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O43813

- LANC1_HUMAN

UniProt

O43813 - LANC1_HUMAN

Protein

LanC-like protein 1

Gene

LANCL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    May play a role in EPS8 signaling. Binds glutathione.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi276 – 2761Zinc
    Binding sitei317 – 3171Glutathione1 Publication
    Metal bindingi322 – 3221Zinc
    Metal bindingi323 – 3231Zinc

    GO - Molecular functioni

    1. catalytic activity Source: InterPro
    2. glutathione binding Source: UniProtKB
    3. G-protein coupled receptor activity Source: ProtInc
    4. low-density lipoprotein particle receptor binding Source: MGI
    5. protein binding Source: IntAct
    6. SH3 domain binding Source: UniProtKB
    7. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: ProtInc

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    LanC-like protein 1
    Alternative name(s):
    40 kDa erythrocyte membrane protein
    Short name:
    p40
    Gene namesi
    Name:LANCL1
    Synonyms:GPR69A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:6508. LANCL1.

    Subcellular locationi

    Cytoplasm. Membrane; Peripheral membrane protein. Nucleus
    Note: Detected at the surface of Maurer's clefts in malaria-infected erythrocytes at late stages of parasite development.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. extracellular vesicular exosome Source: UniProt
    3. integral component of plasma membrane Source: ProtInc
    4. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Membrane, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi4 – 41R → A: Loss of glutathione binding. 1 Publication
    Mutagenesisi317 – 3171K → A: Loss of glutathione binding. 1 Publication
    Mutagenesisi322 – 3221C → A: Loss of glutathione binding. 1 Publication
    Mutagenesisi364 – 3641R → A or E: Loss of glutathione binding. 1 Publication

    Organism-specific databases

    PharmGKBiPA30293.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 399398LanC-like protein 1PRO_0000191268Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei142 – 1421N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiO43813.
    PaxDbiO43813.
    PeptideAtlasiO43813.
    PRIDEiO43813.

    PTM databases

    PhosphoSiteiO43813.

    Expressioni

    Tissue specificityi

    Detected in erythrocytes, brain, kidney, testis, ovary, heart, lung, placenta and spleen (at protein level). Ubiquitous. Strongly expressed in brain, spinal cord, pituitary gland, kidney, heart, skeletal muscle, pancreas, ovary and testis.3 Publications

    Gene expression databases

    ArrayExpressiO43813.
    BgeeiO43813.
    CleanExiHS_LANCL1.
    GenevestigatoriO43813.

    Organism-specific databases

    HPAiHPA034994.

    Interactioni

    Subunit structurei

    Interacts with the C-terminal of STOM. Interacts with the EPS8 SH3 domain. Interaction with EPS8 is inhibited by glutathione binding. Interacts with P.falciparum SBP1.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Eps8Q085092EBI-3046631,EBI-375596From a different organism.

    Protein-protein interaction databases

    BioGridi115599. 6 interactions.
    IntActiO43813. 4 interactions.
    MINTiMINT-3308405.
    STRINGi9606.ENSP00000233714.

    Structurei

    Secondary structure

    1
    399
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi2 – 43
    Helixi15 – 195
    Helixi30 – 5021
    Turni51 – 533
    Beta strandi61 – 644
    Helixi65 – 7915
    Helixi82 – 9615
    Beta strandi106 – 1094
    Helixi111 – 12313
    Helixi127 – 13812
    Helixi139 – 1435
    Turni151 – 1533
    Helixi155 – 16915
    Helixi176 – 19621
    Turni197 – 2026
    Turni217 – 2193
    Helixi221 – 2288
    Helixi231 – 2333
    Helixi237 – 2426
    Helixi244 – 25310
    Beta strandi274 – 2785
    Helixi279 – 29315
    Helixi296 – 31217
    Turni321 – 3233
    Helixi325 – 33915
    Helixi342 – 35514
    Turni356 – 3594
    Turni372 – 3743
    Helixi376 – 38611
    Helixi389 – 3913
    Turni395 – 3973

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3E6UX-ray2.60A/B/C/D1-399[»]
    3E73X-ray2.80A/B1-399[»]
    ProteinModelPortaliO43813.
    SMRiO43813. Positions 1-399.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO43813.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni364 – 3674Glutathione binding

    Sequence similaritiesi

    Belongs to the LanC-like protein family.Curated

    Phylogenomic databases

    eggNOGiNOG245101.
    HOGENOMiHOG000240926.
    HOVERGENiHBG065387.
    InParanoidiO43813.
    OMAiPGVIYML.
    OrthoDBiEOG71VSTN.
    PhylomeDBiO43813.
    TreeFamiTF300068.

    Family and domain databases

    Gene3Di1.50.10.10. 1 hit.
    InterProiIPR012341. 6hp_glycosidase.
    IPR007822. LANC-like.
    IPR020464. LanC-like_prot_euk.
    [Graphical view]
    PfamiPF05147. LANC_like. 1 hit.
    [Graphical view]
    PRINTSiPR01951. LANCEUKARYTE.
    PR01950. LANCSUPER.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O43813-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQRAFPNPY ADYNKSLAEG YFDAAGRLTP EFSQRLTNKI RELLQQMERG    50
    LKSADPRDGT GYTGWAGIAV LYLHLYDVFG DPAYLQLAHG YVKQSLNCLT 100
    KRSITFLCGD AGPLAVAAVL YHKMNNEKQA EDCITRLIHL NKIDPHAPNE 150
    MLYGRIGYIY ALLFVNKNFG VEKIPQSHIQ QICETILTSG ENLARKRNFT 200
    AKSPLMYEWY QEYYVGAAHG LAGIYYYLMQ PSLQVSQGKL HSLVKPSVDY 250
    VCQLKFPSGN YPPCIGDNRD LLVHWCHGAP GVIYMLIQAY KVFREEKYLC 300
    DAYQCADVIW QYGLLKKGYG LCHGSAGNAY AFLTLYNLTQ DMKYLYRACK 350
    FAEWCLEYGE HGCRTPDTPF SLFEGMAGTI YFLADLLVPT KARFPAFEL 399
    Length:399
    Mass (Da):45,283
    Last modified:June 1, 1998 - v1
    Checksum:i2664F275F9281AF2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y11395 mRNA. Translation: CAA72205.1.
    AJ289236
    , AJ289237, AJ289238, AJ289239 Genomic DNA. Translation: CAC21950.1.
    BC028685 mRNA. Translation: AAH28685.1.
    CCDSiCCDS2392.1.
    RefSeqiNP_001130046.1. NM_001136574.1.
    NP_001130047.1. NM_001136575.1.
    NP_006046.1. NM_006055.2.
    UniGeneiHs.13351.

    Genome annotation databases

    EnsembliENST00000233714; ENSP00000233714; ENSG00000115365.
    ENST00000431941; ENSP00000397646; ENSG00000115365.
    ENST00000441020; ENSP00000393323; ENSG00000115365.
    ENST00000443314; ENSP00000388713; ENSG00000115365.
    ENST00000450366; ENSP00000393597; ENSG00000115365.
    GeneIDi10314.
    KEGGihsa:10314.
    UCSCiuc002ved.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y11395 mRNA. Translation: CAA72205.1 .
    AJ289236
    , AJ289237 , AJ289238 , AJ289239 Genomic DNA. Translation: CAC21950.1 .
    BC028685 mRNA. Translation: AAH28685.1 .
    CCDSi CCDS2392.1.
    RefSeqi NP_001130046.1. NM_001136574.1.
    NP_001130047.1. NM_001136575.1.
    NP_006046.1. NM_006055.2.
    UniGenei Hs.13351.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3E6U X-ray 2.60 A/B/C/D 1-399 [» ]
    3E73 X-ray 2.80 A/B 1-399 [» ]
    ProteinModelPortali O43813.
    SMRi O43813. Positions 1-399.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115599. 6 interactions.
    IntActi O43813. 4 interactions.
    MINTi MINT-3308405.
    STRINGi 9606.ENSP00000233714.

    PTM databases

    PhosphoSitei O43813.

    Proteomic databases

    MaxQBi O43813.
    PaxDbi O43813.
    PeptideAtlasi O43813.
    PRIDEi O43813.

    Protocols and materials databases

    DNASUi 10314.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000233714 ; ENSP00000233714 ; ENSG00000115365 .
    ENST00000431941 ; ENSP00000397646 ; ENSG00000115365 .
    ENST00000441020 ; ENSP00000393323 ; ENSG00000115365 .
    ENST00000443314 ; ENSP00000388713 ; ENSG00000115365 .
    ENST00000450366 ; ENSP00000393597 ; ENSG00000115365 .
    GeneIDi 10314.
    KEGGi hsa:10314.
    UCSCi uc002ved.3. human.

    Organism-specific databases

    CTDi 10314.
    GeneCardsi GC02M211259.
    HGNCi HGNC:6508. LANCL1.
    HPAi HPA034994.
    MIMi 604155. gene.
    neXtProti NX_O43813.
    PharmGKBi PA30293.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG245101.
    HOGENOMi HOG000240926.
    HOVERGENi HBG065387.
    InParanoidi O43813.
    OMAi PGVIYML.
    OrthoDBi EOG71VSTN.
    PhylomeDBi O43813.
    TreeFami TF300068.

    Miscellaneous databases

    ChiTaRSi LANCL1. human.
    EvolutionaryTracei O43813.
    GenomeRNAii 10314.
    NextBioi 39095.
    PROi O43813.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O43813.
    Bgeei O43813.
    CleanExi HS_LANCL1.
    Genevestigatori O43813.

    Family and domain databases

    Gene3Di 1.50.10.10. 1 hit.
    InterProi IPR012341. 6hp_glycosidase.
    IPR007822. LANC-like.
    IPR020464. LanC-like_prot_euk.
    [Graphical view ]
    Pfami PF05147. LANC_like. 1 hit.
    [Graphical view ]
    PRINTSi PR01951. LANCEUKARYTE.
    PR01950. LANCSUPER.
    ProtoNeti Search...

    Publicationsi

    1. "Isolation, molecular characterization, and tissue-specific expression of a novel putative G protein-coupled receptor."
      Mayer H., Salzer U., Breuss J., Ziegler S., Marchler-Bauer A., Prohaska R.
      Biochim. Biophys. Acta 1395:301-308(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 5-24; 28-35; 40-50; 198-201 AND 392-399, TISSUE SPECIFICITY, INTERACTION WITH STOM.
      Tissue: Bone marrow, Erythrocyte and Fetal brain.
    2. "Organization and chromosomal localization of the human and mouse genes coding for LanC-like protein 1 (LANCL1)."
      Mayer H., Bauer H., Prohaska R.
      Cytogenet. Cell Genet. 93:100-104(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Tissue: Brain and Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. "Characterization of p40/GPR69A as a peripheral membrane protein related to the lantibiotic synthetase component C."
      Bauer H., Mayer H., Marchler-Bauer A., Salzer U., Prohaska R.
      Biochem. Biophys. Res. Commun. 275:69-74(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    5. "LANCL1, an erythrocyte protein recruited to the Maurer's clefts during Plasmodium falciparum development."
      Blisnick T., Vincensini L., Barale J.C., Namane A., Braun Breton C.
      Mol. Biochem. Parasitol. 141:39-47(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INTERACTION WITH P.FALCIPARUM SBP1, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
    6. "Myristoylation of human LanC-like protein 2 (LANCL2) is essential for the interaction with the plasma membrane and the increase in cellular sensitivity to adriamycin."
      Landlinger C., Salzer U., Prohaska R.
      Biochim. Biophys. Acta 1758:1759-1767(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-142, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Structure of human lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathione."
      Zhang W., Wang L., Liu Y., Xu J., Zhu G., Cang H., Li X., Bartlam M., Hensley K., Li G., Rao Z., Zhang X.C.
      Genes Dev. 23:1387-1392(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) IN COMPLEX WITH GLUTATHIONE AND ZINC IONS, MUTAGENESIS OF ARG-4; LYS-317; CYS-322 AND ARG-364, INTERACTION WITH EPS8, FUNCTION.

    Entry informationi

    Entry nameiLANC1_HUMAN
    AccessioniPrimary (citable) accession number: O43813
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Was originally thought to be a G-protein coupled receptor.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3