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Protein

Olfactory receptor 2T1

Gene

OR2T1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

Caution

It is uncertain whether Met-1 or Met-52 is the initiator.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2T1
Alternative name(s):
Olfactory receptor 1-25
Short name:
OR1-25
Olfactory receptor OR1-61
Gene namesi
Name:OR2T1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000175143.3
HGNCiHGNC:8277 OR2T1
neXtProtiNX_O43869

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 76ExtracellularSequence analysisAdd BLAST76
Transmembranei77 – 97Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini98 – 107CytoplasmicSequence analysis10
Transmembranei108 – 128Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini129 – 148ExtracellularSequence analysisAdd BLAST20
Transmembranei149 – 169Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini170 – 191CytoplasmicSequence analysisAdd BLAST22
Transmembranei192 – 212Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini213 – 247ExtracellularSequence analysisAdd BLAST35
Transmembranei248 – 268Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini269 – 286CytoplasmicSequence analysisAdd BLAST18
Transmembranei287 – 307Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini308 – 321ExtracellularSequence analysisAdd BLAST14
Transmembranei322 – 342Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini343 – 369CytoplasmicSequence analysisAdd BLAST27

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32201

Polymorphism and mutation databases

BioMutaiOR2T1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504961 – 369Olfactory receptor 2T1Add BLAST369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi56N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi147 ↔ 239PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO43869
PRIDEiO43869

PTM databases

iPTMnetiO43869
PhosphoSitePlusiO43869

Expressioni

Gene expression databases

CleanExiHS_OR2T1
ExpressionAtlasiO43869 baseline and differential

Organism-specific databases

HPAiHPA063064

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000355430

Structurei

3D structure databases

ProteinModelPortaliO43869
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGYV Eukaryota
ENOG411199U LUCA
GeneTreeiENSGT00760000118850
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiO43869
KOiK04257
OMAiDFTFMGL
OrthoDBiEOG091G0ECW
PhylomeDBiO43869
TreeFamiTF337295

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O43869-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWQEYYFLNV FFPLLKVCCL TINSHVVILL PWECYHLIWK ILPYIGTTVG
60 70 80 90 100
SMEEYNTSST DFTFMGLFNR KETSGLIFAI ISIIFFTALM ANGVMIFLIQ
110 120 130 140 150
TDLRLHTPMY FLLSHLSLID MMYISTIVPK MLVNYLLDQR TISFVGCTAQ
160 170 180 190 200
HFLYLTLVGA EFFLLGLMAY DRYVAICNPL RYPVLMSRRV CWMIIAGSWF
210 220 230 240 250
GGSLDGFLLT PITMSFPFCN SREINHFFCE APAVLKLACA DTALYETVMY
260 270 280 290 300
VCCVLMLLIP FSVVLASYAR ILTTVQCMSS VEGRKKAFAT CSSHMTVVSL
310 320 330 340 350
FYGAAMYTYM LPHSYHKPAQ DKVLSVFYTI LTPMLNPLIY SLRNKDVTGA
360
LKRALGRFKG PQRVSGGVF
Length:369
Mass (Da):41,996
Last modified:May 5, 2009 - v3
Checksum:i9D8E52A0312BEC3B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05754125H → R. Corresponds to variant dbSNP:rs28599722Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138089 Genomic DNA No translation available.
U86215 Genomic DNA Translation: AAC39611.1
AF399613 Genomic DNA Translation: AAK95098.1
BK004463 Genomic DNA Translation: DAA04861.1
CCDSiCCDS31115.1
RefSeqiNP_112166.1, NM_030904.1
UniGeneiHs.626885

Genome annotation databases

EnsembliENST00000366474; ENSP00000355430; ENSG00000175143
ENST00000611851; ENSP00000479603; ENSG00000273508
ENST00000613540; ENSP00000482752; ENSG00000275244
GeneIDi26696
KEGGihsa:26696
UCSCiuc010pzm.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR2T1_HUMAN
AccessioniPrimary (citable) accession number: O43869
Secondary accession number(s): Q6IEZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 5, 2009
Last modified: February 28, 2018
This is version 148 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health