O43824 (GTPB6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative GTP-binding protein 6

Alternative name(s):
Pseudoautosomal GTP-binding protein-like

Gene names

Name:	GTPBP6
Synonyms:	PGPL

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	516 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Tissue specificity	Ubiquitously expressed. Ref.5
Miscellaneous	The gene encoding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.
Sequence similarities	Belongs to the HflX GTPase family. Contains 1 G (guanine nucleotide-binding) domain.
Sequence caution	The sequence AAH14636.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAP36024.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAD97132.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAA74749.2 differs from that shown. Reason: Has an upstream in-frame stop codon because of a region of poor sequence quality.

Ontologies

Keywords
Ligand	GTP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	GTP binding Traceable author statement Ref.5. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 516	516	Putative GTP-binding protein 6		PRO_0000304798
Regions
	Domain	306 – 391	86	G
	Nucleotide binding	301 – 309	9	GTP By similarity
Experimental info
	Sequence conflict	171	1	V → I in BAD97132. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	O43824 [UniParc]. Last modified October 5, 2010. Version 3. Checksum: AA81CEA655F579C7	FASTA	516	56,883
	10 20 30 40 50 60 MWALRAAVRP GLRLSRVGRG RSAPRAAAPS CPARALAAVG RRSPGNLEGP WGGGRGLRAD 70 80 90 100 110 120 GGRSRTGDDE EEPEDADENA EEELLRGEPL LPAGTQRVCL VHPDVKWGPG KSQMTRAEWQ 130 140 150 160 170 180 VAEATALVHT LDGWSVVQTM VVSTKTPDRK LIFGKGNFEH LTEKIRGSPD VTCVFLNVER 190 200 210 220 230 240 MAAPTKKELE AAWGVEVFDR FTVVLHIFRC NARTKEARLQ VALAEMPLHR SNLKRDVAHL 250 260 270 280 290 300 YRGVGSRYIM GSGESFMQLQ QRLLREKEAK IRKALDRLRK KRHLLRRQRT RREFPVISVV 310 320 330 340 350 360 GYTNCGKTTL IKALTGDAAI QPRDQLFATL DVTAHAGTLP SRMTVLYVDT IGFLSQLPHG 370 380 390 400 410 420 LIESFSATLE DVAHSDLILH VRDVSHPEAE LQKCSVLSTL RGLQLPAPLL DSMVEVHNKV 430 440 450 460 470 480 DLVPGYSPTE PNVVPVSALR GHGLQELKAE LDAAVLKATG RQILTLRVRL AGAQLSWLYK 490 500 510 EATVQEVDVI PEDGAADVRV IISNSAYGKF RKLFPG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-516.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 100-516. Tissue: Muscle.
[4]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 114-516.
[5]	"A novel pseudoautosomal gene encoding a putative GTP-binding protein resides in the vicinity of the Xp/Yp telomere." Gianfrancesco F., Esposito T., Montanini L., Ciccodicola A., Mumm S., Mazzarella R., Rao E., Giglio S., Rappold G., Forabosco A. Hum. Mol. Genet. 7:407-414(1998) [PubMed] [Europe PMC] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC126759 Genomic DNA. No translation available. BX000483 Genomic DNA. Translation: CAI41972.1. AK223412 mRNA. Translation: BAD97132.1. Different initiation. BC014636 mRNA. Translation: AAH14636.1. Different initiation. BT007360 mRNA. Translation: AAP36024.1. Different initiation. Y14391 mRNA. Translation: CAA74749.2. Sequence problems.
IPI	IPI00016763.
RefSeq	NP_036359.2. NM_012227.2.
UniGene	Hs.437145.
3D structure databases
ProteinModelPortal	O43824.
SMR	O43824. Positions 175-451.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000405410.
PTM databases
PhosphoSite	O43824.
Proteomic databases
PaxDb	O43824.
PRIDE	O43824.
Protocols and materials databases
DNASU	8225.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8225.
KEGG	hsa:8225.
UCSC	uc004cpe.1. human.
Organism-specific databases
CTD	8225.
GeneCards	GC0XM000161.
HGNC	HGNC:30189. GTPBP6.
HPA	HPA035467.
MIM	300124. gene.
neXtProt	NX_O43824.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2262.
HOGENOM	HOG000260368.
HOVERGEN	HBG052970.
InParanoid	O43824.
Gene expression databases
ArrayExpress	O43824.
Bgee	O43824.
CleanEx	HS_GTPBP6.
Genevestigator	O43824.
Family and domain databases
InterPro	IPR006073. GTP_binding_domain. IPR016496. GTPase_HflX. [Graphical view]
PANTHER	PTHR10229. PTHR10229. 1 hit.
Pfam	PF01926. MMR_HSR1. 1 hit. [Graphical view]
PIRSF	PIRSF006809. GTP-binding_hflX_prd. 1 hit.
TIGRFAMs	TIGR03156. GTP_HflX. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	8225.
NextBio	30958.
SOURCE	Search...

Entry information

Entry name

GTPB6_HUMAN

Accession

Primary (citable) accession number: O43824
Secondary accession number(s): Q53F77, Q5HYX8

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	October 5, 2010
Last modified:	May 1, 2013
This is version 93 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.