O43815 (STRN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Striatin

Gene names

Name:

STRN

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	780 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca2+ signaling.
Subunit structure	Interacts with protein phosphatase 2A (PP2A) Potential.
Subcellular location	Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity.
Tissue specificity	Preferentially expressed in brain. Ref.1
Sequence similarities	Belongs to the WD repeat striatin family. Contains 6 WD repeats.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane
Coding sequence diversity	Alternative splicing
Domain	Coiled coil Repeat WD repeat
Ligand	Calmodulin-binding
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	Wnt receptor signaling pathway Inferred from mutant phenotype. Source: UniProtKB dendrite development Inferred from sequence or structural similarity. Source: UniProtKB locomotory behavior Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of cell proliferation Inferred from mutant phenotype. Source: UniProtKB tight junction assembly Non-traceable author statement. Source: UniProtKB
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell neuronal cell body Inferred from sequence or structural similarity. Source: UniProtKB postsynaptic density Inferred from sequence or structural similarity. Source: UniProtKB postsynaptic membrane Inferred from sequence or structural similarity. Source: UniProtKB tight junction Inferred from direct assay. Source: UniProtKB
Molecular function	armadillo repeat domain binding Inferred from physical interaction. Source: UniProtKB calmodulin binding Inferred from sequence or structural similarity. Source: UniProtKB estrogen receptor binding Inferred from physical interaction. Source: UniProtKB protein complex binding Inferred from direct assay. Source: UniProtKB protein phosphatase 2A binding Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CTTNBP2NL	Q9P2B4	3	EBI-1046642,EBI-1774273
PDCD10	Q9BUL8	2	EBI-1046642,EBI-740195
PHOCN	Q9Y3A3	3	EBI-1046642,EBI-713935
PPP2CA	P67775	3	EBI-1046642,EBI-712311
PPP2R1A	P30153	4	EBI-1046642,EBI-302388
STK24	Q9Y6E0	2	EBI-1046642,EBI-740175
STK25	O00506	2	EBI-1046642,EBI-618295
STRN3	Q13033	4	EBI-1046642,EBI-1053857
TRAF3IP3	Q9Y228	2	EBI-1046642,EBI-765817

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O43815-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O43815-2)

The sequence of this isoform differs from the canonical sequence as follows:
     29-40: Missing.
     311-348: EKEDQCLMPEAWNVDQGVITKLKEQYKKERKGKKGVKR → G

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 780	780	Striatin		PRO_0000051232
Regions
	Repeat	461 – 500	40	WD 1
	Repeat	514 – 553	40	WD 2
	Repeat	567 – 606	40	WD 3
	Repeat	662 – 701	40	WD 4
	Repeat	704 – 743	40	WD 5
	Repeat	750 – 779	30	WD 6
	Region	55 – 63	9	Caveolin-binding Potential
	Region	149 – 166	18	Calmodulin-binding Potential
	Coiled coil	53 – 120	68	Potential
Amino acid modifications
	Modified residue	245	1	Phosphoserine Ref.4 Ref.5 Ref.6 Ref.7
	Modified residue	264	1	Phosphoserine By similarity
	Modified residue	689	1	N6-acetyllysine Ref.8
Natural variations
	Alternative sequence	29 – 40	12	Missing in isoform 2.		VSP_023495
	Alternative sequence	311 – 348	38	EKEDQ…KGVKR → G in isoform 2.		VSP_023496
Experimental info
	Sequence conflict	191	1	S → I in CAA11560. Ref.1
	Sequence conflict	423	1	L → P in CAA11560. Ref.1
	Sequence conflict	611	1	T → I in CAA11560. Ref.1
	Sequence conflict	677	1	P → S in CAA11560. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 6, 2007. Version 4. Checksum: DDB18A11102BEA35	FASTA	780	86,132
	10 20 30 40 50 60 MDEQAGPGVF FSNNHPGAGG AKGLGPLAEA AAAGDGAAAA GAARAQYSLP GILHFLQHEW 70 80 90 100 110 120 ARFEVERAQW EVERAELQAQ IAFLQGERKG QENLKKDLVR RIKMLEYALK QERAKYHKLK 130 140 150 160 170 180 YGTELNQGDM KPPSYDSDEG NETEVQPQQN SQLMWKQGRQ LLRQYLQEVG YTDTILDVKS 190 200 210 220 230 240 KRVRALLGFS SDVTDREDDK NQDSVVNGTE AEVKETAMIA KSELTDSASV LDNFKFLESA 250 260 270 280 290 300 AADFSDEDED DDVDGREKSV IDTSTIVRKK ALPDSGEDRD TKEALKEFDF LVTSEEGDNE 310 320 330 340 350 360 SRSAGDGTDW EKEDQCLMPE AWNVDQGVIT KLKEQYKKER KGKKGVKRPN RSKLQDMLAN 370 380 390 400 410 420 LRDVDELPSL QPSVGSPSRP SSSRLPEHEI NRADEVEALT FPPSSGKSFI MGADEALESE 430 440 450 460 470 480 LGLGELAGLT VANEADSLTY DIANNKDALR KTWNPKFTLR SHFDGIRALA FHPIEPVLIT 490 500 510 520 530 540 ASEDHTLKMW NLQKTAPAKK STSLDVEPIY TFRAHKGPVL CVVMSSNGEQ CYSGGTDGLI 550 560 570 580 590 600 QGWNTTNPNI DPYDSYDPSV LRGPLLGHTD AVWGLAYSAA HQRLLSCSAD GTLRLWNTTE 610 620 630 640 650 660 VAPALSVFND TKELGIPASV DLVSSDPSHM VASFSKGYTS IFNMETQQRI LTLESNVDTT 670 680 690 700 710 720 ANSSCQINRV ISHPTLPISI TAHEDRHIKF YDNNTGKLIH SMVAHLEAVT SLAVDPNGLY 730 740 750 760 770 780 LMSGSHDCSI RLWNLESKTC IQEFTAHRKK FEESIHDVAF HPSKCYIASA GADALAKVFV
	Isoform 2 [UniParc]. Checksum: 67B5DD94E3499AB7	FASTA	731	80,761
	10 20 30 40 50 60 MDEQAGPGVF FSNNHPGAGG AKGLGPLAGA ARAQYSLPGI LHFLQHEWAR FEVERAQWEV 70 80 90 100 110 120 ERAELQAQIA FLQGERKGQE NLKKDLVRRI KMLEYALKQE RAKYHKLKYG TELNQGDMKP 130 140 150 160 170 180 PSYDSDEGNE TEVQPQQNSQ LMWKQGRQLL RQYLQEVGYT DTILDVKSKR VRALLGFSSD 190 200 210 220 230 240 VTDREDDKNQ DSVVNGTEAE VKETAMIAKS ELTDSASVLD NFKFLESAAA DFSDEDEDDD 250 260 270 280 290 300 VDGREKSVID TSTIVRKKAL PDSGEDRDTK EALKEFDFLV TSEEGDNESR SAGDGTDWGP 310 320 330 340 350 360 NRSKLQDMLA NLRDVDELPS LQPSVGSPSR PSSSRLPEHE INRADEVEAL TFPPSSGKSF 370 380 390 400 410 420 IMGADEALES ELGLGELAGL TVANEADSLT YDIANNKDAL RKTWNPKFTL RSHFDGIRAL 430 440 450 460 470 480 AFHPIEPVLI TASEDHTLKM WNLQKTAPAK KSTSLDVEPI YTFRAHKGPV LCVVMSSNGE 490 500 510 520 530 540 QCYSGGTDGL IQGWNTTNPN IDPYDSYDPS VLRGPLLGHT DAVWGLAYSA AHQRLLSCSA 550 560 570 580 590 600 DGTLRLWNTT EVAPALSVFN DTKELGIPAS VDLVSSDPSH MVASFSKGYT SIFNMETQQR 610 620 630 640 650 660 ILTLESNVDT TANSSCQINR VISHPTLPIS ITAHEDRHIK FYDNNTGKLI HSMVAHLEAV 670 680 690 700 710 720 TSLAVDPNGL YLMSGSHDCS IRLWNLESKT CIQEFTAHRK KFEESIHDVA FHPSKCYIAS 730 AGADALAKVF V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of human striatin cDNA (STRN), gene mapping to 2p22-p21, and preferential expression in brain." Moqrich A., Mattei M.-G., Bartoli M., Rakitina T., Baillat G., Monneron A., Castets F. Genomics 51:136-139(1998) [PubMed: 9693043] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[4]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-245, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[5]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-245, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[6]	"Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed: 19369195] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-245, MASS SPECTROMETRY.
[7]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-245, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[8]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-689, MASS SPECTROMETRY.
[9]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ223814 mRNA. Translation: CAA11560.1. AC007404 Genomic DNA. Translation: AAY24273.1. AC007382 Genomic DNA. Translation: AAF66162.1. BC106879 mRNA. Translation: AAI06880.1.
IPI	IPI00014456. IPI00654594.
RefSeq	NP_003153.2. NM_003162.3.
UniGene	Hs.656726.
3D structure databases
ProteinModelPortal	O43815.
SMR	O43815. Positions 449-779.
ModBase	Search...
Protein-protein interaction databases
IntAct	O43815. 25 interactions.
STRING	O43815.
PTM databases
PhosphoSite	O43815.
Proteomic databases
PRIDE	O43815.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000263918; ENSP00000263918; ENSG00000115808.
GeneID	6801.
KEGG	hsa:6801.
UCSC	uc002rpn.1. human. uc010ezx.1. human.
Organism-specific databases
CTD	6801.
GeneCards	GC02M036987.
H-InvDB	HIX0001969.
HGNC	HGNC:11424. STRN.
HPA	HPA017286.
neXtProt	NX_O43815.
PharmGKB	PA36224.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG10459.
HOGENOM	HBG385782.
HOVERGEN	HBG007117.
InParanoid	O43815.
OMA	FIMGTDE.
OrthoDB	EOG43N7C6.
PhylomeDB	O43815.
Enzyme and pathway databases
Pathway_Interaction_DB	er_nongenomic_pathway. Plasma membrane estrogen receptor signaling.
Gene expression databases
ArrayExpress	O43815.
Bgee	O43815.
CleanEx	HS_STRN.
Genevestigator	O43815.
GermOnline	ENSG00000115808. Homo sapiens.
Family and domain databases
InterPro	IPR020472. G-protein_beta_WD-40_rep. IPR013258. Striatin_N. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR011046. WD40_repeat-like_dom. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
Pfam	PF08232. Striatin. 1 hit. PF00400. WD40. 5 hits. [Graphical view]
PRINTS	PR00320. GPROTEINBRPT.
SMART	SM00320. WD40. 6 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. 4 hits. PS50082. WD_REPEATS_2. 4 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	26559.
PMAP-CutDB	O43815.

Entry information

Entry name

STRN_HUMAN

Accession

Primary (citable) accession number: O43815
Secondary accession number(s): Q3KP65, Q53TQ8, Q9NP38

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	March 6, 2007
Last modified:	January 25, 2012
This is version 109 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.