Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tolloid-like protein 1

Gene

TLL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi240 – 2401Zinc; catalyticPROSITE-ProRule annotation
Active sitei241 – 2411PROSITE-ProRule annotation
Metal bindingi244 – 2441Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi250 – 2501Zinc; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. metalloendopeptidase activity Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. extracellular matrix disassembly Source: Reactome
  3. extracellular matrix organization Source: Reactome
  4. skeletal system development Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Hydrolase, Metalloprotease, Protease

Keywords - Biological processi

Differentiation

Keywords - Ligandi

Calcium, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_118572. Degradation of the extracellular matrix.
REACT_121139. Collagen biosynthesis and modifying enzymes.
REACT_150206. Crosslinking of collagen fibrils.
REACT_150268. Anchoring fibril formation.

Protein family/group databases

MEROPSiM12.016.

Names & Taxonomyi

Protein namesi
Recommended name:
Tolloid-like protein 1 (EC:3.4.24.-)
Gene namesi
Name:TLL1
Synonyms:TLL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:11843. TLL1.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Atrial septal defect 61 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria.

See also OMIM:613087
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti182 – 1821M → L in ASD6. 1 Publication
VAR_062519
Natural varianti238 – 2381V → A in ASD6. 1 Publication
VAR_062520
Natural varianti629 – 6291I → V in ASD6. 1 Publication
VAR_062521

Keywords - Diseasei

Atrial septal defect, Disease mutation

Organism-specific databases

MIMi613087. phenotype.
Orphaneti99106. Atrial septal defect, ostium primum type.
99103. Atrial septal defect, ostium secundum type.
PharmGKBiPA36545.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence AnalysisAdd
BLAST
Propeptidei31 – 147117Sequence AnalysisPRO_0000046023Add
BLAST
Chaini148 – 1013866Tolloid-like protein 1PRO_0000046024Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi190 ↔ 3461 Publication
Disulfide bondi210 ↔ 232By similarity
Disulfide bondi212 ↔ 213By similarity
Disulfide bondi349 ↔ 375By similarity
Glycosylationi359 – 3591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi390 – 3901N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi402 ↔ 424By similarity
Disulfide bondi462 ↔ 488By similarity
Disulfide bondi515 ↔ 537By similarity
Disulfide bondi578 ↔ 590By similarity
Disulfide bondi586 ↔ 599By similarity
Disulfide bondi601 ↔ 614By similarity
Disulfide bondi618 ↔ 644By similarity
Glycosylationi626 – 6261N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi671 ↔ 693By similarity
Disulfide bondi734 ↔ 745By similarity
Disulfide bondi741 ↔ 754By similarity
Disulfide bondi756 ↔ 769By similarity
Disulfide bondi774 ↔ 800By similarity
Disulfide bondi827 ↔ 849By similarity
Disulfide bondi887 ↔ 917By similarity
Disulfide bondi944 ↔ 966By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQBiO43897.
PaxDbiO43897.
PRIDEiO43897.

PTM databases

PhosphoSiteiO43897.

Expressioni

Gene expression databases

BgeeiO43897.
CleanExiHS_TLL1.
ExpressionAtlasiO43897. baseline and differential.
GenevestigatoriO43897.

Interactioni

Protein-protein interaction databases

BioGridi112947. 2 interactions.
STRINGi9606.ENSP00000061240.

Structurei

Secondary structure

1
1013
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi153 – 1553Combined sources
Helixi158 – 1603Combined sources
Beta strandi161 – 1666Combined sources
Helixi172 – 18817Combined sources
Beta strandi192 – 1954Combined sources
Beta strandi203 – 2064Combined sources
Beta strandi224 – 2274Combined sources
Helixi235 – 24612Combined sources
Helixi251 – 2533Combined sources
Helixi257 – 2593Combined sources
Beta strandi261 – 2633Combined sources
Helixi265 – 2673Combined sources
Helixi273 – 2764Combined sources
Helixi281 – 2833Combined sources
Turni301 – 3044Combined sources
Beta strandi305 – 3073Combined sources
Beta strandi312 – 3154Combined sources
Helixi334 – 34310Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3EDIX-ray1.40A148-348[»]
ProteinModelPortaliO43897.
SMRiO43897. Positions 148-1003.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43897.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini349 – 461113CUB 1PROSITE-ProRule annotationAdd
BLAST
Domaini462 – 574113CUB 2PROSITE-ProRule annotationAdd
BLAST
Domaini574 – 61542EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini618 – 730113CUB 3PROSITE-ProRule annotationAdd
BLAST
Domaini730 – 77041EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini774 – 886113CUB 4PROSITE-ProRule annotationAdd
BLAST
Domaini887 – 1003117CUB 5PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni148 – 348201MetalloproteaseBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase M12A family.Curated
Contains 5 CUB domains.PROSITE-ProRule annotation
Contains 2 EGF-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG70307.
GeneTreeiENSGT00760000119018.
HOGENOMiHOG000236339.
HOVERGENiHBG004859.
InParanoidiO43897.
KOiK09608.
OrthoDBiEOG7N8ZTV.
PhylomeDBiO43897.
TreeFamiTF314351.

Family and domain databases

Gene3Di2.60.120.290. 5 hits.
3.40.390.10. 1 hit.
InterProiIPR015446. BMP_1/tolloid-like.
IPR000859. CUB_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024079. MetalloPept_cat_dom.
IPR001506. Peptidase_M12A.
IPR006026. Peptidase_Metallo.
[Graphical view]
PfamiPF01400. Astacin. 1 hit.
PF00431. CUB. 5 hits.
[Graphical view]
PIRSFiPIRSF001199. BMP_1/tolloid-like. 1 hit.
PRINTSiPR00480. ASTACIN.
SMARTiSM00042. CUB. 5 hits.
SM00179. EGF_CA. 2 hits.
SM00235. ZnMc. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 5 hits.
PROSITEiPS01180. CUB. 5 hits.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 2 hits.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O43897-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLGTLSPRM LVWLVASGIV FYGELWVCAG LDYDYTFDGN EEDKTETIDY
60 70 80 90 100
KDPCKAAVFW GDIALDDEDL NIFQIDRTID LTQNPFGNLG HTTGGLGDHA
110 120 130 140 150
MSKKRGALYQ LIDRIRRIGF GLEQNNTVKG KVPLQFSGQN EKNRVPRAAT
160 170 180 190 200
SRTERIWPGG VIPYVIGGNF TGSQRAMFKQ AMRHWEKHTC VTFIERSDEE
210 220 230 240 250
SYIVFTYRPC GCCSYVGRRG NGPQAISIGK NCDKFGIVVH ELGHVIGFWH
260 270 280 290 300
EHTRPDRDNH VTIIRENIQP GQEYNFLKME PGEVNSLGER YDFDSIMHYA
310 320 330 340 350
RNTFSRGMFL DTILPSRDDN GIRPAIGQRT RLSKGDIAQA RKLYRCPACG
360 370 380 390 400
ETLQESNGNL SSPGFPNGYP SYTHCIWRVS VTPGEKIVLN FTTMDLYKSS
410 420 430 440 450
LCWYDYIEVR DGYWRKSPLL GRFCGDKLPE VLTSTDSRMW IEFRSSSNWV
460 470 480 490 500
GKGFAAVYEA ICGGEIRKNE GQIQSPNYPD DYRPMKECVW KITVSESYHV
510 520 530 540 550
GLTFQSFEIE RHDNCAYDYL EVRDGTSENS PLIGRFCGYD KPEDIRSTSN
560 570 580 590 600
TLWMKFVSDG TVNKAGFAAN FFKEEDECAK PDRGGCEQRC LNTLGSYQCA
610 620 630 640 650
CEPGYELGPD RRSCEAACGG LLTKLNGTIT TPGWPKEYPP NKNCVWQVVA
660 670 680 690 700
PTQYRISVKF EFFELEGNEV CKYDYVEIWS GLSSESKLHG KFCGAEVPEV
710 720 730 740 750
ITSQFNNMRI EFKSDNTVSK KGFKAHFFSD KDECSKDNGG CQHECVNTMG
760 770 780 790 800
SYMCQCRNGF VLHDNKHDCK EAECEQKIHS PSGLITSPNW PDKYPSRKEC
810 820 830 840 850
TWEISATPGH RIKLAFSEFE IEQHQECAYD HLEVFDGETE KSPILGRLCG
860 870 880 890 900
NKIPDPLVAT GNKMFVRFVS DASVQRKGFQ ATHSTECGGR LKAESKPRDL
910 920 930 940 950
YSHAQFGDNN YPGQVDCEWL LVSERGSRLE LSFQTFEVEE EADCGYDYVE
960 970 980 990 1000
LFDGLDSTAV GLGRFCGSGP PEEIYSIGDS VLIHFHTDDT INKKGFHIRY
1010
KSIRYPDTTH TKK
Length:1,013
Mass (Da):114,709
Last modified:June 1, 1998 - v1
Checksum:i0FDDB6E8E9032DCC
GO
Isoform 2 (identifier: O43897-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     387-392: IVLNFT → VVFSLC
     393-1013: Missing.

Note: No experimental confirmation available.

Show »
Length:392
Mass (Da):44,186
Checksum:iB240EB78AD353BFE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti156 – 1561I → V in AAF86287. 1 PublicationCurated
Sequence conflicti221 – 2211N → S in AAF86287. 1 PublicationCurated
Sequence conflicti284 – 2841V → A in AAF86287. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti182 – 1821M → L in ASD6. 1 Publication
VAR_062519
Natural varianti238 – 2381V → A in ASD6. 1 Publication
VAR_062520
Natural varianti629 – 6291I → V in ASD6. 1 Publication
VAR_062521
Natural varianti688 – 6881L → V in a breast cancer sample; somatic mutation. 1 Publication
VAR_036142
Natural varianti958 – 9581T → A.
Corresponds to variant rs2291822 [ dbSNP | Ensembl ].
VAR_051585

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei387 – 3926IVLNFT → VVFSLC in isoform 2. 1 PublicationVSP_017197
Alternative sequencei393 – 1013621Missing in isoform 2. 1 PublicationVSP_017198Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91963 mRNA. Translation: AAB93878.1.
AF282732 mRNA. Translation: AAF86287.1.
CH471056 Genomic DNA. Translation: EAX04813.1.
BC016922 mRNA. Translation: AAH16922.1.
BC136429 mRNA. Translation: AAI36430.1.
BC136430 mRNA. Translation: AAI36431.1.
CCDSiCCDS3811.1. [O43897-1]
CCDS56342.1. [O43897-2]
RefSeqiNP_001191689.1. NM_001204760.1. [O43897-2]
NP_036596.3. NM_012464.4. [O43897-1]
UniGeneiHs.106513.

Genome annotation databases

EnsembliENST00000061240; ENSP00000061240; ENSG00000038295. [O43897-1]
ENST00000513213; ENSP00000422937; ENSG00000038295. [O43897-2]
GeneIDi7092.
KEGGihsa:7092.
UCSCiuc003irh.2. human. [O43897-1]
uc021xud.1. human. [O43897-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91963 mRNA. Translation: AAB93878.1.
AF282732 mRNA. Translation: AAF86287.1.
CH471056 Genomic DNA. Translation: EAX04813.1.
BC016922 mRNA. Translation: AAH16922.1.
BC136429 mRNA. Translation: AAI36430.1.
BC136430 mRNA. Translation: AAI36431.1.
CCDSiCCDS3811.1. [O43897-1]
CCDS56342.1. [O43897-2]
RefSeqiNP_001191689.1. NM_001204760.1. [O43897-2]
NP_036596.3. NM_012464.4. [O43897-1]
UniGeneiHs.106513.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3EDIX-ray1.40A148-348[»]
ProteinModelPortaliO43897.
SMRiO43897. Positions 148-1003.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112947. 2 interactions.
STRINGi9606.ENSP00000061240.

Protein family/group databases

MEROPSiM12.016.

PTM databases

PhosphoSiteiO43897.

Proteomic databases

MaxQBiO43897.
PaxDbiO43897.
PRIDEiO43897.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000061240; ENSP00000061240; ENSG00000038295. [O43897-1]
ENST00000513213; ENSP00000422937; ENSG00000038295. [O43897-2]
GeneIDi7092.
KEGGihsa:7092.
UCSCiuc003irh.2. human. [O43897-1]
uc021xud.1. human. [O43897-2]

Organism-specific databases

CTDi7092.
GeneCardsiGC04P166794.
HGNCiHGNC:11843. TLL1.
MIMi606742. gene.
613087. phenotype.
neXtProtiNX_O43897.
Orphaneti99106. Atrial septal defect, ostium primum type.
99103. Atrial septal defect, ostium secundum type.
PharmGKBiPA36545.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG70307.
GeneTreeiENSGT00760000119018.
HOGENOMiHOG000236339.
HOVERGENiHBG004859.
InParanoidiO43897.
KOiK09608.
OrthoDBiEOG7N8ZTV.
PhylomeDBiO43897.
TreeFamiTF314351.

Enzyme and pathway databases

ReactomeiREACT_118572. Degradation of the extracellular matrix.
REACT_121139. Collagen biosynthesis and modifying enzymes.
REACT_150206. Crosslinking of collagen fibrils.
REACT_150268. Anchoring fibril formation.

Miscellaneous databases

EvolutionaryTraceiO43897.
GeneWikiiTLL1.
GenomeRNAii7092.
NextBioi27743.
PROiO43897.
SOURCEiSearch...

Gene expression databases

BgeeiO43897.
CleanExiHS_TLL1.
ExpressionAtlasiO43897. baseline and differential.
GenevestigatoriO43897.

Family and domain databases

Gene3Di2.60.120.290. 5 hits.
3.40.390.10. 1 hit.
InterProiIPR015446. BMP_1/tolloid-like.
IPR000859. CUB_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024079. MetalloPept_cat_dom.
IPR001506. Peptidase_M12A.
IPR006026. Peptidase_Metallo.
[Graphical view]
PfamiPF01400. Astacin. 1 hit.
PF00431. CUB. 5 hits.
[Graphical view]
PIRSFiPIRSF001199. BMP_1/tolloid-like. 1 hit.
PRINTSiPR00480. ASTACIN.
SMARTiSM00042. CUB. 5 hits.
SM00179. EGF_CA. 2 hits.
SM00235. ZnMc. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 5 hits.
PROSITEiPS01180. CUB. 5 hits.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 2 hits.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of human mammalian tolloid-like (mTll) and chromosomal localization of the cognate gene TLL."
    Greenspan D.S., Takahara K.
    Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Placenta.
  2. "Human cardiac/brain tolloid-like protein."
    Arleth A.J., Elshourbagy N.A., Li X., Willette R.N.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Heart.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Prostate.
  5. "Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis."
    Scott I.C., Blitz I.L., Pappano W.N., Imamura Y., Clark T.G., Steiglitz B.M., Thomas C.L., Maas S.A., Takahara K., Cho K.W., Greenspan D.S.
    Dev. Biol. 213:283-300(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION OF ACTION ON COLLAGENS.
  6. Cited for: CHARACTERIZATION OF ACTION ON PROBIGLYCAN.
  7. "Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast cultures."
    Uzel M.I., Scott I.C., Babakhanlou-Chase H., Palamakumbura A.H., Pappano W.N., Hong H.-H., Greenspan D.S., Trackman P.C.
    J. Biol. Chem. 276:22537-22543(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION OF ACTION ON PRO-LYSYL OXIDASE.
  8. "Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases."
    Mac Sweeney A., Gil-Parrado S., Vinzenz D., Bernardi A., Hein A., Bodendorf U., Erbel P., Logel C., Gerhartz B.
    J. Mol. Biol. 384:228-239(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 148-348, DISULFIDE BONDS.
  9. Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-688.
  10. Cited for: VARIANTS ASD6 LEU-182; ALA-238 AND VAL-629.

Entry informationi

Entry nameiTLL1_HUMAN
AccessioniPrimary (citable) accession number: O43897
Secondary accession number(s): B2RMU2, Q96AN3, Q9NQS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: June 1, 1998
Last modified: January 7, 2015
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Peptidase families
    Classification of peptidase families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.