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O43824

- GTPB6_HUMAN

UniProt

O43824 - GTPB6_HUMAN

Protein

Putative GTP-binding protein 6

Gene

GTPBP6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 3 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    Cofactori

    Magnesium.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi308 – 3081MagnesiumPROSITE-ProRule annotation
    Metal bindingi329 – 3291MagnesiumPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi301 – 3088GTPPROSITE-ProRule annotation
    Nucleotide bindingi327 – 3315GTPPROSITE-ProRule annotation
    Nucleotide bindingi349 – 3524GTPPROSITE-ProRule annotation
    Nucleotide bindingi418 – 4214GTPPROSITE-ProRule annotation
    Nucleotide bindingi437 – 4393GTPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. GTP binding Source: ProtInc
    2. metal ion binding Source: UniProtKB-KW

    Keywords - Ligandi

    GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative GTP-binding protein 6
    Alternative name(s):
    Pseudoautosomal GTP-binding protein-like
    Gene namesi
    Name:GTPBP6
    Synonyms:PGPL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:30189. GTPBP6.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 516516Putative GTP-binding protein 6PRO_0000304798Add
    BLAST

    Proteomic databases

    MaxQBiO43824.
    PaxDbiO43824.
    PRIDEiO43824.

    PTM databases

    PhosphoSiteiO43824.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed.1 Publication

    Gene expression databases

    ArrayExpressiO43824.
    BgeeiO43824.
    CleanExiHS_GTPBP6.
    GenevestigatoriO43824.

    Organism-specific databases

    HPAiHPA035467.

    Interactioni

    Protein-protein interaction databases

    BioGridi113858. 1 interaction.
    STRINGi9606.ENSP00000405410.

    Structurei

    3D structure databases

    ProteinModelPortaliO43824.
    SMRiO43824. Positions 175-451.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini295 – 459165Hflx-type GPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.PROSITE-ProRule annotation
    Contains 1 Hflx-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG2262.
    HOGENOMiHOG000260368.
    HOVERGENiHBG052970.
    InParanoidiO43824.
    PhylomeDBiO43824.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR006073. GTP_binding_domain.
    IPR016496. GTPase_HflX.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR10229. PTHR10229. 1 hit.
    PfamiPF01926. MMR_HSR1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006809. GTP-binding_hflX_prd. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR03156. GTP_HflX. 1 hit.
    PROSITEiPS51705. G_HFLX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O43824-1 [UniParc]FASTAAdd to Basket

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    MWALRAAVRP GLRLSRVGRG RSAPRAAAPS CPARALAAVG RRSPGNLEGP    50
    WGGGRGLRAD GGRSRTGDDE EEPEDADENA EEELLRGEPL LPAGTQRVCL 100
    VHPDVKWGPG KSQMTRAEWQ VAEATALVHT LDGWSVVQTM VVSTKTPDRK 150
    LIFGKGNFEH LTEKIRGSPD VTCVFLNVER MAAPTKKELE AAWGVEVFDR 200
    FTVVLHIFRC NARTKEARLQ VALAEMPLHR SNLKRDVAHL YRGVGSRYIM 250
    GSGESFMQLQ QRLLREKEAK IRKALDRLRK KRHLLRRQRT RREFPVISVV 300
    GYTNCGKTTL IKALTGDAAI QPRDQLFATL DVTAHAGTLP SRMTVLYVDT 350
    IGFLSQLPHG LIESFSATLE DVAHSDLILH VRDVSHPEAE LQKCSVLSTL 400
    RGLQLPAPLL DSMVEVHNKV DLVPGYSPTE PNVVPVSALR GHGLQELKAE 450
    LDAAVLKATG RQILTLRVRL AGAQLSWLYK EATVQEVDVI PEDGAADVRV 500
    IISNSAYGKF RKLFPG 516
    Length:516
    Mass (Da):56,883
    Last modified:October 5, 2010 - v3
    Checksum:iAA81CEA655F579C7
    GO

    Sequence cautioni

    The sequence CAA74749.2 differs from that shown. Reason: Has an upstream in-frame stop codon because of a region of poor sequence quality.
    The sequence AAH14636.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAP36024.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAD97132.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti171 – 1711V → I in BAD97132. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC126759 Genomic DNA. No translation available.
    BX000483 Genomic DNA. Translation: CAI41972.1.
    AK223412 mRNA. Translation: BAD97132.1. Different initiation.
    BC014636 mRNA. Translation: AAH14636.1. Different initiation.
    BT007360 mRNA. Translation: AAP36024.1. Different initiation.
    Y14391 mRNA. Translation: CAA74749.2. Sequence problems.
    RefSeqiNP_036359.3. NM_012227.3.
    UniGeneiHs.437145.

    Genome annotation databases

    GeneIDi8225.
    KEGGihsa:8225.
    UCSCiuc004cpe.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC126759 Genomic DNA. No translation available.
    BX000483 Genomic DNA. Translation: CAI41972.1 .
    AK223412 mRNA. Translation: BAD97132.1 . Different initiation.
    BC014636 mRNA. Translation: AAH14636.1 . Different initiation.
    BT007360 mRNA. Translation: AAP36024.1 . Different initiation.
    Y14391 mRNA. Translation: CAA74749.2 . Sequence problems.
    RefSeqi NP_036359.3. NM_012227.3.
    UniGenei Hs.437145.

    3D structure databases

    ProteinModelPortali O43824.
    SMRi O43824. Positions 175-451.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113858. 1 interaction.
    STRINGi 9606.ENSP00000405410.

    PTM databases

    PhosphoSitei O43824.

    Proteomic databases

    MaxQBi O43824.
    PaxDbi O43824.
    PRIDEi O43824.

    Protocols and materials databases

    DNASUi 8225.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8225.
    KEGGi hsa:8225.
    UCSCi uc004cpe.1. human.

    Organism-specific databases

    GeneCardsi GC0XM000161.
    HGNCi HGNC:30189. GTPBP6.
    HPAi HPA035467.
    MIMi 300124. gene.
    neXtProti NX_O43824.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2262.
    HOGENOMi HOG000260368.
    HOVERGENi HBG052970.
    InParanoidi O43824.
    PhylomeDBi O43824.

    Miscellaneous databases

    GeneWikii GTPBP6.
    GenomeRNAii 8225.
    NextBioi 30958.
    PROi O43824.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O43824.
    Bgeei O43824.
    CleanExi HS_GTPBP6.
    Genevestigatori O43824.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR006073. GTP_binding_domain.
    IPR016496. GTPase_HflX.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR10229. PTHR10229. 1 hit.
    Pfami PF01926. MMR_HSR1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006809. GTP-binding_hflX_prd. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR03156. GTP_HflX. 1 hit.
    PROSITEi PS51705. G_HFLX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-516.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 100-516.
      Tissue: Muscle.
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 114-516.
    5. "A novel pseudoautosomal gene encoding a putative GTP-binding protein resides in the vicinity of the Xp/Yp telomere."
      Gianfrancesco F., Esposito T., Montanini L., Ciccodicola A., Mumm S., Mazzarella R., Rao E., Giglio S., Rappold G., Forabosco A.
      Hum. Mol. Genet. 7:407-414(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiGTPB6_HUMAN
    AccessioniPrimary (citable) accession number: O43824
    Secondary accession number(s): Q53F77, Q5HYX8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 104 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3