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O43852

- CALU_HUMAN

UniProt

O43852 - CALU_HUMAN

Protein

Calumenin

Gene

CALU

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 140 (01 Oct 2014)
      Sequence version 2 (15 Jul 1999)
      Previous versions | rss
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    Functioni

    Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi81 – 92121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi117 – 128122PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi164 – 175123; possibly ancestralPROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi201 – 212124PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi242 – 253125PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi278 – 289126PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: UniProtKB
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. blood coagulation Source: Reactome
    2. platelet activation Source: Reactome
    3. platelet degranulation Source: Reactome

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calumenin
    Alternative name(s):
    Crocalbin
    IEF SSP 9302
    Gene namesi
    Name:CALU
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:1458. CALU.

    Subcellular locationi

    Endoplasmic reticulum lumen. Secreted. Melanosome. Sarcoplasmic reticulum lumen By similarity
    Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

    GO - Cellular componenti

    1. endoplasmic reticulum Source: HPA
    2. extracellular region Source: UniProtKB-SubCell
    3. Golgi apparatus Source: ProtInc
    4. melanosome Source: UniProtKB-SubCell
    5. membrane Source: UniProtKB
    6. sarcoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Sarcoplasmic reticulum, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26047.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 19191 PublicationAdd
    BLAST
    Chaini20 – 315296CalumeninPRO_0000004153Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei44 – 441Phosphoserine2 Publications
    Modified residuei65 – 651Phosphothreonine3 Publications
    Glycosylationi131 – 1311N-linked (GlcNAc...) (complex)2 Publications
    Modified residuei165 – 1651N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiO43852.
    PaxDbiO43852.
    PRIDEiO43852.

    2D gel databases

    DOSAC-COBS-2DPAGEO43852.

    PTM databases

    PhosphoSiteiO43852.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed. Expressed at high levels in heart, placenta and skeletal muscle, at lower levels in lung, kidney and pancreas and at very low levels in brain and liver.

    Gene expression databases

    ArrayExpressiO43852.
    BgeeiO43852.
    CleanExiHS_CALU.
    GenevestigatoriO43852.

    Organism-specific databases

    HPAiHPA006018.

    Interactioni

    Subunit structurei

    Interacts with GGCX.By similarity

    Protein-protein interaction databases

    BioGridi107263. 80 interactions.
    IntActiO43852. 18 interactions.
    STRINGi9606.ENSP00000249364.

    Structurei

    3D structure databases

    ProteinModelPortaliO43852.
    SMRiO43852. Positions 61-295.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini68 – 10336EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini104 – 13936EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini151 – 18636EF-hand 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini188 – 22336EF-hand 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini229 – 26436EF-hand 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini265 – 30036EF-hand 6PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi312 – 3154Prevents secretion from ERBy similarity

    Sequence similaritiesi

    Belongs to the CREC family.Curated
    Contains 6 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG271367.
    HOGENOMiHOG000230934.
    HOVERGENiHBG002834.
    OMAiEEPEWVK.
    OrthoDBiEOG73Z2TD.
    PhylomeDBiO43852.
    TreeFamiTF314849.

    Family and domain databases

    Gene3Di1.10.238.10. 2 hits.
    InterProiIPR027239. Calumenin.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view]
    PANTHERiPTHR10827:SF34. PTHR10827:SF34. 1 hit.
    PfamiPF13499. EF-hand_7. 2 hits.
    [Graphical view]
    SMARTiSM00054. EFh. 4 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 4 hits.
    PS50222. EF_HAND_2. 6 hits.
    [Graphical view]

    Sequences (15)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 15 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O43852-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDLRQFLMCL SLCTAFALSK PTEKKDRVHH EPQLSDKVHN DAQSFDYDHD    50
    AFLGAEEAKT FDQLTPEESK ERLGKIVSKI DGDKDGFVTV DELKDWIKFA 100
    QKRWIYEDVE RQWKGHDLNE DGLVSWEEYK NATYGYVLDD PDPDDGFNYK 150
    QMMVRDERRF KMADKDGDLI ATKEEFTAFL HPEEYDYMKD IVVQETMEDI 200
    DKNADGFIDL EEYIGDMYSH DGNTDEPEWV KTEREQFVEF RDKNRDGKMD 250
    KEETKDWILP SDYDHAEAEA RHLVYESDQN KDGKLTKEEI VDKYDLFVGS 300
    QATDFGEALV RHDEF 315
    Length:315
    Mass (Da):37,107
    Last modified:July 15, 1999 - v2
    Checksum:i25BAE5A99B527375
    GO
    Isoform 2 (identifier: O43852-2) [UniParc]FASTAAdd to Basket

    Also known as: Crocalbin

    The sequence of this isoform differs from the canonical sequence as follows:
         75-137: KIVSKIDGDK...EYKNATYGYV → MIVDKIDADK...EYRNVTYGTY

    Show »
    Length:315
    Mass (Da):37,135
    Checksum:iE1BF415B25076676
    GO
    Isoform 3 (identifier: O43852-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MKETDLIIM

    Show »
    Length:323
    Mass (Da):38,051
    Checksum:i0357815A65B4C364
    GO
    Isoform 4 (identifier: O43852-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MKETDLIIM
         75-137: KIVSKIDGDK...EYKNATYGYV → MIVDKIDADK...EYRNVTYGTY

    Show »
    Length:323
    Mass (Da):38,079
    Checksum:iC75225A8DBE1D667
    GO
    Isoform 5 (identifier: O43852-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         164-249: Missing.

    Show »
    Length:229
    Mass (Da):26,892
    Checksum:iB73499A59B44F6D0
    GO
    Isoform 6 (identifier: O43852-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         226-275: Missing.

    Show »
    Length:265
    Mass (Da):30,957
    Checksum:i853B18C78BFD2FD5
    GO
    Isoform 7 (identifier: O43852-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         75-137: KIVSKIDGDK...EYKNATYGYV → MIVDKIDADK...EYRNVTYGTY
         154-161: VRDERRFK → GILMSRNG
         162-315: Missing.

    Show »
    Length:161
    Mass (Da):18,789
    Checksum:i2F30CCD0362501B9
    GO
    Isoform 8 (identifier: O43852-8) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         75-137: KIVSKIDGDK...EYKNATYGYV → MIVDKIDADK...EYRNVTYGTY
         172-285: Missing.

    Show »
    Length:201
    Mass (Da):23,519
    Checksum:i031A48109B3A5721
    GO
    Isoform 9 (identifier: O43852-9) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         94-254: Missing.

    Show »
    Length:154
    Mass (Da):17,639
    Checksum:iC01A8709FEEEE48F
    GO
    Isoform 10 (identifier: O43852-10) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         216-315: DMYSHDGNTD...GEALVRHDEF → WQAYQGGDR

    Show »
    Length:224
    Mass (Da):26,326
    Checksum:iA58B5C4DF48D5C56
    GO
    Isoform 11 (identifier: O43852-11) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         165-170: KDGDLI → RARAVC
         171-315: Missing.

    Show »
    Length:170
    Mass (Da):19,993
    Checksum:iDE2FFE0A2E51C11B
    GO
    Isoform 12 (identifier: O43852-12) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         75-315: Missing.

    Show »
    Length:74
    Mass (Da):8,511
    Checksum:i24C00B317B5508DE
    GO
    Isoform 13 (identifier: O43852-13) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         139-139: D → E
         140-315: Missing.

    Show »
    Length:139
    Mass (Da):16,291
    Checksum:iDC485712A52F6454
    GO
    Isoform 14 (identifier: O43852-14) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MKETDLIIM
         139-139: D → E
         140-315: Missing.

    Show »
    Length:147
    Mass (Da):17,235
    Checksum:i895C953C9569567E
    GO
    Isoform 15 (identifier: O43852-15) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-151: Missing.

    Show »
    Length:164
    Mass (Da):19,455
    Checksum:iE53F4259F8265B8D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti48 – 481D → G in ADG45013. 1 PublicationCurated
    Sequence conflicti84 – 841K → R in ADG45007. 1 PublicationCurated
    Sequence conflicti90 – 901V → A in ADG45010. 1 PublicationCurated
    Sequence conflicti117 – 1171D → G in ADG45007. 1 PublicationCurated
    Sequence conflicti118 – 1181L → H in ADG45011. 1 PublicationCurated
    Sequence conflicti147 – 1471F → S in ADG45012. 1 PublicationCurated
    Sequence conflicti188 – 1881M → V in ADG45015. 1 PublicationCurated
    Sequence conflicti207 – 2071F → L in AAB97725. (PubMed:9675259)Curated
    Sequence conflicti232 – 2321T → S in ADG45015. 1 PublicationCurated
    Sequence conflicti267 – 2671E → V in CAG46634. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti4 – 41R → Q.1 Publication
    Corresponds to variant rs2290228 [ dbSNP | Ensembl ].
    VAR_022051

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 151151Missing in isoform 15. 1 PublicationVSP_045939Add
    BLAST
    Alternative sequencei1 – 11M → MKETDLIIM in isoform 3, isoform 4 and isoform 14. 2 PublicationsVSP_043570
    Alternative sequencei75 – 315241Missing in isoform 12. 1 PublicationVSP_045940Add
    BLAST
    Alternative sequencei75 – 13763KIVSK…TYGYV → MIVDKIDADKDGFVTEGELK SWIKHAQKKYIYDNVENQWQ EFDMNQDGLISWDEYRNVTY GTY in isoform 2, isoform 4, isoform 7 and isoform 8. 3 PublicationsVSP_007317Add
    BLAST
    Alternative sequencei94 – 254161Missing in isoform 9. 1 PublicationVSP_045941Add
    BLAST
    Alternative sequencei139 – 1391D → E in isoform 13 and isoform 14. 1 PublicationVSP_045942
    Alternative sequencei140 – 315176Missing in isoform 13 and isoform 14. 1 PublicationVSP_045943Add
    BLAST
    Alternative sequencei154 – 1618VRDERRFK → GILMSRNG in isoform 7. 1 PublicationVSP_045944
    Alternative sequencei162 – 315154Missing in isoform 7. 1 PublicationVSP_045945Add
    BLAST
    Alternative sequencei164 – 24986Missing in isoform 5. 1 PublicationVSP_045946Add
    BLAST
    Alternative sequencei165 – 1706KDGDLI → RARAVC in isoform 11. 1 PublicationVSP_045947
    Alternative sequencei171 – 315145Missing in isoform 11. 1 PublicationVSP_045948Add
    BLAST
    Alternative sequencei172 – 285114Missing in isoform 8. 1 PublicationVSP_045949Add
    BLAST
    Alternative sequencei216 – 315100DMYSH…RHDEF → WQAYQGGDR in isoform 10. 1 PublicationVSP_045950Add
    BLAST
    Alternative sequencei226 – 27550Missing in isoform 6. 1 PublicationVSP_045951Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U67280 mRNA. Translation: AAB97725.1.
    AF013759 mRNA. Translation: AAC17216.1.
    AF345637 mRNA. Translation: AAK72908.1.
    HM002604 mRNA. Translation: ADG45004.1.
    HM002605 mRNA. Translation: ADG45005.1.
    HM002606 mRNA. Translation: ADG45006.1.
    HM002607 mRNA. Translation: ADG45007.1.
    HM002608 mRNA. Translation: ADG45008.1.
    HM002609 mRNA. Translation: ADG45009.1.
    HM002610 mRNA. Translation: ADG45010.1.
    HM002611 mRNA. Translation: ADG45011.1.
    HM002612 mRNA. Translation: ADG45012.1.
    HM002613 mRNA. Translation: ADG45013.1.
    HM002614 mRNA. Translation: ADG45014.1.
    HM002615 mRNA. Translation: ADG45015.1.
    HM002616 mRNA. Translation: ADG45016.1.
    AK056338 mRNA. Translation: BAG51681.1.
    CR541835 mRNA. Translation: CAG46634.1.
    AC024952 Genomic DNA. No translation available.
    CH471070 Genomic DNA. Translation: EAW83679.1.
    BC013383 mRNA. Translation: AAH13383.1.
    AF257659 mRNA. Translation: AAF76141.1.
    CCDSiCCDS47703.1. [O43852-2]
    CCDS56506.1. [O43852-3]
    CCDS56507.1. [O43852-4]
    CCDS56508.1. [O43852-10]
    CCDS5805.1. [O43852-1]
    RefSeqiNP_001124146.1. NM_001130674.2. [O43852-2]
    NP_001186600.1. NM_001199671.1. [O43852-3]
    NP_001186601.1. NM_001199672.1. [O43852-4]
    NP_001186602.1. NM_001199673.1. [O43852-10]
    NP_001210.1. NM_001219.4. [O43852-1]
    UniGeneiHs.743262.
    Hs.7753.

    Genome annotation databases

    EnsembliENST00000249364; ENSP00000249364; ENSG00000128595. [O43852-1]
    ENST00000449187; ENSP00000408838; ENSG00000128595. [O43852-2]
    ENST00000479257; ENSP00000420381; ENSG00000128595. [O43852-3]
    ENST00000535011; ENSP00000442110; ENSG00000128595. [O43852-10]
    ENST00000542996; ENSP00000438248; ENSG00000128595. [O43852-4]
    GeneIDi813.
    KEGGihsa:813.
    UCSCiuc003vnq.3. human. [O43852-1]
    uc003vnr.3. human. [O43852-3]
    uc003vns.3. human. [O43852-2]
    uc022ald.1. human. [O43852-4]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U67280 mRNA. Translation: AAB97725.1 .
    AF013759 mRNA. Translation: AAC17216.1 .
    AF345637 mRNA. Translation: AAK72908.1 .
    HM002604 mRNA. Translation: ADG45004.1 .
    HM002605 mRNA. Translation: ADG45005.1 .
    HM002606 mRNA. Translation: ADG45006.1 .
    HM002607 mRNA. Translation: ADG45007.1 .
    HM002608 mRNA. Translation: ADG45008.1 .
    HM002609 mRNA. Translation: ADG45009.1 .
    HM002610 mRNA. Translation: ADG45010.1 .
    HM002611 mRNA. Translation: ADG45011.1 .
    HM002612 mRNA. Translation: ADG45012.1 .
    HM002613 mRNA. Translation: ADG45013.1 .
    HM002614 mRNA. Translation: ADG45014.1 .
    HM002615 mRNA. Translation: ADG45015.1 .
    HM002616 mRNA. Translation: ADG45016.1 .
    AK056338 mRNA. Translation: BAG51681.1 .
    CR541835 mRNA. Translation: CAG46634.1 .
    AC024952 Genomic DNA. No translation available.
    CH471070 Genomic DNA. Translation: EAW83679.1 .
    BC013383 mRNA. Translation: AAH13383.1 .
    AF257659 mRNA. Translation: AAF76141.1 .
    CCDSi CCDS47703.1. [O43852-2 ]
    CCDS56506.1. [O43852-3 ]
    CCDS56507.1. [O43852-4 ]
    CCDS56508.1. [O43852-10 ]
    CCDS5805.1. [O43852-1 ]
    RefSeqi NP_001124146.1. NM_001130674.2. [O43852-2 ]
    NP_001186600.1. NM_001199671.1. [O43852-3 ]
    NP_001186601.1. NM_001199672.1. [O43852-4 ]
    NP_001186602.1. NM_001199673.1. [O43852-10 ]
    NP_001210.1. NM_001219.4. [O43852-1 ]
    UniGenei Hs.743262.
    Hs.7753.

    3D structure databases

    ProteinModelPortali O43852.
    SMRi O43852. Positions 61-295.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107263. 80 interactions.
    IntActi O43852. 18 interactions.
    STRINGi 9606.ENSP00000249364.

    PTM databases

    PhosphoSitei O43852.

    2D gel databases

    DOSAC-COBS-2DPAGE O43852.

    Proteomic databases

    MaxQBi O43852.
    PaxDbi O43852.
    PRIDEi O43852.

    Protocols and materials databases

    DNASUi 813.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000249364 ; ENSP00000249364 ; ENSG00000128595 . [O43852-1 ]
    ENST00000449187 ; ENSP00000408838 ; ENSG00000128595 . [O43852-2 ]
    ENST00000479257 ; ENSP00000420381 ; ENSG00000128595 . [O43852-3 ]
    ENST00000535011 ; ENSP00000442110 ; ENSG00000128595 . [O43852-10 ]
    ENST00000542996 ; ENSP00000438248 ; ENSG00000128595 . [O43852-4 ]
    GeneIDi 813.
    KEGGi hsa:813.
    UCSCi uc003vnq.3. human. [O43852-1 ]
    uc003vnr.3. human. [O43852-3 ]
    uc003vns.3. human. [O43852-2 ]
    uc022ald.1. human. [O43852-4 ]

    Organism-specific databases

    CTDi 813.
    GeneCardsi GC07P128438.
    HGNCi HGNC:1458. CALU.
    HPAi HPA006018.
    MIMi 603420. gene.
    neXtProti NX_O43852.
    PharmGKBi PA26047.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG271367.
    HOGENOMi HOG000230934.
    HOVERGENi HBG002834.
    OMAi EEPEWVK.
    OrthoDBi EOG73Z2TD.
    PhylomeDBi O43852.
    TreeFami TF314849.

    Miscellaneous databases

    ChiTaRSi CALU. human.
    GeneWikii CALU_(gene).
    GenomeRNAii 813.
    NextBioi 3296.
    PROi O43852.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O43852.
    Bgeei O43852.
    CleanExi HS_CALU.
    Genevestigatori O43852.

    Family and domain databases

    Gene3Di 1.10.238.10. 2 hits.
    InterProi IPR027239. Calumenin.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view ]
    PANTHERi PTHR10827:SF34. PTHR10827:SF34. 1 hit.
    Pfami PF13499. EF-hand_7. 2 hits.
    [Graphical view ]
    SMARTi SM00054. EFh. 4 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 4 hits.
    PS50222. EF_HAND_2. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a cDNA encoding human calumenin, expression in Escherichia coli and analysis of its Ca2+-binding activity."
      Vorum H., Liu X., Madsen P., Rasmussen H.H., Honore B.
      Biochim. Biophys. Acta 1386:121-131(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE, CALCIUM-BINDING.
      Tissue: Keratinocyte.
    2. "Human calumenin gene (CALU): cDNA isolation and chromosomal mapping to 7q32."
      Yabe D., Taniwaki M., Nakamura T., Kanazawa N., Tashiro K., Honjo T.
      Genomics 49:331-333(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Novel splice variant of human calumenin."
      Peterson R.E. Jr., Watson D.K.
      Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    4. "Calumenin isoforms and their intracellular and extracellular function."
      Wang Q., Chen L., Shen B.R., Feng H., Zheng P.L., Teng J.L., Chen J.G.
      Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 4; 5; 6; 7; 8; 9; 10; 11; 12; 13; 14 AND 15), VARIANT GLN-4.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    7. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    10. Hseu M.-J., Tzeng M.-C.
      Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 20-315 (ISOFORM 2).
      Tissue: Brain.
    11. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
      Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
      Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 20-27.
      Tissue: Platelet.
    12. "Human calumenin localizes to the secretory pathway and is secreted to the medium."
      Vorum H., Hager H., Christensen B.M., Nielsen S., Honore B.
      Exp. Cell Res. 248:473-481(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    13. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Tissue: Melanoma.
    14. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Tissue: Melanoma.
    15. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    16. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-44 AND THR-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    17. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-131.
      Tissue: Liver.
    18. Cited for: GLYCOSYLATION AT ASN-131.
    19. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-44 AND THR-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    20. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCALU_HUMAN
    AccessioniPrimary (citable) accession number: O43852
    Secondary accession number(s): B3KPG9
    , D6QS48, D6QS49, D6QS50, D6QS51, D6QS52, D6QS53, D6QS54, D6QS55, D6QS56, D6QS57, D6QS58, D6QS59, F5H1Q9, F5H879, O60456, Q6FHB9, Q96RL3, Q9NR43
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: July 15, 1999
    Last modified: October 1, 2014
    This is version 140 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3