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Protein

Growth arrest-specific protein 2

Gene

GAS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process (By similarity).By similarity

GO - Biological processi

  • apoptotic process Source: ProtInc
  • cell cycle arrest Source: UniProtKB-KW
  • regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Cell cycle, Cell shape, Growth arrest

Enzyme and pathway databases

BioCyciZFISH:ENSG00000148935-MONOMER.
ReactomeiR-HSA-264870. Caspase-mediated cleavage of cytoskeletal proteins.
SIGNORiO43903.

Names & Taxonomyi

Protein namesi
Recommended name:
Growth arrest-specific protein 2
Short name:
GAS-2
Gene namesi
Name:GAS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:4167. GAS2.

Subcellular locationi

  • Cytoplasmcytoskeleton By similarity
  • Membrane By similarity; Peripheral membrane protein By similarity

  • Note: Component of the microfilament system. Colocalizes with actin fibers at the cell border and along the stress fibers in growth-arrested fibroblasts. Mainly membrane-associated. When hyperphosphorylated, accumulates at membrane ruffles (By similarity).By similarity

GO - Cellular componenti

  • actin filament Source: ProtInc
  • cytosol Source: Reactome
  • membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2620.
OpenTargetsiENSG00000148935.
PharmGKBiPA28580.

Polymorphism and mutation databases

BioMutaiGAS2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001904401 – 313Growth arrest-specific protein 2Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei183PhosphoserineBy similarity1
Modified residuei187PhosphoserineCombined sources1

Post-translational modificationi

Cleaved, during apoptosis, on a specific aspartic residue by caspases.
Phosphorylated on serine residues during the G0-G1 transition phase.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei278 – 279Cleavage; by a caspase during apoptosis2

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO43903.
PaxDbiO43903.
PeptideAtlasiO43903.
PRIDEiO43903.

PTM databases

iPTMnetiO43903.
PhosphoSitePlusiO43903.

Miscellaneous databases

PMAP-CutDBO43903.

Expressioni

Tissue specificityi

Ubiquitously expressed with highest levels in liver, lung, and kidney. Not found in spleen.

Developmental stagei

Specifically expressed at growth arrest.

Gene expression databases

BgeeiENSG00000148935.
CleanExiHS_GAS2.
ExpressionAtlasiO43903. baseline and differential.
GenevisibleiO43903. HS.

Organism-specific databases

HPAiHPA058904.

Interactioni

Protein-protein interaction databases

BioGridi108890. 2 interactors.
MINTiMINT-200056.
STRINGi9606.ENSP00000278187.

Structurei

3D structure databases

ProteinModelPortaliO43903.
SMRiO43903.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 156CHPROSITE-ProRule annotationAdd BLAST123
Domaini197 – 270GARPROSITE-ProRule annotationAdd BLAST74

Sequence similaritiesi

Belongs to the GAS2 family.Curated
Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation
Contains 1 GAR domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IQBT. Eukaryota.
ENOG4111BF1. LUCA.
GeneTreeiENSGT00390000002205.
HOGENOMiHOG000007404.
HOVERGENiHBG005805.
InParanoidiO43903.
OMAiKFKESME.
OrthoDBiEOG091G0PJ6.
PhylomeDBiO43903.
TreeFamiTF323754.

Family and domain databases

CDDicd00014. CH. 1 hit.
Gene3Di1.10.418.10. 1 hit.
3.30.920.20. 1 hit.
InterProiIPR001715. CH-domain.
IPR029929. GAS2.
IPR003108. GAS_dom.
[Graphical view]
PANTHERiPTHR11915:SF298. PTHR11915:SF298. 1 hit.
PfamiPF00307. CH. 1 hit.
PF02187. GAS2. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 1 hit.
SM00243. GAS2. 1 hit.
[Graphical view]
SUPFAMiSSF143575. SSF143575. 1 hit.
SSF47576. SSF47576. 1 hit.
PROSITEiPS50021. CH. 1 hit.
PS51460. GAR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O43903-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCTALSPKVR SGPGLSDMHQ YSQWLASRHE ANLLPMKEDL ALWLTNLLGK
60 70 80 90 100
EITAETFMEK LDNGALLCQL AETMQEKFKE SMDANKPTKN LPLKKIPCKT
110 120 130 140 150
SAPSGSFFAR DNTANFLSWC RDLGVDETCL FESEGLVLHK QPREVCLCLL
160 170 180 190 200
ELGRIAARYG VEPPGLIKLE KEIEQEETLS APSPSPSPSS KSSGKKSTGN
210 220 230 240 250
LLDDAVKRIS EDPPCKCPNK FCVERLSQGR YRVGEKILFI RMLHNKHVMV
260 270 280 290 300
RVGGGWETFA GYLLKHDPCR MLQISRVDGK TSPIQSKSPT LKDMNPDNYL
310
VVSASYKAKK EIK
Length:313
Mass (Da):34,945
Last modified:June 1, 1998 - v1
Checksum:iA5FBA611A0C8B36F
GO
Isoform 2 (identifier: O43903-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     137-141: VLHKQ → GFGGQ
     142-313: Missing.

Note: No experimental confirmation available.
Show »
Length:141
Mass (Da):15,635
Checksum:i22C8443039AADADF
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055080137 – 141VLHKQ → GFGGQ in isoform 2. 1 Publication5
Alternative sequenceiVSP_055081142 – 313Missing in isoform 2. 1 PublicationAdd BLAST172

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95032 mRNA. Translation: AAC52058.1.
CR450285 mRNA. Translation: CAG29281.1.
AK313734 mRNA. Translation: BAG36475.1.
AC006299 Genomic DNA. No translation available.
AC103801 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68317.1.
CH471064 Genomic DNA. Translation: EAW68318.1.
BC013326 mRNA. Translation: AAH13326.1.
BC040470 mRNA. Translation: AAH40470.1.
CCDSiCCDS7858.1. [O43903-1]
RefSeqiNP_001137302.1. NM_001143830.1. [O43903-1]
NP_005247.1. NM_005256.3. [O43903-1]
NP_808221.1. NM_177553.2. [O43903-1]
XP_016873017.1. XM_017017528.1. [O43903-1]
XP_016873018.1. XM_017017529.1. [O43903-1]
XP_016873019.1. XM_017017530.1. [O43903-1]
XP_016873020.1. XM_017017531.1. [O43903-1]
UniGeneiHs.711297.

Genome annotation databases

EnsembliENST00000278187; ENSP00000278187; ENSG00000148935. [O43903-1]
ENST00000454584; ENSP00000401145; ENSG00000148935. [O43903-1]
ENST00000524701; ENSP00000432026; ENSG00000148935. [O43903-2]
ENST00000630668; ENSP00000485708; ENSG00000148935. [O43903-2]
GeneIDi2620.
KEGGihsa:2620.
UCSCiuc001mqm.4. human. [O43903-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95032 mRNA. Translation: AAC52058.1.
CR450285 mRNA. Translation: CAG29281.1.
AK313734 mRNA. Translation: BAG36475.1.
AC006299 Genomic DNA. No translation available.
AC103801 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68317.1.
CH471064 Genomic DNA. Translation: EAW68318.1.
BC013326 mRNA. Translation: AAH13326.1.
BC040470 mRNA. Translation: AAH40470.1.
CCDSiCCDS7858.1. [O43903-1]
RefSeqiNP_001137302.1. NM_001143830.1. [O43903-1]
NP_005247.1. NM_005256.3. [O43903-1]
NP_808221.1. NM_177553.2. [O43903-1]
XP_016873017.1. XM_017017528.1. [O43903-1]
XP_016873018.1. XM_017017529.1. [O43903-1]
XP_016873019.1. XM_017017530.1. [O43903-1]
XP_016873020.1. XM_017017531.1. [O43903-1]
UniGeneiHs.711297.

3D structure databases

ProteinModelPortaliO43903.
SMRiO43903.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108890. 2 interactors.
MINTiMINT-200056.
STRINGi9606.ENSP00000278187.

PTM databases

iPTMnetiO43903.
PhosphoSitePlusiO43903.

Polymorphism and mutation databases

BioMutaiGAS2.

Proteomic databases

MaxQBiO43903.
PaxDbiO43903.
PeptideAtlasiO43903.
PRIDEiO43903.

Protocols and materials databases

DNASUi2620.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278187; ENSP00000278187; ENSG00000148935. [O43903-1]
ENST00000454584; ENSP00000401145; ENSG00000148935. [O43903-1]
ENST00000524701; ENSP00000432026; ENSG00000148935. [O43903-2]
ENST00000630668; ENSP00000485708; ENSG00000148935. [O43903-2]
GeneIDi2620.
KEGGihsa:2620.
UCSCiuc001mqm.4. human. [O43903-1]

Organism-specific databases

CTDi2620.
DisGeNETi2620.
GeneCardsiGAS2.
HGNCiHGNC:4167. GAS2.
HPAiHPA058904.
MIMi602835. gene.
neXtProtiNX_O43903.
OpenTargetsiENSG00000148935.
PharmGKBiPA28580.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQBT. Eukaryota.
ENOG4111BF1. LUCA.
GeneTreeiENSGT00390000002205.
HOGENOMiHOG000007404.
HOVERGENiHBG005805.
InParanoidiO43903.
OMAiKFKESME.
OrthoDBiEOG091G0PJ6.
PhylomeDBiO43903.
TreeFamiTF323754.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000148935-MONOMER.
ReactomeiR-HSA-264870. Caspase-mediated cleavage of cytoskeletal proteins.
SIGNORiO43903.

Miscellaneous databases

GeneWikiiGAS2.
GenomeRNAii2620.
PMAP-CutDBO43903.
PROiO43903.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000148935.
CleanExiHS_GAS2.
ExpressionAtlasiO43903. baseline and differential.
GenevisibleiO43903. HS.

Family and domain databases

CDDicd00014. CH. 1 hit.
Gene3Di1.10.418.10. 1 hit.
3.30.920.20. 1 hit.
InterProiIPR001715. CH-domain.
IPR029929. GAS2.
IPR003108. GAS_dom.
[Graphical view]
PANTHERiPTHR11915:SF298. PTHR11915:SF298. 1 hit.
PfamiPF00307. CH. 1 hit.
PF02187. GAS2. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 1 hit.
SM00243. GAS2. 1 hit.
[Graphical view]
SUPFAMiSSF143575. SSF143575. 1 hit.
SSF47576. SSF47576. 1 hit.
PROSITEiPS50021. CH. 1 hit.
PS51460. GAR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGAS2_HUMAN
AccessioniPrimary (citable) accession number: O43903
Secondary accession number(s): B2R9C8
, D3DQZ0, Q6ICV8, Q7Z3X8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.