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O43824

- GTPB6_HUMAN

UniProt

O43824 - GTPB6_HUMAN

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Protein
Putative GTP-binding protein 6
Gene
GTPBP6, PGPL
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cofactori

Magnesium By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi308 – 3081Magnesium By similarity
Metal bindingi329 – 3291Magnesium By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi301 – 3088GTP By similarity
Nucleotide bindingi327 – 3315GTP By similarity
Nucleotide bindingi349 – 3524GTP By similarity
Nucleotide bindingi418 – 4214GTP By similarity
Nucleotide bindingi437 – 4393GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: ProtInc
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative GTP-binding protein 6
Alternative name(s):
Pseudoautosomal GTP-binding protein-like
Gene namesi
Name:GTPBP6
Synonyms:PGPL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:30189. GTPBP6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 516516Putative GTP-binding protein 6
PRO_0000304798Add
BLAST

Proteomic databases

MaxQBiO43824.
PaxDbiO43824.
PRIDEiO43824.

PTM databases

PhosphoSiteiO43824.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

ArrayExpressiO43824.
BgeeiO43824.
CleanExiHS_GTPBP6.
GenevestigatoriO43824.

Organism-specific databases

HPAiHPA035467.

Interactioni

Protein-protein interaction databases

BioGridi113858. 1 interaction.
STRINGi9606.ENSP00000405410.

Structurei

3D structure databases

ProteinModelPortaliO43824.
SMRiO43824. Positions 175-451.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini295 – 459165Hflx-type G
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2262.
HOGENOMiHOG000260368.
HOVERGENiHBG052970.
InParanoidiO43824.
PhylomeDBiO43824.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR006073. GTP_binding_domain.
IPR016496. GTPase_HflX.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10229. PTHR10229. 1 hit.
PfamiPF01926. MMR_HSR1. 1 hit.
[Graphical view]
PIRSFiPIRSF006809. GTP-binding_hflX_prd. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03156. GTP_HflX. 1 hit.
PROSITEiPS51705. G_HFLX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43824-1 [UniParc]FASTAAdd to Basket

« Hide

MWALRAAVRP GLRLSRVGRG RSAPRAAAPS CPARALAAVG RRSPGNLEGP    50
WGGGRGLRAD GGRSRTGDDE EEPEDADENA EEELLRGEPL LPAGTQRVCL 100
VHPDVKWGPG KSQMTRAEWQ VAEATALVHT LDGWSVVQTM VVSTKTPDRK 150
LIFGKGNFEH LTEKIRGSPD VTCVFLNVER MAAPTKKELE AAWGVEVFDR 200
FTVVLHIFRC NARTKEARLQ VALAEMPLHR SNLKRDVAHL YRGVGSRYIM 250
GSGESFMQLQ QRLLREKEAK IRKALDRLRK KRHLLRRQRT RREFPVISVV 300
GYTNCGKTTL IKALTGDAAI QPRDQLFATL DVTAHAGTLP SRMTVLYVDT 350
IGFLSQLPHG LIESFSATLE DVAHSDLILH VRDVSHPEAE LQKCSVLSTL 400
RGLQLPAPLL DSMVEVHNKV DLVPGYSPTE PNVVPVSALR GHGLQELKAE 450
LDAAVLKATG RQILTLRVRL AGAQLSWLYK EATVQEVDVI PEDGAADVRV 500
IISNSAYGKF RKLFPG 516
Length:516
Mass (Da):56,883
Last modified:October 5, 2010 - v3
Checksum:iAA81CEA655F579C7
GO

Sequence cautioni

The sequence CAA74749.2 differs from that shown. Reason: Has an upstream in-frame stop codon because of a region of poor sequence quality.
The sequence AAH14636.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAP36024.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAD97132.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti171 – 1711V → I in BAD97132. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC126759 Genomic DNA. No translation available.
BX000483 Genomic DNA. Translation: CAI41972.1.
AK223412 mRNA. Translation: BAD97132.1. Different initiation.
BC014636 mRNA. Translation: AAH14636.1. Different initiation.
BT007360 mRNA. Translation: AAP36024.1. Different initiation.
Y14391 mRNA. Translation: CAA74749.2. Sequence problems.
RefSeqiNP_036359.3. NM_012227.3.
UniGeneiHs.437145.

Genome annotation databases

GeneIDi8225.
KEGGihsa:8225.
UCSCiuc004cpe.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC126759 Genomic DNA. No translation available.
BX000483 Genomic DNA. Translation: CAI41972.1 .
AK223412 mRNA. Translation: BAD97132.1 . Different initiation.
BC014636 mRNA. Translation: AAH14636.1 . Different initiation.
BT007360 mRNA. Translation: AAP36024.1 . Different initiation.
Y14391 mRNA. Translation: CAA74749.2 . Sequence problems.
RefSeqi NP_036359.3. NM_012227.3.
UniGenei Hs.437145.

3D structure databases

ProteinModelPortali O43824.
SMRi O43824. Positions 175-451.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113858. 1 interaction.
STRINGi 9606.ENSP00000405410.

PTM databases

PhosphoSitei O43824.

Proteomic databases

MaxQBi O43824.
PaxDbi O43824.
PRIDEi O43824.

Protocols and materials databases

DNASUi 8225.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8225.
KEGGi hsa:8225.
UCSCi uc004cpe.1. human.

Organism-specific databases

CTDi 8225.
GeneCardsi GC0XM000161.
HGNCi HGNC:30189. GTPBP6.
HPAi HPA035467.
MIMi 300124. gene.
neXtProti NX_O43824.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2262.
HOGENOMi HOG000260368.
HOVERGENi HBG052970.
InParanoidi O43824.
PhylomeDBi O43824.

Miscellaneous databases

GeneWikii GTPBP6.
GenomeRNAii 8225.
NextBioi 30958.
PROi O43824.
SOURCEi Search...

Gene expression databases

ArrayExpressi O43824.
Bgeei O43824.
CleanExi HS_GTPBP6.
Genevestigatori O43824.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR006073. GTP_binding_domain.
IPR016496. GTPase_HflX.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR10229. PTHR10229. 1 hit.
Pfami PF01926. MMR_HSR1. 1 hit.
[Graphical view ]
PIRSFi PIRSF006809. GTP-binding_hflX_prd. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR03156. GTP_HflX. 1 hit.
PROSITEi PS51705. G_HFLX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-516.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 100-516.
    Tissue: Muscle.
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 114-516.
  5. "A novel pseudoautosomal gene encoding a putative GTP-binding protein resides in the vicinity of the Xp/Yp telomere."
    Gianfrancesco F., Esposito T., Montanini L., Ciccodicola A., Mumm S., Mazzarella R., Rao E., Giglio S., Rappold G., Forabosco A.
    Hum. Mol. Genet. 7:407-414(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.

Entry informationi

Entry nameiGTPB6_HUMAN
AccessioniPrimary (citable) accession number: O43824
Secondary accession number(s): Q53F77, Q5HYX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 5, 2010
Last modified: July 9, 2014
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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