Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O43897

- TLL1_HUMAN

UniProt

O43897 - TLL1_HUMAN

Protein

Tolloid-like protein 1

Gene

TLL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi240 – 2401Zinc; catalyticPROSITE-ProRule annotation
    Active sitei241 – 2411PROSITE-ProRule annotation
    Metal bindingi244 – 2441Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi250 – 2501Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. metalloendopeptidase activity Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. extracellular matrix disassembly Source: Reactome
    3. extracellular matrix organization Source: Reactome
    4. skeletal system development Source: ProtInc

    Keywords - Molecular functioni

    Developmental protein, Hydrolase, Metalloprotease, Protease

    Keywords - Biological processi

    Differentiation

    Keywords - Ligandi

    Calcium, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_118572. Degradation of the extracellular matrix.
    REACT_121139. Collagen biosynthesis and modifying enzymes.
    REACT_150206. Crosslinking of collagen fibrils.
    REACT_150268. Anchoring fibril formation.

    Protein family/group databases

    MEROPSiM12.016.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tolloid-like protein 1 (EC:3.4.24.-)
    Gene namesi
    Name:TLL1
    Synonyms:TLL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:11843. TLL1.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: Reactome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Atrial septal defect 6 (ASD6) [MIM:613087]: A congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti182 – 1821M → L in ASD6. 1 Publication
    VAR_062519
    Natural varianti238 – 2381V → A in ASD6. 1 Publication
    VAR_062520
    Natural varianti629 – 6291I → V in ASD6. 1 Publication
    VAR_062521

    Keywords - Diseasei

    Atrial septal defect, Disease mutation

    Organism-specific databases

    MIMi613087. phenotype.
    Orphaneti99106. Atrial septal defect, ostium primum type.
    99103. Atrial septal defect, ostium secundum type.
    PharmGKBiPA36545.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Propeptidei31 – 147117Sequence AnalysisPRO_0000046023Add
    BLAST
    Chaini148 – 1013866Tolloid-like protein 1PRO_0000046024Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi190 ↔ 3461 Publication
    Disulfide bondi210 ↔ 232By similarity
    Disulfide bondi212 ↔ 213By similarity
    Disulfide bondi349 ↔ 375By similarity
    Glycosylationi359 – 3591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi390 – 3901N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi402 ↔ 424By similarity
    Disulfide bondi462 ↔ 488By similarity
    Disulfide bondi515 ↔ 537By similarity
    Disulfide bondi578 ↔ 590By similarity
    Disulfide bondi586 ↔ 599By similarity
    Disulfide bondi601 ↔ 614By similarity
    Disulfide bondi618 ↔ 644By similarity
    Glycosylationi626 – 6261N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi671 ↔ 693By similarity
    Disulfide bondi734 ↔ 745By similarity
    Disulfide bondi741 ↔ 754By similarity
    Disulfide bondi756 ↔ 769By similarity
    Disulfide bondi774 ↔ 800By similarity
    Disulfide bondi827 ↔ 849By similarity
    Disulfide bondi887 ↔ 917By similarity
    Disulfide bondi944 ↔ 966By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    MaxQBiO43897.
    PaxDbiO43897.
    PRIDEiO43897.

    PTM databases

    PhosphoSiteiO43897.

    Expressioni

    Gene expression databases

    ArrayExpressiO43897.
    BgeeiO43897.
    CleanExiHS_TLL1.
    GenevestigatoriO43897.

    Interactioni

    Protein-protein interaction databases

    BioGridi112947. 2 interactions.
    STRINGi9606.ENSP00000061240.

    Structurei

    Secondary structure

    1
    1013
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi153 – 1553
    Helixi158 – 1603
    Beta strandi161 – 1666
    Helixi172 – 18817
    Beta strandi192 – 1954
    Beta strandi203 – 2064
    Beta strandi224 – 2274
    Helixi235 – 24612
    Helixi251 – 2533
    Helixi257 – 2593
    Beta strandi261 – 2633
    Helixi265 – 2673
    Helixi273 – 2764
    Helixi281 – 2833
    Turni301 – 3044
    Beta strandi305 – 3073
    Beta strandi312 – 3154
    Helixi334 – 34310

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3EDIX-ray1.40A148-348[»]
    ProteinModelPortaliO43897.
    SMRiO43897. Positions 148-1001.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO43897.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini349 – 461113CUB 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini462 – 574113CUB 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini574 – 61542EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini618 – 730113CUB 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini730 – 77041EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini774 – 886113CUB 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini887 – 1003117CUB 5PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni148 – 348201MetalloproteaseBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase M12A family.Curated
    Contains 5 CUB domains.PROSITE-ProRule annotation
    Contains 2 EGF-like domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG70307.
    HOGENOMiHOG000236339.
    HOVERGENiHBG004859.
    InParanoidiO43897.
    KOiK09608.
    OrthoDBiEOG7N8ZTV.
    PhylomeDBiO43897.
    TreeFamiTF314351.

    Family and domain databases

    Gene3Di2.60.120.290. 5 hits.
    3.40.390.10. 1 hit.
    InterProiIPR015446. BMP_1/tolloid-like.
    IPR000859. CUB_dom.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR024079. MetalloPept_cat_dom.
    IPR001506. Peptidase_M12A.
    IPR006026. Peptidase_Metallo.
    [Graphical view]
    PfamiPF01400. Astacin. 1 hit.
    PF00431. CUB. 5 hits.
    [Graphical view]
    PIRSFiPIRSF001199. BMP_1/tolloid-like. 1 hit.
    PRINTSiPR00480. ASTACIN.
    SMARTiSM00042. CUB. 5 hits.
    SM00179. EGF_CA. 2 hits.
    SM00235. ZnMc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49854. SSF49854. 5 hits.
    PROSITEiPS01180. CUB. 5 hits.
    PS01186. EGF_2. 2 hits.
    PS50026. EGF_3. 2 hits.
    PS01187. EGF_CA. 2 hits.
    PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O43897-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGLGTLSPRM LVWLVASGIV FYGELWVCAG LDYDYTFDGN EEDKTETIDY     50
    KDPCKAAVFW GDIALDDEDL NIFQIDRTID LTQNPFGNLG HTTGGLGDHA 100
    MSKKRGALYQ LIDRIRRIGF GLEQNNTVKG KVPLQFSGQN EKNRVPRAAT 150
    SRTERIWPGG VIPYVIGGNF TGSQRAMFKQ AMRHWEKHTC VTFIERSDEE 200
    SYIVFTYRPC GCCSYVGRRG NGPQAISIGK NCDKFGIVVH ELGHVIGFWH 250
    EHTRPDRDNH VTIIRENIQP GQEYNFLKME PGEVNSLGER YDFDSIMHYA 300
    RNTFSRGMFL DTILPSRDDN GIRPAIGQRT RLSKGDIAQA RKLYRCPACG 350
    ETLQESNGNL SSPGFPNGYP SYTHCIWRVS VTPGEKIVLN FTTMDLYKSS 400
    LCWYDYIEVR DGYWRKSPLL GRFCGDKLPE VLTSTDSRMW IEFRSSSNWV 450
    GKGFAAVYEA ICGGEIRKNE GQIQSPNYPD DYRPMKECVW KITVSESYHV 500
    GLTFQSFEIE RHDNCAYDYL EVRDGTSENS PLIGRFCGYD KPEDIRSTSN 550
    TLWMKFVSDG TVNKAGFAAN FFKEEDECAK PDRGGCEQRC LNTLGSYQCA 600
    CEPGYELGPD RRSCEAACGG LLTKLNGTIT TPGWPKEYPP NKNCVWQVVA 650
    PTQYRISVKF EFFELEGNEV CKYDYVEIWS GLSSESKLHG KFCGAEVPEV 700
    ITSQFNNMRI EFKSDNTVSK KGFKAHFFSD KDECSKDNGG CQHECVNTMG 750
    SYMCQCRNGF VLHDNKHDCK EAECEQKIHS PSGLITSPNW PDKYPSRKEC 800
    TWEISATPGH RIKLAFSEFE IEQHQECAYD HLEVFDGETE KSPILGRLCG 850
    NKIPDPLVAT GNKMFVRFVS DASVQRKGFQ ATHSTECGGR LKAESKPRDL 900
    YSHAQFGDNN YPGQVDCEWL LVSERGSRLE LSFQTFEVEE EADCGYDYVE 950
    LFDGLDSTAV GLGRFCGSGP PEEIYSIGDS VLIHFHTDDT INKKGFHIRY 1000
    KSIRYPDTTH TKK 1013
    Length:1,013
    Mass (Da):114,709
    Last modified:June 1, 1998 - v1
    Checksum:i0FDDB6E8E9032DCC
    GO
    Isoform 2 (identifier: O43897-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         387-392: IVLNFT → VVFSLC
         393-1013: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:392
    Mass (Da):44,186
    Checksum:iB240EB78AD353BFE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti156 – 1561I → V in AAF86287. 1 PublicationCurated
    Sequence conflicti221 – 2211N → S in AAF86287. 1 PublicationCurated
    Sequence conflicti284 – 2841V → A in AAF86287. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti182 – 1821M → L in ASD6. 1 Publication
    VAR_062519
    Natural varianti238 – 2381V → A in ASD6. 1 Publication
    VAR_062520
    Natural varianti629 – 6291I → V in ASD6. 1 Publication
    VAR_062521
    Natural varianti688 – 6881L → V in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036142
    Natural varianti958 – 9581T → A.
    Corresponds to variant rs2291822 [ dbSNP | Ensembl ].
    VAR_051585

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei387 – 3926IVLNFT → VVFSLC in isoform 2. 1 PublicationVSP_017197
    Alternative sequencei393 – 1013621Missing in isoform 2. 1 PublicationVSP_017198Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U91963 mRNA. Translation: AAB93878.1.
    AF282732 mRNA. Translation: AAF86287.1.
    CH471056 Genomic DNA. Translation: EAX04813.1.
    BC016922 mRNA. Translation: AAH16922.1.
    BC136429 mRNA. Translation: AAI36430.1.
    BC136430 mRNA. Translation: AAI36431.1.
    CCDSiCCDS3811.1. [O43897-1]
    CCDS56342.1. [O43897-2]
    RefSeqiNP_001191689.1. NM_001204760.1. [O43897-2]
    NP_036596.3. NM_012464.4. [O43897-1]
    UniGeneiHs.106513.

    Genome annotation databases

    EnsembliENST00000061240; ENSP00000061240; ENSG00000038295. [O43897-1]
    ENST00000513213; ENSP00000422937; ENSG00000038295. [O43897-2]
    GeneIDi7092.
    KEGGihsa:7092.
    UCSCiuc003irh.2. human. [O43897-1]
    uc021xud.1. human. [O43897-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U91963 mRNA. Translation: AAB93878.1 .
    AF282732 mRNA. Translation: AAF86287.1 .
    CH471056 Genomic DNA. Translation: EAX04813.1 .
    BC016922 mRNA. Translation: AAH16922.1 .
    BC136429 mRNA. Translation: AAI36430.1 .
    BC136430 mRNA. Translation: AAI36431.1 .
    CCDSi CCDS3811.1. [O43897-1 ]
    CCDS56342.1. [O43897-2 ]
    RefSeqi NP_001191689.1. NM_001204760.1. [O43897-2 ]
    NP_036596.3. NM_012464.4. [O43897-1 ]
    UniGenei Hs.106513.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3EDI X-ray 1.40 A 148-348 [» ]
    ProteinModelPortali O43897.
    SMRi O43897. Positions 148-1001.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112947. 2 interactions.
    STRINGi 9606.ENSP00000061240.

    Protein family/group databases

    MEROPSi M12.016.

    PTM databases

    PhosphoSitei O43897.

    Proteomic databases

    MaxQBi O43897.
    PaxDbi O43897.
    PRIDEi O43897.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000061240 ; ENSP00000061240 ; ENSG00000038295 . [O43897-1 ]
    ENST00000513213 ; ENSP00000422937 ; ENSG00000038295 . [O43897-2 ]
    GeneIDi 7092.
    KEGGi hsa:7092.
    UCSCi uc003irh.2. human. [O43897-1 ]
    uc021xud.1. human. [O43897-2 ]

    Organism-specific databases

    CTDi 7092.
    GeneCardsi GC04P166794.
    HGNCi HGNC:11843. TLL1.
    MIMi 606742. gene.
    613087. phenotype.
    neXtProti NX_O43897.
    Orphaneti 99106. Atrial septal defect, ostium primum type.
    99103. Atrial septal defect, ostium secundum type.
    PharmGKBi PA36545.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG70307.
    HOGENOMi HOG000236339.
    HOVERGENi HBG004859.
    InParanoidi O43897.
    KOi K09608.
    OrthoDBi EOG7N8ZTV.
    PhylomeDBi O43897.
    TreeFami TF314351.

    Enzyme and pathway databases

    Reactomei REACT_118572. Degradation of the extracellular matrix.
    REACT_121139. Collagen biosynthesis and modifying enzymes.
    REACT_150206. Crosslinking of collagen fibrils.
    REACT_150268. Anchoring fibril formation.

    Miscellaneous databases

    EvolutionaryTracei O43897.
    GeneWikii TLL1.
    GenomeRNAii 7092.
    NextBioi 27743.
    PROi O43897.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O43897.
    Bgeei O43897.
    CleanExi HS_TLL1.
    Genevestigatori O43897.

    Family and domain databases

    Gene3Di 2.60.120.290. 5 hits.
    3.40.390.10. 1 hit.
    InterProi IPR015446. BMP_1/tolloid-like.
    IPR000859. CUB_dom.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR024079. MetalloPept_cat_dom.
    IPR001506. Peptidase_M12A.
    IPR006026. Peptidase_Metallo.
    [Graphical view ]
    Pfami PF01400. Astacin. 1 hit.
    PF00431. CUB. 5 hits.
    [Graphical view ]
    PIRSFi PIRSF001199. BMP_1/tolloid-like. 1 hit.
    PRINTSi PR00480. ASTACIN.
    SMARTi SM00042. CUB. 5 hits.
    SM00179. EGF_CA. 2 hits.
    SM00235. ZnMc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49854. SSF49854. 5 hits.
    PROSITEi PS01180. CUB. 5 hits.
    PS01186. EGF_2. 2 hits.
    PS50026. EGF_3. 2 hits.
    PS01187. EGF_CA. 2 hits.
    PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of human mammalian tolloid-like (mTll) and chromosomal localization of the cognate gene TLL."
      Greenspan D.S., Takahara K.
      Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Placenta.
    2. "Human cardiac/brain tolloid-like protein."
      Arleth A.J., Elshourbagy N.A., Li X., Willette R.N.
      Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Heart.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Prostate.
    5. "Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis."
      Scott I.C., Blitz I.L., Pappano W.N., Imamura Y., Clark T.G., Steiglitz B.M., Thomas C.L., Maas S.A., Takahara K., Cho K.W., Greenspan D.S.
      Dev. Biol. 213:283-300(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION OF ACTION ON COLLAGENS.
    6. Cited for: CHARACTERIZATION OF ACTION ON PROBIGLYCAN.
    7. "Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast cultures."
      Uzel M.I., Scott I.C., Babakhanlou-Chase H., Palamakumbura A.H., Pappano W.N., Hong H.-H., Greenspan D.S., Trackman P.C.
      J. Biol. Chem. 276:22537-22543(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION OF ACTION ON PRO-LYSYL OXIDASE.
    8. "Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases."
      Mac Sweeney A., Gil-Parrado S., Vinzenz D., Bernardi A., Hein A., Bodendorf U., Erbel P., Logel C., Gerhartz B.
      J. Mol. Biol. 384:228-239(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 148-348, DISULFIDE BONDS.
    9. Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-688.
    10. Cited for: VARIANTS ASD6 LEU-182; ALA-238 AND VAL-629.

    Entry informationi

    Entry nameiTLL1_HUMAN
    AccessioniPrimary (citable) accession number: O43897
    Secondary accession number(s): B2RMU2, Q96AN3, Q9NQS4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 7, 2006
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Peptidase families
      Classification of peptidase families and list of entries
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3