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O43820

- HYAL3_HUMAN

UniProt

O43820 - HYAL3_HUMAN

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Protein

Hyaluronidase-3

Gene

HYAL3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei129 – 1291Proton donorBy similarity

GO - Molecular functioni

  1. hyaluronoglucuronidase activity Source: UniProtKB
  2. hyalurononglucosaminidase activity Source: UniProtKB

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. cartilage development Source: UniProtKB
  3. cellular response to interleukin-1 Source: UniProtKB
  4. cellular response to tumor necrosis factor Source: UniProtKB
  5. cellular response to UV-B Source: UniProtKB
  6. hyaluronan catabolic process Source: UniProtKB
  7. inflammatory response Source: UniProtKB
  8. response to antibiotic Source: UniProtKB
  9. response to virus Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000114366-MONOMER.
BRENDAi3.2.1.35. 2681.
ReactomeiREACT_120888. CS/DS degradation.
REACT_120996. Hyaluronan uptake and degradation.

Protein family/group databases

CAZyiGH56. Glycoside Hydrolase Family 56.

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronidase-3 (EC:3.2.1.35)
Short name:
Hyal-3
Alternative name(s):
Hyaluronoglucosaminidase-3
Lung carcinoma protein 3
Short name:
LuCa-3
Gene namesi
Name:HYAL3
Synonyms:LUCA3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:5322. HYAL3.

Subcellular locationi

Secreted By similarity. Lysosome By similarity

GO - Cellular componenti

  1. cytoplasmic vesicle Source: UniProtKB
  2. extracellular region Source: UniProtKB-KW
  3. lysosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29573.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 417397Hyaluronidase-3PRO_0000248200Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi42 ↔ 331By similarity
Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi205 ↔ 220By similarity
Glycosylationi215 – 2151N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi356 ↔ 367By similarity
Disulfide bondi361 ↔ 395By similarity
Disulfide bondi397 ↔ 406By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO43820.
PRIDEiO43820.

Expressioni

Tissue specificityi

Bone marrow, testis and kidney. Isoform 4 is detected in all bladder tumor and prostate tumor cells.2 Publications

Gene expression databases

BgeeiO43820.
CleanExiHS_HYAL3.
ExpressionAtlasiO43820. baseline.
GenevestigatoriO43820.

Organism-specific databases

HPAiHPA049402.

Interactioni

Protein-protein interaction databases

BioGridi113967. 1 interaction.
IntActiO43820. 1 interaction.
STRINGi9606.ENSP00000337425.

Structurei

3D structure databases

ProteinModelPortaliO43820.
SMRiO43820. Positions 24-407.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini352 – 40756EGF-likeAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 56 family.Curated
Contains 1 EGF-like domain.Curated

Keywords - Domaini

EGF-like domain, Signal

Phylogenomic databases

eggNOGiNOG69101.
GeneTreeiENSGT00550000074476.
HOVERGENiHBG052053.
InParanoidiO43820.
KOiK01197.
OMAiWEEWCPL.
PhylomeDBiO43820.
TreeFamiTF321598.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000742. EG-like_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
IPR027260. Hyaluronidase-3.
[Graphical view]
PANTHERiPTHR11769. PTHR11769. 1 hit.
PfamiPF01630. Glyco_hydro_56. 1 hit.
[Graphical view]
PIRSFiPIRSF038193. Hyaluronidase. 1 hit.
PIRSF500776. Hyaluronidase_3. 1 hit.
PRINTSiPR00846. GLHYDRLASE56.
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O43820-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTTQLGPALV LGVALCLGCG QPLPQVPERP FSVLWNVPSA HCEARFGVHL
60 70 80 90 100
PLNALGIIAN RGQHFHGQNM TIFYKNQLGL YPYFGPRGTA HNGGIPQALP
110 120 130 140 150
LDRHLALAAY QIHHSLRPGF AGPAVLDWEE WCPLWAGNWG RRRAYQAASW
160 170 180 190 200
AWAQQVFPDL DPQEQLYKAY TGFEQAARAL MEDTLRVAQA LRPHGLWGFY
210 220 230 240 250
HYPACGNGWH SMASNYTGRC HAATLARNTQ LHWLWAASSA LFPSIYLPPR
260 270 280 290 300
LPPAHHQAFV RHRLEEAFRV ALVGHRHPLP VLAYVRLTHR RSGRFLSQDD
310 320 330 340 350
LVQSIGVSAA LGAAGVVLWG DLSLSSSEEE CWHLHDYLVD TLGPYVINVT
360 370 380 390 400
RAAMACSHQR CHGHGRCARR DPGQMEAFLH LWPDGSLGDW KSFSCHCYWG
410
WAGPTCQEPR PGPKEAV
Length:417
Mass (Da):46,501
Last modified:June 1, 1998 - v1
Checksum:iA6E7DE5369EF2BB8
GO
Isoform 2 (identifier: O43820-2) [UniParc]FASTAAdd to Basket

Also known as: HYAL3v1

The sequence of this isoform differs from the canonical sequence as follows:
     299-328: Missing.

Note: Enzymatically inactive.

Show »
Length:387
Mass (Da):43,602
Checksum:i32FE18A2329307A6
GO
Isoform 3 (identifier: O43820-3) [UniParc]FASTAAdd to Basket

Also known as: HYAL3v2

The sequence of this isoform differs from the canonical sequence as follows:
     1-249: Missing.
     250-250: R → M

Note: Enzymatically inactive.

Show »
Length:168
Mass (Da):18,764
Checksum:iC29CE942F2F784F8
GO
Isoform 4 (identifier: O43820-4) [UniParc]FASTAAdd to Basket

Also known as: HYAL3v3

The sequence of this isoform differs from the canonical sequence as follows:
     1-249: Missing.
     250-250: R → M
     299-328: Missing.

Note: Enzymatically inactive.

Show »
Length:138
Mass (Da):15,865
Checksum:i8E94BC56A7606001
GO

Sequence cautioni

The sequence AAC70915.1 differs from that shown. Reason: Frameshift at position 410.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti54 – 541A → S in AAH05896. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti113 – 1131H → Y.1 Publication
Corresponds to variant rs13100173 [ dbSNP | Ensembl ].
VAR_027263

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 249249Missing in isoform 3 and isoform 4. 1 PublicationVSP_020192Add
BLAST
Alternative sequencei250 – 2501R → M in isoform 3 and isoform 4. 1 PublicationVSP_020193
Alternative sequencei299 – 32830Missing in isoform 2 and isoform 4. 1 PublicationVSP_020194Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF036035 mRNA. Translation: AAD04257.1.
AF502909 mRNA. Translation: AAM60775.1.
AF502910 mRNA. Translation: AAM60776.1.
AF502911 mRNA. Translation: AAM60777.1.
AF502912 mRNA. Translation: AAM60778.1.
AF040710 mRNA. Translation: AAC70915.1. Frameshift.
U73167 Genomic DNA. Translation: AAC02729.1.
BC005896 mRNA. Translation: AAH05896.1.
BC012892 mRNA. Translation: AAH12892.1.
CCDSiCCDS2815.1. [O43820-1]
CCDS56257.1. [O43820-2]
CCDS56259.1. [O43820-4]
CCDS56260.1. [O43820-3]
RefSeqiNP_001186958.1. NM_001200029.1. [O43820-1]
NP_001186959.1. NM_001200030.1. [O43820-2]
NP_001186960.1. NM_001200031.1. [O43820-3]
NP_001186961.1. NM_001200032.1. [O43820-4]
NP_003540.2. NM_003549.3. [O43820-1]
UniGeneiHs.129910.
Hs.729310.

Genome annotation databases

EnsembliENST00000336307; ENSP00000337425; ENSG00000186792. [O43820-1]
ENST00000359051; ENSP00000351946; ENSG00000186792. [O43820-2]
ENST00000415204; ENSP00000401092; ENSG00000186792. [O43820-3]
ENST00000450982; ENSP00000391922; ENSG00000186792. [O43820-2]
ENST00000513170; ENSP00000424633; ENSG00000186792. [O43820-4]
ENST00000621157; ENSP00000479935; ENSG00000186792. [O43820-1]
GeneIDi8372.
KEGGihsa:8372.
UCSCiuc003czd.2. human. [O43820-1]
uc003cze.2. human. [O43820-3]
uc003czf.2. human. [O43820-4]
uc003czg.2. human. [O43820-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF036035 mRNA. Translation: AAD04257.1 .
AF502909 mRNA. Translation: AAM60775.1 .
AF502910 mRNA. Translation: AAM60776.1 .
AF502911 mRNA. Translation: AAM60777.1 .
AF502912 mRNA. Translation: AAM60778.1 .
AF040710 mRNA. Translation: AAC70915.1 . Frameshift.
U73167 Genomic DNA. Translation: AAC02729.1 .
BC005896 mRNA. Translation: AAH05896.1 .
BC012892 mRNA. Translation: AAH12892.1 .
CCDSi CCDS2815.1. [O43820-1 ]
CCDS56257.1. [O43820-2 ]
CCDS56259.1. [O43820-4 ]
CCDS56260.1. [O43820-3 ]
RefSeqi NP_001186958.1. NM_001200029.1. [O43820-1 ]
NP_001186959.1. NM_001200030.1. [O43820-2 ]
NP_001186960.1. NM_001200031.1. [O43820-3 ]
NP_001186961.1. NM_001200032.1. [O43820-4 ]
NP_003540.2. NM_003549.3. [O43820-1 ]
UniGenei Hs.129910.
Hs.729310.

3D structure databases

ProteinModelPortali O43820.
SMRi O43820. Positions 24-407.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113967. 1 interaction.
IntActi O43820. 1 interaction.
STRINGi 9606.ENSP00000337425.

Protein family/group databases

CAZyi GH56. Glycoside Hydrolase Family 56.

Proteomic databases

PaxDbi O43820.
PRIDEi O43820.

Protocols and materials databases

DNASUi 8372.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000336307 ; ENSP00000337425 ; ENSG00000186792 . [O43820-1 ]
ENST00000359051 ; ENSP00000351946 ; ENSG00000186792 . [O43820-2 ]
ENST00000415204 ; ENSP00000401092 ; ENSG00000186792 . [O43820-3 ]
ENST00000450982 ; ENSP00000391922 ; ENSG00000186792 . [O43820-2 ]
ENST00000513170 ; ENSP00000424633 ; ENSG00000186792 . [O43820-4 ]
ENST00000621157 ; ENSP00000479935 ; ENSG00000186792 . [O43820-1 ]
GeneIDi 8372.
KEGGi hsa:8372.
UCSCi uc003czd.2. human. [O43820-1 ]
uc003cze.2. human. [O43820-3 ]
uc003czf.2. human. [O43820-4 ]
uc003czg.2. human. [O43820-2 ]

Organism-specific databases

CTDi 8372.
GeneCardsi GC03M050331.
HGNCi HGNC:5322. HYAL3.
HPAi HPA049402.
MIMi 604038. gene.
neXtProti NX_O43820.
PharmGKBi PA29573.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG69101.
GeneTreei ENSGT00550000074476.
HOVERGENi HBG052053.
InParanoidi O43820.
KOi K01197.
OMAi WEEWCPL.
PhylomeDBi O43820.
TreeFami TF321598.

Enzyme and pathway databases

BioCyci MetaCyc:ENSG00000114366-MONOMER.
BRENDAi 3.2.1.35. 2681.
Reactomei REACT_120888. CS/DS degradation.
REACT_120996. Hyaluronan uptake and degradation.

Miscellaneous databases

GeneWikii HYAL3.
GenomeRNAii 8372.
NextBioi 31358.
PROi O43820.
SOURCEi Search...

Gene expression databases

Bgeei O43820.
CleanExi HS_HYAL3.
ExpressionAtlasi O43820. baseline.
Genevestigatori O43820.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR000742. EG-like_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
IPR027260. Hyaluronidase-3.
[Graphical view ]
PANTHERi PTHR11769. PTHR11769. 1 hit.
Pfami PF01630. Glyco_hydro_56. 1 hit.
[Graphical view ]
PIRSFi PIRSF038193. Hyaluronidase. 1 hit.
PIRSF500776. Hyaluronidase_3. 1 hit.
PRINTSi PR00846. GLHYDRLASE56.
SMARTi SM00181. EGF. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression analysis of six paralogous human hyaluronidase genes clustered on chromosomes 3p21 and 7q31."
    Csoka A.B., Scherer S.W., Stern R.
    Genomics 60:356-361(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "Regulation of hyaluronidase activity by alternative mRNA splicing."
    Lokeshwar V.B., Schroeder G.L., Carey R.I., Soloway M.S., Iida N.
    J. Biol. Chem. 277:33654-33663(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
  3. "LUCA-3 a third hyaluronidase gene and candidate tumor suppressor gene located in the 3p21.3 homozygous deletion region."
    Fong K., Bader S., Lee C.-C., Latif F., Sekido Y., Duh F.-M., Wei M.-H., Cundiff S., Lerman M.I., Minna J.D.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT TYR-113.
    Tissue: Bone marrow and Ovary.

Entry informationi

Entry nameiHYAL3_HUMAN
AccessioniPrimary (citable) accession number: O43820
Secondary accession number(s): O60540
, Q8NFK2, Q8NFK3, Q8NFK4, Q96E56, Q9BRW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: June 1, 1998
Last modified: October 29, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3