##gff-version 3 O43865 UniProtKB Initiator methionine 1 1 . . . Note=Removed;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21406692;Dbxref=PMID:21406692 O43865 UniProtKB Chain 2 530 . . . ID=PRO_0000116908;Note=S-adenosylhomocysteine hydrolase-like protein 1 O43865 UniProtKB Region 53 103 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O43865 UniProtKB Region 65 92 . . . Note=PEST;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25237103;Dbxref=PMID:25237103 O43865 UniProtKB Region 138 201 . . . Note=Interaction with BCL2L10;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27995898;Dbxref=PMID:27995898 O43865 UniProtKB Region 281 448 . . . Note=NAD binding;Ontology_term=ECO:0000250;evidence=ECO:0000250 O43865 UniProtKB Region 520 530 . . . Note=PDZ-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250 O43865 UniProtKB Compositional bias 55 85 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O43865 UniProtKB Binding site 155 155 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 O43865 UniProtKB Binding site 229 229 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 O43865 UniProtKB Binding site 254 254 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 O43865 UniProtKB Binding site 284 284 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 O43865 UniProtKB Binding site 288 288 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 O43865 UniProtKB Binding site 318 322 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25237103;Dbxref=PMID:25237103 O43865 UniProtKB Binding site 341 341 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25237103;Dbxref=PMID:25237103 O43865 UniProtKB Binding site 376 376 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25237103;Dbxref=PMID:25237103 O43865 UniProtKB Binding site 397 399 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25237103;Dbxref=PMID:25237103 O43865 UniProtKB Modified residue 2 2 . . . Note=N-acetylserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21406692;Dbxref=PMID:21406692 O43865 UniProtKB Modified residue 2 2 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163 O43865 UniProtKB Modified residue 40 40 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q80SW1 O43865 UniProtKB Modified residue 68 68 . . . Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0000305,ECO:0000305;evidence=ECO:0000269|PubMed:27995898,ECO:0000305|PubMed:16793548,ECO:0000305|PubMed:19220705;Dbxref=PMID:16793548,PMID:19220705,PMID:27995898 O43865 UniProtKB Modified residue 71 71 . . . Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0000305,ECO:0000305;evidence=ECO:0000269|PubMed:27995898,ECO:0000305|PubMed:16793548,ECO:0000305|PubMed:19220705;Dbxref=PMID:16793548,PMID:19220705,PMID:27995898 O43865 UniProtKB Modified residue 74 74 . . . Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:27995898,ECO:0000305|PubMed:19220705;Dbxref=PMID:19220705,PMID:27995898 O43865 UniProtKB Modified residue 77 77 . . . Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:27995898,ECO:0000305|PubMed:19220705;Dbxref=PMID:19220705,PMID:27995898 O43865 UniProtKB Modified residue 84 84 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q80SW1 O43865 UniProtKB Modified residue 391 391 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 O43865 UniProtKB Alternative sequence 1 47 . . . ID=VSP_021751;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12878157,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005,ECO:0000303|PubMed:7782076;Dbxref=PMID:12878157,PMID:14702039,PMID:15489334,PMID:17974005,PMID:7782076 O43865 UniProtKB Mutagenesis 52 52 . . . Note=No effect on interaction with SLC4A4. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16769890;Dbxref=PMID:16769890 O43865 UniProtKB Mutagenesis 58 58 . . . Note=No effect on interaction with SLC4A4. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16769890;Dbxref=PMID:16769890 O43865 UniProtKB Mutagenesis 62 62 . . . Note=No effect on interaction with SLC4A4. No effect on interaction with FIP1L1. S->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16769890,ECO:0000269|PubMed:19224921;Dbxref=PMID:16769890,PMID:19224921 O43865 UniProtKB Mutagenesis 64 64 . . . Note=No effect on interaction with ITPR1. No effect on phosphorylation. No effect on interaction with SLC4A4. No effect on interaction with FIP1L1. S->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16769890,ECO:0000269|PubMed:16793548,ECO:0000269|PubMed:19224921;Dbxref=PMID:16769890,PMID:16793548,PMID:19224921 O43865 UniProtKB Mutagenesis 66 66 . . . Note=Slightly decreases interaction with ITPR1. Slightly decreases phosphorylation. No effect on interaction with SLC4A4. Abolishes interaction with FIP1L1. S->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16769890,ECO:0000269|PubMed:16793548,ECO:0000269|PubMed:19224921;Dbxref=PMID:16769890,PMID:16793548,PMID:19224921 O43865 UniProtKB Mutagenesis 68 68 . . . Note=Highly decreases phosphorylation. Abolishes interaction with ITPR1. No effect on interaction with BCL2L10. Marked decrease in interaction of BCL2L10 with ITPR1. Decreased ability of BCL2L10 to reduce ITPR1-mediated calcium release and to prevent apoptosis. No effect on formation of multimers. Abolishes interaction with SLC4A4. Abolishes interaction with FIP1L1. Highly decreases interaction with SLC9A3. Highly decreases interaction with SLC9A3%3B when associated with A-71 and A-74. S->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16769890,ECO:0000269|PubMed:16793548,ECO:0000269|PubMed:19224921,ECO:0000269|PubMed:20584908,ECO:0000269|PubMed:27995898;Dbxref=PMID:16769890,PMID:16793548,PMID:19224921,PMID:20584908,PMID:27995898 O43865 UniProtKB Mutagenesis 70 70 . . . Note=Highly decreases interaction with ITPR1. No effect on phosphorylation. No effect on interaction with SLC4A4. Abolishes interaction with FIP1L1. S->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16769890,ECO:0000269|PubMed:16793548,ECO:0000269|PubMed:19224921;Dbxref=PMID:16769890,PMID:16793548,PMID:19224921 O43865 UniProtKB Mutagenesis 71 71 . . . Note=Abolishes interaction with ITPR1. Highly decreases phosphorylation. Abolishes interaction with SLC4A4. Abolishes interaction with FIP1L1. Highly decreases interaction with SLC9A3%3B when associated with A-68 and A-74. S->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16769890,ECO:0000269|PubMed:16793548,ECO:0000269|PubMed:19224921,ECO:0000269|PubMed:20584908;Dbxref=PMID:16769890,PMID:16793548,PMID:19224921,PMID:20584908 O43865 UniProtKB Mutagenesis 72 72 . . . Note=Highly decreases interaction with ITPR1. Slightly increases phosphorylation. No effect on interaction with SLC4A4. Highly decreases interaction with FIP1L1. T->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16769890,ECO:0000269|PubMed:16793548,ECO:0000269|PubMed:19224921;Dbxref=PMID:16769890,PMID:16793548,PMID:19224921 O43865 UniProtKB Mutagenesis 74 74 . . . Note=Abolishes interaction with ITPR1. Slightly decreases phosphorylation. Strongly decreases interaction with SLC4A4. Abolishes interaction with FIP1L1. Highly decreases interaction with SLC9A3%3B when associated with A-68 and A-71. S->G;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16769890,ECO:0000269|PubMed:16793548,ECO:0000269|PubMed:19224921,ECO:0000269|PubMed:20584908;Dbxref=PMID:16769890,PMID:16793548,PMID:19224921,PMID:20584908 O43865 UniProtKB Mutagenesis 76 76 . . . Note=No effect on interaction with ITPR1. No effect on phosphorylation. No effect on interaction with SLC4A4. No effect on interaction with FIP1L1. S->G;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16769890,ECO:0000269|PubMed:16793548,ECO:0000269|PubMed:19224921;Dbxref=PMID:16769890,PMID:16793548,PMID:19224921 O43865 UniProtKB Mutagenesis 77 77 . . . Note=Highly decreases interaction with ITPR1. Slightly decreases phosphorylation. Strongly decreases interaction with SLC4A4. Abolishes interaction with FIP1L1. S->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16769890,ECO:0000269|PubMed:16793548,ECO:0000269|PubMed:19224921;Dbxref=PMID:16769890,PMID:16793548,PMID:19224921 O43865 UniProtKB Mutagenesis 80 80 . . . Note=No effect on interaction with SLC4A4. Highly decreases interaction with FIP1L1. S->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16769890,ECO:0000269|PubMed:16793548,ECO:0000269|PubMed:19224921;Dbxref=PMID:16769890,PMID:16793548,PMID:19224921 O43865 UniProtKB Mutagenesis 82 82 . . . Note=No effect on interaction with ITPR1. No effect on phosphorylation. No effect on interaction with SLC4A4. Decreases interaction with FIP1L1. T->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16769890,ECO:0000269|PubMed:16793548,ECO:0000269|PubMed:19224921;Dbxref=PMID:16769890,PMID:16793548,PMID:19224921 O43865 UniProtKB Mutagenesis 84 84 . . . Note=Slightly decreases interaction with ITPR1. No effect on phosphorylation. No effect on interaction with SLC4A4. Decreases interaction with FIP1L1. S->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16769890,ECO:0000269|PubMed:16793548,ECO:0000269|PubMed:19224921;Dbxref=PMID:16769890,PMID:16793548,PMID:19224921 O43865 UniProtKB Mutagenesis 85 85 . . . Note=Slightly decreases interaction with ITPR1. No effect on phosphorylation. No effect on interaction with SLC4A4. Decreases interaction with FIP1L1. S->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16769890,ECO:0000269|PubMed:16793548,ECO:0000269|PubMed:19224921;Dbxref=PMID:16769890,PMID:16793548,PMID:19224921 O43865 UniProtKB Mutagenesis 90 90 . . . Note=No effect on interaction with ITPR1. No effect on phosphorylation. No effect on interaction with SLC4A4. No effect on interaction with FIP1L1. S->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16769890,ECO:0000269|PubMed:16793548,ECO:0000269|PubMed:19224921;Dbxref=PMID:16769890,PMID:16793548,PMID:19224921 O43865 UniProtKB Mutagenesis 97 97 . . . Note=No effect on interaction with ITPR1. No effect on interaction with SLC4A4. No effect on interaction with FIP1L1. T->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16769890,ECO:0000269|PubMed:16793548,ECO:0000269|PubMed:19224921;Dbxref=PMID:16769890,PMID:16793548,PMID:19224921 O43865 UniProtKB Sequence conflict 94 94 . . . Note=K->M;Ontology_term=ECO:0000305;evidence=ECO:0000305 O43865 UniProtKB Sequence conflict 99 99 . . . Note=S->F;Ontology_term=ECO:0000305;evidence=ECO:0000305 O43865 UniProtKB Helix 113 124 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Helix 128 137 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Turn 142 145 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Beta strand 147 152 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Helix 156 167 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Beta strand 171 175 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Beta strand 177 180 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Helix 184 193 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Beta strand 196 198 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Helix 205 216 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Beta strand 224 231 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Helix 232 240 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Helix 242 245 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Beta strand 249 253 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Helix 256 265 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Turn 266 269 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Beta strand 275 277 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Helix 282 293 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Helix 299 305 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Beta strand 313 317 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Helix 321 333 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Beta strand 336 340 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Helix 344 352 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Helix 360 362 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Turn 363 366 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Beta strand 368 372 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Helix 382 387 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Beta strand 392 396 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Turn 400 403 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Helix 406 409 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Beta strand 415 420 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Beta strand 423 427 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Beta strand 433 437 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Helix 438 440 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Helix 444 446 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Helix 452 471 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Beta strand 479 482 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Helix 486 496 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Helix 497 500 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Helix 509 514 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Beta strand 519 521 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MTG O43865 UniProtKB Modified residue 1 1 . . . Note=N-acetylmethionine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22814378;Dbxref=PMID:22814378