Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger and BTB domain-containing protein 14

Gene

ZBTB14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri277 – 304C2H2-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri305 – 332C2H2-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri333 – 360C2H2-type 3PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri361 – 388C2H2-type 4PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri389 – 417C2H2-type 5PROSITE-ProRule annotationAdd BLAST29

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • sequence-specific DNA binding Source: UniProtKB
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB
  • transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

SIGNORiO43829.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 14
Alternative name(s):
Zinc finger protein 161 homolog
Short name:
Zfp-161
Zinc finger protein 478
Zinc finger protein 5 homolog
Short name:
ZF5
Short name:
Zfp-5
Short name:
hZF5
Gene namesi
Name:ZBTB14
Synonyms:ZFP161, ZNF478
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:12860. ZBTB14.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7541.
OpenTargetsiENSG00000198081.
PharmGKBiPA37449.

Polymorphism and mutation databases

BioMutaiZBTB14.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473171 – 449Zinc finger and BTB domain-containing protein 14Add BLAST449

Proteomic databases

EPDiO43829.
MaxQBiO43829.
PaxDbiO43829.
PeptideAtlasiO43829.
PRIDEiO43829.

PTM databases

iPTMnetiO43829.
PhosphoSitePlusiO43829.

Expressioni

Gene expression databases

BgeeiENSG00000198081.
CleanExiHS_ZFP161.
ExpressionAtlasiO43829. baseline and differential.
GenevisibleiO43829. HS.

Organism-specific databases

HPAiHPA050758.

Interactioni

Subunit structurei

Interacts with ZBTB21.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
AP1M1Q9BXS55EBI-10176632,EBI-541426
ATP5OP480473EBI-10176632,EBI-355815
BAZ2BQ9UIF8-23EBI-10176632,EBI-10321972
BYSLQ138955EBI-10176632,EBI-358049
CBX8Q9HC525EBI-10176632,EBI-712912
CDK16Q005363EBI-10176632,EBI-726261
CDKL3Q8IVW43EBI-10176632,EBI-3919850
CEP19Q96LK05EBI-10176632,EBI-741885
EAF1Q96JC93EBI-10176632,EBI-769261
EIF1ADQ8N9N83EBI-10176632,EBI-750700
ENKD1Q9H0I23EBI-10176632,EBI-744099
EPM2AIP1Q7L7755EBI-10176632,EBI-6255981
FAM161AQ3B8203EBI-10176632,EBI-719941
FAM90A1Q86YD73EBI-10176632,EBI-6658203
GORASP2Q9H8Y83EBI-10176632,EBI-739467
INTS3Q68E013EBI-10176632,EBI-2680854
KAT5Q929933EBI-10176632,EBI-399080
MAD2L1BPQ150135EBI-10176632,EBI-712181
MFAP1P550813EBI-10176632,EBI-1048159
MORF4L2Q150143EBI-10176632,EBI-399257
NAA10P412275EBI-10176632,EBI-747693
PCTK1Q9BRL43EBI-10176632,EBI-10296950
PIN1Q135263EBI-10176632,EBI-714158
PNKPQ96T605EBI-10176632,EBI-1045072
POLR2LP628753EBI-10176632,EBI-359527
RNPS1D3DU923EBI-10176632,EBI-10176640
RPL9P9P329693EBI-10176632,EBI-358122
RPS7P620813EBI-10176632,EBI-354360
SCNM1Q9BWG63EBI-10176632,EBI-748391
SDCBPO005603EBI-10176632,EBI-727004
SNRPB2P085795EBI-10176632,EBI-1053651
SYT16Q17RD73EBI-10176632,EBI-10238936
TCEANCQ8N8B73EBI-10176632,EBI-954696
TXN2Q997573EBI-10176632,EBI-2932492
ZCCHC10Q8TBK63EBI-10176632,EBI-597063
ZMAT2Q96NC03EBI-10176632,EBI-2682299

Protein-protein interaction databases

BioGridi113373. 46 interactors.
IntActiO43829. 46 interactors.
STRINGi9606.ENSP00000349503.

Structurei

3D structure databases

ProteinModelPortaliO43829.
SMRiO43829.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 102BTBPROSITE-ProRule annotationAdd BLAST67

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi50 – 66Nuclear localization signalSequence analysisAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi154 – 179Asp/Glu-rich (acidic)Add BLAST26

Domaini

The BTB/POZ domain seems to direct the protein to discrete regions in the nucleus.

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri277 – 304C2H2-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri305 – 332C2H2-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri333 – 360C2H2-type 3PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri361 – 388C2H2-type 4PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri389 – 417C2H2-type 5PROSITE-ProRule annotationAdd BLAST29

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00810000125416.
HOGENOMiHOG000136853.
HOVERGENiHBG054222.
InParanoidiO43829.
OMAiQEVEPME.
OrthoDBiEOG091G06U1.
PhylomeDBiO43829.
TreeFamiTF333100.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43829-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFFISMSET IKYNDDDHKT LFLKTLNEQR LEGEFCDIAI VVEDVKFRAH
60 70 80 90 100
RCVLAACSTY FKKLFKKLEV DSSSVIEIDF LRSDIFEEVL NYMYTAKISV
110 120 130 140 150
KKEDVNLMMS SGQILGIRFL DKLCSQKRDV SSPDENNGQS KSKYCLKINR
160 170 180 190 200
PIGDAADTQD DDVEEIGDQD DSPSDDTVEG TPPSQEDGKS PTTTLRVQEA
210 220 230 240 250
ILKELGSEEV RKVNCYGQEV ESMETPESKD LGSQTPQALT FNDGMSEVKD
260 270 280 290 300
EQTPGWTTAA SDMKFEYLLY GHHREQIACQ ACGKTFSDEG RLRKHEKLHT
310 320 330 340 350
ADRPFVCEMC TKGFTTQAHL KEHLKIHTGY KPYSCEVCGK SFIRAPDLKK
360 370 380 390 400
HERVHSNERP FACHMCDKAF KHKSHLKDHE RRHRGEKPFV CGSCTKAFAK
410 420 430 440
ASDLKRHENN MHSERKQVTP SAIQSETEQL QAAAMAAEAE QQLETIACS
Length:449
Mass (Da):50,956
Last modified:October 3, 2006 - v2
Checksum:iB99F22E3B1D4E6CE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5I → V in CAA73258 (PubMed:9244432).Curated1
Sequence conflicti160 – 161DD → GC in CAA73258 (PubMed:9244432).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02781077E → G.Corresponds to variant rs7235740dbSNPEnsembl.1
Natural variantiVAR_027811139Q → R.Corresponds to variant rs7235420dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12726 mRNA. Translation: CAA73258.1.
D89859 mRNA. Translation: BAA20131.1.
BC110519 mRNA. Translation: AAI10520.1.
CCDSiCCDS11837.1.
RefSeqiNP_001137295.1. NM_001143823.2.
NP_001230631.1. NM_001243702.1.
NP_001230633.1. NM_001243704.1.
NP_003400.2. NM_003409.4.
UniGeneiHs.592340.

Genome annotation databases

EnsembliENST00000357006; ENSP00000349503; ENSG00000198081.
ENST00000400143; ENSP00000383009; ENSG00000198081.
ENST00000614697; ENSP00000484129; ENSG00000198081.
ENST00000615385; ENSP00000478971; ENSG00000198081.
GeneIDi7541.
KEGGihsa:7541.
UCSCiuc002kmq.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12726 mRNA. Translation: CAA73258.1.
D89859 mRNA. Translation: BAA20131.1.
BC110519 mRNA. Translation: AAI10520.1.
CCDSiCCDS11837.1.
RefSeqiNP_001137295.1. NM_001143823.2.
NP_001230631.1. NM_001243702.1.
NP_001230633.1. NM_001243704.1.
NP_003400.2. NM_003409.4.
UniGeneiHs.592340.

3D structure databases

ProteinModelPortaliO43829.
SMRiO43829.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113373. 46 interactors.
IntActiO43829. 46 interactors.
STRINGi9606.ENSP00000349503.

PTM databases

iPTMnetiO43829.
PhosphoSitePlusiO43829.

Polymorphism and mutation databases

BioMutaiZBTB14.

Proteomic databases

EPDiO43829.
MaxQBiO43829.
PaxDbiO43829.
PeptideAtlasiO43829.
PRIDEiO43829.

Protocols and materials databases

DNASUi7541.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357006; ENSP00000349503; ENSG00000198081.
ENST00000400143; ENSP00000383009; ENSG00000198081.
ENST00000614697; ENSP00000484129; ENSG00000198081.
ENST00000615385; ENSP00000478971; ENSG00000198081.
GeneIDi7541.
KEGGihsa:7541.
UCSCiuc002kmq.4. human.

Organism-specific databases

CTDi7541.
DisGeNETi7541.
GeneCardsiZBTB14.
HGNCiHGNC:12860. ZBTB14.
HPAiHPA050758.
MIMi602126. gene.
neXtProtiNX_O43829.
OpenTargetsiENSG00000198081.
PharmGKBiPA37449.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00810000125416.
HOGENOMiHOG000136853.
HOVERGENiHBG054222.
InParanoidiO43829.
OMAiQEVEPME.
OrthoDBiEOG091G06U1.
PhylomeDBiO43829.
TreeFamiTF333100.

Enzyme and pathway databases

SIGNORiO43829.

Miscellaneous databases

GeneWikiiZFP161.
GenomeRNAii7541.
PROiO43829.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198081.
CleanExiHS_ZFP161.
ExpressionAtlasiO43829. baseline and differential.
GenevisibleiO43829. HS.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZBT14_HUMAN
AccessioniPrimary (citable) accession number: O43829
Secondary accession number(s): O00403, Q2TB80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: October 3, 2006
Last modified: November 30, 2016
This is version 150 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.