SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O43861

- ATP9B_HUMAN

UniProt

O43861 - ATP9B_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Probable phospholipid-transporting ATPase IIB
Gene
ATP9B, ATPIIB, NEO1L, HUSSY-20
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei468 – 46814-aspartylphosphate intermediate By similarity
Metal bindingi874 – 8741Magnesium By similarity
Metal bindingi878 – 8781Magnesium By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cation-transporting ATPase activity Source: InterPro
  3. magnesium ion binding Source: InterPro
  4. phospholipid-translocating ATPase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. establishment of protein localization to Golgi Source: UniProtKB
  2. phospholipid translocation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_25149. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phospholipid-transporting ATPase IIB (EC:3.6.3.1)
Alternative name(s):
ATPase class II type 9B
Gene namesi
Name:ATP9B
Synonyms:ATPIIB, NEO1L
ORF Names:HUSSY-20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:13541. ATP9B.

Subcellular locationi

Golgi apparatustrans-Golgi network membrane; Multi-pass membrane protein
Note: Efficient exit from the endoplasmic reticulum does not require TMEM30A, nor TMEM30B.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 146146Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei147 – 16822Helical; Reviewed prediction
Add
BLAST
Topological domaini169 – 1735Extracellular Reviewed prediction
Transmembranei174 – 19623Helical; Reviewed prediction
Add
BLAST
Topological domaini197 – 380184Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei381 – 40121Helical; Reviewed prediction
Add
BLAST
Topological domaini402 – 4098Extracellular Reviewed prediction
Transmembranei410 – 43122Helical; Reviewed prediction
Add
BLAST
Topological domaini432 – 930499Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei931 – 95121Helical; Reviewed prediction
Add
BLAST
Topological domaini952 – 96312Extracellular Reviewed prediction
Add
BLAST
Transmembranei964 – 98219Helical; Reviewed prediction
Add
BLAST
Topological domaini983 – 101230Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei1013 – 103119Helical; Reviewed prediction
Add
BLAST
Topological domaini1032 – 10387Extracellular Reviewed prediction
Transmembranei1039 – 106123Helical; Reviewed prediction
Add
BLAST
Topological domaini1062 – 10676Cytoplasmic Reviewed prediction
Transmembranei1068 – 108821Helical; Reviewed prediction
Add
BLAST
Topological domaini1089 – 110517Extracellular Reviewed prediction
Add
BLAST
Transmembranei1106 – 113025Helical; Reviewed prediction
Add
BLAST
Topological domaini1131 – 114717Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. perinuclear region of cytoplasm Source: UniProtKB
  3. trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25172.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11471147Probable phospholipid-transporting ATPase IIB
PRO_0000046377Add
BLAST

Proteomic databases

MaxQBiO43861.
PaxDbiO43861.
PRIDEiO43861.

PTM databases

PhosphoSiteiO43861.

Expressioni

Gene expression databases

ArrayExpressiO43861.
BgeeiO43861.
CleanExiHS_ATP9B.
GenevestigatoriO43861.

Organism-specific databases

HPAiHPA029364.

Interactioni

Protein-protein interaction databases

BioGridi131925. 1 interaction.
STRINGi9606.ENSP00000304500.

Structurei

3D structure databases

ProteinModelPortaliO43861.
SMRiO43861. Positions 707-985.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0474.
HOGENOMiHOG000201571.
HOVERGENiHBG050617.
InParanoidiO43861.
KOiK01530.
OMAiSYANEAM.
PhylomeDBiO43861.
TreeFamiTF300590.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 2 hits.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR006539. ATPase_P-typ_Plipid-transp.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 1 hit.
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 2 hits.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O43861-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MADQIPLYPV RSAAAAAANR KRAAYYSAAG PRPGADRHSR YQLEDESAHL     50
DEMPLMMSEE GFENEESDYH TLPRARIMQR KRGLEWFVCD GWKFLCTSCC 100
GWLINICRRK KELKARTVWL GCPEKCEEKH PRNSIKNQKY NVFTFIPGVL 150
YEQFKFFLNL YFLVISCSQF VPALKIGYLY TYWAPLGFVL AVTMTREAID 200
EFRRFQRDKE VNSQLYSKLT VRGKVQVKSS DIQVGDLIIV EKNQRIPSDM 250
VFLRTSEKAG SCFIRTDQLD GETDWKLKVA VSCTQQLPAL GDLFSISAYV 300
YAQKPQMDIH SFEGTFTRED SDPPIHESLS IENTLWASTI VASGTVIGVV 350
IYTGKETRSV MNTSNPKNKV GLLDLELNRL TKALFLALVA LSIVMVTLQG 400
FVGPWYRNLF RFLLLFSYII PISLRVNLDM GKAVYGWMMM KDENIPGTVV 450
RTSTIPEELG RLVYLLTDKT GTLTQNEMIF KRLHLGTVSY GADTMDEIQS 500
HVRDSYSQMQ SQAGGNNTGS TPLRKAQSSA PKVRKSVSSR IHEAVKAIVL 550
CHNVTPVYES RAGVTEETEF AEADQDFSDE NRTYQASSPD EVALVQWTES 600
VGLTLVSRDL TSMQLKTPSG QVLSFCILQL FPFTSESKRM GVIVRDESTA 650
EITFYMKGAD VAMSPIVQYN DWLEEECGNM AREGLRTLVV AKKALTEEQY 700
QDFESRYTQA KLSMHDRSLK VAAVVESLER EMELLCLTGV EDQLQADVRP 750
TLEMLRNAGI KIWMLTGDKL ETATCIAKSS HLVSRTQDIH IFRQVTSRGE 800
AHLELNAFRR KHDCALVISG DSLEVCLKYY EHEFVELACQ CPAVVCCRCS 850
PTQKARIVTL LQQHTGRRTC AIGDGGNDVS MIQAADCGIG IEGKEGKQAS 900
LAADFSITQF RHIGRLLMVH GRNSYKRSAA LGQFVMHRGL IISTMQAVFS 950
SVFYFASVPL YQGFLMVGYA TIYTMFPVFS LVLDQDVKPE MAMLYPELYK 1000
DLTKGRSLSF KTFLIWVLIS IYQGGILMYG ALVLFESEFV HVVAISFTAL 1050
ILTELLMVAL TVRTWHWLMV VAEFLSLGCY VSSLAFLNEY FGIGRVSFGA 1100
FLDVAFITTV TFLWKVSAIT VVSCLPLYVL KYLRRKLSPP SYCKLAS 1147
Length:1,147
Mass (Da):129,304
Last modified:November 25, 2008 - v4
Checksum:i1C3787BF07EFD637
GO
Isoform 2 (identifier: O43861-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1092-1102: Missing.

Show »
Length:1,136
Mass (Da):128,198
Checksum:iEE75E3FF2C930873
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti39 – 391S → G.1 Publication
Corresponds to variant rs4078115 [ dbSNP | Ensembl ].
VAR_047557
Natural varianti108 – 1081R → Q.
Corresponds to variant rs34938281 [ dbSNP | Ensembl ].
VAR_061037
Natural varianti504 – 5041D → N.
Corresponds to variant rs36034863 [ dbSNP | Ensembl ].
VAR_047558
Natural varianti732 – 7321M → L.
Corresponds to variant rs585033 [ dbSNP | Ensembl ].
VAR_047559

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1092 – 110211Missing in isoform 2.
VSP_035790Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti886 – 8861D → N in AAC05243. 1 Publication
Sequence conflicti1006 – 10061R → K in AAC05243. 1 Publication
Sequence conflicti1020 – 10201S → I in AAC05243. 1 Publication
Sequence conflicti1036 – 10361E → D in AAC05243. 1 Publication
Sequence conflicti1073 – 10731E → D in AAC05243. 1 Publication
Sequence conflicti1095 – 10951R → K in AAC05243. 1 Publication
Sequence conflicti1103 – 11031D → N in AAC05243. 1 Publication
Sequence conflicti1131 – 11311K → N in AAC05243. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC023090 Genomic DNA. No translation available.
AC099689 Genomic DNA. No translation available.
AC104423 Genomic DNA. No translation available.
AC125437 Genomic DNA. No translation available.
BC125219 mRNA. Translation: AAI25220.1.
BC125220 mRNA. Translation: AAI25221.1.
AK097757 mRNA. No translation available.
U78978 mRNA. Translation: AAC05243.1.
AJ006268 mRNA. Translation: CAA06934.1.
CCDSiCCDS12014.1. [O43861-1]
RefSeqiNP_940933.3. NM_198531.3. [O43861-1]
XP_005266748.1. XM_005266691.1. [O43861-2]
UniGeneiHs.465475.

Genome annotation databases

EnsembliENST00000307671; ENSP00000304500; ENSG00000166377. [O43861-2]
ENST00000426216; ENSP00000398076; ENSG00000166377. [O43861-1]
ENST00000575536; ENSP00000458245; ENSG00000262782. [O43861-1]
GeneIDi374868.
KEGGihsa:374868.
UCSCiuc002lmw.1. human. [O43861-2]
uc002lmx.3. human. [O43861-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC023090 Genomic DNA. No translation available.
AC099689 Genomic DNA. No translation available.
AC104423 Genomic DNA. No translation available.
AC125437 Genomic DNA. No translation available.
BC125219 mRNA. Translation: AAI25220.1 .
BC125220 mRNA. Translation: AAI25221.1 .
AK097757 mRNA. No translation available.
U78978 mRNA. Translation: AAC05243.1 .
AJ006268 mRNA. Translation: CAA06934.1 .
CCDSi CCDS12014.1. [O43861-1 ]
RefSeqi NP_940933.3. NM_198531.3. [O43861-1 ]
XP_005266748.1. XM_005266691.1. [O43861-2 ]
UniGenei Hs.465475.

3D structure databases

ProteinModelPortali O43861.
SMRi O43861. Positions 707-985.
ModBasei Search...

Protein-protein interaction databases

BioGridi 131925. 1 interaction.
STRINGi 9606.ENSP00000304500.

PTM databases

PhosphoSitei O43861.

Proteomic databases

MaxQBi O43861.
PaxDbi O43861.
PRIDEi O43861.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000307671 ; ENSP00000304500 ; ENSG00000166377 . [O43861-2 ]
ENST00000426216 ; ENSP00000398076 ; ENSG00000166377 . [O43861-1 ]
ENST00000575536 ; ENSP00000458245 ; ENSG00000262782 . [O43861-1 ]
GeneIDi 374868.
KEGGi hsa:374868.
UCSCi uc002lmw.1. human. [O43861-2 ]
uc002lmx.3. human. [O43861-1 ]

Organism-specific databases

CTDi 374868.
GeneCardsi GC18P076855.
HGNCi HGNC:13541. ATP9B.
HPAi HPA029364.
MIMi 614446. gene.
neXtProti NX_O43861.
PharmGKBi PA25172.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0474.
HOGENOMi HOG000201571.
HOVERGENi HBG050617.
InParanoidi O43861.
KOi K01530.
OMAi SYANEAM.
PhylomeDBi O43861.
TreeFami TF300590.

Enzyme and pathway databases

Reactomei REACT_25149. Ion transport by P-type ATPases.

Miscellaneous databases

GenomeRNAii 374868.
NextBioi 100277.
PROi O43861.
SOURCEi Search...

Gene expression databases

ArrayExpressi O43861.
Bgeei O43861.
CleanExi HS_ATP9B.
Genevestigatori O43861.

Family and domain databases

Gene3Di 2.70.150.10. 2 hits.
3.40.1110.10. 2 hits.
3.40.50.1000. 2 hits.
InterProi IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR006539. ATPase_P-typ_Plipid-transp.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view ]
PANTHERi PTHR24092. PTHR24092. 1 hit.
Pfami PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
SUPFAMi SSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 2 hits.
TIGRFAMsi TIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT GLY-39.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 41-472 (ISOFORMS 1/2).
    Tissue: Testis.
  4. "Multiple members of a third subfamily of P-type ATPases identified by genomic sequences and ESTs."
    Halleck M.S., Pradhan D., Blackman C.F., Berkes C., Williamson P.L., Schlegel R.A.
    Genome Res. 8:354-361(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 811-1147 (ISOFORM 1).
    Tissue: Brain.
  5. "Characterization of 16 novel human genes showing high similarity to yeast sequences."
    Stanchi F., Bertocco E., Toppo S., Dioguardi R., Simionati B., Cannata N., Zimbello R., Lanfranchi G., Valle G.
    Yeast 18:69-80(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 820-1147 (ISOFORM 1).
    Tissue: Brain.
  6. "ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner."
    Takatsu H., Baba K., Shima T., Umino H., Kato U., Umeda M., Nakayama K., Shin H.W.
    J. Biol. Chem. 286:38159-38167(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiATP9B_HUMAN
AccessioniPrimary (citable) accession number: O43861
Secondary accession number(s): O60872, Q08AD8, Q08AD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 25, 2008
Last modified: September 3, 2014
This is version 133 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-53 is the initiator.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi