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Protein

Zinc finger and BTB domain-containing protein 14

Gene

ZBTB14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri277 – 304C2H2-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri305 – 332C2H2-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri333 – 360C2H2-type 3PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri361 – 388C2H2-type 4PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri389 – 417C2H2-type 5PROSITE-ProRule annotationAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiO43829.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 14
Alternative name(s):
Zinc finger protein 161 homolog
Short name:
Zfp-161
Zinc finger protein 478
Zinc finger protein 5 homolog
Short name:
ZF5
Short name:
Zfp-5
Short name:
hZF5
Gene namesi
Name:ZBTB14
Synonyms:ZFP161, ZNF478
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000198081.10.
HGNCiHGNC:12860. ZBTB14.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7541.
OpenTargetsiENSG00000198081.
PharmGKBiPA37449.

Polymorphism and mutation databases

BioMutaiZBTB14.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473171 – 449Zinc finger and BTB domain-containing protein 14Add BLAST449

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki46Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki203Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki249Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiO43829.
MaxQBiO43829.
PaxDbiO43829.
PeptideAtlasiO43829.
PRIDEiO43829.

PTM databases

iPTMnetiO43829.
PhosphoSitePlusiO43829.

Expressioni

Gene expression databases

BgeeiENSG00000198081.
CleanExiHS_ZFP161.
ExpressionAtlasiO43829. baseline and differential.
GenevisibleiO43829. HS.

Organism-specific databases

HPAiHPA050758.
HPA070819.

Interactioni

Subunit structurei

Interacts with ZBTB21.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi113373. 48 interactors.
IntActiO43829. 47 interactors.
STRINGi9606.ENSP00000349503.

Structurei

3D structure databases

ProteinModelPortaliO43829.
SMRiO43829.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 102BTBPROSITE-ProRule annotationAdd BLAST67

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi50 – 66Nuclear localization signalSequence analysisAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi154 – 179Asp/Glu-rich (acidic)Add BLAST26

Domaini

The BTB/POZ domain seems to direct the protein to discrete regions in the nucleus.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri277 – 304C2H2-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri305 – 332C2H2-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri333 – 360C2H2-type 3PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri361 – 388C2H2-type 4PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri389 – 417C2H2-type 5PROSITE-ProRule annotationAdd BLAST29

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00810000125416.
HOGENOMiHOG000136853.
HOVERGENiHBG054222.
InParanoidiO43829.
OMAiLYGHREQ.
OrthoDBiEOG091G06U1.
PhylomeDBiO43829.
TreeFamiTF333100.

Family and domain databases

InterProiView protein in InterPro
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
PfamiView protein in Pfam
PF00651. BTB. 1 hit.
SMARTiView protein in SMART
SM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
SUPFAMiSSF54695. SSF54695. 1 hit.
SSF57667. SSF57667. 3 hits.
PROSITEiView protein in PROSITE
PS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.

Sequencei

Sequence statusi: Complete.

O43829-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFFISMSET IKYNDDDHKT LFLKTLNEQR LEGEFCDIAI VVEDVKFRAH
60 70 80 90 100
RCVLAACSTY FKKLFKKLEV DSSSVIEIDF LRSDIFEEVL NYMYTAKISV
110 120 130 140 150
KKEDVNLMMS SGQILGIRFL DKLCSQKRDV SSPDENNGQS KSKYCLKINR
160 170 180 190 200
PIGDAADTQD DDVEEIGDQD DSPSDDTVEG TPPSQEDGKS PTTTLRVQEA
210 220 230 240 250
ILKELGSEEV RKVNCYGQEV ESMETPESKD LGSQTPQALT FNDGMSEVKD
260 270 280 290 300
EQTPGWTTAA SDMKFEYLLY GHHREQIACQ ACGKTFSDEG RLRKHEKLHT
310 320 330 340 350
ADRPFVCEMC TKGFTTQAHL KEHLKIHTGY KPYSCEVCGK SFIRAPDLKK
360 370 380 390 400
HERVHSNERP FACHMCDKAF KHKSHLKDHE RRHRGEKPFV CGSCTKAFAK
410 420 430 440
ASDLKRHENN MHSERKQVTP SAIQSETEQL QAAAMAAEAE QQLETIACS
Length:449
Mass (Da):50,956
Last modified:October 3, 2006 - v2
Checksum:iB99F22E3B1D4E6CE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5I → V in CAA73258 (PubMed:9244432).Curated1
Sequence conflicti160 – 161DD → GC in CAA73258 (PubMed:9244432).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02781077E → G. Corresponds to variant dbSNP:rs7235740Ensembl.1
Natural variantiVAR_027811139Q → R. Corresponds to variant dbSNP:rs7235420Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12726 mRNA. Translation: CAA73258.1.
D89859 mRNA. Translation: BAA20131.1.
BC110519 mRNA. Translation: AAI10520.1.
CCDSiCCDS11837.1.
RefSeqiNP_001137295.1. NM_001143823.2.
NP_001230631.1. NM_001243702.1.
NP_001230633.1. NM_001243704.1.
NP_003400.2. NM_003409.4.
UniGeneiHs.592340.

Genome annotation databases

EnsembliENST00000357006; ENSP00000349503; ENSG00000198081.
ENST00000400143; ENSP00000383009; ENSG00000198081.
ENST00000614697; ENSP00000484129; ENSG00000198081.
ENST00000615385; ENSP00000478971; ENSG00000198081.
GeneIDi7541.
KEGGihsa:7541.
UCSCiuc002kmq.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZBT14_HUMAN
AccessioniPrimary (citable) accession number: O43829
Secondary accession number(s): O00403, Q2TB80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: October 3, 2006
Last modified: October 25, 2017
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families