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Protein

Olfactory receptor 2T1

Gene

OR2T1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000175143-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2T1
Alternative name(s):
Olfactory receptor 1-25
Short name:
OR1-25
Olfactory receptor OR1-61
Gene namesi
Name:OR2T1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:8277. OR2T1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 76ExtracellularSequence analysisAdd BLAST76
Transmembranei77 – 97Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini98 – 107CytoplasmicSequence analysis10
Transmembranei108 – 128Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini129 – 148ExtracellularSequence analysisAdd BLAST20
Transmembranei149 – 169Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini170 – 191CytoplasmicSequence analysisAdd BLAST22
Transmembranei192 – 212Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini213 – 247ExtracellularSequence analysisAdd BLAST35
Transmembranei248 – 268Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini269 – 286CytoplasmicSequence analysisAdd BLAST18
Transmembranei287 – 307Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini308 – 321ExtracellularSequence analysisAdd BLAST14
Transmembranei322 – 342Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini343 – 369CytoplasmicSequence analysisAdd BLAST27

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi26696.
OpenTargetsiENSG00000175143.
ENSG00000273508.
ENSG00000275244.
PharmGKBiPA32201.

Polymorphism and mutation databases

BioMutaiOR2T1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504961 – 369Olfactory receptor 2T1Add BLAST369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi56N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi147 ↔ 239PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO43869.
PRIDEiO43869.

PTM databases

iPTMnetiO43869.
PhosphoSitePlusiO43869.

Expressioni

Gene expression databases

CleanExiHS_OR2T1.
ExpressionAtlasiO43869. baseline and differential.

Organism-specific databases

HPAiHPA063064.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000355430.

Structurei

3D structure databases

ProteinModelPortaliO43869.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGYV. Eukaryota.
ENOG411199U. LUCA.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiO43869.
KOiK04257.
OMAiMEEYNTS.
OrthoDBiEOG091G0ECW.
PhylomeDBiO43869.
TreeFamiTF337295.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43869-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWQEYYFLNV FFPLLKVCCL TINSHVVILL PWECYHLIWK ILPYIGTTVG
60 70 80 90 100
SMEEYNTSST DFTFMGLFNR KETSGLIFAI ISIIFFTALM ANGVMIFLIQ
110 120 130 140 150
TDLRLHTPMY FLLSHLSLID MMYISTIVPK MLVNYLLDQR TISFVGCTAQ
160 170 180 190 200
HFLYLTLVGA EFFLLGLMAY DRYVAICNPL RYPVLMSRRV CWMIIAGSWF
210 220 230 240 250
GGSLDGFLLT PITMSFPFCN SREINHFFCE APAVLKLACA DTALYETVMY
260 270 280 290 300
VCCVLMLLIP FSVVLASYAR ILTTVQCMSS VEGRKKAFAT CSSHMTVVSL
310 320 330 340 350
FYGAAMYTYM LPHSYHKPAQ DKVLSVFYTI LTPMLNPLIY SLRNKDVTGA
360
LKRALGRFKG PQRVSGGVF
Length:369
Mass (Da):41,996
Last modified:May 5, 2009 - v3
Checksum:i9D8E52A0312BEC3B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05754125H → R.Corresponds to variant rs28599722dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138089 Genomic DNA. No translation available.
U86215 Genomic DNA. Translation: AAC39611.1.
AF399613 Genomic DNA. Translation: AAK95098.1.
BK004463 Genomic DNA. Translation: DAA04861.1.
CCDSiCCDS31115.1.
RefSeqiNP_112166.1. NM_030904.1.
UniGeneiHs.626885.

Genome annotation databases

EnsembliENST00000366474; ENSP00000355430; ENSG00000175143.
ENST00000611851; ENSP00000479603; ENSG00000273508.
ENST00000613540; ENSP00000482752; ENSG00000275244.
GeneIDi26696.
KEGGihsa:26696.
UCSCiuc010pzm.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138089 Genomic DNA. No translation available.
U86215 Genomic DNA. Translation: AAC39611.1.
AF399613 Genomic DNA. Translation: AAK95098.1.
BK004463 Genomic DNA. Translation: DAA04861.1.
CCDSiCCDS31115.1.
RefSeqiNP_112166.1. NM_030904.1.
UniGeneiHs.626885.

3D structure databases

ProteinModelPortaliO43869.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000355430.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO43869.
PhosphoSitePlusiO43869.

Polymorphism and mutation databases

BioMutaiOR2T1.

Proteomic databases

PaxDbiO43869.
PRIDEiO43869.

Protocols and materials databases

DNASUi26696.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366474; ENSP00000355430; ENSG00000175143.
ENST00000611851; ENSP00000479603; ENSG00000273508.
ENST00000613540; ENSP00000482752; ENSG00000275244.
GeneIDi26696.
KEGGihsa:26696.
UCSCiuc010pzm.2. human.

Organism-specific databases

CTDi26696.
DisGeNETi26696.
GeneCardsiOR2T1.
H-InvDBHIX0200051.
HGNCiHGNC:8277. OR2T1.
HPAiHPA063064.
neXtProtiNX_O43869.
OpenTargetsiENSG00000175143.
ENSG00000273508.
ENSG00000275244.
PharmGKBiPA32201.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGYV. Eukaryota.
ENOG411199U. LUCA.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiO43869.
KOiK04257.
OMAiMEEYNTS.
OrthoDBiEOG091G0ECW.
PhylomeDBiO43869.
TreeFamiTF337295.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000175143-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2T1.
GenomeRNAii26696.
PROiO43869.

Gene expression databases

CleanExiHS_OR2T1.
ExpressionAtlasiO43869. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR2T1_HUMAN
AccessioniPrimary (citable) accession number: O43869
Secondary accession number(s): Q6IEZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 5, 2009
Last modified: November 30, 2016
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-52 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.