O43852 (CALU_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Calumenin

Alternative name(s):
Crocalbin
IEF SSP 9302

Gene names

Name:

CALU

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	315 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity By similarity.
Subunit structure	Interacts with GGCX By similarity.
Subcellular location	Endoplasmic reticulum lumen. Secreted. Melanosome. Sarcoplasmic reticulum lumen By similarity. Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Ref.12 Ref.13 Ref.14
Tissue specificity	Ubiquitously expressed. Expressed at high levels in heart, placenta and skeletal muscle, at lower levels in lung, kidney and pancreas and at very low levels in brain and liver.
Sequence similarities	Belongs to the CREC family. Contains 6 EF-hand domains.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Sarcoplasmic reticulum Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal
Ligand	Calcium Metal-binding
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	platelet activation Traceable author statement. Source: Reactome platelet degranulation Traceable author statement. Source: Reactome
Cellular_component	Golgi apparatus Traceable author statement PubMed 9218460. Source: ProtInc endoplasmic reticulum Inferred from direct assay. Source: HPA extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell melanosome Inferred from electronic annotation. Source: UniProtKB-SubCell sarcoplasmic reticulum lumen Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	calcium ion binding Inferred from direct assay PubMed 10094503. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 15 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O43852-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O43852-2)

Also known as: Crocalbin;

The sequence of this isoform differs from the canonical sequence as follows:
     75-137: KIVSKIDGDK...EYKNATYGYV → MIVDKIDADK...EYRNVTYGTY

Isoform 3 (identifier: O43852-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKETDLIIM

Isoform 4 (identifier: O43852-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKETDLIIM
     75-137: KIVSKIDGDK...EYKNATYGYV → MIVDKIDADK...EYRNVTYGTY

Isoform 5 (identifier: O43852-5)

The sequence of this isoform differs from the canonical sequence as follows:
     164-249: Missing.

Isoform 6 (identifier: O43852-6)

The sequence of this isoform differs from the canonical sequence as follows:
     226-275: Missing.

Isoform 7 (identifier: O43852-7)

The sequence of this isoform differs from the canonical sequence as follows:
     75-137: KIVSKIDGDK...EYKNATYGYV → MIVDKIDADK...EYRNVTYGTY
     154-161: VRDERRFK → GILMSRNG
     162-315: Missing.

Isoform 8 (identifier: O43852-8)

The sequence of this isoform differs from the canonical sequence as follows:
     75-137: KIVSKIDGDK...EYKNATYGYV → MIVDKIDADK...EYRNVTYGTY
     172-285: Missing.

Isoform 9 (identifier: O43852-9)

The sequence of this isoform differs from the canonical sequence as follows:
     94-254: Missing.

Isoform 10 (identifier: O43852-10)

The sequence of this isoform differs from the canonical sequence as follows:
     216-315: DMYSHDGNTD...GEALVRHDEF → WQAYQGGDR

Isoform 11 (identifier: O43852-11)

The sequence of this isoform differs from the canonical sequence as follows:
     165-170: KDGDLI → RARAVC
     171-315: Missing.

Isoform 12 (identifier: O43852-12)

The sequence of this isoform differs from the canonical sequence as follows:
     75-315: Missing.

Isoform 13 (identifier: O43852-13)

The sequence of this isoform differs from the canonical sequence as follows:
     139-139: D → E
     140-315: Missing.

Isoform 14 (identifier: O43852-14)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKETDLIIM
     139-139: D → E
     140-315: Missing.

Isoform 15 (identifier: O43852-15)

The sequence of this isoform differs from the canonical sequence as follows:
     1-151: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Ref.11
	Chain	20 – 315	296	Calumenin		PRO_0000004153
Regions
	Domain	68 – 103	36	EF-hand 1
	Domain	104 – 139	36	EF-hand 2
	Domain	151 – 186	36	EF-hand 3
	Domain	188 – 223	36	EF-hand 4
	Domain	229 – 264	36	EF-hand 5
	Domain	265 – 300	36	EF-hand 6
	Calcium binding	81 – 92	12	1 Potential
	Calcium binding	117 – 128	12	2 Potential
	Calcium binding	164 – 175	12	3; possibly ancestral Potential
	Calcium binding	201 – 212	12	4 Potential
	Calcium binding	242 – 253	12	5 Potential
	Calcium binding	278 – 289	12	6 Potential
	Motif	312 – 315	4	Prevents secretion from ER By similarity
Amino acid modifications
	Modified residue	44	1	Phosphoserine Ref.16 Ref.18
	Modified residue	65	1	Phosphothreonine Ref.15 Ref.16 Ref.18
	Glycosylation	131	1	N-linked (GlcNAc...) Ref.17
Natural variations
	Alternative sequence	1 – 151	151	Missing in isoform 15.		VSP_045939
	Alternative sequence	1	1	M → MKETDLIIM in isoform 3, isoform 4 and isoform 14.		VSP_043570
	Alternative sequence	75 – 315	241	Missing in isoform 12.		VSP_045940
	Alternative sequence	75 – 137	63	KIVSK…TYGYV → MIVDKIDADKDGFVTEGELK SWIKHAQKKYIYDNVENQWQ EFDMNQDGLISWDEYRNVTY GTY in isoform 2, isoform 4, isoform 7 and isoform 8.		VSP_007317
	Alternative sequence	94 – 254	161	Missing in isoform 9.		VSP_045941
	Alternative sequence	139	1	D → E in isoform 13 and isoform 14.		VSP_045942
	Alternative sequence	140 – 315	176	Missing in isoform 13 and isoform 14.		VSP_045943
	Alternative sequence	154 – 161	8	VRDERRFK → GILMSRNG in isoform 7.		VSP_045944
	Alternative sequence	162 – 315	154	Missing in isoform 7.		VSP_045945
	Alternative sequence	164 – 249	86	Missing in isoform 5.		VSP_045946
	Alternative sequence	165 – 170	6	KDGDLI → RARAVC in isoform 11.		VSP_045947
	Alternative sequence	171 – 315	145	Missing in isoform 11.		VSP_045948
	Alternative sequence	172 – 285	114	Missing in isoform 8.		VSP_045949
	Alternative sequence	216 – 315	100	DMYSH…RHDEF → WQAYQGGDR in isoform 10.		VSP_045950
	Alternative sequence	226 – 275	50	Missing in isoform 6.		VSP_045951
	Natural variant	4	1	R → Q. Ref.4 Corresponds to variant rs2290228 [ dbSNP | Ensembl ].		VAR_022051
Experimental info
	Sequence conflict	48	1	D → G in ADG45013. Ref.4
	Sequence conflict	84	1	K → R in ADG45007. Ref.4
	Sequence conflict	90	1	V → A in ADG45010. Ref.4
	Sequence conflict	117	1	D → G in ADG45007. Ref.4
	Sequence conflict	118	1	L → H in ADG45011. Ref.4
	Sequence conflict	147	1	F → S in ADG45012. Ref.4
	Sequence conflict	188	1	M → V in ADG45015. Ref.4
	Sequence conflict	207	1	F → L in AAB97725. Ref.1
	Sequence conflict	232	1	T → S in ADG45015. Ref.4
	Sequence conflict	267	1	E → V in CAG46634. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 15, 1999. Version 2. Checksum: 25BAE5A99B527375	FASTA	315	37,107
	10 20 30 40 50 60 MDLRQFLMCL SLCTAFALSK PTEKKDRVHH EPQLSDKVHN DAQSFDYDHD AFLGAEEAKT 70 80 90 100 110 120 FDQLTPEESK ERLGKIVSKI DGDKDGFVTV DELKDWIKFA QKRWIYEDVE RQWKGHDLNE 130 140 150 160 170 180 DGLVSWEEYK NATYGYVLDD PDPDDGFNYK QMMVRDERRF KMADKDGDLI ATKEEFTAFL 190 200 210 220 230 240 HPEEYDYMKD IVVQETMEDI DKNADGFIDL EEYIGDMYSH DGNTDEPEWV KTEREQFVEF 250 260 270 280 290 300 RDKNRDGKMD KEETKDWILP SDYDHAEAEA RHLVYESDQN KDGKLTKEEI VDKYDLFVGS 310 QATDFGEALV RHDEF
	Isoform 2 (Crocalbin) [UniParc]. Checksum: E1BF415B25076676	FASTA	315	37,135
	10 20 30 40 50 60 MDLRQFLMCL SLCTAFALSK PTEKKDRVHH EPQLSDKVHN DAQSFDYDHD AFLGAEEAKT 70 80 90 100 110 120 FDQLTPEESK ERLGMIVDKI DADKDGFVTE GELKSWIKHA QKKYIYDNVE NQWQEFDMNQ 130 140 150 160 170 180 DGLISWDEYR NVTYGTYLDD PDPDDGFNYK QMMVRDERRF KMADKDGDLI ATKEEFTAFL 190 200 210 220 230 240 HPEEYDYMKD IVVQETMEDI DKNADGFIDL EEYIGDMYSH DGNTDEPEWV KTEREQFVEF 250 260 270 280 290 300 RDKNRDGKMD KEETKDWILP SDYDHAEAEA RHLVYESDQN KDGKLTKEEI VDKYDLFVGS 310 QATDFGEALV RHDEF
	Isoform 3 [UniParc]. Checksum: 0357815A65B4C364	FASTA	323	38,051
	10 20 30 40 50 60 MKETDLIIMD LRQFLMCLSL CTAFALSKPT EKKDRVHHEP QLSDKVHNDA QSFDYDHDAF 70 80 90 100 110 120 LGAEEAKTFD QLTPEESKER LGKIVSKIDG DKDGFVTVDE LKDWIKFAQK RWIYEDVERQ 130 140 150 160 170 180 WKGHDLNEDG LVSWEEYKNA TYGYVLDDPD PDDGFNYKQM MVRDERRFKM ADKDGDLIAT 190 200 210 220 230 240 KEEFTAFLHP EEYDYMKDIV VQETMEDIDK NADGFIDLEE YIGDMYSHDG NTDEPEWVKT 250 260 270 280 290 300 EREQFVEFRD KNRDGKMDKE ETKDWILPSD YDHAEAEARH LVYESDQNKD GKLTKEEIVD 310 320 KYDLFVGSQA TDFGEALVRH DEF
	Isoform 4 [UniParc]. Checksum: C75225A8DBE1D667	FASTA	323	38,079
	10 20 30 40 50 60 MKETDLIIMD LRQFLMCLSL CTAFALSKPT EKKDRVHHEP QLSDKVHNDA QSFDYDHDAF 70 80 90 100 110 120 LGAEEAKTFD QLTPEESKER LGMIVDKIDA DKDGFVTEGE LKSWIKHAQK KYIYDNVENQ 130 140 150 160 170 180 WQEFDMNQDG LISWDEYRNV TYGTYLDDPD PDDGFNYKQM MVRDERRFKM ADKDGDLIAT 190 200 210 220 230 240 KEEFTAFLHP EEYDYMKDIV VQETMEDIDK NADGFIDLEE YIGDMYSHDG NTDEPEWVKT 250 260 270 280 290 300 EREQFVEFRD KNRDGKMDKE ETKDWILPSD YDHAEAEARH LVYESDQNKD GKLTKEEIVD 310 320 KYDLFVGSQA TDFGEALVRH DEF
	Isoform 5 [UniParc]. Checksum: B73499A59B44F6D0	FASTA	229	26,892
	10 20 30 40 50 60 MDLRQFLMCL SLCTAFALSK PTEKKDRVHH EPQLSDKVHN DAQSFDYDHD AFLGAEEAKT 70 80 90 100 110 120 FDQLTPEESK ERLGKIVSKI DGDKDGFVTV DELKDWIKFA QKRWIYEDVE RQWKGHDLNE 130 140 150 160 170 180 DGLVSWEEYK NATYGYVLDD PDPDDGFNYK QMMVRDERRF KMADKEETKD WILPSDYDHA 190 200 210 220 EAEARHLVYE SDQNKDGKLT KEEIVDKYDL FVGSQATDFG EALVRHDEF
	Isoform 6 [UniParc]. Checksum: 853B18C78BFD2FD5	FASTA	265	30,957
	10 20 30 40 50 60 MDLRQFLMCL SLCTAFALSK PTEKKDRVHH EPQLSDKVHN DAQSFDYDHD AFLGAEEAKT 70 80 90 100 110 120 FDQLTPEESK ERLGKIVSKI DGDKDGFVTV DELKDWIKFA QKRWIYEDVE RQWKGHDLNE 130 140 150 160 170 180 DGLVSWEEYK NATYGYVLDD PDPDDGFNYK QMMVRDERRF KMADKDGDLI ATKEEFTAFL 190 200 210 220 230 240 HPEEYDYMKD IVVQETMEDI DKNADGFIDL EEYIGDMYSH DGNTDESDQN KDGKLTKEEI 250 260 VDKYDLFVGS QATDFGEALV RHDEF
	Isoform 7 [UniParc]. Checksum: 2F30CCD0362501B9	FASTA	161	18,789
	10 20 30 40 50 60 MDLRQFLMCL SLCTAFALSK PTEKKDRVHH EPQLSDKVHN DAQSFDYDHD AFLGAEEAKT 70 80 90 100 110 120 FDQLTPEESK ERLGMIVDKI DADKDGFVTE GELKSWIKHA QKKYIYDNVE NQWQEFDMNQ 130 140 150 160 DGLISWDEYR NVTYGTYLDD PDPDDGFNYK QMMGILMSRN G
	Isoform 8 [UniParc]. Checksum: 031A48109B3A5721	FASTA	201	23,519
	10 20 30 40 50 60 MDLRQFLMCL SLCTAFALSK PTEKKDRVHH EPQLSDKVHN DAQSFDYDHD AFLGAEEAKT 70 80 90 100 110 120 FDQLTPEESK ERLGMIVDKI DADKDGFVTE GELKSWIKHA QKKYIYDNVE NQWQEFDMNQ 130 140 150 160 170 180 DGLISWDEYR NVTYGTYLDD PDPDDGFNYK QMMVRDERRF KMADKDGDLI ATKEEIVDKY 190 200 DLFVGSQATD FGEALVRHDE F
	Isoform 9 [UniParc]. Checksum: C01A8709FEEEE48F	FASTA	154	17,639
	10 20 30 40 50 60 MDLRQFLMCL SLCTAFALSK PTEKKDRVHH EPQLSDKVHN DAQSFDYDHD AFLGAEEAKT 70 80 90 100 110 120 FDQLTPEESK ERLGKIVSKI DGDKDGFVTV DELKDWILPS DYDHAEAEAR HLVYESDQNK 130 140 150 DGKLTKEEIV DKYDLFVGSQ ATDFGEALVR HDEF
	Isoform 10 [UniParc]. Checksum: A58B5C4DF48D5C56	FASTA	224	26,326
	10 20 30 40 50 60 MDLRQFLMCL SLCTAFALSK PTEKKDRVHH EPQLSDKVHN DAQSFDYDHD AFLGAEEAKT 70 80 90 100 110 120 FDQLTPEESK ERLGKIVSKI DGDKDGFVTV DELKDWIKFA QKRWIYEDVE RQWKGHDLNE 130 140 150 160 170 180 DGLVSWEEYK NATYGYVLDD PDPDDGFNYK QMMVRDERRF KMADKDGDLI ATKEEFTAFL 190 200 210 220 HPEEYDYMKD IVVQETMEDI DKNADGFIDL EEYIGWQAYQ GGDR
	Isoform 11 [UniParc]. Checksum: DE2FFE0A2E51C11B	FASTA	170	19,993
	10 20 30 40 50 60 MDLRQFLMCL SLCTAFALSK PTEKKDRVHH EPQLSDKVHN DAQSFDYDHD AFLGAEEAKT 70 80 90 100 110 120 FDQLTPEESK ERLGKIVSKI DGDKDGFVTV DELKDWIKFA QKRWIYEDVE RQWKGHDLNE 130 140 150 160 170 DGLVSWEEYK NATYGYVLDD PDPDDGFNYK QMMVRDERRF KMADRARAVC
	Isoform 12 [UniParc]. Checksum: 24C00B317B5508DE	FASTA	74	8,511
	10 20 30 40 50 60 MDLRQFLMCL SLCTAFALSK PTEKKDRVHH EPQLSDKVHN DAQSFDYDHD AFLGAEEAKT 70 FDQLTPEESK ERLG
	Isoform 13 [UniParc]. Checksum: DC485712A52F6454	FASTA	139	16,291
	10 20 30 40 50 60 MDLRQFLMCL SLCTAFALSK PTEKKDRVHH EPQLSDKVHN DAQSFDYDHD AFLGAEEAKT 70 80 90 100 110 120 FDQLTPEESK ERLGKIVSKI DGDKDGFVTV DELKDWIKFA QKRWIYEDVE RQWKGHDLNE 130 DGLVSWEEYK NATYGYVLE
	Isoform 14 [UniParc]. Checksum: 895C953C9569567E	FASTA	147	17,235
	10 20 30 40 50 60 MKETDLIIMD LRQFLMCLSL CTAFALSKPT EKKDRVHHEP QLSDKVHNDA QSFDYDHDAF 70 80 90 100 110 120 LGAEEAKTFD QLTPEESKER LGKIVSKIDG DKDGFVTVDE LKDWIKFAQK RWIYEDVERQ 130 140 WKGHDLNEDG LVSWEEYKNA TYGYVLE
	Isoform 15 [UniParc]. Checksum: E53F4259F8265B8D	FASTA	164	19,455
	10 20 30 40 50 60 MMVRDERRFK MADKDGDLIA TKEEFTAFLH PEEYDYMKDI VVQETMEDID KNADGFIDLE 70 80 90 100 110 120 EYIGDMYSHD GNTDEPEWVK TEREQFVEFR DKNRDGKMDK EETKDWILPS DYDHAEAEAR 130 140 150 160 HLVYESDQNK DGKLTKEEIV DKYDLFVGSQ ATDFGEALVR HDEF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of a cDNA encoding human calumenin, expression in Escherichia coli and analysis of its Ca2+-binding activity." Vorum H., Liu X., Madsen P., Rasmussen H.H., Honore B. Biochim. Biophys. Acta 1386:121-131(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE, CALCIUM-BINDING. Tissue: Keratinocyte.
[2]	"Human calumenin gene (CALU): cDNA isolation and chromosomal mapping to 7q32." Yabe D., Taniwaki M., Nakamura T., Kanazawa N., Tashiro K., Honjo T. Genomics 49:331-333(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"Novel splice variant of human calumenin." Peterson R.E. Jr., Watson D.K. Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[4]	"Calumenin isoforms and their intracellular and extracellular function." Wang Q., Chen L., Shen B.R., Feng H., Zheng P.L., Teng J.L., Chen J.G. Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 4; 5; 6; 7; 8; 9; 10; 11; 12; 13; 14 AND 15), VARIANT GLN-4.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[6]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[7]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[10]	Hseu M.-J., Tzeng M.-C. Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 20-315 (ISOFORM 2). Tissue: Brain.
[11]	"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides." Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J. Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 20-27. Tissue: Platelet.
[12]	"Human calumenin localizes to the secretory pathway and is secreted to the medium." Vorum H., Hager H., Christensen B.M., Nielsen S., Honore B. Exp. Cell Res. 248:473-481(1999) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[13]	"Proteomic analysis of early melanosomes: identification of novel melanosomal proteins." Basrur V., Yang F., Kushimoto T., Higashimoto Y., Yasumoto K., Valencia J., Muller J., Vieira W.D., Watabe H., Shabanowitz J., Hearing V.J., Hunt D.F., Appella E. J. Proteome Res. 2:69-79(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. Tissue: Melanoma.
[14]	"Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes." Chi A., Valencia J.C., Hu Z.-Z., Watabe H., Yamaguchi H., Mangini N.J., Huang H., Canfield V.A., Cheng K.C., Yang F., Abe R., Yamagishi S., Shabanowitz J., Hearing V.J., Wu C., Appella E., Hunt D.F. J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. Tissue: Melanoma.
[15]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-65, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[16]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-44 AND THR-65, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[17]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-131, MASS SPECTROMETRY. Tissue: Liver.
[18]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-44 AND THR-65, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[19]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U67280 mRNA. Translation: AAB97725.1. AF013759 mRNA. Translation: AAC17216.1. AF345637 mRNA. Translation: AAK72908.1. HM002604 mRNA. Translation: ADG45004.1. HM002605 mRNA. Translation: ADG45005.1. HM002606 mRNA. Translation: ADG45006.1. HM002607 mRNA. Translation: ADG45007.1. HM002608 mRNA. Translation: ADG45008.1. HM002609 mRNA. Translation: ADG45009.1. HM002610 mRNA. Translation: ADG45010.1. HM002611 mRNA. Translation: ADG45011.1. HM002612 mRNA. Translation: ADG45012.1. HM002613 mRNA. Translation: ADG45013.1. HM002614 mRNA. Translation: ADG45014.1. HM002615 mRNA. Translation: ADG45015.1. HM002616 mRNA. Translation: ADG45016.1. AK056338 mRNA. Translation: BAG51681.1. CR541835 mRNA. Translation: CAG46634.1. AC024952 Genomic DNA. No translation available. CH471070 Genomic DNA. Translation: EAW83679.1. BC013383 mRNA. Translation: AAH13383.1. AF257659 mRNA. Translation: AAF76141.1.
IPI	IPI00045396. IPI00789155. IPI00941900. IPI00969064. IPI00969136. IPI00982476. IPI01009160. IPI01013361. IPI01015093.
RefSeq	NP_001124146.1. NM_001130674.2. NP_001186600.1. NM_001199671.1. NP_001186601.1. NM_001199672.1. NP_001186602.1. NM_001199673.1. NP_001186603.1. NM_001199674.1. NP_001210.1. NM_001219.4.
UniGene	Hs.7753.
3D structure databases
ProteinModelPortal	O43852.
ModBase	Search...
Protein-protein interaction databases
IntAct	O43852. 13 interactions.
STRING	9606.ENSP00000249364.
PTM databases
PhosphoSite	O43852.
2D gel databases
DOSAC-COBS-2DPAGE	O43852.
Proteomic databases
PaxDb	O43852.
PRIDE	O43852.
Protocols and materials databases
DNASU	813.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000249364; ENSP00000249364; ENSG00000128595. ENST00000449187; ENSP00000408838; ENSG00000128595. ENST00000479257; ENSP00000420381; ENSG00000128595. ENST00000535011; ENSP00000442110; ENSG00000128595. ENST00000535623; ENSP00000439139; ENSG00000128595. ENST00000538546; ENSP00000438994; ENSG00000128595. ENST00000542996; ENSP00000438248; ENSG00000128595.
GeneID	813.
KEGG	hsa:813.
UCSC	uc003vnq.3. human. uc003vns.3. human.
Organism-specific databases
CTD	813.
GeneCards	GC07P128380.
HGNC	HGNC:1458. CALU.
HPA	HPA006018.
MIM	603420. gene.
neXtProt	NX_O43852.
PharmGKB	PA26047.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG271367.
HOGENOM	HOG000230934.
HOVERGEN	HBG002834.
OMA	QYTQRRY.
OrthoDB	EOG444KKM.
Enzyme and pathway databases
Reactome	REACT_604. Hemostasis.
Gene expression databases
ArrayExpress	O43852.
Bgee	O43852.
CleanEx	HS_CALU.
Genevestigator	O43852.
GermOnline	ENSG00000128595. Homo sapiens.
Family and domain databases
Gene3D	1.10.238.10. 2 hits.
InterPro	IPR027239. Calumenin. IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom. [Graphical view]
PANTHER	PTHR10827:SF34. PTHR10827:SF34. 1 hit.
Pfam	PF13499. EF_hand_5. 2 hits. [Graphical view]
SMART	SM00054. EFh. 4 hits. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 4 hits. PS50222. EF_HAND_2. 6 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CALU. human.
GenomeRNAi	813.
NextBio	3296.
SOURCE	Search...

Entry information

Entry name

CALU_HUMAN

Accession

Primary (citable) accession number: O43852
Secondary accession number(s): B3KPG9 , D6QS48, D6QS49, D6QS50, D6QS51, D6QS52, D6QS53, D6QS54, D6QS55, D6QS56, D6QS57, D6QS58, D6QS59, F5H1Q9, F5H879, O60456, Q6FHB9, Q96RL3, Q9NR43

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	July 15, 1999
Last modified:	May 1, 2013
This is version 125 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.