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O43852

- CALU_HUMAN

UniProt

O43852 - CALU_HUMAN

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Protein
Calumenin
Gene
CALU
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi81 – 92121 Reviewed prediction
Add
BLAST
Calcium bindingi117 – 128122 Reviewed prediction
Add
BLAST
Calcium bindingi164 – 175123; possibly ancestral Reviewed prediction
Add
BLAST
Calcium bindingi201 – 212124 Reviewed prediction
Add
BLAST
Calcium bindingi242 – 253125 Reviewed prediction
Add
BLAST
Calcium bindingi278 – 289126 Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: UniProtKB
  2. protein binding Source: UniProtKB

GO - Biological processi

  1. blood coagulation Source: Reactome
  2. platelet activation Source: Reactome
  3. platelet degranulation Source: Reactome
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calumenin
Alternative name(s):
Crocalbin
IEF SSP 9302
Gene namesi
Name:CALU
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:1458. CALU.

Subcellular locationi

Endoplasmic reticulum lumen. Secreted. Melanosome. Sarcoplasmic reticulum lumen By similarity
Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.3 Publications

GO - Cellular componenti

  1. Golgi apparatus Source: ProtInc
  2. endoplasmic reticulum Source: HPA
  3. extracellular region Source: UniProtKB-SubCell
  4. melanosome Source: UniProtKB-SubCell
  5. sarcoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Sarcoplasmic reticulum, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26047.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19191 Publication
Add
BLAST
Chaini20 – 315296Calumenin
PRO_0000004153Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei44 – 441Phosphoserine2 Publications
Modified residuei65 – 651Phosphothreonine3 Publications
Glycosylationi131 – 1311N-linked (GlcNAc...) (complex)2 Publications
Modified residuei165 – 1651N6-acetyllysine By similarity

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO43852.
PaxDbiO43852.
PRIDEiO43852.

2D gel databases

DOSAC-COBS-2DPAGEO43852.

PTM databases

PhosphoSiteiO43852.

Expressioni

Tissue specificityi

Ubiquitously expressed. Expressed at high levels in heart, placenta and skeletal muscle, at lower levels in lung, kidney and pancreas and at very low levels in brain and liver.

Gene expression databases

ArrayExpressiO43852.
BgeeiO43852.
CleanExiHS_CALU.
GenevestigatoriO43852.

Organism-specific databases

HPAiHPA006018.

Interactioni

Subunit structurei

Interacts with GGCX By similarity.

Protein-protein interaction databases

BioGridi107263. 80 interactions.
IntActiO43852. 17 interactions.
STRINGi9606.ENSP00000249364.

Structurei

3D structure databases

ProteinModelPortaliO43852.
SMRiO43852. Positions 61-295.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 10336EF-hand 1
Add
BLAST
Domaini104 – 13936EF-hand 2
Add
BLAST
Domaini151 – 18636EF-hand 3
Add
BLAST
Domaini188 – 22336EF-hand 4
Add
BLAST
Domaini229 – 26436EF-hand 5
Add
BLAST
Domaini265 – 30036EF-hand 6
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi312 – 3154Prevents secretion from ER By similarity

Sequence similaritiesi

Belongs to the CREC family.
Contains 6 EF-hand domains.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG271367.
HOGENOMiHOG000230934.
HOVERGENiHBG002834.
OMAiEEPEWVK.
OrthoDBiEOG73Z2TD.
PhylomeDBiO43852.
TreeFamiTF314849.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR027239. Calumenin.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PANTHERiPTHR10827:SF34. PTHR10827:SF34. 1 hit.
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 6 hits.
[Graphical view]

Sequences (15)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 15 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O43852-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDLRQFLMCL SLCTAFALSK PTEKKDRVHH EPQLSDKVHN DAQSFDYDHD    50
AFLGAEEAKT FDQLTPEESK ERLGKIVSKI DGDKDGFVTV DELKDWIKFA 100
QKRWIYEDVE RQWKGHDLNE DGLVSWEEYK NATYGYVLDD PDPDDGFNYK 150
QMMVRDERRF KMADKDGDLI ATKEEFTAFL HPEEYDYMKD IVVQETMEDI 200
DKNADGFIDL EEYIGDMYSH DGNTDEPEWV KTEREQFVEF RDKNRDGKMD 250
KEETKDWILP SDYDHAEAEA RHLVYESDQN KDGKLTKEEI VDKYDLFVGS 300
QATDFGEALV RHDEF 315
Length:315
Mass (Da):37,107
Last modified:July 15, 1999 - v2
Checksum:i25BAE5A99B527375
GO
Isoform 2 (identifier: O43852-2) [UniParc]FASTAAdd to Basket

Also known as: Crocalbin

The sequence of this isoform differs from the canonical sequence as follows:
     75-137: KIVSKIDGDK...EYKNATYGYV → MIVDKIDADK...EYRNVTYGTY

Show »
Length:315
Mass (Da):37,135
Checksum:iE1BF415B25076676
GO
Isoform 3 (identifier: O43852-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKETDLIIM

Show »
Length:323
Mass (Da):38,051
Checksum:i0357815A65B4C364
GO
Isoform 4 (identifier: O43852-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKETDLIIM
     75-137: KIVSKIDGDK...EYKNATYGYV → MIVDKIDADK...EYRNVTYGTY

Show »
Length:323
Mass (Da):38,079
Checksum:iC75225A8DBE1D667
GO
Isoform 5 (identifier: O43852-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     164-249: Missing.

Show »
Length:229
Mass (Da):26,892
Checksum:iB73499A59B44F6D0
GO
Isoform 6 (identifier: O43852-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     226-275: Missing.

Show »
Length:265
Mass (Da):30,957
Checksum:i853B18C78BFD2FD5
GO
Isoform 7 (identifier: O43852-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     75-137: KIVSKIDGDK...EYKNATYGYV → MIVDKIDADK...EYRNVTYGTY
     154-161: VRDERRFK → GILMSRNG
     162-315: Missing.

Show »
Length:161
Mass (Da):18,789
Checksum:i2F30CCD0362501B9
GO
Isoform 8 (identifier: O43852-8) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     75-137: KIVSKIDGDK...EYKNATYGYV → MIVDKIDADK...EYRNVTYGTY
     172-285: Missing.

Show »
Length:201
Mass (Da):23,519
Checksum:i031A48109B3A5721
GO
Isoform 9 (identifier: O43852-9) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     94-254: Missing.

Show »
Length:154
Mass (Da):17,639
Checksum:iC01A8709FEEEE48F
GO
Isoform 10 (identifier: O43852-10) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     216-315: DMYSHDGNTD...GEALVRHDEF → WQAYQGGDR

Show »
Length:224
Mass (Da):26,326
Checksum:iA58B5C4DF48D5C56
GO
Isoform 11 (identifier: O43852-11) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     165-170: KDGDLI → RARAVC
     171-315: Missing.

Show »
Length:170
Mass (Da):19,993
Checksum:iDE2FFE0A2E51C11B
GO
Isoform 12 (identifier: O43852-12) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     75-315: Missing.

Show »
Length:74
Mass (Da):8,511
Checksum:i24C00B317B5508DE
GO
Isoform 13 (identifier: O43852-13) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     139-139: D → E
     140-315: Missing.

Show »
Length:139
Mass (Da):16,291
Checksum:iDC485712A52F6454
GO
Isoform 14 (identifier: O43852-14) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKETDLIIM
     139-139: D → E
     140-315: Missing.

Show »
Length:147
Mass (Da):17,235
Checksum:i895C953C9569567E
GO
Isoform 15 (identifier: O43852-15) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-151: Missing.

Show »
Length:164
Mass (Da):19,455
Checksum:iE53F4259F8265B8D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41R → Q.1 Publication
Corresponds to variant rs2290228 [ dbSNP | Ensembl ].
VAR_022051

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 151151Missing in isoform 15.
VSP_045939Add
BLAST
Alternative sequencei1 – 11M → MKETDLIIM in isoform 3, isoform 4 and isoform 14.
VSP_043570
Alternative sequencei75 – 315241Missing in isoform 12.
VSP_045940Add
BLAST
Alternative sequencei75 – 13763KIVSK…TYGYV → MIVDKIDADKDGFVTEGELK SWIKHAQKKYIYDNVENQWQ EFDMNQDGLISWDEYRNVTY GTY in isoform 2, isoform 4, isoform 7 and isoform 8.
VSP_007317Add
BLAST
Alternative sequencei94 – 254161Missing in isoform 9.
VSP_045941Add
BLAST
Alternative sequencei139 – 1391D → E in isoform 13 and isoform 14.
VSP_045942
Alternative sequencei140 – 315176Missing in isoform 13 and isoform 14.
VSP_045943Add
BLAST
Alternative sequencei154 – 1618VRDERRFK → GILMSRNG in isoform 7.
VSP_045944
Alternative sequencei162 – 315154Missing in isoform 7.
VSP_045945Add
BLAST
Alternative sequencei164 – 24986Missing in isoform 5.
VSP_045946Add
BLAST
Alternative sequencei165 – 1706KDGDLI → RARAVC in isoform 11.
VSP_045947
Alternative sequencei171 – 315145Missing in isoform 11.
VSP_045948Add
BLAST
Alternative sequencei172 – 285114Missing in isoform 8.
VSP_045949Add
BLAST
Alternative sequencei216 – 315100DMYSH…RHDEF → WQAYQGGDR in isoform 10.
VSP_045950Add
BLAST
Alternative sequencei226 – 27550Missing in isoform 6.
VSP_045951Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti48 – 481D → G in ADG45013. 1 Publication
Sequence conflicti84 – 841K → R in ADG45007. 1 Publication
Sequence conflicti90 – 901V → A in ADG45010. 1 Publication
Sequence conflicti117 – 1171D → G in ADG45007. 1 Publication
Sequence conflicti118 – 1181L → H in ADG45011. 1 Publication
Sequence conflicti147 – 1471F → S in ADG45012. 1 Publication
Sequence conflicti188 – 1881M → V in ADG45015. 1 Publication
Sequence conflicti207 – 2071F → L in AAB97725. 1 Publication
Sequence conflicti232 – 2321T → S in ADG45015. 1 Publication
Sequence conflicti267 – 2671E → V in CAG46634. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U67280 mRNA. Translation: AAB97725.1.
AF013759 mRNA. Translation: AAC17216.1.
AF345637 mRNA. Translation: AAK72908.1.
HM002604 mRNA. Translation: ADG45004.1.
HM002605 mRNA. Translation: ADG45005.1.
HM002606 mRNA. Translation: ADG45006.1.
HM002607 mRNA. Translation: ADG45007.1.
HM002608 mRNA. Translation: ADG45008.1.
HM002609 mRNA. Translation: ADG45009.1.
HM002610 mRNA. Translation: ADG45010.1.
HM002611 mRNA. Translation: ADG45011.1.
HM002612 mRNA. Translation: ADG45012.1.
HM002613 mRNA. Translation: ADG45013.1.
HM002614 mRNA. Translation: ADG45014.1.
HM002615 mRNA. Translation: ADG45015.1.
HM002616 mRNA. Translation: ADG45016.1.
AK056338 mRNA. Translation: BAG51681.1.
CR541835 mRNA. Translation: CAG46634.1.
AC024952 Genomic DNA. No translation available.
CH471070 Genomic DNA. Translation: EAW83679.1.
BC013383 mRNA. Translation: AAH13383.1.
AF257659 mRNA. Translation: AAF76141.1.
CCDSiCCDS47703.1. [O43852-2]
CCDS56506.1. [O43852-3]
CCDS56507.1. [O43852-4]
CCDS56508.1. [O43852-10]
CCDS5805.1. [O43852-1]
RefSeqiNP_001124146.1. NM_001130674.2. [O43852-2]
NP_001186600.1. NM_001199671.1. [O43852-3]
NP_001186601.1. NM_001199672.1. [O43852-4]
NP_001186602.1. NM_001199673.1. [O43852-10]
NP_001210.1. NM_001219.4. [O43852-1]
UniGeneiHs.743262.
Hs.7753.

Genome annotation databases

EnsembliENST00000249364; ENSP00000249364; ENSG00000128595. [O43852-1]
ENST00000449187; ENSP00000408838; ENSG00000128595. [O43852-2]
ENST00000479257; ENSP00000420381; ENSG00000128595. [O43852-3]
ENST00000535011; ENSP00000442110; ENSG00000128595. [O43852-10]
ENST00000535623; ENSP00000439139; ENSG00000128595. [O43852-14]
ENST00000538546; ENSP00000438994; ENSG00000128595. [O43852-15]
ENST00000542996; ENSP00000438248; ENSG00000128595. [O43852-4]
GeneIDi813.
KEGGihsa:813.
UCSCiuc003vnq.3. human. [O43852-1]
uc003vnr.3. human. [O43852-3]
uc003vns.3. human. [O43852-2]
uc022ald.1. human. [O43852-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U67280 mRNA. Translation: AAB97725.1 .
AF013759 mRNA. Translation: AAC17216.1 .
AF345637 mRNA. Translation: AAK72908.1 .
HM002604 mRNA. Translation: ADG45004.1 .
HM002605 mRNA. Translation: ADG45005.1 .
HM002606 mRNA. Translation: ADG45006.1 .
HM002607 mRNA. Translation: ADG45007.1 .
HM002608 mRNA. Translation: ADG45008.1 .
HM002609 mRNA. Translation: ADG45009.1 .
HM002610 mRNA. Translation: ADG45010.1 .
HM002611 mRNA. Translation: ADG45011.1 .
HM002612 mRNA. Translation: ADG45012.1 .
HM002613 mRNA. Translation: ADG45013.1 .
HM002614 mRNA. Translation: ADG45014.1 .
HM002615 mRNA. Translation: ADG45015.1 .
HM002616 mRNA. Translation: ADG45016.1 .
AK056338 mRNA. Translation: BAG51681.1 .
CR541835 mRNA. Translation: CAG46634.1 .
AC024952 Genomic DNA. No translation available.
CH471070 Genomic DNA. Translation: EAW83679.1 .
BC013383 mRNA. Translation: AAH13383.1 .
AF257659 mRNA. Translation: AAF76141.1 .
CCDSi CCDS47703.1. [O43852-2 ]
CCDS56506.1. [O43852-3 ]
CCDS56507.1. [O43852-4 ]
CCDS56508.1. [O43852-10 ]
CCDS5805.1. [O43852-1 ]
RefSeqi NP_001124146.1. NM_001130674.2. [O43852-2 ]
NP_001186600.1. NM_001199671.1. [O43852-3 ]
NP_001186601.1. NM_001199672.1. [O43852-4 ]
NP_001186602.1. NM_001199673.1. [O43852-10 ]
NP_001210.1. NM_001219.4. [O43852-1 ]
UniGenei Hs.743262.
Hs.7753.

3D structure databases

ProteinModelPortali O43852.
SMRi O43852. Positions 61-295.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107263. 80 interactions.
IntActi O43852. 17 interactions.
STRINGi 9606.ENSP00000249364.

PTM databases

PhosphoSitei O43852.

2D gel databases

DOSAC-COBS-2DPAGE O43852.

Proteomic databases

MaxQBi O43852.
PaxDbi O43852.
PRIDEi O43852.

Protocols and materials databases

DNASUi 813.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000249364 ; ENSP00000249364 ; ENSG00000128595 . [O43852-1 ]
ENST00000449187 ; ENSP00000408838 ; ENSG00000128595 . [O43852-2 ]
ENST00000479257 ; ENSP00000420381 ; ENSG00000128595 . [O43852-3 ]
ENST00000535011 ; ENSP00000442110 ; ENSG00000128595 . [O43852-10 ]
ENST00000535623 ; ENSP00000439139 ; ENSG00000128595 . [O43852-14 ]
ENST00000538546 ; ENSP00000438994 ; ENSG00000128595 . [O43852-15 ]
ENST00000542996 ; ENSP00000438248 ; ENSG00000128595 . [O43852-4 ]
GeneIDi 813.
KEGGi hsa:813.
UCSCi uc003vnq.3. human. [O43852-1 ]
uc003vnr.3. human. [O43852-3 ]
uc003vns.3. human. [O43852-2 ]
uc022ald.1. human. [O43852-4 ]

Organism-specific databases

CTDi 813.
GeneCardsi GC07P128438.
HGNCi HGNC:1458. CALU.
HPAi HPA006018.
MIMi 603420. gene.
neXtProti NX_O43852.
PharmGKBi PA26047.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG271367.
HOGENOMi HOG000230934.
HOVERGENi HBG002834.
OMAi EEPEWVK.
OrthoDBi EOG73Z2TD.
PhylomeDBi O43852.
TreeFami TF314849.

Miscellaneous databases

ChiTaRSi CALU. human.
GeneWikii CALU_(gene).
GenomeRNAii 813.
NextBioi 3296.
PROi O43852.
SOURCEi Search...

Gene expression databases

ArrayExpressi O43852.
Bgeei O43852.
CleanExi HS_CALU.
Genevestigatori O43852.

Family and domain databases

Gene3Di 1.10.238.10. 2 hits.
InterProi IPR027239. Calumenin.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view ]
PANTHERi PTHR10827:SF34. PTHR10827:SF34. 1 hit.
Pfami PF13499. EF-hand_7. 2 hits.
[Graphical view ]
SMARTi SM00054. EFh. 4 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a cDNA encoding human calumenin, expression in Escherichia coli and analysis of its Ca2+-binding activity."
    Vorum H., Liu X., Madsen P., Rasmussen H.H., Honore B.
    Biochim. Biophys. Acta 1386:121-131(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE, CALCIUM-BINDING.
    Tissue: Keratinocyte.
  2. "Human calumenin gene (CALU): cDNA isolation and chromosomal mapping to 7q32."
    Yabe D., Taniwaki M., Nakamura T., Kanazawa N., Tashiro K., Honjo T.
    Genomics 49:331-333(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Novel splice variant of human calumenin."
    Peterson R.E. Jr., Watson D.K.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  4. "Calumenin isoforms and their intracellular and extracellular function."
    Wang Q., Chen L., Shen B.R., Feng H., Zheng P.L., Teng J.L., Chen J.G.
    Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 4; 5; 6; 7; 8; 9; 10; 11; 12; 13; 14 AND 15), VARIANT GLN-4.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  7. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  10. Hseu M.-J., Tzeng M.-C.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 20-315 (ISOFORM 2).
    Tissue: Brain.
  11. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
    Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
    Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 20-27.
    Tissue: Platelet.
  12. "Human calumenin localizes to the secretory pathway and is secreted to the medium."
    Vorum H., Hager H., Christensen B.M., Nielsen S., Honore B.
    Exp. Cell Res. 248:473-481(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  13. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Melanoma.
  14. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Melanoma.
  15. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-44 AND THR-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  17. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-131.
    Tissue: Liver.
  18. Cited for: GLYCOSYLATION AT ASN-131.
  19. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-44 AND THR-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  20. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCALU_HUMAN
AccessioniPrimary (citable) accession number: O43852
Secondary accession number(s): B3KPG9
, D6QS48, D6QS49, D6QS50, D6QS51, D6QS52, D6QS53, D6QS54, D6QS55, D6QS56, D6QS57, D6QS58, D6QS59, F5H1Q9, F5H879, O60456, Q6FHB9, Q96RL3, Q9NR43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 15, 1999
Last modified: September 3, 2014
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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