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Protein

Sodium/nucleoside cotransporter 2

Gene

SLC28A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues.

Enzyme regulationi

Inhibited by formycin B.

GO - Molecular functioni

  • nucleoside:sodium symporter activity Source: GO_Central
  • purine nucleoside transmembrane transporter activity Source: ProtInc

GO - Biological processi

  • nucleobase-containing compound metabolic process Source: ProtInc
  • purine nucleoside transmembrane transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137860-MONOMER.
ReactomeiR-HSA-83936. Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane.

Protein family/group databases

TCDBi2.A.41.2.4. the concentrative nucleoside transporter (cnt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/nucleoside cotransporter 2
Alternative name(s):
Concentrative nucleoside transporter 2
Short name:
CNT 2
Short name:
hCNT2
Na(+)/nucleoside cotransporter 2
Sodium-coupled nucleoside transporter 2
Sodium/purine nucleoside co-transporter
Short name:
SPNT
Solute carrier family 28 member 2
Gene namesi
Name:SLC28A2
Synonyms:CNT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:11002. SLC28A2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Transmembranei104 – 123HelicalSequence analysisAdd BLAST20
Transmembranei148 – 166HelicalSequence analysisAdd BLAST19
Transmembranei172 – 192HelicalSequence analysisAdd BLAST21
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Transmembranei260 – 280HelicalSequence analysisAdd BLAST21
Transmembranei295 – 314HelicalSequence analysisAdd BLAST20
Transmembranei336 – 355HelicalSequence analysisAdd BLAST20
Transmembranei362 – 381HelicalSequence analysisAdd BLAST20
Transmembranei423 – 443HelicalSequence analysisAdd BLAST21
Transmembranei454 – 474HelicalSequence analysisAdd BLAST21
Transmembranei529 – 549HelicalSequence analysisAdd BLAST21
Transmembranei567 – 587HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9153.
OpenTargetsiENSG00000137860.
PharmGKBiPA386.

Chemistry databases

ChEMBLiCHEMBL5780.
DrugBankiDB01033. Mercaptopurine.
GuidetoPHARMACOLOGYi1115.

Polymorphism and mutation databases

BioMutaiSLC28A2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000704501 – 658Sodium/nucleoside cotransporter 2Add BLAST658

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei45PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO43868.
PeptideAtlasiO43868.
PRIDEiO43868.

PTM databases

iPTMnetiO43868.
PhosphoSitePlusiO43868.

Expressioni

Tissue specificityi

Expressed in heart and skeletal muscle followed by liver, kidney, intestine, pancreas, placenta and brain. Weak expression in lung.

Gene expression databases

BgeeiENSG00000137860.
CleanExiHS_SLC28A2.
ExpressionAtlasiO43868. baseline and differential.
GenevisibleiO43868. HS.

Organism-specific databases

HPAiHPA046068.
HPA055623.

Interactioni

Protein-protein interaction databases

IntActiO43868. 1 interactor.
STRINGi9606.ENSP00000315006.

Chemistry databases

BindingDBiO43868.

Structurei

3D structure databases

ProteinModelPortaliO43868.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3747. Eukaryota.
COG1972. LUCA.
GeneTreeiENSGT00390000016025.
HOGENOMiHOG000267658.
HOVERGENiHBG054073.
InParanoidiO43868.
KOiK11536.
OMAiFCKTHAS.
OrthoDBiEOG091G05D5.
PhylomeDBiO43868.
TreeFamiTF314131.

Family and domain databases

InterProiIPR008276. C_nuclsd_transpt.
IPR018270. C_nuclsd_transpt_met_bac.
IPR030212. CNT1/CNT2.
IPR011657. CNT_C_dom.
IPR002668. CNT_N_dom.
IPR011642. Gate_dom.
[Graphical view]
PANTHERiPTHR10590. PTHR10590. 1 hit.
PTHR10590:SF11. PTHR10590:SF11. 1 hit.
PfamiPF07670. Gate. 1 hit.
PF07662. Nucleos_tra2_C. 1 hit.
PF01773. Nucleos_tra2_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00804. nupC. 1 hit.

Sequencei

Sequence statusi: Complete.

O43868-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKASGRQSI ALSTVETGTV NPGLELMEKE VEPEGSKRTD AQGHSLGDGL
60 70 80 90 100
GPSTYQRRSR WPFSKARSFC KTHASLFKKI LLGLLCLAYA AYLLAACILN
110 120 130 140 150
FQRALALFVI TCLVIFVLVH SFLKKLLGKK LTRCLKPFEN SRLRLWTKWV
160 170 180 190 200
FAGVSLVGLI LWLALDTAQR PEQLIPFAGI CMFILILFAC SKHHSAVSWR
210 220 230 240 250
TVFSGLGLQF VFGILVIRTD LGYTVFQWLG EQVQIFLNYT VAGSSFVFGD
260 270 280 290 300
TLVKDVFAFQ ALPIIIFFGC VVSILYYLGL VQWVVQKVAW FLQITMGTTA
310 320 330 340 350
TETLAVAGNI FVGMTEAPLL IRPYLGDMTL SEIHAVMTGG FATISGTVLG
360 370 380 390 400
AFIAFGVDAS SLISASVMAA PCALASSKLA YPEVEESKFK SEEGVKLPRG
410 420 430 440 450
KERNVLEAAS NGAVDAIGLA TNVAANLIAF LAVLAFINAA LSWLGELVDI
460 470 480 490 500
QGLTFQVICS YLLRPMVFMM GVEWTDCPMV AEMVGIKFFI NEFVAYQQLS
510 520 530 540 550
QYKNKRLSGM EEWIEGEKQW ISVRAEIITT FSLCGFANLS SIGITLGGLT
560 570 580 590 600
SIVPHRKSDL SKVVVRALFT GACVSLISAC MAGILYVPRG AEADCVSFPN
610 620 630 640 650
TSFTNRTYET YMCCRGLFQS TSLNGTNPPS FSGPWEDKEF SAMALTNCCG

FYNNTVCA
Length:658
Mass (Da):71,926
Last modified:October 17, 2006 - v2
Checksum:i273545EE75E0D663
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03681712L → P.1 PublicationCorresponds to variant rs567096708dbSNPEnsembl.1
Natural variantiVAR_02463922P → L.2 PublicationsCorresponds to variant rs11854484dbSNPEnsembl.1
Natural variantiVAR_02464075S → R.3 PublicationsCorresponds to variant rs1060896dbSNPEnsembl.1
Natural variantiVAR_036818142R → H.1 PublicationCorresponds to variant rs115740452dbSNPEnsembl.1
Natural variantiVAR_022001163L → W.2 PublicationsCorresponds to variant rs2271437dbSNPEnsembl.1
Natural variantiVAR_036819172E → D.1 PublicationCorresponds to variant rs113624548dbSNPEnsembl.1
Natural variantiVAR_024641245S → T.1 PublicationCorresponds to variant rs10519020dbSNPEnsembl.1
Natural variantiVAR_024642355F → S.1 PublicationCorresponds to variant rs17215633dbSNPEnsembl.1
Natural variantiVAR_036820385E → K.1 PublicationCorresponds to variant rs376327143dbSNPEnsembl.1
Natural variantiVAR_024643462L → F.1 PublicationCorresponds to variant rs17222057dbSNPEnsembl.1
Natural variantiVAR_028724509G → E.Corresponds to variant rs9635306dbSNPEnsembl.1
Natural variantiVAR_036821612M → T.1 PublicationCorresponds to variant rs373539209dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U84392 mRNA. Translation: AAC51930.1.
AF036109 mRNA. Translation: AAB88539.1.
AK291974 mRNA. Translation: BAF84663.1.
BC093737 mRNA. Translation: AAH93737.1.
CCDSiCCDS10121.1.
RefSeqiNP_004203.2. NM_004212.3.
XP_011520500.1. XM_011522198.2.
UniGeneiHs.367833.

Genome annotation databases

EnsembliENST00000347644; ENSP00000315006; ENSG00000137860.
GeneIDi9153.
KEGGihsa:9153.
UCSCiuc001zva.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U84392 mRNA. Translation: AAC51930.1.
AF036109 mRNA. Translation: AAB88539.1.
AK291974 mRNA. Translation: BAF84663.1.
BC093737 mRNA. Translation: AAH93737.1.
CCDSiCCDS10121.1.
RefSeqiNP_004203.2. NM_004212.3.
XP_011520500.1. XM_011522198.2.
UniGeneiHs.367833.

3D structure databases

ProteinModelPortaliO43868.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO43868. 1 interactor.
STRINGi9606.ENSP00000315006.

Chemistry databases

BindingDBiO43868.
ChEMBLiCHEMBL5780.
DrugBankiDB01033. Mercaptopurine.
GuidetoPHARMACOLOGYi1115.

Protein family/group databases

TCDBi2.A.41.2.4. the concentrative nucleoside transporter (cnt) family.

PTM databases

iPTMnetiO43868.
PhosphoSitePlusiO43868.

Polymorphism and mutation databases

BioMutaiSLC28A2.

Proteomic databases

PaxDbiO43868.
PeptideAtlasiO43868.
PRIDEiO43868.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000347644; ENSP00000315006; ENSG00000137860.
GeneIDi9153.
KEGGihsa:9153.
UCSCiuc001zva.3. human.

Organism-specific databases

CTDi9153.
DisGeNETi9153.
GeneCardsiSLC28A2.
HGNCiHGNC:11002. SLC28A2.
HPAiHPA046068.
HPA055623.
MIMi606208. gene.
neXtProtiNX_O43868.
OpenTargetsiENSG00000137860.
PharmGKBiPA386.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3747. Eukaryota.
COG1972. LUCA.
GeneTreeiENSGT00390000016025.
HOGENOMiHOG000267658.
HOVERGENiHBG054073.
InParanoidiO43868.
KOiK11536.
OMAiFCKTHAS.
OrthoDBiEOG091G05D5.
PhylomeDBiO43868.
TreeFamiTF314131.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137860-MONOMER.
ReactomeiR-HSA-83936. Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane.

Miscellaneous databases

GeneWikiiConcentrative_nucleoside_transporter_2.
GenomeRNAii9153.
PROiO43868.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137860.
CleanExiHS_SLC28A2.
ExpressionAtlasiO43868. baseline and differential.
GenevisibleiO43868. HS.

Family and domain databases

InterProiIPR008276. C_nuclsd_transpt.
IPR018270. C_nuclsd_transpt_met_bac.
IPR030212. CNT1/CNT2.
IPR011657. CNT_C_dom.
IPR002668. CNT_N_dom.
IPR011642. Gate_dom.
[Graphical view]
PANTHERiPTHR10590. PTHR10590. 1 hit.
PTHR10590:SF11. PTHR10590:SF11. 1 hit.
PfamiPF07670. Gate. 1 hit.
PF07662. Nucleos_tra2_C. 1 hit.
PF01773. Nucleos_tra2_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00804. nupC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiS28A2_HUMAN
AccessioniPrimary (citable) accession number: O43868
Secondary accession number(s): A8K7F9, O43239, Q52LZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 17, 2006
Last modified: November 30, 2016
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.