O43849 (O43849_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
PDE4C-791 EMBL AAB96875.1

Gene names

Name:

PDE4C EMBL AAB96875.1

Organism

Homo sapiens (Human) EMBL AAB96875.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	791 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Cofactor

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity. SAAS SAAS002073

Ontologies

Keywords
Ligand	Metal-binding SAAS SAAS023088
Molecular function	Hydrolase SAAS SAAS023088
Gene Ontology (GO)
Biological_process	metabolic process Inferred from electronic annotation. Source: GOC signal transduction Inferred from electronic annotation. Source: InterPro
Molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAB96875.1

Sequences

	Sequence		Length	Mass (Da)
	O43849 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 616F6606E39719B8	FASTA	791	88,143
	10 20 30 40 50 60 GTQAGLRSGA PSGHRQLLGV GPTLSPSSTF YRFSTSGADS SSLSPPLPAL GRTREQTLLG 70 80 90 100 110 120 ARSRGRVLLP AIPDPFLWRM ENLGVGEGAE ACSRLSRSRG RHSMTRAPKH LWRQPRRPIR 130 140 150 160 170 180 IQQRFYSDPD KSAGCRERDL SPRPELRKSR LSWPVSSCRR FDLENGLSCG RRALDPQSSP 190 200 210 220 230 240 GLGRIMQAPV PHSQRRESFL YRSDSDYELS PKAMSRNSSV ASDLHGEDMI VTPFAQVLAS 250 260 270 280 290 300 LRTVRSNVAA LARQQCLGAA KQGPVGNPSS SNQLPPAEDT GQKLALETLD ELDWCLDQLE 310 320 330 340 350 360 TLQTRHSVGE MASNKFKRIL NRELTHLSET SRSGNQVSEY ISRTFLDQQT EVELPKVTAE 370 380 390 400 410 420 EAPQPMSRIS GLHGLCHSAS LSSATVPRFG VQTDQEEQLA KELEDTNKWG LDVFKVAELS 430 440 450 460 470 480 GNQPLTAIIF SIFQERDLLK TFQIPADTLA TYLLMLEGHY HANVAYHNSL HAADVAQSTH 490 500 510 520 530 540 VLLATPALEA VFTDLEILAA LFASAIHDVD HPGVSNQFLI NTNSELALMY NDASVLENHH 550 560 570 580 590 600 LAVGFKLLQA ENCDIFQNLS AKQRLSLRRM VIDMVLATDM SKHMNLLADL KTMVETKKVT 610 620 630 640 650 660 SLGVLLLDNY SDRIQVLQNL VHCADLSNPT KPLPLYRQWT DRIMAEFFQQ GDRERESGLD 670 680 690 700 710 720 ISPMCDKHTA SVEKSQVGFI DYIAHPLWET WADLVHPDAQ DLLDTLEDNR EWYQSKIPRS 730 740 750 760 770 780 PSDLTNPERD GPDRFQFELT LEEAEEEDEE EEEEGEETAL AKEALELPDT ELLSPEAGPD 790 PGDLPLDNQR T

References

[1]	"Molecular cloning and functional expression in yeast of a human cAMP-specific phosphodiesterase subtype (PDE IV-C)." Engels P., Sullivan M., Mueller T., Luebbert H. FEBS Lett. 358:305-310(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Lung EMBL AAB96875.1.
[2]	"Multiple splice variants of phosphodiesterase PDE4C cloned from human lung and testis." Obernolte R., Ratzliff J., Baecker P.A., Daniels D.V., Zuppan P., Jarnagin K., Shelton E.R. Biochim. Biophys. Acta 1353:287-297(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Lung EMBL AAB96875.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U66346 mRNA. Translation: AAB96875.1.
IPI	IPI01010417.
RefSeq	NP_000914.2. NM_000923.4.
UniGene	Hs.132584.
3D structure databases
ProteinModelPortal	O43849.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5143.
KEGG	hsa:5143.
Organism-specific databases
CTD	5143.
PharmGKB	PA264.
Phylogenomic databases
HOVERGEN	HBG108239.
KO	K01120.
Family and domain databases
Gene3D	1.10.1300.10. 1 hit.
InterPro	IPR003607. HD/PDEase_dom. IPR023088. PDEase. IPR002073. PDEase_catalytic_dom. IPR023174. PDEase_CS. [Graphical view]
Pfam	PF00233. PDEase_I. 1 hit. [Graphical view]
PRINTS	PR00387. PDIESTERASE1.
SMART	SM00471. HDc. 1 hit. [Graphical view]
PROSITE	PS00126. PDEASE_I. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	5143.
NextBio	19838.

Entry information

Entry name

O43849_HUMAN

Accession

Primary (citable) accession number: O43849

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 1998
Last sequence update:	June 1, 1998
Last modified:	May 29, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.