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O43900 (PRIC3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Prickle-like protein 3
Alternative name(s):
LIM domain only protein 6
Short name=LMO-6
Triple LIM domain protein 6
Gene names
Name:PRICKLE3
Synonyms:LMO6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length615 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Tissue specificity

Widely expressed.

Sequence similarities

Belongs to the prickle / espinas / testin family.

Contains 3 LIM zinc-binding domains.

Contains 1 PET domain.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainLIM domain
Repeat
   LigandMetal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionzinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 615615Prickle-like protein 3
PRO_0000075822

Regions

Domain74 – 182109PET
Domain184 – 24966LIM zinc-binding 1
Domain250 – 30960LIM zinc-binding 2
Domain310 – 37364LIM zinc-binding 3
Compositional bias150 – 1534Poly-Glu
Compositional bias513 – 52210Poly-His
Compositional bias544 – 55714Poly-Ser

Natural variations

Natural variant3431R → C.
Corresponds to variant rs7065449 [ dbSNP | Ensembl ].
VAR_050169
Natural variant5581E → D in a breast cancer sample; somatic mutation. Ref.7
VAR_036188

Experimental info

Sequence conflict1851I → S in AAB92357. Ref.5
Sequence conflict370 – 509140Missing in AAB92357. Ref.5

Sequences

Sequence LengthMass (Da)Tools
O43900 [UniParc].

Last modified August 2, 2002. Version 2.
Checksum: CD024365C072B052

FASTA61568,609
        10         20         30         40         50         60 
MFARGSRRRR SGRAPPEAED PDRGQPCNSC REQCPGFLLH GWRKICQHCK CPREEHAVHA 

        70         80         90        100        110        120 
VPVDLERIMC RLISDFQRHS ISDDDSGCAS EEYAWVPPGL KPEQVYQFFS CLPEDKVPYV 

       130        140        150        160        170        180 
NSPGEKYRIK QLLHQLPPHD SEAQYCTALE EEEKKELRAF SQQRKRENLG RGIVRIFPVT 

       190        200        210        220        230        240 
ITGAICEECG KQIGGGDIAV FASRAGLGAC WHPQCFVCTT CQELLVDLIY FYHVGKVYCG 

       250        260        270        280        290        300 
RHHAECLRPR CQACDEIIFS PECTEAEGRH WHMDHFCCFE CEASLGGQRY VMRQSRPHCC 

       310        320        330        340        350        360 
ACYEARHAEY CDGCGEHIGL DQGQMAYEGQ HWHASDRCFC CSRCGRALLG RPFLPRRGLI 

       370        380        390        400        410        420 
FCSRACSLGS EPTAPGPSRR SWSAGPVTAP LAASTASFSA VKGASETTTK GTSTELAPAT 

       430        440        450        460        470        480 
GPEEPSRFLR GAPHRHSMPE LGLRSVPEPP PESPGQPNLR PDDSAFGRQS TPRVSFRDPL 

       490        500        510        520        530        540 
VSEGGPRRTL SAPPAQRRRP RSPPPRAPSR RRHHHHNHHH HHNRHPSRRR HYQCDAGSGS 

       550        560        570        580        590        600 
DSESCSSSPS SSSSESSEDD GFFLGERIPL PPHLCRPMPA QDTAMETFNS PSLSLPRDSR 

       610 
AGMPRQARDK NCIVA 

« Hide

References

« Hide 'large scale' references
[1]"Transcription map in Xp11.23."
Strom T.M., Gutwillinger N., Nyakatura G., Hellebrand H., Drescher B., Rosenthal A., Meindl A.
Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart.
[2]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon and Kidney.
[5]"Sequence-based exon prediction around the synaptophysin locus reveals a gene-rich area containing novel genes in human proximal Xp."
Fisher S.E., Ciccodicola A., Tanaka K., Curci A., Desicato S., D'Urso M., Craig I.W.
Genomics 45:340-347(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-615.
[6]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-558.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ011654 mRNA. Translation: CAA09726.1.
BT007423 mRNA. Translation: AAP36091.1.
CH471224 Genomic DNA. Translation: EAW50686.1.
BC002468 mRNA. Translation: AAH02468.1.
BC016856 mRNA. Translation: AAH16856.1.
U93305 Genomic DNA. Translation: AAB92357.1.
RefSeqNP_006141.2. NM_006150.3.
UniGeneHs.732712.

3D structure databases

ProteinModelPortalO43900.
SMRO43900. Positions 183-366.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110192. 4 interactions.
IntActO43900. 10 interactions.
MINTMINT-6772012.
STRING9606.ENSP00000365494.

PTM databases

PhosphoSiteO43900.

Proteomic databases

PaxDbO43900.
PRIDEO43900.

Protocols and materials databases

DNASU4007.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000376317; ENSP00000365494; ENSG00000012211.
GeneID4007.
KEGGhsa:4007.
UCSCuc004dmy.1. human.

Organism-specific databases

CTD4007.
GeneCardsGC0XM049031.
HGNCHGNC:6645. PRICKLE3.
HPAHPA000998.
HPA001442.
MIM300111. gene.
neXtProtNX_O43900.
PharmGKBPA162400060.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG314122.
HOGENOMHOG000115694.
HOVERGENHBG106338.
InParanoidO43900.
OMAQCFVCST.
OrthoDBEOG7P8P7M.
PhylomeDBO43900.
TreeFamTF313265.

Enzyme and pathway databases

SignaLinkO43900.

Gene expression databases

ArrayExpressO43900.
BgeeO43900.
CleanExHS_PRICKLE3.
GenevestigatorO43900.

Family and domain databases

Gene3D2.10.110.10. 3 hits.
InterProIPR010442. PET_domain.
IPR001781. Znf_LIM.
[Graphical view]
PfamPF00412. LIM. 3 hits.
PF06297. PET. 1 hit.
[Graphical view]
SMARTSM00132. LIM. 3 hits.
[Graphical view]
PROSITEPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 3 hits.
PS51303. PET. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi4007.
NextBio15716.
PROO43900.
SOURCESearch...

Entry information

Entry namePRIC3_HUMAN
AccessionPrimary (citable) accession number: O43900
Secondary accession number(s): O76007, Q53XR5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 2, 2002
Last modified: March 19, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM