Prickle-like protein 3 - Homo sapiens (Human)

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O43900 (PRIC3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 116. History...

Clusters with 100%, 90%, 50% identity |

Documents (5) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Prickle-like protein 3

Alternative name(s):
LIM domain only protein 6
Short name=LMO-6
Triple LIM domain protein 6

Gene names

Name:	PRICKLE3
Synonyms:	LMO6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	615 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Tissue specificity

Widely expressed.

Sequence similarities

Belongs to the prickle / espinas / testin family.

Contains 3 LIM zinc-binding domains.

Contains 1 PET domain.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	LIM domain Repeat
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ABL1	P00519	2	EBI-1751761,EBI-375543
FYN	P06241	2	EBI-1751761,EBI-515315

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 615

615

Prickle-like protein 3

PRO_0000075822

Regions

Domain

74 – 182

109

PET

Domain

184 – 249

LIM zinc-binding 1

Domain

250 – 309

LIM zinc-binding 2

Domain

310 – 373

LIM zinc-binding 3

Compositional bias

150 – 153

Poly-Glu

Compositional bias

513 – 522

Poly-His

Compositional bias

544 – 557

Poly-Ser

Natural variations

Natural variant

343

R → C.
Corresponds to variant rs7065449 [ dbSNP | Ensembl ].

VAR_050169

Natural variant

558

E → D in a breast cancer sample; somatic mutation. Ref.7

VAR_036188

Experimental info

Sequence conflict

185

I → S in AAB92357. Ref.5

Sequence conflict

370 – 509

140

Missing in AAB92357. Ref.5

Sequences

Sequence

Length

Mass (Da)

Tools

O43900 [UniParc].

Last modified August 2, 2002. Version 2.
Checksum: CD024365C072B052
Show »

FASTA

615

68,609

        10         20         30         40         50         60 
MFARGSRRRR SGRAPPEAED PDRGQPCNSC REQCPGFLLH GWRKICQHCK CPREEHAVHA 

        70         80         90        100        110        120 
VPVDLERIMC RLISDFQRHS ISDDDSGCAS EEYAWVPPGL KPEQVYQFFS CLPEDKVPYV 

       130        140        150        160        170        180 
NSPGEKYRIK QLLHQLPPHD SEAQYCTALE EEEKKELRAF SQQRKRENLG RGIVRIFPVT 

       190        200        210        220        230        240 
ITGAICEECG KQIGGGDIAV FASRAGLGAC WHPQCFVCTT CQELLVDLIY FYHVGKVYCG 

       250        260        270        280        290        300 
RHHAECLRPR CQACDEIIFS PECTEAEGRH WHMDHFCCFE CEASLGGQRY VMRQSRPHCC 

       310        320        330        340        350        360 
ACYEARHAEY CDGCGEHIGL DQGQMAYEGQ HWHASDRCFC CSRCGRALLG RPFLPRRGLI 

       370        380        390        400        410        420 
FCSRACSLGS EPTAPGPSRR SWSAGPVTAP LAASTASFSA VKGASETTTK GTSTELAPAT 

       430        440        450        460        470        480 
GPEEPSRFLR GAPHRHSMPE LGLRSVPEPP PESPGQPNLR PDDSAFGRQS TPRVSFRDPL 

       490        500        510        520        530        540 
VSEGGPRRTL SAPPAQRRRP RSPPPRAPSR RRHHHHNHHH HHNRHPSRRR HYQCDAGSGS 

       550        560        570        580        590        600 
DSESCSSSPS SSSSESSEDD GFFLGERIPL PPHLCRPMPA QDTAMETFNS PSLSLPRDSR 

       610 
AGMPRQARDK NCIVA

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Transcription map in Xp11.23." Strom T.M., Gutwillinger N., Nyakatura G., Hellebrand H., Drescher B., Rosenthal A., Meindl A. Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart.
[2]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon and Kidney.
[5]	"Sequence-based exon prediction around the synaptophysin locus reveals a gene-rich area containing novel genes in human proximal Xp." Fisher S.E., Ciccodicola A., Tanaka K., Curci A., Desicato S., D'Urso M., Craig I.W. Genomics 45:340-347(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-615.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[7]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-558.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ011654 mRNA. Translation: CAA09726.1. BT007423 mRNA. Translation: AAP36091.1. CH471224 Genomic DNA. Translation: EAW50686.1. BC002468 mRNA. Translation: AAH02468.1. BC016856 mRNA. Translation: AAH16856.1. U93305 Genomic DNA. Translation: AAB92357.1.
IPI	IPI00015129.
RefSeq	NP_006141.2. NM_006150.3.
UniGene	Hs.732712.
3D structure databases
ProteinModelPortal	O43900.
ModBase	Search...
Protein-protein interaction databases
IntAct	O43900. 8 interactions.
MINT	MINT-6772012.
STRING	9606.ENSP00000365494.
PTM databases
PhosphoSite	O43900.
Proteomic databases
PaxDb	O43900.
PRIDE	O43900.
Protocols and materials databases
DNASU	4007.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000376317; ENSP00000365494; ENSG00000012211.
GeneID	4007.
KEGG	hsa:4007.
UCSC	uc004dmy.1. human.
Organism-specific databases
CTD	4007.
GeneCards	GC0XM049031.
HGNC	HGNC:6645. PRICKLE3.
HPA	HPA000998.
MIM	300111. gene.
neXtProt	NX_O43900.
PharmGKB	PA162400060.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG314122.
HOGENOM	HOG000115694.
HOVERGEN	HBG106338.
InParanoid	O43900.
OrthoDB	EOG47H5Q3.
PhylomeDB	O43900.
Gene expression databases
ArrayExpress	O43900.
Bgee	O43900.
CleanEx	HS_PRICKLE3.
Genevestigator	O43900.
GermOnline	ENSG00000012211. Homo sapiens.
Family and domain databases
Gene3D	2.10.110.10. 3 hits.
InterPro	IPR010442. PET_domain. IPR001781. Znf_LIM. [Graphical view]
Pfam	PF00412. LIM. 3 hits. PF06297. PET. 1 hit. [Graphical view]
SMART	SM00132. LIM. 3 hits. [Graphical view]
PROSITE	PS00478. LIM_DOMAIN_1. 2 hits. PS50023. LIM_DOMAIN_2. 3 hits. PS51303. PET. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	4007.
NextBio	15716.
SOURCE	Search...

Entry information

Entry name

PRIC3_HUMAN

Accession

Primary (citable) accession number: O43900
Secondary accession number(s): O76007, Q53XR5

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	August 2, 2002
Last modified:	May 1, 2013
This is version 116 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents