Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

LanC-like protein 1

Gene

LANCL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in EPS8 signaling. Binds glutathione.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi276Zinc1
Binding sitei317Glutathione1 Publication1
Metal bindingi322Zinc1
Metal bindingi323Zinc1

GO - Molecular functioni

  • catalytic activity Source: InterPro
  • glutathione binding Source: UniProtKB
  • G-protein coupled receptor activity Source: ProtInc
  • low-density lipoprotein particle receptor binding Source: MGI
  • SH3 domain binding Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115365-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
LanC-like protein 1
Alternative name(s):
40 kDa erythrocyte membrane protein
Short name:
p40
Gene namesi
Name:LANCL1
Synonyms:GPR69A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:6508. LANCL1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi4R → A: Loss of glutathione binding. 1 Publication1
Mutagenesisi317K → A: Loss of glutathione binding. 1 Publication1
Mutagenesisi322C → A: Loss of glutathione binding. 1 Publication1
Mutagenesisi364R → A or E: Loss of glutathione binding. 1 Publication1

Organism-specific databases

DisGeNETi10314.
OpenTargetsiENSG00000115365.
PharmGKBiPA30293.

Polymorphism and mutation databases

BioMutaiLANCL1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001912682 – 399LanC-like protein 1Add BLAST398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei142N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO43813.
PaxDbiO43813.
PeptideAtlasiO43813.
PRIDEiO43813.

PTM databases

iPTMnetiO43813.
PhosphoSitePlusiO43813.
SwissPalmiO43813.

Expressioni

Tissue specificityi

Detected in erythrocytes, brain, kidney, testis, ovary, heart, lung, placenta and spleen (at protein level). Ubiquitous. Strongly expressed in brain, spinal cord, pituitary gland, kidney, heart, skeletal muscle, pancreas, ovary and testis.3 Publications

Gene expression databases

BgeeiENSG00000115365.
CleanExiHS_LANCL1.
ExpressionAtlasiO43813. baseline and differential.
GenevisibleiO43813. HS.

Organism-specific databases

HPAiHPA034994.

Interactioni

Subunit structurei

Interacts with the C-terminal of STOM. Interacts with the EPS8 SH3 domain. Interaction with EPS8 is inhibited by glutathione binding. Interacts with P.falciparum SBP1.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Eps8Q085092EBI-3046631,EBI-375596From a different organism.

GO - Molecular functioni

  • low-density lipoprotein particle receptor binding Source: MGI
  • SH3 domain binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115599. 18 interactors.
IntActiO43813. 6 interactors.
MINTiMINT-3308405.
STRINGi9606.ENSP00000233714.

Structurei

Secondary structure

1399
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 4Combined sources3
Helixi15 – 19Combined sources5
Helixi30 – 50Combined sources21
Turni51 – 53Combined sources3
Beta strandi61 – 64Combined sources4
Helixi65 – 79Combined sources15
Helixi82 – 96Combined sources15
Beta strandi106 – 109Combined sources4
Helixi111 – 123Combined sources13
Helixi127 – 138Combined sources12
Helixi139 – 143Combined sources5
Turni151 – 153Combined sources3
Helixi155 – 169Combined sources15
Helixi176 – 196Combined sources21
Turni197 – 202Combined sources6
Turni217 – 219Combined sources3
Helixi221 – 228Combined sources8
Helixi231 – 233Combined sources3
Helixi237 – 242Combined sources6
Helixi244 – 253Combined sources10
Beta strandi274 – 278Combined sources5
Helixi279 – 293Combined sources15
Helixi296 – 312Combined sources17
Turni321 – 323Combined sources3
Helixi325 – 339Combined sources15
Helixi342 – 355Combined sources14
Turni356 – 359Combined sources4
Turni372 – 374Combined sources3
Helixi376 – 386Combined sources11
Helixi389 – 391Combined sources3
Turni395 – 397Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3E6UX-ray2.60A/B/C/D1-399[»]
3E73X-ray2.80A/B1-399[»]
ProteinModelPortaliO43813.
SMRiO43813.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43813.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni364 – 367Glutathione binding4

Sequence similaritiesi

Belongs to the LanC-like protein family.Curated

Phylogenomic databases

eggNOGiKOG2787. Eukaryota.
ENOG410XQIA. LUCA.
GeneTreeiENSGT00530000063186.
HOGENOMiHOG000240926.
HOVERGENiHBG065387.
InParanoidiO43813.
OMAiNPYADFN.
OrthoDBiEOG091G02TS.
PhylomeDBiO43813.
TreeFamiTF300068.

Family and domain databases

CDDicd04794. euk_LANCL. 1 hit.
Gene3Di1.50.10.10. 1 hit.
InterProiIPR012341. 6hp_glycosidase.
IPR007822. LANC-like.
IPR020464. LanC-like_prot_euk.
[Graphical view]
PfamiPF05147. LANC_like. 1 hit.
[Graphical view]
PRINTSiPR01951. LANCEUKARYTE.
PR01950. LANCSUPER.
SMARTiSM01260. LANC_like. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O43813-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQRAFPNPY ADYNKSLAEG YFDAAGRLTP EFSQRLTNKI RELLQQMERG
60 70 80 90 100
LKSADPRDGT GYTGWAGIAV LYLHLYDVFG DPAYLQLAHG YVKQSLNCLT
110 120 130 140 150
KRSITFLCGD AGPLAVAAVL YHKMNNEKQA EDCITRLIHL NKIDPHAPNE
160 170 180 190 200
MLYGRIGYIY ALLFVNKNFG VEKIPQSHIQ QICETILTSG ENLARKRNFT
210 220 230 240 250
AKSPLMYEWY QEYYVGAAHG LAGIYYYLMQ PSLQVSQGKL HSLVKPSVDY
260 270 280 290 300
VCQLKFPSGN YPPCIGDNRD LLVHWCHGAP GVIYMLIQAY KVFREEKYLC
310 320 330 340 350
DAYQCADVIW QYGLLKKGYG LCHGSAGNAY AFLTLYNLTQ DMKYLYRACK
360 370 380 390
FAEWCLEYGE HGCRTPDTPF SLFEGMAGTI YFLADLLVPT KARFPAFEL
Length:399
Mass (Da):45,283
Last modified:June 1, 1998 - v1
Checksum:i2664F275F9281AF2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11395 mRNA. Translation: CAA72205.1.
AJ289236
, AJ289237, AJ289238, AJ289239 Genomic DNA. Translation: CAC21950.1.
BC028685 mRNA. Translation: AAH28685.1.
CCDSiCCDS2392.1.
RefSeqiNP_001130046.1. NM_001136574.1.
NP_001130047.1. NM_001136575.1.
NP_006046.1. NM_006055.2.
UniGeneiHs.13351.

Genome annotation databases

EnsembliENST00000233714; ENSP00000233714; ENSG00000115365.
ENST00000431941; ENSP00000397646; ENSG00000115365.
ENST00000441020; ENSP00000393323; ENSG00000115365.
ENST00000443314; ENSP00000388713; ENSG00000115365.
ENST00000450366; ENSP00000393597; ENSG00000115365.
GeneIDi10314.
KEGGihsa:10314.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11395 mRNA. Translation: CAA72205.1.
AJ289236
, AJ289237, AJ289238, AJ289239 Genomic DNA. Translation: CAC21950.1.
BC028685 mRNA. Translation: AAH28685.1.
CCDSiCCDS2392.1.
RefSeqiNP_001130046.1. NM_001136574.1.
NP_001130047.1. NM_001136575.1.
NP_006046.1. NM_006055.2.
UniGeneiHs.13351.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3E6UX-ray2.60A/B/C/D1-399[»]
3E73X-ray2.80A/B1-399[»]
ProteinModelPortaliO43813.
SMRiO43813.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115599. 18 interactors.
IntActiO43813. 6 interactors.
MINTiMINT-3308405.
STRINGi9606.ENSP00000233714.

PTM databases

iPTMnetiO43813.
PhosphoSitePlusiO43813.
SwissPalmiO43813.

Polymorphism and mutation databases

BioMutaiLANCL1.

Proteomic databases

EPDiO43813.
PaxDbiO43813.
PeptideAtlasiO43813.
PRIDEiO43813.

Protocols and materials databases

DNASUi10314.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233714; ENSP00000233714; ENSG00000115365.
ENST00000431941; ENSP00000397646; ENSG00000115365.
ENST00000441020; ENSP00000393323; ENSG00000115365.
ENST00000443314; ENSP00000388713; ENSG00000115365.
ENST00000450366; ENSP00000393597; ENSG00000115365.
GeneIDi10314.
KEGGihsa:10314.

Organism-specific databases

CTDi10314.
DisGeNETi10314.
GeneCardsiLANCL1.
HGNCiHGNC:6508. LANCL1.
HPAiHPA034994.
MIMi604155. gene.
neXtProtiNX_O43813.
OpenTargetsiENSG00000115365.
PharmGKBiPA30293.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2787. Eukaryota.
ENOG410XQIA. LUCA.
GeneTreeiENSGT00530000063186.
HOGENOMiHOG000240926.
HOVERGENiHBG065387.
InParanoidiO43813.
OMAiNPYADFN.
OrthoDBiEOG091G02TS.
PhylomeDBiO43813.
TreeFamiTF300068.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115365-MONOMER.

Miscellaneous databases

ChiTaRSiLANCL1. human.
EvolutionaryTraceiO43813.
GenomeRNAii10314.
PROiO43813.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115365.
CleanExiHS_LANCL1.
ExpressionAtlasiO43813. baseline and differential.
GenevisibleiO43813. HS.

Family and domain databases

CDDicd04794. euk_LANCL. 1 hit.
Gene3Di1.50.10.10. 1 hit.
InterProiIPR012341. 6hp_glycosidase.
IPR007822. LANC-like.
IPR020464. LanC-like_prot_euk.
[Graphical view]
PfamiPF05147. LANC_like. 1 hit.
[Graphical view]
PRINTSiPR01951. LANCEUKARYTE.
PR01950. LANCSUPER.
SMARTiSM01260. LANC_like. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLANC1_HUMAN
AccessioniPrimary (citable) accession number: O43813
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was originally thought to be a G-protein coupled receptor.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.