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Protein

Glucose-6-phosphate exchanger SLC37A4

Gene

SLC37A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inorganic phosphate and glucose-6-phosphate antiporter of the endoplasmic reticulum. Transports cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocates inorganic phosphate into the opposite direction. Forms with glucose-6-phosphatase the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it plays a central role in homeostatic regulation of blood glucose levels.2 Publications

Enzyme regulationi

Inhibited by vanadate and chlorogenic acid.1 Publication

GO - Molecular functioni

  • glucose 6-phosphate:inorganic phosphate antiporter activity Source: UniProtKB
  • glucose-6-phosphate transmembrane transporter activity Source: UniProtKB
  • transporter activity Source: UniProtKB

GO - Biological processi

  • glucose-6-phosphate transport Source: UniProtKB
  • glucose homeostasis Source: UniProtKB
  • glucose metabolic process Source: UniProtKB
  • glucose transport Source: Reactome
  • phosphate ion transmembrane transport Source: UniProtKB
  • transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Antiport, Sugar transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137700-MONOMER.
ReactomeiR-HSA-70153. Glucose transport.

Protein family/group databases

TCDBi2.A.1.4.5. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate exchanger SLC37A42 Publications
Alternative name(s):
Glucose-5-phosphate transporter
Glucose-6-phosphate translocase1 Publication
Solute carrier family 37 member 4Imported
Transformation-related gene 19 proteinImported
Short name:
TRG-19Imported
Gene namesi
Name:SLC37A4Imported
Synonyms:G6PT, G6PT1
ORF Names:PRO0685, TRG19Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:4061. SLC37A4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Transmembranei260 – 280HelicalSequence analysisAdd BLAST21
Transmembranei302 – 322HelicalSequence analysisAdd BLAST21
Transmembranei329 – 349HelicalSequence analysisAdd BLAST21
Transmembranei368 – 388HelicalSequence analysisAdd BLAST21
Transmembranei394 – 414HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB
  • endoplasmic reticulum membrane Source: Reactome
  • integral component of endoplasmic reticulum membrane Source: UniProtKB
  • integral component of membrane Source: UniProtKB
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Involvement in diseasei

Glycogen storage disease 1B (GSD1B)21 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA metabolic disorder characterized by impairment of terminal steps of glycogenolysis and gluconeogenesis. Patients manifest a wide range of clinical symptoms and biochemical abnormalities, including hypoglycemia, severe hepatomegaly due to excessive accumulation of glycogen, kidney enlargement, growth retardation, lactic acidemia, hyperlipidemia, and hyperuricemia. Glycogen storage disease type 1B patients also present a tendency towards infections associated with neutropenia, relapsing aphthous gingivostomatitis, and inflammatory bowel disease.
See also OMIM:232220
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02558120G → D in GSD1B. 1 PublicationCorresponds to variant rs193302881dbSNPEnsembl.1
Natural variantiVAR_02558224Y → H in GSD1B. 1 PublicationCorresponds to variant rs193302887dbSNPEnsembl.1
Natural variantiVAR_02558327N → K in GSD1B. 1 PublicationCorresponds to variant rs193302889dbSNPEnsembl.1
Natural variantiVAR_02558428R → C in GSD1B. 1 PublicationCorresponds to variant rs193302882dbSNPEnsembl.1
Natural variantiVAR_01684028R → H in GSD1B; inactive glucose-6-phosphate transport. 2 PublicationsCorresponds to variant rs121908978dbSNPEnsembl.1
Natural variantiVAR_06639450G → E in GSD1B. 1 PublicationCorresponds to variant rs193302877dbSNPEnsembl.1
Natural variantiVAR_02558550G → R in GSD1B. 1 PublicationCorresponds to variant rs193302894dbSNPEnsembl.1
Natural variantiVAR_02558654S → R in GSD1B. 1 PublicationCorresponds to variant rs193302898dbSNPEnsembl.1
Natural variantiVAR_02558755S → R in GSD1B. 1 PublicationCorresponds to variant rs193302884dbSNPEnsembl.1
Natural variantiVAR_02558868G → R in GSD1B. 1 PublicationCorresponds to variant rs193302885dbSNPEnsembl.1
Natural variantiVAR_02558985L → P in GSD1B. 1 PublicationCorresponds to variant rs193302899dbSNPEnsembl.1
Natural variantiVAR_02559088G → D in GSD1B. 1 PublicationCorresponds to variant rs193302886dbSNPEnsembl.1
Natural variantiVAR_007850118W → R in GSD1B. 4 PublicationsCorresponds to variant rs80356489dbSNPEnsembl.1
Natural variantiVAR_066395148A → V in GSD1B. 1 PublicationCorresponds to variant rs193302879dbSNPEnsembl.1
Natural variantiVAR_003184149G → E in GSD1B. 1 PublicationCorresponds to variant rs193302892dbSNPEnsembl.1
Natural variantiVAR_025592150G → R in GSD1B. 1 PublicationCorresponds to variant rs193302883dbSNPEnsembl.1
Natural variantiVAR_025593153P → L in GSD1B. 1 PublicationCorresponds to variant rs193302890dbSNPEnsembl.1
Natural variantiVAR_025594176C → R in GSD1B. 1 PublicationCorresponds to variant rs193302895dbSNPEnsembl.1
Natural variantiVAR_025595183C → R in GSD1B. 1 PublicationCorresponds to variant rs193302893dbSNPEnsembl.1
Natural variantiVAR_032113191P → L in GSD1B. 1 PublicationCorresponds to variant rs193302888dbSNPEnsembl.1
Natural variantiVAR_025597229L → P in GSD1B. 1 PublicationCorresponds to variant rs193302902dbSNPEnsembl.1
Natural variantiVAR_012356235Missing in GSD1B. 1 Publication1
Natural variantiVAR_066396246W → R in GSD1B. 1 PublicationCorresponds to variant rs193302878dbSNPEnsembl.1
Natural variantiVAR_025598278I → N in GSD1B. 1 PublicationCorresponds to variant rs193302900dbSNPEnsembl.1
Natural variantiVAR_066397300R → C in GSD1B. 1 PublicationCorresponds to variant rs193302880dbSNPEnsembl.1
Natural variantiVAR_025599300R → H in GSD1B. 1 PublicationCorresponds to variant rs193302903dbSNPEnsembl.1
Natural variantiVAR_025600301H → P in GSD1B. 1 PublicationCorresponds to variant rs193302891dbSNPEnsembl.1
Natural variantiVAR_003185339G → C in GSD1B. 1 PublicationCorresponds to variant rs80356490dbSNPEnsembl.1
Natural variantiVAR_025601339G → D in GSD1B. 2 PublicationsCorresponds to variant rs121908980dbSNPEnsembl.1
Natural variantiVAR_025602367A → T in GSD1B. 1 PublicationCorresponds to variant rs80356492dbSNPEnsembl.1
Natural variantiVAR_025603373A → D in GSD1B. 1 PublicationCorresponds to variant rs193302901dbSNPEnsembl.1
Glycogen storage disease 1C (GSD1C)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA metabolic disorder characterized by impairment of terminal steps of glycogenolysis and gluconeogenesis. Patients manifest a wide range of clinical symptoms and biochemical abnormalities, including hypoglycemia, severe hepatomegaly due to excessive accumulation of glycogen, kidney enlargement, growth retardation, lactic acidemia, hyperlipidemia, and hyperuricemia.
See also OMIM:232240
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025591133Q → P in GSD1C. 1 PublicationCorresponds to variant rs193302896dbSNPEnsembl.1
Natural variantiVAR_025604376G → S in GSD1C. 1 PublicationCorresponds to variant rs193302897dbSNPEnsembl.1
Glycogen storage disease 1D (GSD1D)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA metabolic disorder characterized by impairment of terminal steps of glycogenolysis and gluconeogenesis. Patients manifest a wide range of clinical symptoms and biochemical abnormalities, including hypoglycemia, severe hepatomegaly due to excessive accumulation of glycogen, kidney enlargement, growth retardation, lactic acidemia, hyperlipidemia, and hyperuricemia.
See also OMIM:232240

Keywords - Diseasei

Disease mutation, Glycogen storage disease

Organism-specific databases

DisGeNETi2542.
MalaCardsiSLC37A4.
MIMi232220. phenotype.
232240. phenotype.
OpenTargetsiENSG00000281500.
Orphaneti79259. Glycogen storage disease due to glucose-6-phosphatase deficiency type b.
PharmGKBiPA28472.

Chemistry databases

ChEMBLiCHEMBL3217398.

Polymorphism and mutation databases

BioMutaiSLC37A4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001998911 – 429Glucose-6-phosphate exchanger SLC37A4Add BLAST429

Proteomic databases

EPDiO43826.
MaxQBiO43826.
PeptideAtlasiO43826.
PRIDEiO43826.

PTM databases

iPTMnetiO43826.
PhosphoSitePlusiO43826.

Expressioni

Tissue specificityi

Mostly expressed in liver and kidney.

Gene expression databases

BgeeiENSG00000262676.
CleanExiHS_SLC37A4.

Organism-specific databases

HPAiHPA038939.
HPA038940.

Interactioni

Protein-protein interaction databases

BioGridi108817. 2 interactors.
IntActiO43826. 2 interactors.

Structurei

3D structure databases

ProteinModelPortaliO43826.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000274730.
HOVERGENiHBG051682.
InParanoidiO43826.
KOiK08171.
OMAiDISHAGW.
OrthoDBiEOG091G06B9.
PhylomeDBiO43826.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR021159. Sugar-P_transporter_CS.
IPR000849. Sugar_P_transporter.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PIRSFiPIRSF002808. Hexose_phosphate_transp. 1 hit.
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS00942. GLPT. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O43826-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAQGYGYYR TVIFSAMFGG YSLYYFNRKT FSFVMPSLVE EIPLDKDDLG
60 70 80 90 100
FITSSQSAAY AISKFVSGVL SDQMSARWLF SSGLLLVGLV NIFFAWSSTV
110 120 130 140 150
PVFAALWFLN GLAQGLGWPP CGKVLRKWFE PSQFGTWWAI LSTSMNLAGG
160 170 180 190 200
LGPILATILA QSYSWRSTLA LSGALCVVVS FLCLLLIHNE PADVGLRNLD
210 220 230 240 250
PMPSEGKKGS LKEESTLQEL LLSPYLWVLS TGYLVVFGVK TCCTDWGQFF
260 270 280 290 300
LIQEKGQSAL VGSSYMSALE VGGLVGSIAA GYLSDRAMAK AGLSNYGNPR
310 320 330 340 350
HGLLLFMMAG MTVSMYLFRV TVTSDSPKLW ILVLGAVFGF SSYGPIALFG
360 370 380 390 400
VIANESAPPN LCGTSHAIVG LMANVGGFLA GLPFSTIAKH YSWSTAFWVA
410 420
EVICAASTAA FFLLRNIRTK MGRVSKKAE
Length:429
Mass (Da):46,360
Last modified:June 1, 1998 - v1
Checksum:iC0399332FE72694B
GO
Isoform 2 (identifier: O43826-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     328-328: K → KDVAFWTLALHPLAELTGFTEHE

Show »
Length:451
Mass (Da):48,840
Checksum:iA5696ADCDC67D90A
GO

Sequence cautioni

The sequence AAF16691 differs from that shown. Reason: Frameshift at position 128.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti109L → F in AAD19898 (PubMed:10026167).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02558120G → D in GSD1B. 1 PublicationCorresponds to variant rs193302881dbSNPEnsembl.1
Natural variantiVAR_02558224Y → H in GSD1B. 1 PublicationCorresponds to variant rs193302887dbSNPEnsembl.1
Natural variantiVAR_02558327N → K in GSD1B. 1 PublicationCorresponds to variant rs193302889dbSNPEnsembl.1
Natural variantiVAR_02558428R → C in GSD1B. 1 PublicationCorresponds to variant rs193302882dbSNPEnsembl.1
Natural variantiVAR_01684028R → H in GSD1B; inactive glucose-6-phosphate transport. 2 PublicationsCorresponds to variant rs121908978dbSNPEnsembl.1
Natural variantiVAR_06639450G → E in GSD1B. 1 PublicationCorresponds to variant rs193302877dbSNPEnsembl.1
Natural variantiVAR_02558550G → R in GSD1B. 1 PublicationCorresponds to variant rs193302894dbSNPEnsembl.1
Natural variantiVAR_02558654S → R in GSD1B. 1 PublicationCorresponds to variant rs193302898dbSNPEnsembl.1
Natural variantiVAR_02558755S → R in GSD1B. 1 PublicationCorresponds to variant rs193302884dbSNPEnsembl.1
Natural variantiVAR_02558868G → R in GSD1B. 1 PublicationCorresponds to variant rs193302885dbSNPEnsembl.1
Natural variantiVAR_02558985L → P in GSD1B. 1 PublicationCorresponds to variant rs193302899dbSNPEnsembl.1
Natural variantiVAR_02559088G → D in GSD1B. 1 PublicationCorresponds to variant rs193302886dbSNPEnsembl.1
Natural variantiVAR_007850118W → R in GSD1B. 4 PublicationsCorresponds to variant rs80356489dbSNPEnsembl.1
Natural variantiVAR_025591133Q → P in GSD1C. 1 PublicationCorresponds to variant rs193302896dbSNPEnsembl.1
Natural variantiVAR_066395148A → V in GSD1B. 1 PublicationCorresponds to variant rs193302879dbSNPEnsembl.1
Natural variantiVAR_003184149G → E in GSD1B. 1 PublicationCorresponds to variant rs193302892dbSNPEnsembl.1
Natural variantiVAR_025592150G → R in GSD1B. 1 PublicationCorresponds to variant rs193302883dbSNPEnsembl.1
Natural variantiVAR_025593153P → L in GSD1B. 1 PublicationCorresponds to variant rs193302890dbSNPEnsembl.1
Natural variantiVAR_025594176C → R in GSD1B. 1 PublicationCorresponds to variant rs193302895dbSNPEnsembl.1
Natural variantiVAR_025595183C → R in GSD1B. 1 PublicationCorresponds to variant rs193302893dbSNPEnsembl.1
Natural variantiVAR_032113191P → L in GSD1B. 1 PublicationCorresponds to variant rs193302888dbSNPEnsembl.1
Natural variantiVAR_025596198N → I.1 PublicationCorresponds to variant rs34203644dbSNPEnsembl.1
Natural variantiVAR_025597229L → P in GSD1B. 1 PublicationCorresponds to variant rs193302902dbSNPEnsembl.1
Natural variantiVAR_012356235Missing in GSD1B. 1 Publication1
Natural variantiVAR_066396246W → R in GSD1B. 1 PublicationCorresponds to variant rs193302878dbSNPEnsembl.1
Natural variantiVAR_025598278I → N in GSD1B. 1 PublicationCorresponds to variant rs193302900dbSNPEnsembl.1
Natural variantiVAR_066397300R → C in GSD1B. 1 PublicationCorresponds to variant rs193302880dbSNPEnsembl.1
Natural variantiVAR_025599300R → H in GSD1B. 1 PublicationCorresponds to variant rs193302903dbSNPEnsembl.1
Natural variantiVAR_025600301H → P in GSD1B. 1 PublicationCorresponds to variant rs193302891dbSNPEnsembl.1
Natural variantiVAR_003185339G → C in GSD1B. 1 PublicationCorresponds to variant rs80356490dbSNPEnsembl.1
Natural variantiVAR_025601339G → D in GSD1B. 2 PublicationsCorresponds to variant rs121908980dbSNPEnsembl.1
Natural variantiVAR_025602367A → T in GSD1B. 1 PublicationCorresponds to variant rs80356492dbSNPEnsembl.1
Natural variantiVAR_025603373A → D in GSD1B. 1 PublicationCorresponds to variant rs193302901dbSNPEnsembl.1
Natural variantiVAR_025604376G → S in GSD1C. 1 PublicationCorresponds to variant rs193302897dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006171328K → KDVAFWTLALHPLAELTGFT EHE in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15409 mRNA. Translation: CAA75608.1.
AF078163 Genomic DNA. Translation: AAC72916.1.
AF097831 Genomic DNA. Translation: AAD19898.1.
AF111852 mRNA. Translation: AAF16691.1. Frameshift.
AF110819 mRNA. Translation: AAF37735.1.
AF110820 mRNA. Translation: AAF37736.1.
Y17864 Genomic DNA. Translation: CAA76898.1.
AF116864, AF116862, AF116863 Genomic DNA. Translation: AAD13111.1.
AY423732 mRNA. Translation: AAS00495.1.
CH471065 Genomic DNA. Translation: EAW67432.1.
BC002400 mRNA. Translation: AAH02400.1.
BC003589 mRNA. Translation: AAH03589.1.
BC014663 mRNA. Translation: AAH14663.1.
BC015650 mRNA. Translation: AAH15650.1.
BC064563 mRNA. Translation: AAH64563.1.
RefSeqiNP_001157749.1. NM_001164277.1. [O43826-1]
NP_001157750.1. NM_001164278.1. [O43826-2]
NP_001157751.1. NM_001164279.1.
NP_001157752.1. NM_001164280.1. [O43826-1]
NP_001458.1. NM_001467.5. [O43826-1]
UniGeneiHs.719203.

Genome annotation databases

EnsembliENST00000631372; ENSP00000486168; ENSG00000281500. [O43826-1]
GeneIDi2542.
KEGGihsa:2542.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Mendelian genes solute carrier family 37 (glucose-6-phosphate transporter), member 4 (SLC37A4)

Leiden Open Variation Database (LOVD)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15409 mRNA. Translation: CAA75608.1.
AF078163 Genomic DNA. Translation: AAC72916.1.
AF097831 Genomic DNA. Translation: AAD19898.1.
AF111852 mRNA. Translation: AAF16691.1. Frameshift.
AF110819 mRNA. Translation: AAF37735.1.
AF110820 mRNA. Translation: AAF37736.1.
Y17864 Genomic DNA. Translation: CAA76898.1.
AF116864, AF116862, AF116863 Genomic DNA. Translation: AAD13111.1.
AY423732 mRNA. Translation: AAS00495.1.
CH471065 Genomic DNA. Translation: EAW67432.1.
BC002400 mRNA. Translation: AAH02400.1.
BC003589 mRNA. Translation: AAH03589.1.
BC014663 mRNA. Translation: AAH14663.1.
BC015650 mRNA. Translation: AAH15650.1.
BC064563 mRNA. Translation: AAH64563.1.
RefSeqiNP_001157749.1. NM_001164277.1. [O43826-1]
NP_001157750.1. NM_001164278.1. [O43826-2]
NP_001157751.1. NM_001164279.1.
NP_001157752.1. NM_001164280.1. [O43826-1]
NP_001458.1. NM_001467.5. [O43826-1]
UniGeneiHs.719203.

3D structure databases

ProteinModelPortaliO43826.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108817. 2 interactors.
IntActiO43826. 2 interactors.

Chemistry databases

ChEMBLiCHEMBL3217398.

Protein family/group databases

TCDBi2.A.1.4.5. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiO43826.
PhosphoSitePlusiO43826.

Polymorphism and mutation databases

BioMutaiSLC37A4.

Proteomic databases

EPDiO43826.
MaxQBiO43826.
PeptideAtlasiO43826.
PRIDEiO43826.

Protocols and materials databases

DNASUi2542.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000631372; ENSP00000486168; ENSG00000281500. [O43826-1]
GeneIDi2542.
KEGGihsa:2542.

Organism-specific databases

CTDi2542.
DisGeNETi2542.
GeneCardsiSLC37A4.
GeneReviewsiSLC37A4.
HGNCiHGNC:4061. SLC37A4.
HPAiHPA038939.
HPA038940.
MalaCardsiSLC37A4.
MIMi232220. phenotype.
232240. phenotype.
602671. gene.
neXtProtiNX_O43826.
OpenTargetsiENSG00000281500.
Orphaneti79259. Glycogen storage disease due to glucose-6-phosphatase deficiency type b.
PharmGKBiPA28472.
GenAtlasiSearch...

Phylogenomic databases

HOGENOMiHOG000274730.
HOVERGENiHBG051682.
InParanoidiO43826.
KOiK08171.
OMAiDISHAGW.
OrthoDBiEOG091G06B9.
PhylomeDBiO43826.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137700-MONOMER.
ReactomeiR-HSA-70153. Glucose transport.

Miscellaneous databases

GeneWikiiSLC37A4.
GenomeRNAii2542.
PROiO43826.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000262676.
CleanExiHS_SLC37A4.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR021159. Sugar-P_transporter_CS.
IPR000849. Sugar_P_transporter.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PIRSFiPIRSF002808. Hexose_phosphate_transp. 1 hit.
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS00942. GLPT. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG6PT1_HUMAN
AccessioniPrimary (citable) accession number: O43826
Secondary accession number(s): O96016
, Q5J7V4, Q9UI19, Q9UNS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 168 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.