O43896 (KIF1C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kinesin-like protein KIF1C

Gene names

Name:	KIF1C
Synonyms:	KIAA0706

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1103 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility. Ref.1
Subunit structure	Monomer Potential.
Subcellular location	Cytoplasm › cytoskeleton Probable.
Tissue specificity	Expressed in all tissues examined, with most abundant expression in heart and skeletal muscle. Ref.1
Post-translational modification	Phosphorylated on tyrosine residues. Ref.1 Ref.5 Ref.6 Ref.7 Ref.8 Ref.9 Ref.10
Sequence similarities	Belongs to the kinesin-like protein family. Unc-104 subfamily. Contains 1 FHA domain. Contains 1 kinesin-motor domain.
Sequence caution	The sequence BAA31681.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Microtubule
Domain	Coiled coil
Ligand	ATP-binding Nucleotide-binding
Molecular function	Motor protein
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	microtubule-based movement Inferred from electronic annotation. Source: InterPro retrograde vesicle-mediated transport, Golgi to ER Traceable author statement. Source: ProtInc
Cellular component	Golgi apparatus Traceable author statement. Source: ProtInc endoplasmic reticulum Traceable author statement. Source: ProtInc microtubule Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW microtubule motor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1103

1103

Kinesin-like protein KIF1C

PRO_0000125410

Regions

Domain

1 – 273

273

Kinesin-motor

Domain

523 – 590

68

FHA

Nucleotide binding

97 – 104

8

ATP By similarity

Coiled coil

359 – 388

30

Potential

Coiled coil

438 – 479

42

Potential

Coiled coil

633 – 674

42

Potential

Coiled coil

828 – 872

45

Potential

Compositional bias

965 – 1085

121

Pro-rich

Amino acid modifications

Modified residue

494

1

Phosphoserine Ref.5 Ref.10

Modified residue

674

1

Phosphoserine By similarity

Modified residue

676

1

Phosphoserine By similarity

Modified residue

1033

1

Phosphoserine Ref.6

Modified residue

1082

1

Phosphothreonine Ref.9

Modified residue

1083

1

Phosphothreonine Ref.7 Ref.8

Modified residue

1092

1

Phosphoserine Ref.6 Ref.8 Ref.10

Experimental info

Sequence conflict

669

1

R → Q in AAC52117. Ref.1

Sequence conflict

955 – 962

8

SGGRGGGL → LWGPGRGV in AAC52117. Ref.1

Sequence conflict

976 – 977

2

KL → NV in AAC52117. Ref.1

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1103

Helix Strand Turn

Details...

Beta strand

500 – 503

4

Beta strand

510 – 512

3

Beta strand

515 – 517

3

Beta strand

520 – 529

10

Beta strand

531 – 533

3

Beta strand

541 – 550

10

Beta strand

556 – 562

7

Beta strand

568 – 570

3

Beta strand

586 – 589

4

Turn

590 – 592

3

Beta strand

593 – 598

6

Sequences

	Sequence		Length	Mass (Da)
	O43896 [UniParc]. Last modified October 17, 2006. Version 3. Checksum: 5FDEEB8C91B3C46B	FASTA	1,103	122,947
	10 20 30 40 50 60 MAGASVKVAV RVRPFNARET SQDAKCVVSM QGNTTSIINP KQSKDAPKSF TFDYSYWSHT 70 80 90 100 110 120 STEDPQFASQ QQVYRDIGEE MLLHAFEGYN VCIFAYGQTG AGKSYTMMGR QEPGQQGIVP 130 140 150 160 170 180 QLCEDLFSRV SENQSAQLSY SVEVSYMEIY CERVRDLLNP KSRGSLRVRE HPILGPYVQD 190 200 210 220 230 240 LSKLAVTSYA DIADLMDCGN KARTVAATNM NETSSRSHAV FTIVFTQRCH DQLTGLDSEK 250 260 270 280 290 300 VSKISLVDLA GSERADSSGA RGMRLKEGAN INKSLTTLGK VISALADMQS KKRKSDFIPY 310 320 330 340 350 360 RDSVLTWLLK ENLGGNSRTA MIAALSPADI NYEETLSTLR YADRTKQIRC NAIINEDPNA 370 380 390 400 410 420 RLIRELQEEV ARLRELLMAQ GLSASALEGL KTEEGSVRGA LPAVSSPPAP VSPSSPTTHN 430 440 450 460 470 480 GELEPSFSPN TESQIGPEEA MERLQETEKI IAELNETWEE KLRKTEALRM EREALLAEMG 490 500 510 520 530 540 VAVREDGGTV GVFSPKKTPH LVNLNEDPLM SECLLYHIKD GVTRVGQVDM DIKLTGQFIR 550 560 570 580 590 600 EQHCLFRSIP QPDGEVVVTL EPCEGAETYV NGKLVTEPLV LKSGNRIVMG KNHVFRFNHP 610 620 630 640 650 660 EQARLERERG VPPPPGPPSE PVDWNFAQKE LLEQQGIDIK LEMEKRLQDL ENQYRKEKEE 670 680 690 700 710 720 ADLLLEQQRL YADSDSGDDS DKRSCEESWR LISSLREQLP PTTVQTIVKR CGLPSSGKRR 730 740 750 760 770 780 APRRVYQIPQ RRRLQGKDPR WATMADLKMQ AVKEICYEVA LADFRHGRAE IEALAALKMR 790 800 810 820 830 840 ELCRTYGKPD GPGDAWRAVA RDVWDTVGEE EGGGAGSGGG SEEGARGAEV EDLRAHIDKL 850 860 870 880 890 900 TGILQEVKLQ NSSKDRELQA LRDRMLRMER VIPLAQDHED ENEEGGEVPW APPEGSEAAE 910 920 930 940 950 960 EAAPSDRMPS ARPPSPPLSS WERVSRLMEE DPAFRRGRLR WLKQEQLRLQ GLQGSGGRGG 970 980 990 1000 1010 1020 GLRRPPARFV PPHDCKLRFP FKSNPQHRES WPGMGSGEAP TPLQPPEEVT PHPATPARRP 1030 1040 1050 1060 1070 1080 PSPRRSHHPR RNSLDGGGRS RGAGSAQPEP QHFQPKKHNS YPQPPQPYPA QRPPGPRYPP 1090 1100 YTTPPRMRRQ RSAPDLKESG AAV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of KIF1C, a new kinesin-like protein involved in vesicle transport from the Golgi apparatus to the endoplasmic reticulum." Dorner C., Ciossek T., Mueller S., Moeller N.P.H., Ullrich A., Lammers R. J. Biol. Chem. 273:20267-20275(1998) [PubMed: 9685376] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, PHOSPHORYLATION, TISSUE SPECIFICITY. Tissue: Hippocampus.
[2]	"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:169-176(1998) [PubMed: 9734811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[5]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-494, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1033 AND SER-1092, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1083, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1083 AND SER-1092, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1082, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[10]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-494 AND SER-1092, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[11]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]	"Crystal structure of the FHA domain of human kinesin family member C." Structural genomics consortium (SGC) Submitted (FEB-2006) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 498-599.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U91329 mRNA. Translation: AAC52117.1.
AB014606 mRNA. Translation: BAA31681.2. Different initiation.
CH471108 Genomic DNA. Translation: EAW90366.1.
CH471108 Genomic DNA. Translation: EAW90367.1.
CH471108 Genomic DNA. Translation: EAW90368.1.
CH471108 Genomic DNA. Translation: EAW90369.1.
BC034993 mRNA. Translation: AAH34993.1.

IPI

IPI00179757.

RefSeq

NP_006603.2. NM_006612.5.

UniGene

Hs.435120.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2G1L	X-ray	2.60	A	498-599	[»]

ProteinModelPortal

O43896.

SMR

O43896. Positions 4-347, 498-599.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-40376N.

IntAct

O43896. 8 interactions.

STRING

O43896.

PTM databases

PhosphoSite

O43896.

Proteomic databases

PRIDE

O43896.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000320785; ENSP00000320821; ENSG00000129250.

GeneID

10749.

KEGG

hsa:10749.

UCSC

uc002gan.1. human.

Organism-specific databases

CTD

10749.

GeneCards

GC17P004901.

H-InvDB

HIX0013460.

HGNC

HGNC:6317. KIF1C.

HPA

HPA021831.
HPA024602.

MIM

603060. gene.

neXtProt

NX_O43896.

PharmGKB

PA30100.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG14745.

GeneTree

ENSGT00570000078823.

HOGENOM

HBG746568.

HOVERGEN

HBG057158.

InParanoid

O43896.

OMA

QSAQLSY.

OrthoDB

EOG4W3SM7.

PhylomeDB

O43896.

Gene expression databases

ArrayExpress

O43896.

Bgee

O43896.

CleanEx

HS_KIF1C.

Genevestigator

O43896.

GermOnline

ENSG00000129250. Homo sapiens.

Family and domain databases

InterPro

IPR000253. FHA_dom.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR008984. SMAD_FHA_domain.
[Graphical view]

Gene3D

G3DSA:2.60.200.20. FHA. 1 hit.
G3DSA:3.40.850.10. kinesin_motor. 1 hit.

KO

K10392.

Pfam

PF00498. FHA. 1 hit.
PF00225. Kinesin. 1 hit.
[Graphical view]

PRINTS

PR00380. KINESINHEAVY.

SMART

SM00240. FHA. 1 hit.
SM00129. KISc. 1 hit.
[Graphical view]

SUPFAM

SSF49879. SMAD_FHA. 1 hit.

PROSITE

PS50006. FHA_DOMAIN. False negative.
PS00411. KINESIN_MOTOR_DOMAIN1. 1 hit.
PS50067. KINESIN_MOTOR_DOMAIN2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

40821.

SOURCE

Search...

Entry information

Entry name

KIF1C_HUMAN

Accession

Primary (citable) accession number: O43896
Secondary accession number(s): D3DTL6, O75186, Q5U618

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	October 17, 2006
Last modified:	January 25, 2012
This is version 111 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.