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Protein

Kinesin-like protein KIF1C

Gene

KIF1C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi97 – 104ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • microtubule motor activity Source: GO_Central
  • motor activity Source: ProtInc
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000129250-MONOMER.
ReactomeiR-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-HSA-983189. Kinesins.
SIGNORiO43896.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF1C
Gene namesi
Name:KIF1C
Synonyms:KIAA0706
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:6317. KIF1C.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: ProtInc
  • Golgi apparatus Source: ProtInc
  • kinesin complex Source: GO_Central
  • microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Involvement in diseasei

Spastic ataxia 2, autosomal recessive (SPAX2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA neurologic disorder characterized by cerebellar ataxia, dysarthria, and variable spasticity of the lower limbs. Cognition is not affected.
See also OMIM:611302
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070937169R → W in SPAX2. 1 PublicationCorresponds to variant rs587777198dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation, Neurodegeneration

Organism-specific databases

DisGeNETi10749.
MalaCardsiKIF1C.
MIMi611302. phenotype.
OpenTargetsiENSG00000129250.
Orphaneti397946. Autosomal recessive spastic paraplegia type 58.
PharmGKBiPA30100.

Polymorphism and mutation databases

BioMutaiKIF1C.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001254101 – 1103Kinesin-like protein KIF1CAdd BLAST1103

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei295PhosphoserineCombined sources1
Modified residuei494PhosphoserineCombined sources1
Modified residuei674PhosphoserineCombined sources1
Modified residuei676PhosphoserineCombined sources1
Modified residuei915PhosphoserineCombined sources1
Modified residuei1033PhosphoserineCombined sources1
Modified residuei1041Omega-N-methylarginineCombined sources1
Modified residuei1083PhosphothreonineCombined sources1
Modified residuei1092PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated on tyrosine residues.1 Publication

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiO43896.
MaxQBiO43896.
PaxDbiO43896.
PeptideAtlasiO43896.
PRIDEiO43896.

PTM databases

iPTMnetiO43896.
PhosphoSitePlusiO43896.

Expressioni

Tissue specificityi

Expressed in all tissues examined, with most abundant expression in heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000129250.
CleanExiHS_KIF1C.
ExpressionAtlasiO43896. baseline and differential.
GenevisibleiO43896. HS.

Organism-specific databases

HPAiHPA021831.
HPA024602.
HPA045020.

Interactioni

Subunit structurei

Monomer.Curated

Binary interactionsi

WithEntry#Exp.IntActNotes
Ccdc64A0JNT93EBI-1644048,EBI-7893170From a different organism.

Protein-protein interaction databases

BioGridi115972. 32 interactors.
DIPiDIP-40376N.
IntActiO43896. 31 interactors.
MINTiMINT-7899683.
STRINGi9606.ENSP00000320821.

Structurei

Secondary structure

11103
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi500 – 503Combined sources4
Beta strandi510 – 512Combined sources3
Beta strandi515 – 517Combined sources3
Beta strandi520 – 529Combined sources10
Beta strandi531 – 533Combined sources3
Beta strandi541 – 550Combined sources10
Beta strandi556 – 562Combined sources7
Beta strandi568 – 570Combined sources3
Beta strandi586 – 589Combined sources4
Turni590 – 592Combined sources3
Beta strandi593 – 598Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2G1LX-ray2.60A498-599[»]
ProteinModelPortaliO43896.
SMRiO43896.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43896.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 348Kinesin motorPROSITE-ProRule annotationAdd BLAST344
Domaini523 – 590FHAAdd BLAST68

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili359 – 388Sequence analysisAdd BLAST30
Coiled coili438 – 479Sequence analysisAdd BLAST42
Coiled coili633 – 674Sequence analysisAdd BLAST42
Coiled coili828 – 872Sequence analysisAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi965 – 1085Pro-richAdd BLAST121

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily.PROSITE-ProRule annotation
Contains 1 FHA domain.Curated
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0245. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00840000129680.
HOGENOMiHOG000231453.
HOVERGENiHBG057158.
InParanoidiO43896.
KOiK10392.
OMAiPLTQDHE.
OrthoDBiEOG091G009V.
PhylomeDBiO43896.
TreeFamiTF105221.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
3.40.850.10. 1 hit.
InterProiIPR000253. FHA_dom.
IPR027640. Kinesin-like_fam.
IPR032405. Kinesin_assoc.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 3 hits.
PfamiPF00498. FHA. 1 hit.
PF00225. Kinesin. 1 hit.
PF16183. Kinesin_assoc. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43896-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGASVKVAV RVRPFNARET SQDAKCVVSM QGNTTSIINP KQSKDAPKSF
60 70 80 90 100
TFDYSYWSHT STEDPQFASQ QQVYRDIGEE MLLHAFEGYN VCIFAYGQTG
110 120 130 140 150
AGKSYTMMGR QEPGQQGIVP QLCEDLFSRV SENQSAQLSY SVEVSYMEIY
160 170 180 190 200
CERVRDLLNP KSRGSLRVRE HPILGPYVQD LSKLAVTSYA DIADLMDCGN
210 220 230 240 250
KARTVAATNM NETSSRSHAV FTIVFTQRCH DQLTGLDSEK VSKISLVDLA
260 270 280 290 300
GSERADSSGA RGMRLKEGAN INKSLTTLGK VISALADMQS KKRKSDFIPY
310 320 330 340 350
RDSVLTWLLK ENLGGNSRTA MIAALSPADI NYEETLSTLR YADRTKQIRC
360 370 380 390 400
NAIINEDPNA RLIRELQEEV ARLRELLMAQ GLSASALEGL KTEEGSVRGA
410 420 430 440 450
LPAVSSPPAP VSPSSPTTHN GELEPSFSPN TESQIGPEEA MERLQETEKI
460 470 480 490 500
IAELNETWEE KLRKTEALRM EREALLAEMG VAVREDGGTV GVFSPKKTPH
510 520 530 540 550
LVNLNEDPLM SECLLYHIKD GVTRVGQVDM DIKLTGQFIR EQHCLFRSIP
560 570 580 590 600
QPDGEVVVTL EPCEGAETYV NGKLVTEPLV LKSGNRIVMG KNHVFRFNHP
610 620 630 640 650
EQARLERERG VPPPPGPPSE PVDWNFAQKE LLEQQGIDIK LEMEKRLQDL
660 670 680 690 700
ENQYRKEKEE ADLLLEQQRL YADSDSGDDS DKRSCEESWR LISSLREQLP
710 720 730 740 750
PTTVQTIVKR CGLPSSGKRR APRRVYQIPQ RRRLQGKDPR WATMADLKMQ
760 770 780 790 800
AVKEICYEVA LADFRHGRAE IEALAALKMR ELCRTYGKPD GPGDAWRAVA
810 820 830 840 850
RDVWDTVGEE EGGGAGSGGG SEEGARGAEV EDLRAHIDKL TGILQEVKLQ
860 870 880 890 900
NSSKDRELQA LRDRMLRMER VIPLAQDHED ENEEGGEVPW APPEGSEAAE
910 920 930 940 950
EAAPSDRMPS ARPPSPPLSS WERVSRLMEE DPAFRRGRLR WLKQEQLRLQ
960 970 980 990 1000
GLQGSGGRGG GLRRPPARFV PPHDCKLRFP FKSNPQHRES WPGMGSGEAP
1010 1020 1030 1040 1050
TPLQPPEEVT PHPATPARRP PSPRRSHHPR RNSLDGGGRS RGAGSAQPEP
1060 1070 1080 1090 1100
QHFQPKKHNS YPQPPQPYPA QRPPGPRYPP YTTPPRMRRQ RSAPDLKESG

AAV
Length:1,103
Mass (Da):122,947
Last modified:October 17, 2006 - v3
Checksum:i5FDEEB8C91B3C46B
GO

Sequence cautioni

The sequence BAA31681 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti669R → Q in AAC52117 (PubMed:9685376).Curated1
Sequence conflicti955 – 962SGGRGGGL → LWGPGRGV in AAC52117 (PubMed:9685376).Curated8
Sequence conflicti976 – 977KL → NV in AAC52117 (PubMed:9685376).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070937169R → W in SPAX2. 1 PublicationCorresponds to variant rs587777198dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91329 mRNA. Translation: AAC52117.1.
AB014606 mRNA. Translation: BAA31681.2. Different initiation.
CH471108 Genomic DNA. Translation: EAW90366.1.
CH471108 Genomic DNA. Translation: EAW90367.1.
CH471108 Genomic DNA. Translation: EAW90368.1.
CH471108 Genomic DNA. Translation: EAW90369.1.
BC034993 mRNA. Translation: AAH34993.1.
CCDSiCCDS11065.1.
RefSeqiNP_006603.2. NM_006612.5.
XP_005256481.1. XM_005256424.2.
UniGeneiHs.435120.

Genome annotation databases

EnsembliENST00000320785; ENSP00000320821; ENSG00000129250.
GeneIDi10749.
KEGGihsa:10749.
UCSCiuc002gan.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91329 mRNA. Translation: AAC52117.1.
AB014606 mRNA. Translation: BAA31681.2. Different initiation.
CH471108 Genomic DNA. Translation: EAW90366.1.
CH471108 Genomic DNA. Translation: EAW90367.1.
CH471108 Genomic DNA. Translation: EAW90368.1.
CH471108 Genomic DNA. Translation: EAW90369.1.
BC034993 mRNA. Translation: AAH34993.1.
CCDSiCCDS11065.1.
RefSeqiNP_006603.2. NM_006612.5.
XP_005256481.1. XM_005256424.2.
UniGeneiHs.435120.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2G1LX-ray2.60A498-599[»]
ProteinModelPortaliO43896.
SMRiO43896.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115972. 32 interactors.
DIPiDIP-40376N.
IntActiO43896. 31 interactors.
MINTiMINT-7899683.
STRINGi9606.ENSP00000320821.

PTM databases

iPTMnetiO43896.
PhosphoSitePlusiO43896.

Polymorphism and mutation databases

BioMutaiKIF1C.

Proteomic databases

EPDiO43896.
MaxQBiO43896.
PaxDbiO43896.
PeptideAtlasiO43896.
PRIDEiO43896.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320785; ENSP00000320821; ENSG00000129250.
GeneIDi10749.
KEGGihsa:10749.
UCSCiuc002gan.3. human.

Organism-specific databases

CTDi10749.
DisGeNETi10749.
GeneCardsiKIF1C.
HGNCiHGNC:6317. KIF1C.
HPAiHPA021831.
HPA024602.
HPA045020.
MalaCardsiKIF1C.
MIMi603060. gene.
611302. phenotype.
neXtProtiNX_O43896.
OpenTargetsiENSG00000129250.
Orphaneti397946. Autosomal recessive spastic paraplegia type 58.
PharmGKBiPA30100.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0245. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00840000129680.
HOGENOMiHOG000231453.
HOVERGENiHBG057158.
InParanoidiO43896.
KOiK10392.
OMAiPLTQDHE.
OrthoDBiEOG091G009V.
PhylomeDBiO43896.
TreeFamiTF105221.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000129250-MONOMER.
ReactomeiR-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-HSA-983189. Kinesins.
SIGNORiO43896.

Miscellaneous databases

ChiTaRSiKIF1C. human.
EvolutionaryTraceiO43896.
GeneWikiiKIF1C.
GenomeRNAii10749.
PROiO43896.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000129250.
CleanExiHS_KIF1C.
ExpressionAtlasiO43896. baseline and differential.
GenevisibleiO43896. HS.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
3.40.850.10. 1 hit.
InterProiIPR000253. FHA_dom.
IPR027640. Kinesin-like_fam.
IPR032405. Kinesin_assoc.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 3 hits.
PfamiPF00498. FHA. 1 hit.
PF00225. Kinesin. 1 hit.
PF16183. Kinesin_assoc. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKIF1C_HUMAN
AccessioniPrimary (citable) accession number: O43896
Secondary accession number(s): D3DTL6, O75186, Q5U618
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: October 17, 2006
Last modified: November 2, 2016
This is version 159 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.