Unreviewed, UniProtKB/TrEMBL O43816 (O43816_HUMAN)

Names and origin

Protein names	Submitted name:     Tyrosine hydroxylase EMBL BAA25095.2     EC=1.14.16.2
Organism	Homo sapiens (Human) EMBL BAA25095.2
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	134 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

Ontologies

Keywords
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	aromatic amino acid family metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	iron ion binding Inferred from electronic annotation. Source: InterPro tyrosine 3-monooxygenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	134	1	EMBL BAA25095.2

Sequences

	Sequence		Length	Mass (Da)
	O43816-1 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 67EE6258E3C5877C	FASTA	134	14,058
	10 20 30 40 50 60 MPTPDATTPQ AKGFRRAVSE LDAKQAEAIM GAPGPSLTGS PWPGTAAPAA SYTPTPRSPR 70 80 90 100 110 120 FIGRRQSLIE DARKEREAAV AAAAAAVPSE PGDPLEAVAF EEKEGKAVLN LLFSPRATKP 130 SALSRAVKVF ETFE

References

[1]	"Structure of the human tyrosine hydroxylase gene: alternative splicing from a single gene accounts for generation of four mRNA types." Kobayashi K., Kaneda N., Ichinose H., Kishi F., Nakazawa A., Kurosawa Y., Fujita K., Nagatsu T. J. Biochem. 103:907-912(1988) [PubMed: 2902075] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Placenta EMBL BAA25095.2.
[2]	"Isolation and characterization of the human tyrosine hydroxylase gene: identification of 5' alternative splice sites responsible for multiple mRNAs." O'Malley K.L., Anhalt M.J., Martin B.M., Kelsoe J.R., Winfield S.L., Ginns E.I. Biochemistry 26:6910-6914(1987) [PubMed: 2892528] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Placenta EMBL BAA25095.2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D00269 Genomic DNA. Translation: BAA25095.2.
IPI	IPI00218275.
UniGene	Hs.435609 Hs.523414
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000180176. Homo sapiens. [Contig view]
Organism-specific databases
HGNC	HGNC:11782. TH.
Phylogenomic databases
HOVERGEN	O43816.
Gene expression databases
ArrayExpress	O43816.
Bgee	O43816.
Family and domain databases
InterPro	IPR001273. ArAA_hydroxylase. [Graphical view]
PANTHER	PTHR11473. Aaa_hydroxylase. 1 hit.
ProtoNet	Search...
Other Resources
LinkHub	O43816.

Entry information

Entry name

O43816_HUMAN

Accession

Primary (citable) accession number: O43816

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 1998
Last sequence update:	June 1, 1998
Last modified:	June 16, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)