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Protein

Double homeobox protein 1

Gene

DUX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable transcription activator. Binds the P5 DNA element sequence 5'-GATCTGAGTCTAATTGAGAATTACTGTAC-3'.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi19 – 78Homeobox 1PROSITE-ProRule annotationAdd BLAST60
DNA bindingi94 – 153Homeobox 2PROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:G66-33198-MONOMER.

Protein family/group databases

TCDBi1.I.1.1.3. the nuclear pore complex (npc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Double homeobox protein 1
Gene namesi
Name:DUX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:3079. DUX1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi26581.
26584.
PharmGKBiPA27535.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002524101 – 170Double homeobox protein 1Add BLAST170

Proteomic databases

PeptideAtlasiO43812.
PRIDEiO43812.

Expressioni

Tissue specificityi

Expressed in rhabdomyosarcoma TE671 cells as well as in several other normal and cancer cells.1 Publication

Gene expression databases

CleanExiHS_DUX1.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DESP176614EBI-11599346,EBI-1055572

Protein-protein interaction databases

IntActiO43812. 7 interactors.

Structurei

3D structure databases

ProteinModelPortaliO43812.
SMRiO43812.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Homeobox domain 2 confers nuclear targeting.

Sequence similaritiesi

Belongs to the paired homeobox family.Curated
Contains 2 homeobox DNA-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox, Repeat

Phylogenomic databases

HOVERGENiHBG081466.
InParanoidiO43812.
PhylomeDBiO43812.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 2 hits.
[Graphical view]
PRINTSiPR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43812-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLTALDDT LPEEAQGPGR RMILLSTPSQ SDALRACFER NLYPGIATKE
60 70 80 90 100
ELAQGIDIPE PRVQIWFQNE RSCQLRQHRR QSRPWPGRRD PQKGRRKRTA
110 120 130 140 150
ITGSQTALLL RAFEKDRFPG IAAREELARE TGLPESRIQI WFQNRRARHR
160 170
GQSGRAPTQA SIRCNAAPIG
Length:170
Mass (Da):19,347
Last modified:June 1, 1998 - v1
Checksum:i7E3B34169B081F08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001481 mRNA. Translation: CAA04776.1.
RefSeqiNP_036278.1. NM_012146.1.
UniGeneiHs.274469.

Genome annotation databases

GeneIDi26584.
KEGGihsa:26584.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001481 mRNA. Translation: CAA04776.1.
RefSeqiNP_036278.1. NM_012146.1.
UniGeneiHs.274469.

3D structure databases

ProteinModelPortaliO43812.
SMRiO43812.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO43812. 7 interactors.

Protein family/group databases

TCDBi1.I.1.1.3. the nuclear pore complex (npc) family.

Proteomic databases

PeptideAtlasiO43812.
PRIDEiO43812.

Protocols and materials databases

DNASUi26584.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi26584.
KEGGihsa:26584.

Organism-specific databases

CTDi26584.
DisGeNETi26581.
26584.
GeneCardsiDUX1.
HGNCiHGNC:3079. DUX1.
MIMi611441. gene.
neXtProtiNX_O43812.
PharmGKBiPA27535.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG081466.
InParanoidiO43812.
PhylomeDBiO43812.

Enzyme and pathway databases

BioCyciZFISH:G66-33198-MONOMER.

Miscellaneous databases

GenomeRNAii26584.
PROiO43812.
SOURCEiSearch...

Gene expression databases

CleanExiHS_DUX1.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 2 hits.
[Graphical view]
PRINTSiPR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDUX1_HUMAN
AccessioniPrimary (citable) accession number: O43812
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: June 1, 1998
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

DUX genes are present in 3.3-kilobase elements, a tandem repeat family scattered in the genome found on the short arms of all acrocentric chromosomes as well as on several other chromosomes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.