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O43852 (CALU_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 135. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Calumenin
Alternative name(s):
Crocalbin
IEF SSP 9302
Gene names
Name:CALU
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity By similarity.

Subunit structure

Interacts with GGCX By similarity.

Subcellular location

Endoplasmic reticulum lumen. Secreted. Melanosome. Sarcoplasmic reticulum lumen By similarity. Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Ref.12 Ref.13 Ref.14

Tissue specificity

Ubiquitously expressed. Expressed at high levels in heart, placenta and skeletal muscle, at lower levels in lung, kidney and pancreas and at very low levels in brain and liver.

Sequence similarities

Belongs to the CREC family.

Contains 6 EF-hand domains.

Alternative products

This entry describes 15 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O43852-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O43852-2)

Also known as: Crocalbin;

The sequence of this isoform differs from the canonical sequence as follows:
     75-137: KIVSKIDGDK...EYKNATYGYV → MIVDKIDADK...EYRNVTYGTY
Isoform 3 (identifier: O43852-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKETDLIIM
Isoform 4 (identifier: O43852-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKETDLIIM
     75-137: KIVSKIDGDK...EYKNATYGYV → MIVDKIDADK...EYRNVTYGTY
Isoform 5 (identifier: O43852-5)

The sequence of this isoform differs from the canonical sequence as follows:
     164-249: Missing.
Isoform 6 (identifier: O43852-6)

The sequence of this isoform differs from the canonical sequence as follows:
     226-275: Missing.
Isoform 7 (identifier: O43852-7)

The sequence of this isoform differs from the canonical sequence as follows:
     75-137: KIVSKIDGDK...EYKNATYGYV → MIVDKIDADK...EYRNVTYGTY
     154-161: VRDERRFK → GILMSRNG
     162-315: Missing.
Isoform 8 (identifier: O43852-8)

The sequence of this isoform differs from the canonical sequence as follows:
     75-137: KIVSKIDGDK...EYKNATYGYV → MIVDKIDADK...EYRNVTYGTY
     172-285: Missing.
Isoform 9 (identifier: O43852-9)

The sequence of this isoform differs from the canonical sequence as follows:
     94-254: Missing.
Isoform 10 (identifier: O43852-10)

The sequence of this isoform differs from the canonical sequence as follows:
     216-315: DMYSHDGNTD...GEALVRHDEF → WQAYQGGDR
Isoform 11 (identifier: O43852-11)

The sequence of this isoform differs from the canonical sequence as follows:
     165-170: KDGDLI → RARAVC
     171-315: Missing.
Isoform 12 (identifier: O43852-12)

The sequence of this isoform differs from the canonical sequence as follows:
     75-315: Missing.
Isoform 13 (identifier: O43852-13)

The sequence of this isoform differs from the canonical sequence as follows:
     139-139: D → E
     140-315: Missing.
Isoform 14 (identifier: O43852-14)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKETDLIIM
     139-139: D → E
     140-315: Missing.
Isoform 15 (identifier: O43852-15)

The sequence of this isoform differs from the canonical sequence as follows:
     1-151: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Ref.11
Chain20 – 315296Calumenin
PRO_0000004153

Regions

Domain68 – 10336EF-hand 1
Domain104 – 13936EF-hand 2
Domain151 – 18636EF-hand 3
Domain188 – 22336EF-hand 4
Domain229 – 26436EF-hand 5
Domain265 – 30036EF-hand 6
Calcium binding81 – 92121 Potential
Calcium binding117 – 128122 Potential
Calcium binding164 – 175123; possibly ancestral Potential
Calcium binding201 – 212124 Potential
Calcium binding242 – 253125 Potential
Calcium binding278 – 289126 Potential
Motif312 – 3154Prevents secretion from ER By similarity

Amino acid modifications

Modified residue441Phosphoserine Ref.16 Ref.19
Modified residue651Phosphothreonine Ref.15 Ref.16 Ref.19
Modified residue1651N6-acetyllysine By similarity
Glycosylation1311N-linked (GlcNAc...) (complex) Ref.17 Ref.18

Natural variations

Alternative sequence1 – 151151Missing in isoform 15.
VSP_045939
Alternative sequence11M → MKETDLIIM in isoform 3, isoform 4 and isoform 14.
VSP_043570
Alternative sequence75 – 315241Missing in isoform 12.
VSP_045940
Alternative sequence75 – 13763KIVSK…TYGYV → MIVDKIDADKDGFVTEGELK SWIKHAQKKYIYDNVENQWQ EFDMNQDGLISWDEYRNVTY GTY in isoform 2, isoform 4, isoform 7 and isoform 8.
VSP_007317
Alternative sequence94 – 254161Missing in isoform 9.
VSP_045941
Alternative sequence1391D → E in isoform 13 and isoform 14.
VSP_045942
Alternative sequence140 – 315176Missing in isoform 13 and isoform 14.
VSP_045943
Alternative sequence154 – 1618VRDERRFK → GILMSRNG in isoform 7.
VSP_045944
Alternative sequence162 – 315154Missing in isoform 7.
VSP_045945
Alternative sequence164 – 24986Missing in isoform 5.
VSP_045946
Alternative sequence165 – 1706KDGDLI → RARAVC in isoform 11.
VSP_045947
Alternative sequence171 – 315145Missing in isoform 11.
VSP_045948
Alternative sequence172 – 285114Missing in isoform 8.
VSP_045949
Alternative sequence216 – 315100DMYSH…RHDEF → WQAYQGGDR in isoform 10.
VSP_045950
Alternative sequence226 – 27550Missing in isoform 6.
VSP_045951
Natural variant41R → Q. Ref.4
Corresponds to variant rs2290228 [ dbSNP | Ensembl ].
VAR_022051

Experimental info

Sequence conflict481D → G in ADG45013. Ref.4
Sequence conflict841K → R in ADG45007. Ref.4
Sequence conflict901V → A in ADG45010. Ref.4
Sequence conflict1171D → G in ADG45007. Ref.4
Sequence conflict1181L → H in ADG45011. Ref.4
Sequence conflict1471F → S in ADG45012. Ref.4
Sequence conflict1881M → V in ADG45015. Ref.4
Sequence conflict2071F → L in AAB97725. Ref.1
Sequence conflict2321T → S in ADG45015. Ref.4
Sequence conflict2671E → V in CAG46634. Ref.6

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 15, 1999. Version 2.
Checksum: 25BAE5A99B527375

FASTA31537,107
        10         20         30         40         50         60 
MDLRQFLMCL SLCTAFALSK PTEKKDRVHH EPQLSDKVHN DAQSFDYDHD AFLGAEEAKT 

        70         80         90        100        110        120 
FDQLTPEESK ERLGKIVSKI DGDKDGFVTV DELKDWIKFA QKRWIYEDVE RQWKGHDLNE 

       130        140        150        160        170        180 
DGLVSWEEYK NATYGYVLDD PDPDDGFNYK QMMVRDERRF KMADKDGDLI ATKEEFTAFL 

       190        200        210        220        230        240 
HPEEYDYMKD IVVQETMEDI DKNADGFIDL EEYIGDMYSH DGNTDEPEWV KTEREQFVEF 

       250        260        270        280        290        300 
RDKNRDGKMD KEETKDWILP SDYDHAEAEA RHLVYESDQN KDGKLTKEEI VDKYDLFVGS 

       310 
QATDFGEALV RHDEF 

« Hide

Isoform 2 (Crocalbin) [UniParc].

Checksum: E1BF415B25076676
Show »

FASTA31537,135
Isoform 3 [UniParc].

Checksum: 0357815A65B4C364
Show »

FASTA32338,051
Isoform 4 [UniParc].

Checksum: C75225A8DBE1D667
Show »

FASTA32338,079
Isoform 5 [UniParc].

Checksum: B73499A59B44F6D0
Show »

FASTA22926,892
Isoform 6 [UniParc].

Checksum: 853B18C78BFD2FD5
Show »

FASTA26530,957
Isoform 7 [UniParc].

Checksum: 2F30CCD0362501B9
Show »

FASTA16118,789
Isoform 8 [UniParc].

Checksum: 031A48109B3A5721
Show »

FASTA20123,519
Isoform 9 [UniParc].

Checksum: C01A8709FEEEE48F
Show »

FASTA15417,639
Isoform 10 [UniParc].

Checksum: A58B5C4DF48D5C56
Show »

FASTA22426,326
Isoform 11 [UniParc].

Checksum: DE2FFE0A2E51C11B
Show »

FASTA17019,993
Isoform 12 [UniParc].

Checksum: 24C00B317B5508DE
Show »

FASTA748,511
Isoform 13 [UniParc].

Checksum: DC485712A52F6454
Show »

FASTA13916,291
Isoform 14 [UniParc].

Checksum: 895C953C9569567E
Show »

FASTA14717,235
Isoform 15 [UniParc].

Checksum: E53F4259F8265B8D
Show »

FASTA16419,455

References

« Hide 'large scale' references
[1]"Molecular cloning of a cDNA encoding human calumenin, expression in Escherichia coli and analysis of its Ca2+-binding activity."
Vorum H., Liu X., Madsen P., Rasmussen H.H., Honore B.
Biochim. Biophys. Acta 1386:121-131(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE, CALCIUM-BINDING.
Tissue: Keratinocyte.
[2]"Human calumenin gene (CALU): cDNA isolation and chromosomal mapping to 7q32."
Yabe D., Taniwaki M., Nakamura T., Kanazawa N., Tashiro K., Honjo T.
Genomics 49:331-333(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"Novel splice variant of human calumenin."
Peterson R.E. Jr., Watson D.K.
Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[4]"Calumenin isoforms and their intracellular and extracellular function."
Wang Q., Chen L., Shen B.R., Feng H., Zheng P.L., Teng J.L., Chen J.G.
Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 4; 5; 6; 7; 8; 9; 10; 11; 12; 13; 14 AND 15), VARIANT GLN-4.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[6]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[7]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[10]Hseu M.-J., Tzeng M.-C.
Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 20-315 (ISOFORM 2).
Tissue: Brain.
[11]"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 20-27.
Tissue: Platelet.
[12]"Human calumenin localizes to the secretory pathway and is secreted to the medium."
Vorum H., Hager H., Christensen B.M., Nielsen S., Honore B.
Exp. Cell Res. 248:473-481(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[13]"Proteomic analysis of early melanosomes: identification of novel melanosomal proteins."
Basrur V., Yang F., Kushimoto T., Higashimoto Y., Yasumoto K., Valencia J., Muller J., Vieira W.D., Watabe H., Shabanowitz J., Hearing V.J., Hunt D.F., Appella E.
J. Proteome Res. 2:69-79(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
Tissue: Melanoma.
[14]"Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."
Chi A., Valencia J.C., Hu Z.-Z., Watabe H., Yamaguchi H., Mangini N.J., Huang H., Canfield V.A., Cheng K.C., Yang F., Abe R., Yamagishi S., Shabanowitz J., Hearing V.J., Wu C., Appella E., Hunt D.F.
J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
Tissue: Melanoma.
[15]"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[16]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-44 AND THR-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[17]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-131.
Tissue: Liver.
[18]"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Jia W., Lu Z., Fu Y., Wang H.P., Wang L.H., Chi H., Yuan Z.F., Zheng Z.B., Song L.N., Han H.H., Liang Y.M., Wang J.L., Cai Y., Zhang Y.K., Deng Y.L., Ying W.T., He S.M., Qian X.H.
Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION AT ASN-131.
[19]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-44 AND THR-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[20]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U67280 mRNA. Translation: AAB97725.1.
AF013759 mRNA. Translation: AAC17216.1.
AF345637 mRNA. Translation: AAK72908.1.
HM002604 mRNA. Translation: ADG45004.1.
HM002605 mRNA. Translation: ADG45005.1.
HM002606 mRNA. Translation: ADG45006.1.
HM002607 mRNA. Translation: ADG45007.1.
HM002608 mRNA. Translation: ADG45008.1.
HM002609 mRNA. Translation: ADG45009.1.
HM002610 mRNA. Translation: ADG45010.1.
HM002611 mRNA. Translation: ADG45011.1.
HM002612 mRNA. Translation: ADG45012.1.
HM002613 mRNA. Translation: ADG45013.1.
HM002614 mRNA. Translation: ADG45014.1.
HM002615 mRNA. Translation: ADG45015.1.
HM002616 mRNA. Translation: ADG45016.1.
AK056338 mRNA. Translation: BAG51681.1.
CR541835 mRNA. Translation: CAG46634.1.
AC024952 Genomic DNA. No translation available.
CH471070 Genomic DNA. Translation: EAW83679.1.
BC013383 mRNA. Translation: AAH13383.1.
AF257659 mRNA. Translation: AAF76141.1.
RefSeqNP_001124146.1. NM_001130674.2.
NP_001186600.1. NM_001199671.1.
NP_001186601.1. NM_001199672.1.
NP_001186602.1. NM_001199673.1.
NP_001210.1. NM_001219.4.
UniGeneHs.743262.
Hs.7753.

3D structure databases

ProteinModelPortalO43852.
SMRO43852. Positions 62-292.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107263. 86 interactions.
IntActO43852. 17 interactions.
STRING9606.ENSP00000249364.

PTM databases

PhosphoSiteO43852.

2D gel databases

DOSAC-COBS-2DPAGEO43852.

Proteomic databases

PaxDbO43852.
PRIDEO43852.

Protocols and materials databases

DNASU813.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000249364; ENSP00000249364; ENSG00000128595. [O43852-1]
ENST00000449187; ENSP00000408838; ENSG00000128595. [O43852-2]
ENST00000479257; ENSP00000420381; ENSG00000128595. [O43852-3]
ENST00000535011; ENSP00000442110; ENSG00000128595. [O43852-10]
ENST00000535623; ENSP00000439139; ENSG00000128595. [O43852-14]
ENST00000538546; ENSP00000438994; ENSG00000128595. [O43852-15]
ENST00000542996; ENSP00000438248; ENSG00000128595. [O43852-4]
GeneID813.
KEGGhsa:813.
UCSCuc003vnq.3. human. [O43852-1]
uc003vnr.3. human. [O43852-3]
uc003vns.3. human. [O43852-2]
uc022ald.1. human. [O43852-4]

Organism-specific databases

CTD813.
GeneCardsGC07P128438.
HGNCHGNC:1458. CALU.
HPAHPA006018.
MIM603420. gene.
neXtProtNX_O43852.
PharmGKBPA26047.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG271367.
HOGENOMHOG000230934.
HOVERGENHBG002834.
OMAWIQYTQR.
OrthoDBEOG73Z2TD.
PhylomeDBO43852.
TreeFamTF314849.

Enzyme and pathway databases

ReactomeREACT_604. Hemostasis.

Gene expression databases

ArrayExpressO43852.
BgeeO43852.
CleanExHS_CALU.
GenevestigatorO43852.

Family and domain databases

Gene3D1.10.238.10. 2 hits.
InterProIPR027239. Calumenin.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PANTHERPTHR10827:SF34. PTHR10827:SF34. 1 hit.
PfamPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTSM00054. EFh. 4 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCALU. human.
GeneWikiCALU_(gene).
GenomeRNAi813.
NextBio3296.
PROO43852.
SOURCESearch...

Entry information

Entry nameCALU_HUMAN
AccessionPrimary (citable) accession number: O43852
Secondary accession number(s): B3KPG9 expand/collapse secondary AC list , D6QS48, D6QS49, D6QS50, D6QS51, D6QS52, D6QS53, D6QS54, D6QS55, D6QS56, D6QS57, D6QS58, D6QS59, F5H1Q9, F5H879, O60456, Q6FHB9, Q96RL3, Q9NR43
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 15, 1999
Last modified: April 16, 2014
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM