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O43900

- PRIC3_HUMAN

UniProt

O43900 - PRIC3_HUMAN

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Protein
Prickle-like protein 3
Gene
PRICKLE3, LMO6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkiO43900.

Names & Taxonomyi

Protein namesi
Recommended name:
Prickle-like protein 3
Alternative name(s):
LIM domain only protein 6
Short name:
LMO-6
Triple LIM domain protein 6
Gene namesi
Synonyms:LMO6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:6645. PRICKLE3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162400060.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 615615Prickle-like protein 3
PRO_0000075822Add
BLAST

Proteomic databases

MaxQBiO43900.
PaxDbiO43900.
PRIDEiO43900.

PTM databases

PhosphoSiteiO43900.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

ArrayExpressiO43900.
BgeeiO43900.
CleanExiHS_PRICKLE3.
GenevestigatoriO43900.

Organism-specific databases

HPAiHPA000998.
HPA001442.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ABL1P005192EBI-1751761,EBI-375543
FYNP062412EBI-1751761,EBI-515315

Protein-protein interaction databases

BioGridi110192. 4 interactions.
IntActiO43900. 10 interactions.
MINTiMINT-6772012.
STRINGi9606.ENSP00000365494.

Structurei

3D structure databases

ProteinModelPortaliO43900.
SMRiO43900. Positions 182-366.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini74 – 182109PET
Add
BLAST
Domaini184 – 24966LIM zinc-binding 1
Add
BLAST
Domaini250 – 30960LIM zinc-binding 2
Add
BLAST
Domaini310 – 37364LIM zinc-binding 3
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi150 – 1534Poly-Glu
Compositional biasi513 – 52210Poly-His
Compositional biasi544 – 55714Poly-Ser
Add
BLAST

Sequence similaritiesi

Contains 1 PET domain.

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiNOG314122.
HOGENOMiHOG000115694.
HOVERGENiHBG106338.
InParanoidiO43900.
OMAiQCFVCST.
OrthoDBiEOG7P8P7M.
PhylomeDBiO43900.
TreeFamiTF313265.

Family and domain databases

Gene3Di2.10.110.10. 3 hits.
InterProiIPR010442. PET_domain.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 3 hits.
PF06297. PET. 1 hit.
[Graphical view]
SMARTiSM00132. LIM. 3 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 3 hits.
PS51303. PET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43900-1 [UniParc]FASTAAdd to Basket

« Hide

MFARGSRRRR SGRAPPEAED PDRGQPCNSC REQCPGFLLH GWRKICQHCK    50
CPREEHAVHA VPVDLERIMC RLISDFQRHS ISDDDSGCAS EEYAWVPPGL 100
KPEQVYQFFS CLPEDKVPYV NSPGEKYRIK QLLHQLPPHD SEAQYCTALE 150
EEEKKELRAF SQQRKRENLG RGIVRIFPVT ITGAICEECG KQIGGGDIAV 200
FASRAGLGAC WHPQCFVCTT CQELLVDLIY FYHVGKVYCG RHHAECLRPR 250
CQACDEIIFS PECTEAEGRH WHMDHFCCFE CEASLGGQRY VMRQSRPHCC 300
ACYEARHAEY CDGCGEHIGL DQGQMAYEGQ HWHASDRCFC CSRCGRALLG 350
RPFLPRRGLI FCSRACSLGS EPTAPGPSRR SWSAGPVTAP LAASTASFSA 400
VKGASETTTK GTSTELAPAT GPEEPSRFLR GAPHRHSMPE LGLRSVPEPP 450
PESPGQPNLR PDDSAFGRQS TPRVSFRDPL VSEGGPRRTL SAPPAQRRRP 500
RSPPPRAPSR RRHHHHNHHH HHNRHPSRRR HYQCDAGSGS DSESCSSSPS 550
SSSSESSEDD GFFLGERIPL PPHLCRPMPA QDTAMETFNS PSLSLPRDSR 600
AGMPRQARDK NCIVA 615
Length:615
Mass (Da):68,609
Last modified:August 2, 2002 - v2
Checksum:iCD024365C072B052
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti343 – 3431R → C.
Corresponds to variant rs7065449 [ dbSNP | Ensembl ].
VAR_050169
Natural varianti558 – 5581E → D in a breast cancer sample; somatic mutation. 1 Publication
VAR_036188

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti185 – 1851I → S in AAB92357. 1 Publication
Sequence conflicti370 – 509140Missing in AAB92357. 1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ011654 mRNA. Translation: CAA09726.1.
BT007423 mRNA. Translation: AAP36091.1.
CH471224 Genomic DNA. Translation: EAW50686.1.
BC002468 mRNA. Translation: AAH02468.1.
BC016856 mRNA. Translation: AAH16856.1.
U93305 Genomic DNA. Translation: AAB92357.1.
CCDSiCCDS14320.1.
RefSeqiNP_006141.2. NM_006150.3.
UniGeneiHs.732712.

Genome annotation databases

EnsembliENST00000376317; ENSP00000365494; ENSG00000012211.
GeneIDi4007.
KEGGihsa:4007.
UCSCiuc004dmy.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ011654 mRNA. Translation: CAA09726.1 .
BT007423 mRNA. Translation: AAP36091.1 .
CH471224 Genomic DNA. Translation: EAW50686.1 .
BC002468 mRNA. Translation: AAH02468.1 .
BC016856 mRNA. Translation: AAH16856.1 .
U93305 Genomic DNA. Translation: AAB92357.1 .
CCDSi CCDS14320.1.
RefSeqi NP_006141.2. NM_006150.3.
UniGenei Hs.732712.

3D structure databases

ProteinModelPortali O43900.
SMRi O43900. Positions 182-366.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110192. 4 interactions.
IntActi O43900. 10 interactions.
MINTi MINT-6772012.
STRINGi 9606.ENSP00000365494.

PTM databases

PhosphoSitei O43900.

Proteomic databases

MaxQBi O43900.
PaxDbi O43900.
PRIDEi O43900.

Protocols and materials databases

DNASUi 4007.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000376317 ; ENSP00000365494 ; ENSG00000012211 .
GeneIDi 4007.
KEGGi hsa:4007.
UCSCi uc004dmy.1. human.

Organism-specific databases

CTDi 4007.
GeneCardsi GC0XM049031.
HGNCi HGNC:6645. PRICKLE3.
HPAi HPA000998.
HPA001442.
MIMi 300111. gene.
neXtProti NX_O43900.
PharmGKBi PA162400060.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG314122.
HOGENOMi HOG000115694.
HOVERGENi HBG106338.
InParanoidi O43900.
OMAi QCFVCST.
OrthoDBi EOG7P8P7M.
PhylomeDBi O43900.
TreeFami TF313265.

Enzyme and pathway databases

SignaLinki O43900.

Miscellaneous databases

GenomeRNAii 4007.
NextBioi 15716.
PROi O43900.
SOURCEi Search...

Gene expression databases

ArrayExpressi O43900.
Bgeei O43900.
CleanExi HS_PRICKLE3.
Genevestigatori O43900.

Family and domain databases

Gene3Di 2.10.110.10. 3 hits.
InterProi IPR010442. PET_domain.
IPR001781. Znf_LIM.
[Graphical view ]
Pfami PF00412. LIM. 3 hits.
PF06297. PET. 1 hit.
[Graphical view ]
SMARTi SM00132. LIM. 3 hits.
[Graphical view ]
PROSITEi PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 3 hits.
PS51303. PET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Transcription map in Xp11.23."
    Strom T.M., Gutwillinger N., Nyakatura G., Hellebrand H., Drescher B., Rosenthal A., Meindl A.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon and Kidney.
  5. "Sequence-based exon prediction around the synaptophysin locus reveals a gene-rich area containing novel genes in human proximal Xp."
    Fisher S.E., Ciccodicola A., Tanaka K., Curci A., Desicato S., D'Urso M., Craig I.W.
    Genomics 45:340-347(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-615.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-558.

Entry informationi

Entry nameiPRIC3_HUMAN
AccessioniPrimary (citable) accession number: O43900
Secondary accession number(s): O76007, Q53XR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 2, 2002
Last modified: July 9, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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