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Protein

LanC-like protein 1

Gene

LANCL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in EPS8 signaling. Binds glutathione.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi276Zinc1
Binding sitei317Glutathione1 Publication1
Metal bindingi322Zinc1
Metal bindingi323Zinc1

GO - Molecular functioni

  • glutathione binding Source: UniProtKB
  • G-protein coupled receptor activity Source: ProtInc
  • low-density lipoprotein particle receptor binding Source: MGI
  • SH3 domain binding Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: ProtInc

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LanC-like protein 1
Alternative name(s):
40 kDa erythrocyte membrane protein
Short name:
p40
Gene namesi
Name:LANCL1
Synonyms:GPR69A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115365.11.
HGNCiHGNC:6508. LANCL1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi4R → A: Loss of glutathione binding. 1 Publication1
Mutagenesisi317K → A: Loss of glutathione binding. 1 Publication1
Mutagenesisi322C → A: Loss of glutathione binding. 1 Publication1
Mutagenesisi364R → A or E: Loss of glutathione binding. 1 Publication1

Organism-specific databases

DisGeNETi10314.
OpenTargetsiENSG00000115365.
PharmGKBiPA30293.

Polymorphism and mutation databases

BioMutaiLANCL1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedND:
ChainiPRO_00001912682 – 399LanC-like protein 1Add BLAST398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineND:1
Modified residuei142N6-acetyllysineND:1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO43813.
PaxDbiO43813.
PeptideAtlasiO43813.
PRIDEiO43813.

PTM databases

iPTMnetiO43813.
PhosphoSitePlusiO43813.
SwissPalmiO43813.

Expressioni

Tissue specificityi

Detected in erythrocytes, brain, kidney, testis, ovary, heart, lung, placenta and spleen (at protein level). Ubiquitous. Strongly expressed in brain, spinal cord, pituitary gland, kidney, heart, skeletal muscle, pancreas, ovary and testis.3 Publications

Gene expression databases

BgeeiENSG00000115365.
CleanExiHS_LANCL1.
ExpressionAtlasiO43813. baseline and differential.
GenevisibleiO43813. HS.

Organism-specific databases

HPAiHPA034994.

Interactioni

Subunit structurei

Interacts with the C-terminal of STOM. Interacts with the EPS8 SH3 domain. Interaction with EPS8 is inhibited by glutathione binding. Interacts with P.falciparum SBP1.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Eps8Q085092EBI-3046631,EBI-375596From Mus musculus.

GO - Molecular functioni

  • low-density lipoprotein particle receptor binding Source: MGI
  • SH3 domain binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115599. 20 interactors.
IntActiO43813. 8 interactors.
MINTiMINT-3308405.
STRINGi9606.ENSP00000233714.

Structurei

Secondary structure

1399
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 4ND:3
Helixi15 – 19ND:5
Helixi30 – 50ND:21
Turni51 – 53ND:3
Beta strandi61 – 64ND:4
Helixi65 – 79ND:15
Helixi82 – 96ND:15
Beta strandi106 – 109ND:4
Helixi111 – 123ND:13
Helixi127 – 138ND:12
Helixi139 – 143ND:5
Turni151 – 153ND:3
Helixi155 – 169ND:15
Helixi176 – 196ND:21
Turni197 – 202ND:6
Turni217 – 219ND:3
Helixi221 – 228ND:8
Helixi231 – 233ND:3
Helixi237 – 242ND:6
Helixi244 – 253ND:10
Beta strandi274 – 278ND:5
Helixi279 – 293ND:15
Helixi296 – 312ND:17
Turni321 – 323ND:3
Helixi325 – 339ND:15
Helixi342 – 355ND:14
Turni356 – 359ND:4
Turni372 – 374ND:3
Helixi376 – 386ND:11
Helixi389 – 391ND:3
Turni395 – 397ND:3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3E6UX-ray2.60A/B/C/D1-399[»]
3E73X-ray2.80A/B1-399[»]
ProteinModelPortaliO43813.
SMRiO43813.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43813.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni364 – 367Glutathione binding4

Sequence similaritiesi

Belongs to the LanC-like protein family.IKR:

Phylogenomic databases

eggNOGiKOG2787. Eukaryota.
ENOG410XQIA. LUCA.
GeneTreeiENSGT00530000063186.
HOGENOMiHOG000240926.
HOVERGENiHBG065387.
InParanoidiO43813.
OMAiNYPPCVD.
OrthoDBiEOG091G02TS.
PhylomeDBiO43813.
TreeFamiTF300068.

Family and domain databases

CDDicd04794. euk_LANCL. 1 hit.
InterProiView protein in InterPro
IPR007822. LANC-like.
IPR020464. LanC-like_prot_euk.
PfamiView protein in Pfam
PF05147. LANC_like. 1 hit.
PRINTSiPR01951. LANCEUKARYTE.
PR01950. LANCSUPER.
SMARTiView protein in SMART
SM01260. LANC_like. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O43813-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQRAFPNPY ADYNKSLAEG YFDAAGRLTP EFSQRLTNKI RELLQQMERG
60 70 80 90 100
LKSADPRDGT GYTGWAGIAV LYLHLYDVFG DPAYLQLAHG YVKQSLNCLT
110 120 130 140 150
KRSITFLCGD AGPLAVAAVL YHKMNNEKQA EDCITRLIHL NKIDPHAPNE
160 170 180 190 200
MLYGRIGYIY ALLFVNKNFG VEKIPQSHIQ QICETILTSG ENLARKRNFT
210 220 230 240 250
AKSPLMYEWY QEYYVGAAHG LAGIYYYLMQ PSLQVSQGKL HSLVKPSVDY
260 270 280 290 300
VCQLKFPSGN YPPCIGDNRD LLVHWCHGAP GVIYMLIQAY KVFREEKYLC
310 320 330 340 350
DAYQCADVIW QYGLLKKGYG LCHGSAGNAY AFLTLYNLTQ DMKYLYRACK
360 370 380 390
FAEWCLEYGE HGCRTPDTPF SLFEGMAGTI YFLADLLVPT KARFPAFEL
Length:399
Mass (Da):45,283
Last modified:June 1, 1998 - v1
Checksum:i2664F275F9281AF2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11395 mRNA. Translation: CAA72205.1.
AJ289236
, AJ289237, AJ289238, AJ289239 Genomic DNA. Translation: CAC21950.1.
BC028685 mRNA. Translation: AAH28685.1.
CCDSiCCDS2392.1.
RefSeqiNP_001130046.1. NM_001136574.1.
NP_001130047.1. NM_001136575.1.
NP_006046.1. NM_006055.2.
UniGeneiHs.13351.

Genome annotation databases

EnsembliENST00000233714; ENSP00000233714; ENSG00000115365.
ENST00000431941; ENSP00000397646; ENSG00000115365.
ENST00000441020; ENSP00000393323; ENSG00000115365.
ENST00000443314; ENSP00000388713; ENSG00000115365.
ENST00000450366; ENSP00000393597; ENSG00000115365.
GeneIDi10314.
KEGGihsa:10314.

Similar proteinsi

Entry informationi

Entry nameiLANC1_HUMAN
AccessioniPrimary (citable) accession number: O43813
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 1, 1998
Last modified: September 27, 2017
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was originally thought to be a G-protein coupled receptor.IKR:

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families