O43854 (EDIL3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
EGF-like repeat and discoidin I-like domain-containing protein 3

Alternative name(s):
Developmentally-regulated endothelial cell locus 1 protein
Integrin-binding protein DEL1

Gene names

Name:	EDIL3
Synonyms:	DEL1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	480 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development.
Subcellular location	Secreted.
Sequence similarities	Contains 3 EGF-like domains. Contains 2 F5/8 type C domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Secreted
Coding sequence diversity	Alternative splicing
Domain	EGF-like domain Repeat Signal
Molecular function	Developmental protein
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	calcium ion binding Inferred from electronic annotation. Source: InterPro integrin binding Traceable author statement. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O43854-1)

Also known as: Long;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O43854-2)

Also known as: Short; Z20;

The sequence of this isoform differs from the canonical sequence as follows:
     66-66: A → G
     67-76: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Chain	17 – 480	464	EGF-like repeat and discoidin I-like domain-containing protein 3		PRO_0000007522
Regions
	Domain	22 – 60	39	EGF-like 1
	Domain	74 – 117	44	EGF-like 2
	Domain	119 – 155	37	EGF-like 3
	Domain	158 – 314	157	F5/8 type C 1
	Domain	319 – 476	158	F5/8 type C 2
	Motif	96 – 98	3	Cell attachment site Potential
Amino acid modifications
	Disulfide bond	26 ↔ 37		By similarity
	Disulfide bond	31 ↔ 48		By similarity
	Disulfide bond	50 ↔ 59		By similarity
	Disulfide bond	78 ↔ 89		By similarity
	Disulfide bond	83 ↔ 105		By similarity
	Disulfide bond	107 ↔ 116		By similarity
	Disulfide bond	123 ↔ 134		By similarity
	Disulfide bond	128 ↔ 143		By similarity
	Disulfide bond	145 ↔ 154		By similarity
	Disulfide bond	158 ↔ 314		By similarity
	Disulfide bond	301 ↔ 305		By similarity
	Disulfide bond	319 ↔ 476		By similarity
Natural variations
	Alternative sequence	66	1	A → G in isoform 2.		VSP_050006
	Alternative sequence	67 – 76	10	Missing in isoform 2.		VSP_050007

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Long) [UniParc]. Last modified June 1, 1998. Version 1. Checksum: F7171E23A309FD48	FASTA	480	53,765
	10 20 30 40 50 60 MKRSVAVWLL VGLSLGVPQF GKGDICDPNP CENGGICLPG LADGSFSCEC PDGFTDPNCS 70 80 90 100 110 120 SVVEVASDEE EPTSAGPCTP NPCHNGGTCE ISEAYRGDTF IGYVCKCPRG FNGIHCQHNI 130 140 150 160 170 180 NECEVEPCKN GGICTDLVAN YSCECPGEFM GRNCQYKCSG PLGIEGGIIS NQQITASSTH 190 200 210 220 230 240 RALFGLQKWY PYYARLNKKG LINAWTAAEN DRWPWIQINL QRKMRVTGVI TQGAKRIGSP 250 260 270 280 290 300 EYIKSYKIAY SNDGKTWAMY KVKGTNEDMV FRGNIDNNTP YANSFTPPIK AQYVRLYPQV 310 320 330 340 350 360 CRRHCTLRME LLGCELSGCS EPLGMKSGHI QDYQITASSI FRTLNMDMFT WEPRKARLDK 370 380 390 400 410 420 QGKVNAWTSG HNDQSQWLQV DLLVPTKVTG IITQGAKDFG HVQFVGSYKL AYSNDGEHWT 430 440 450 460 470 480 VYQDEKQRKD KVFQGNFDND THRKNVIDPP IYARHIRILP WSWYGRITLR SELLGCTEEE
	Isoform 2 (Short) (Z20) [UniParc]. Checksum: EFF139A13FE5337A	FASTA	470	52,748
	10 20 30 40 50 60 MKRSVAVWLL VGLSLGVPQF GKGDICDPNP CENGGICLPG LADGSFSCEC PDGFTDPNCS 70 80 90 100 110 120 SVVEVGPCTP NPCHNGGTCE ISEAYRGDTF IGYVCKCPRG FNGIHCQHNI NECEVEPCKN 130 140 150 160 170 180 GGICTDLVAN YSCECPGEFM GRNCQYKCSG PLGIEGGIIS NQQITASSTH RALFGLQKWY 190 200 210 220 230 240 PYYARLNKKG LINAWTAAEN DRWPWIQINL QRKMRVTGVI TQGAKRIGSP EYIKSYKIAY 250 260 270 280 290 300 SNDGKTWAMY KVKGTNEDMV FRGNIDNNTP YANSFTPPIK AQYVRLYPQV CRRHCTLRME 310 320 330 340 350 360 LLGCELSGCS EPLGMKSGHI QDYQITASSI FRTLNMDMFT WEPRKARLDK QGKVNAWTSG 370 380 390 400 410 420 HNDQSQWLQV DLLVPTKVTG IITQGAKDFG HVQFVGSYKL AYSNDGEHWT VYQDEKQRKD 430 440 450 460 470 KVFQGNFDND THRKNVIDPP IYARHIRILP WSWYGRITLR SELLGCTEEE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of developmental endothelial locus-1: an embryonic endothelial cell protein that binds the alphavbeta3 integrin receptor." Hidai C., Zupancic T.J., Penta K., Mikhail A., Kawana M., Quertermous E.E., Aoka Y., Fukagawa M., Matsui Y., Platika D., Auerbach R., Hogan B.L.M., Snodgrass R., Quertermous T. Genes Dev. 12:21-33(1998) [PubMed: 9420328] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), CHARACTERIZATION. Tissue: Embryonic lung.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Trachea.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U70312 mRNA. Translation: AAC02648.1. U70313 mRNA. Translation: AAC02649.1. AK312858 mRNA. Translation: BAG35710.1. CH471084 Genomic DNA. Translation: EAW95917.1. CH471084 Genomic DNA. Translation: EAW95918.1. BC053656 mRNA. Translation: AAH53656.1.
IPI	IPI00306046. IPI00399105.
RefSeq	NP_005702.3. NM_005711.3.
UniGene	Hs.482730.
3D structure databases
ProteinModelPortal	O43854.
SMR	O43854. Positions 22-480.
ModBase	Search...
Protein-protein interaction databases
IntAct	O43854. 1 interaction.
STRING	O43854.
PTM databases
PhosphoSite	O43854.
Proteomic databases
PRIDE	O43854.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000296591; ENSP00000296591; ENSG00000164176.
GeneID	10085.
KEGG	hsa:10085.
UCSC	uc003kio.1. human.
Organism-specific databases
CTD	10085.
GeneCards	GC05M083272.
H-InvDB	HIX0005012.
HGNC	HGNC:3173. EDIL3.
MIM	606018. gene.
neXtProt	NX_O43854.
PharmGKB	PA27613.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG08047.
HOGENOM	HBG714573.
HOVERGEN	HBG002385.
InParanoid	O43854.
OMA	PEYVKSY.
OrthoDB	EOG4SXNC7.
PhylomeDB	O43854.
Enzyme and pathway databases
Pathway_Interaction_DB	avb3_integrin_pathway. Integrins in angiogenesis.
Gene expression databases
ArrayExpress	O43854.
Bgee	O43854.
CleanEx	HS_EDIL3.
Genevestigator	O43854.
GermOnline	ENSG00000164176. Homo sapiens.
Family and domain databases
InterPro	IPR000421. Coagulation_fac_5/8-C_type_dom. IPR006209. EGF. IPR006210. EGF-like. IPR001881. EGF-like_Ca-bd. IPR013032. EGF-like_reg_CS. IPR000152. EGF-type_Asp/Asn_hydroxyl_site. IPR000742. EGF_3. IPR018097. EGF_Ca-bd_CS. IPR008979. Galactose-bd-like. [Graphical view]
Pfam	PF00008. EGF. 2 hits. PF00754. F5_F8_type_C. 2 hits. [Graphical view]
SMART	SM00181. EGF. 2 hits. SM00179. EGF_CA. 1 hit. SM00231. FA58C. 2 hits. [Graphical view]
SUPFAM	SSF49785. Gal_bind_like. 2 hits.
PROSITE	PS00010. ASX_HYDROXYL. 1 hit. PS00022. EGF_1. 2 hits. PS01186. EGF_2. 2 hits. PS50026. EGF_3. 3 hits. PS01187. EGF_CA. 1 hit. PS01285. FA58C_1. 2 hits. PS01286. FA58C_2. 2 hits. PS50022. FA58C_3. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	38137.
SOURCE	Search...

Entry information

Entry name

EDIL3_HUMAN

Accession

Primary (citable) accession number: O43854
Secondary accession number(s): B2R763, O43855, Q5D094

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	June 1, 1998
Last modified:	January 25, 2012
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.