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Protein

Angiopoietin-related protein 7

Gene

ANGPTL7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • response to oxidative stress Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171819-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Angiopoietin-related protein 7
Alternative name(s):
Angiopoietin-like factor
Angiopoietin-like protein 7
Cornea-derived transcript 6 protein
Gene namesi
Name:ANGPTL7
Synonyms:CDT6
ORF Names:UNQ313/PRO356
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:24078. ANGPTL7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi10218.
OpenTargetsiENSG00000171819.
PharmGKBiPA134959516.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 261 PublicationAdd BLAST26
ChainiPRO_000000913127 – 346Angiopoietin-related protein 7Add BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi58N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi131 ↔ 162PROSITE-ProRule annotation
Glycosylationi253N-linked (GlcNAc...)Sequence analysis1
Glycosylationi267N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi285 ↔ 298PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO43827.
PeptideAtlasiO43827.
PRIDEiO43827.

PTM databases

iPTMnetiO43827.
PhosphoSitePlusiO43827.

Expressioni

Tissue specificityi

Highly and specifically expressed in the cornea where is confined to the stromal layer.1 Publication

Gene expression databases

BgeeiENSG00000171819.
CleanExiHS_ANGPTL7.
GenevisibleiO43827. HS.

Organism-specific databases

HPAiCAB005079.
CAB058689.

Interactioni

Protein-protein interaction databases

BioGridi115513. 14 interactors.
STRINGi9606.ENSP00000366015.

Structurei

3D structure databases

ProteinModelPortaliO43827.
SMRiO43827.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini122 – 343Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST222

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili39 – 119Sequence analysisAdd BLAST81

Sequence similaritiesi

Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00760000118809.
HOGENOMiHOG000037127.
HOVERGENiHBG001644.
InParanoidiO43827.
OMAiFVSHPVW.
OrthoDBiEOG091G03M1.
PhylomeDBiO43827.
TreeFamiTF329953.

Family and domain databases

CDDicd00087. FReD. 1 hit.
Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
[Graphical view]
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O43827-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKKPLSAVT WLCIFIVAFV SHPAWLQKLS KHKTPAQPQL KAANCCEEVK
60 70 80 90 100
ELKAQVANLS SLLSELNKKQ ERDWVSVVMQ VMELESNSKR MESRLTDAES
110 120 130 140 150
KYSEMNNQID IMQLQAAQTV TQTSADAIYD CSSLYQKNYR ISGVYKLPPD
160 170 180 190 200
DFLGSPELEV FCDMETSGGG WTIIQRRKSG LVSFYRDWKQ YKQGFGSIRG
210 220 230 240 250
DFWLGNEHIH RLSRQPTRLR VEMEDWEGNL RYAEYSHFVL GNELNSYRLF
260 270 280 290 300
LGNYTGNVGN DALQYHNNTA FSTKDKDNDN CLDKCAQLRK GGYWYNCCTD
310 320 330 340
SNLNGVYYRL GEHNKHLDGI TWYGWHGSTY SLKRVEMKIR PEDFKP
Length:346
Mass (Da):40,018
Last modified:June 1, 1998 - v1
Checksum:iAEC0A601CC498B43
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02507551E → D.1 PublicationCorresponds to variant rs28990992dbSNPEnsembl.1
Natural variantiVAR_025076140R → H.1 PublicationCorresponds to variant rs28991002dbSNPEnsembl.1
Natural variantiVAR_025077175Q → H.1 PublicationCorresponds to variant rs28991009dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16132 mRNA. Translation: CAA76078.1.
AJ300188 Genomic DNA. Translation: CAC15571.1.
AY358301 mRNA. Translation: AAQ88668.1.
BT009802 mRNA. Translation: AAP88804.1.
AK313716 mRNA. Translation: BAG36459.1.
DQ012507 Genomic DNA. Translation: AAY22173.1.
AB593026 mRNA. Translation: BAJ83980.1.
AB593027 mRNA. Translation: BAJ83981.1.
AL049653, AL391561 Genomic DNA. Translation: CAB44734.1.
AL391561, AL049653 Genomic DNA. Translation: CAI17229.1.
CH471130 Genomic DNA. Translation: EAW71685.1.
BC001881 mRNA. Translation: AAH01881.1.
CCDSiCCDS128.1.
RefSeqiNP_066969.1. NM_021146.3.
UniGeneiHs.146559.

Genome annotation databases

EnsembliENST00000376819; ENSP00000366015; ENSG00000171819.
GeneIDi10218.
KEGGihsa:10218.
UCSCiuc001ase.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16132 mRNA. Translation: CAA76078.1.
AJ300188 Genomic DNA. Translation: CAC15571.1.
AY358301 mRNA. Translation: AAQ88668.1.
BT009802 mRNA. Translation: AAP88804.1.
AK313716 mRNA. Translation: BAG36459.1.
DQ012507 Genomic DNA. Translation: AAY22173.1.
AB593026 mRNA. Translation: BAJ83980.1.
AB593027 mRNA. Translation: BAJ83981.1.
AL049653, AL391561 Genomic DNA. Translation: CAB44734.1.
AL391561, AL049653 Genomic DNA. Translation: CAI17229.1.
CH471130 Genomic DNA. Translation: EAW71685.1.
BC001881 mRNA. Translation: AAH01881.1.
CCDSiCCDS128.1.
RefSeqiNP_066969.1. NM_021146.3.
UniGeneiHs.146559.

3D structure databases

ProteinModelPortaliO43827.
SMRiO43827.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115513. 14 interactors.
STRINGi9606.ENSP00000366015.

PTM databases

iPTMnetiO43827.
PhosphoSitePlusiO43827.

Proteomic databases

PaxDbiO43827.
PeptideAtlasiO43827.
PRIDEiO43827.

Protocols and materials databases

DNASUi10218.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376819; ENSP00000366015; ENSG00000171819.
GeneIDi10218.
KEGGihsa:10218.
UCSCiuc001ase.5. human.

Organism-specific databases

CTDi10218.
DisGeNETi10218.
GeneCardsiANGPTL7.
HGNCiHGNC:24078. ANGPTL7.
HPAiCAB005079.
CAB058689.
neXtProtiNX_O43827.
OpenTargetsiENSG00000171819.
PharmGKBiPA134959516.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00760000118809.
HOGENOMiHOG000037127.
HOVERGENiHBG001644.
InParanoidiO43827.
OMAiFVSHPVW.
OrthoDBiEOG091G03M1.
PhylomeDBiO43827.
TreeFamiTF329953.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171819-MONOMER.

Miscellaneous databases

GeneWikiiANGPTL7.
GenomeRNAii10218.
PROiO43827.

Gene expression databases

BgeeiENSG00000171819.
CleanExiHS_ANGPTL7.
GenevisibleiO43827. HS.

Family and domain databases

CDDicd00087. FReD. 1 hit.
Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
[Graphical view]
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANGL7_HUMAN
AccessioniPrimary (citable) accession number: O43827
Secondary accession number(s): B2R9B2, F1T0A6, Q4ZGK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.