ID   ANGL7_HUMAN             Reviewed;         346 AA.
AC   O43827; Q4ZGK4;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   16-JUN-2009, entry version 64.
DE   RecName: Full=Angiopoietin-related protein 7;
DE   AltName: Full=Angiopoietin-like 7;
DE   AltName: Full=Angiopoietin-like factor;
DE   AltName: Full=Cornea-derived transcript 6 protein;
DE   Flags: Precursor;
GN   Name=ANGPTL7; Synonyms=CDT6; ORFNames=UNQ313/PRO356;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Cornea;
RX   MEDLINE=98394383; PubMed=9727400;
RA   Peek R., van Gelderen B.E., Bruinenberg M., Kijlstra A.;
RT   "Molecular cloning of a new angiopoietin-like factor from the human
RT   cornea.";
RL   Invest. Ophthalmol. Vis. Sci. 39:1782-1788(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=21318995; PubMed=11426320; DOI=10.1038/sj.gene.6363745;
RA   Stover C., Endo Y., Takahashi M., Lynch N., Constantinescu C.,
RA   Vorup-Jensen T., Thiel S., Friedl H., Hankeln T., Hall R., Gregory S.,
RA   Fujita T., Schwaeble W.;
RT   "The human gene for mannan-binding lectin-associated serine protease-2
RT   (MASP-2), the effector component of the lectin route of complement
RT   activation, is part of a tightly linked gene cluster on chromosome
RT   1p36.2-3.";
RL   Genes Immun. 2:119-127(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   MEDLINE=22887296; PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA   Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA   Phelan M., Farmer A.;
RT   "Cloning of human full-length CDSs in BD Creator(TM) system donor
RT   vector.";
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ASP-51; HIS-140 AND
RP   HIS-175.
RG   NIEHS SNPs program;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA   Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA   Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA   Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA   Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA   Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA   Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA   Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA   Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA   Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA   Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA   Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA   Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA   Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Skin;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [8]
RP   PROTEIN SEQUENCE OF 27-41.
RX   PubMed=15340161; DOI=10.1110/ps.04682504;
RA   Zhang Z., Henzel W.J.;
RT   "Signal peptide prediction based on analysis of experimentally
RT   verified cleavage sites.";
RL   Protein Sci. 13:2819-2824(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted (Probable).
CC   -!- TISSUE SPECIFICITY: Highly and specifically expressed in the
CC       cornea where is confined to the stromal layer.
CC   -!- SIMILARITY: Contains 1 fibrinogen C-terminal domain.
CC   -!- WEB RESOURCE: Name=NIEHS-SNPs;
CC       URL="http://egp.gs.washington.edu/data/angptl7/";
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DR   EMBL; Y16132; CAA76078.1; -; mRNA.
DR   EMBL; AJ300188; CAC15571.1; -; Genomic_DNA.
DR   EMBL; AY358301; AAQ88668.1; -; mRNA.
DR   EMBL; BT009802; AAP88804.1; -; mRNA.
DR   EMBL; DQ012507; AAY22173.1; -; Genomic_DNA.
DR   EMBL; AL049653; CAB44734.1; -; Genomic_DNA.
DR   EMBL; AL391561; CAB44734.1; JOINED; Genomic_DNA.
DR   EMBL; AL391561; CAI17229.1; -; Genomic_DNA.
DR   EMBL; AL049653; CAI17229.1; JOINED; Genomic_DNA.
DR   EMBL; BC001881; AAH01881.1; -; mRNA.
DR   IPI; IPI00171928; -.
DR   RefSeq; NP_066969.1; -.
DR   UniGene; Hs.146559; -.
DR   HSSP; Q9U8W8; 1JC9.
DR   PRIDE; O43827; -.
DR   Ensembl; ENSG00000171819; Homo sapiens.
DR   GeneID; 10218; -.
DR   KEGG; hsa:10218; -.
DR   GeneCards; GC01P011184; -.
DR   H-InvDB; HIX0000122; -.
DR   HGNC; HGNC:24078; ANGPTL7.
DR   PharmGKB; PA134959516; -.
DR   HOGENOM; O43827; -.
DR   HOVERGEN; O43827; -.
DR   OMA; O43827; IMQLQAA.
DR   NextBio; 38692; -.
DR   ArrayExpress; O43827; -.
DR   Bgee; O43827; -.
DR   CleanEx; HS_ANGPTL7; -.
DR   GermOnline; ENSG00000171819; Homo sapiens.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005102; F:receptor binding; IEA:InterPro.
DR   GO; GO:0006979; P:response to oxidative stress; TAS:ProtInc.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   InterPro; IPR002181; Fibrinogen_a/b/g_C.
DR   InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR   Gene3D; G3DSA:3.90.215.10; Fibrinogen_a/b/g_C_1; 1.
DR   Pfam; PF00147; Fibrinogen_C; 1.
DR   SMART; SM00186; FBG; 1.
DR   PROSITE; PS00514; FIBRINOGEN_C_1; FALSE_NEG.
DR   PROSITE; PS51406; FIBRINOGEN_C_2; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Direct protein sequencing; Disulfide bond; Glycoprotein;
KW   Polymorphism; Secreted; Signal.
FT   SIGNAL        1     26
FT   CHAIN        27    346       Angiopoietin-related protein 7.
FT                                /FTId=PRO_0000009131.
FT   DOMAIN      122    343       Fibrinogen C-terminal.
FT   COILED       39    119       Potential.
FT   CARBOHYD     58     58       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    253    253       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    267    267       N-linked (GlcNAc...) (Potential).
FT   DISULFID    131    162       By similarity.
FT   DISULFID    285    298       By similarity.
FT   VARIANT      51     51       E -> D (in dbSNP:rs28990992).
FT                                /FTId=VAR_025075.
FT   VARIANT     140    140       R -> H.
FT                                /FTId=VAR_025076.
FT   VARIANT     175    175       Q -> H.
FT                                /FTId=VAR_025077.
SQ   SEQUENCE   346 AA;  40018 MW;  AEC0A601CC498B43 CRC64;
     MLKKPLSAVT WLCIFIVAFV SHPAWLQKLS KHKTPAQPQL KAANCCEEVK ELKAQVANLS
     SLLSELNKKQ ERDWVSVVMQ VMELESNSKR MESRLTDAES KYSEMNNQID IMQLQAAQTV
     TQTSADAIYD CSSLYQKNYR ISGVYKLPPD DFLGSPELEV FCDMETSGGG WTIIQRRKSG
     LVSFYRDWKQ YKQGFGSIRG DFWLGNEHIH RLSRQPTRLR VEMEDWEGNL RYAEYSHFVL
     GNELNSYRLF LGNYTGNVGN DALQYHNNTA FSTKDKDNDN CLDKCAQLRK GGYWYNCCTD
     SNLNGVYYRL GEHNKHLDGI TWYGWHGSTY SLKRVEMKIR PEDFKP
//