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O43820

- HYAL3_HUMAN

UniProt

O43820 - HYAL3_HUMAN

Protein

Hyaluronidase-3

Gene

HYAL3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei129 – 1291Proton donorBy similarity

    GO - Molecular functioni

    1. hyaluronoglucuronidase activity Source: UniProtKB
    2. hyalurononglucosaminidase activity Source: UniProtKB

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. cartilage development Source: UniProtKB
    3. cellular response to interleukin-1 Source: UniProtKB
    4. cellular response to tumor necrosis factor Source: UniProtKB
    5. cellular response to UV-B Source: UniProtKB
    6. hyaluronan catabolic process Source: UniProtKB
    7. inflammatory response Source: UniProtKB
    8. response to antibiotic Source: UniProtKB
    9. response to virus Source: UniProtKB

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Enzyme and pathway databases

    BioCyciMetaCyc:ENSG00000114366-MONOMER.
    BRENDAi3.2.1.35. 2681.
    ReactomeiREACT_120888. CS/DS degradation.
    REACT_120996. Hyaluronan uptake and degradation.

    Protein family/group databases

    CAZyiGH56. Glycoside Hydrolase Family 56.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hyaluronidase-3 (EC:3.2.1.35)
    Short name:
    Hyal-3
    Alternative name(s):
    Hyaluronoglucosaminidase-3
    Lung carcinoma protein 3
    Short name:
    LuCa-3
    Gene namesi
    Name:HYAL3
    Synonyms:LUCA3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:5322. HYAL3.

    Subcellular locationi

    Secreted By similarity. Lysosome By similarity

    GO - Cellular componenti

    1. cytoplasmic vesicle Source: UniProtKB
    2. extracellular region Source: UniProtKB-SubCell
    3. lysosome Source: UniProtKB

    Keywords - Cellular componenti

    Lysosome, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29573.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 417397Hyaluronidase-3PRO_0000248200Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi42 ↔ 331By similarity
    Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi205 ↔ 220By similarity
    Glycosylationi215 – 2151N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi356 ↔ 367By similarity
    Disulfide bondi361 ↔ 395By similarity
    Disulfide bondi397 ↔ 406By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO43820.
    PRIDEiO43820.

    Expressioni

    Tissue specificityi

    Bone marrow, testis and kidney. Isoform 4 is detected in all bladder tumor and prostate tumor cells.2 Publications

    Gene expression databases

    BgeeiO43820.
    CleanExiHS_HYAL3.
    GenevestigatoriO43820.

    Organism-specific databases

    HPAiHPA049402.

    Interactioni

    Protein-protein interaction databases

    BioGridi113967. 1 interaction.
    IntActiO43820. 1 interaction.
    STRINGi9606.ENSP00000337425.

    Structurei

    3D structure databases

    ProteinModelPortaliO43820.
    SMRiO43820. Positions 24-407.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini352 – 40756EGF-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 56 family.Curated
    Contains 1 EGF-like domain.Curated

    Keywords - Domaini

    EGF-like domain, Signal

    Phylogenomic databases

    eggNOGiNOG69101.
    HOVERGENiHBG052053.
    KOiK01197.
    OMAiWEEWCPL.
    PhylomeDBiO43820.
    TreeFamiTF321598.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR000742. EG-like_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR018155. Hyaluronidase.
    IPR027260. Hyaluronidase-3.
    [Graphical view]
    PANTHERiPTHR11769. PTHR11769. 1 hit.
    PfamiPF01630. Glyco_hydro_56. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038193. Hyaluronidase. 1 hit.
    PIRSF500776. Hyaluronidase_3. 1 hit.
    PRINTSiPR00846. GLHYDRLASE56.
    SMARTiSM00181. EGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.
    PROSITEiPS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O43820-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTTQLGPALV LGVALCLGCG QPLPQVPERP FSVLWNVPSA HCEARFGVHL    50
    PLNALGIIAN RGQHFHGQNM TIFYKNQLGL YPYFGPRGTA HNGGIPQALP 100
    LDRHLALAAY QIHHSLRPGF AGPAVLDWEE WCPLWAGNWG RRRAYQAASW 150
    AWAQQVFPDL DPQEQLYKAY TGFEQAARAL MEDTLRVAQA LRPHGLWGFY 200
    HYPACGNGWH SMASNYTGRC HAATLARNTQ LHWLWAASSA LFPSIYLPPR 250
    LPPAHHQAFV RHRLEEAFRV ALVGHRHPLP VLAYVRLTHR RSGRFLSQDD 300
    LVQSIGVSAA LGAAGVVLWG DLSLSSSEEE CWHLHDYLVD TLGPYVINVT 350
    RAAMACSHQR CHGHGRCARR DPGQMEAFLH LWPDGSLGDW KSFSCHCYWG 400
    WAGPTCQEPR PGPKEAV 417
    Length:417
    Mass (Da):46,501
    Last modified:June 1, 1998 - v1
    Checksum:iA6E7DE5369EF2BB8
    GO
    Isoform 2 (identifier: O43820-2) [UniParc]FASTAAdd to Basket

    Also known as: HYAL3v1

    The sequence of this isoform differs from the canonical sequence as follows:
         299-328: Missing.

    Note: Enzymatically inactive.

    Show »
    Length:387
    Mass (Da):43,602
    Checksum:i32FE18A2329307A6
    GO
    Isoform 3 (identifier: O43820-3) [UniParc]FASTAAdd to Basket

    Also known as: HYAL3v2

    The sequence of this isoform differs from the canonical sequence as follows:
         1-249: Missing.
         250-250: R → M

    Note: Enzymatically inactive.

    Show »
    Length:168
    Mass (Da):18,764
    Checksum:iC29CE942F2F784F8
    GO
    Isoform 4 (identifier: O43820-4) [UniParc]FASTAAdd to Basket

    Also known as: HYAL3v3

    The sequence of this isoform differs from the canonical sequence as follows:
         1-249: Missing.
         250-250: R → M
         299-328: Missing.

    Note: Enzymatically inactive.

    Show »
    Length:138
    Mass (Da):15,865
    Checksum:i8E94BC56A7606001
    GO

    Sequence cautioni

    The sequence AAC70915.1 differs from that shown. Reason: Frameshift at position 410.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti54 – 541A → S in AAH05896. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti113 – 1131H → Y.1 Publication
    Corresponds to variant rs13100173 [ dbSNP | Ensembl ].
    VAR_027263

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 249249Missing in isoform 3 and isoform 4. 1 PublicationVSP_020192Add
    BLAST
    Alternative sequencei250 – 2501R → M in isoform 3 and isoform 4. 1 PublicationVSP_020193
    Alternative sequencei299 – 32830Missing in isoform 2 and isoform 4. 1 PublicationVSP_020194Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF036035 mRNA. Translation: AAD04257.1.
    AF502909 mRNA. Translation: AAM60775.1.
    AF502910 mRNA. Translation: AAM60776.1.
    AF502911 mRNA. Translation: AAM60777.1.
    AF502912 mRNA. Translation: AAM60778.1.
    AF040710 mRNA. Translation: AAC70915.1. Frameshift.
    U73167 Genomic DNA. Translation: AAC02729.1.
    BC005896 mRNA. Translation: AAH05896.1.
    BC012892 mRNA. Translation: AAH12892.1.
    CCDSiCCDS2815.1. [O43820-1]
    CCDS56257.1. [O43820-2]
    CCDS56259.1. [O43820-4]
    CCDS56260.1. [O43820-3]
    RefSeqiNP_001186958.1. NM_001200029.1. [O43820-1]
    NP_001186959.1. NM_001200030.1. [O43820-2]
    NP_001186960.1. NM_001200031.1. [O43820-3]
    NP_001186961.1. NM_001200032.1. [O43820-4]
    NP_003540.2. NM_003549.3. [O43820-1]
    UniGeneiHs.129910.
    Hs.729310.

    Genome annotation databases

    EnsembliENST00000336307; ENSP00000337425; ENSG00000186792. [O43820-1]
    ENST00000359051; ENSP00000351946; ENSG00000186792. [O43820-2]
    ENST00000415204; ENSP00000401092; ENSG00000186792. [O43820-3]
    ENST00000450982; ENSP00000391922; ENSG00000186792. [O43820-2]
    ENST00000513170; ENSP00000424633; ENSG00000186792. [O43820-4]
    GeneIDi8372.
    KEGGihsa:8372.
    UCSCiuc003czd.2. human. [O43820-1]
    uc003cze.2. human. [O43820-3]
    uc003czf.2. human. [O43820-4]
    uc003czg.2. human. [O43820-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF036035 mRNA. Translation: AAD04257.1 .
    AF502909 mRNA. Translation: AAM60775.1 .
    AF502910 mRNA. Translation: AAM60776.1 .
    AF502911 mRNA. Translation: AAM60777.1 .
    AF502912 mRNA. Translation: AAM60778.1 .
    AF040710 mRNA. Translation: AAC70915.1 . Frameshift.
    U73167 Genomic DNA. Translation: AAC02729.1 .
    BC005896 mRNA. Translation: AAH05896.1 .
    BC012892 mRNA. Translation: AAH12892.1 .
    CCDSi CCDS2815.1. [O43820-1 ]
    CCDS56257.1. [O43820-2 ]
    CCDS56259.1. [O43820-4 ]
    CCDS56260.1. [O43820-3 ]
    RefSeqi NP_001186958.1. NM_001200029.1. [O43820-1 ]
    NP_001186959.1. NM_001200030.1. [O43820-2 ]
    NP_001186960.1. NM_001200031.1. [O43820-3 ]
    NP_001186961.1. NM_001200032.1. [O43820-4 ]
    NP_003540.2. NM_003549.3. [O43820-1 ]
    UniGenei Hs.129910.
    Hs.729310.

    3D structure databases

    ProteinModelPortali O43820.
    SMRi O43820. Positions 24-407.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113967. 1 interaction.
    IntActi O43820. 1 interaction.
    STRINGi 9606.ENSP00000337425.

    Protein family/group databases

    CAZyi GH56. Glycoside Hydrolase Family 56.

    Proteomic databases

    PaxDbi O43820.
    PRIDEi O43820.

    Protocols and materials databases

    DNASUi 8372.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000336307 ; ENSP00000337425 ; ENSG00000186792 . [O43820-1 ]
    ENST00000359051 ; ENSP00000351946 ; ENSG00000186792 . [O43820-2 ]
    ENST00000415204 ; ENSP00000401092 ; ENSG00000186792 . [O43820-3 ]
    ENST00000450982 ; ENSP00000391922 ; ENSG00000186792 . [O43820-2 ]
    ENST00000513170 ; ENSP00000424633 ; ENSG00000186792 . [O43820-4 ]
    GeneIDi 8372.
    KEGGi hsa:8372.
    UCSCi uc003czd.2. human. [O43820-1 ]
    uc003cze.2. human. [O43820-3 ]
    uc003czf.2. human. [O43820-4 ]
    uc003czg.2. human. [O43820-2 ]

    Organism-specific databases

    CTDi 8372.
    GeneCardsi GC03M050331.
    HGNCi HGNC:5322. HYAL3.
    HPAi HPA049402.
    MIMi 604038. gene.
    neXtProti NX_O43820.
    PharmGKBi PA29573.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG69101.
    HOVERGENi HBG052053.
    KOi K01197.
    OMAi WEEWCPL.
    PhylomeDBi O43820.
    TreeFami TF321598.

    Enzyme and pathway databases

    BioCyci MetaCyc:ENSG00000114366-MONOMER.
    BRENDAi 3.2.1.35. 2681.
    Reactomei REACT_120888. CS/DS degradation.
    REACT_120996. Hyaluronan uptake and degradation.

    Miscellaneous databases

    GeneWikii HYAL3.
    GenomeRNAii 8372.
    NextBioi 31358.
    PROi O43820.
    SOURCEi Search...

    Gene expression databases

    Bgeei O43820.
    CleanExi HS_HYAL3.
    Genevestigatori O43820.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR000742. EG-like_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR018155. Hyaluronidase.
    IPR027260. Hyaluronidase-3.
    [Graphical view ]
    PANTHERi PTHR11769. PTHR11769. 1 hit.
    Pfami PF01630. Glyco_hydro_56. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038193. Hyaluronidase. 1 hit.
    PIRSF500776. Hyaluronidase_3. 1 hit.
    PRINTSi PR00846. GLHYDRLASE56.
    SMARTi SM00181. EGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    PROSITEi PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression analysis of six paralogous human hyaluronidase genes clustered on chromosomes 3p21 and 7q31."
      Csoka A.B., Scherer S.W., Stern R.
      Genomics 60:356-361(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    2. "Regulation of hyaluronidase activity by alternative mRNA splicing."
      Lokeshwar V.B., Schroeder G.L., Carey R.I., Soloway M.S., Iida N.
      J. Biol. Chem. 277:33654-33663(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
    3. "LUCA-3 a third hyaluronidase gene and candidate tumor suppressor gene located in the 3p21.3 homozygous deletion region."
      Fong K., Bader S., Lee C.-C., Latif F., Sekido Y., Duh F.-M., Wei M.-H., Cundiff S., Lerman M.I., Minna J.D.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT TYR-113.
      Tissue: Bone marrow and Ovary.

    Entry informationi

    Entry nameiHYAL3_HUMAN
    AccessioniPrimary (citable) accession number: O43820
    Secondary accession number(s): O60540
    , Q8NFK2, Q8NFK3, Q8NFK4, Q96E56, Q9BRW9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3