C., Nguyen C., Lehrach H., Hofer E., Francis F. Immunogenetics 48:163-173(1998) [PubMed: 9683661] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANTS SER-29 AND SER-104.
[4]	"Conservation and variation in human and common chimpanzee CD94 and NKG2 genes." Shum B.P., Flodin L.R., Muir D.G., Rajalingam R., Khakoo S.I., Cleland S., Guethlein L.A., Uhrberg M., Parham P. J. Immunol. 168:240-252(2002) [PubMed: 11751968] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS SER-29 AND SER-104.
[5]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed: 16541075] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U96846 Genomic DNA. Translation: AAC51910.1. U96845 mRNA. Translation: AAC51909.1. AF027164 Genomic DNA. Translation: AAC17491.1. AJ001683 mRNA. Translation: CAA04921.1. AJ001686 Genomic DNA. Translation: CAA04924.1. AF350018 mRNA. Translation: AAK83805.1. AF350019 mRNA. Translation: AAK83806.1. AC022075 Genomic DNA. No translation available. BC017784 mRNA. Translation: AAH17784.1.
IPI	IPI00307816.
RefSeq	NP_038459.1. NM_013431.2.
UniGene	Hs.721094.
3D structure databases
ProteinModelPortal	O43908.
SMR	O43908. Positions 72-97, 114-143.
ModBase	Search...
Protein-protein interaction databases
STRING	O43908.
Proteomic databases
PRIDE	O43908.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000309384; ENSP00000310216; ENSG00000183542.
GeneID	8302.
KEGG	hsa:8302.
UCSC	uc001qye.1. human.
Organism-specific databases
CTD	8302.
GeneCards	GC12M010559.
HGNC	HGNC:6377. KLRC4.
MIM	602893. gene.
neXtProt	NX_O43908.
PharmGKB	PA30166.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00600000084065.
HOVERGEN	HBG077044.
InParanoid	O43908.
OMA	ERVCWPV.
OrthoDB	EOG4R23W2.
Gene expression databases
ArrayExpress	O43908.
Bgee	O43908.
Genevestigator	O43908.
GermOnline	ENSG00000183542. Homo sapiens.
Family and domain databases
InterPro	IPR016186. C-type_lectin-like. IPR016187. C-type_lectin_fold. [Graphical view]
Gene3D	G3DSA:3.10.100.10. C-type_lectin-like. 1 hit.
KO	K06541.
SUPFAM	SSF56436. C-type_lectin_fold. 1 hit.
ProtoNet	Search...
Other
NextBio	31107.
SOURCE	Search...

Entry information

Entry name

NKG2F_HUMAN

Accession

Primary (citable) accession number: O43908
Secondary accession number(s): O60851

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2002
Last sequence update:	January 11, 2011
Last modified:	January 25, 2012
This is version 91 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.