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Protein

Peroxisomal membrane protein PMP34

Gene

SLC25A17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extent for nicotinamide adenine dinucleotide (NAD+), adenosine diphosphate (ADP) and adenosine 3',5'-diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD+ from the cytosol into the peroxisomal matrix by a counter-exchange mechanism. Inhibited by pyridoxal 5'-phosphate and bathophenanthroline in vitro.2 Publications

GO - Molecular functioni

  • adenine nucleotide transmembrane transporter activity Source: Reactome
  • ADP transmembrane transporter activity Source: UniProtKB
  • AMP transmembrane transporter activity Source: UniProtKB
  • ATP transmembrane transporter activity Source: BHF-UCL
  • chaperone binding Source: BHF-UCL
  • coenzyme A transmembrane transporter activity Source: UniProtKB
  • FAD transmembrane transporter activity Source: UniProtKB
  • FMN transmembrane transporter activity Source: UniProtKB
  • NAD transporter activity Source: UniProtKB

GO - Biological processi

  • ATP transport Source: BHF-UCL
  • fatty acid alpha-oxidation Source: Reactome
  • fatty acid beta-oxidation Source: BHF-UCL
  • fatty acid transport Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100372-MONOMER.
ReactomeiR-HSA-389599. Alpha-oxidation of phytanate.

Protein family/group databases

TCDBi2.A.29.20.1. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein PMP34
Alternative name(s):
34 kDa peroxisomal membrane protein
Solute carrier family 25 member 17
Gene namesi
Name:SLC25A17
Synonyms:PMP34
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:10987. SLC25A17.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9Cytoplasmic9
Transmembranei10 – 30Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini31 – 66LumenalSequence analysisAdd BLAST36
Transmembranei67 – 87Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini88 – 104CytoplasmicSequence analysisAdd BLAST17
Transmembranei105 – 125Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini126 – 160LumenalSequence analysisAdd BLAST35
Transmembranei161 – 181Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini182 – 202CytoplasmicSequence analysisAdd BLAST21
Transmembranei203 – 223Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini224 – 280LumenalSequence analysisAdd BLAST57
Transmembranei281 – 301Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini302 – 307Cytoplasmic6

GO - Cellular componenti

  • integral component of peroxisomal membrane Source: UniProtKB
  • intracellular membrane-bounded organelle Source: HPA
  • membrane Source: UniProtKB
  • mitochondrion Source: Ensembl
  • peroxisomal membrane Source: UniProtKB
  • peroxisome Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Peroxisome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi190 – 199KRQLLKKRMK → AAQLLAAAMA: Localizes in the cytoplasm. 1 Publication10
Mutagenesisi283 – 285LMF → KKK: Impairs interaction with PEX19. 1 Publication3
Mutagenesisi289 – 290EK → LL: Impairs interaction with PEX19. 1 Publication2
Mutagenesisi302 – 303KR → EE: No effect on interaction with PEX19. 1 Publication2

Organism-specific databases

OpenTargetsiENSG00000100372.
PharmGKBiPA35863.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000907051 – 307Peroxisomal membrane protein PMP34Add BLAST307

Proteomic databases

EPDiO43808.
MaxQBiO43808.
PaxDbiO43808.
PeptideAtlasiO43808.
PRIDEiO43808.

PTM databases

iPTMnetiO43808.
PhosphoSitePlusiO43808.

Expressioni

Tissue specificityi

Ubiquitous. Expressed in liver.1 Publication

Gene expression databases

BgeeiENSG00000100372.
CleanExiHS_SLC25A17.
ExpressionAtlasiO43808. baseline and differential.
GenevisibleiO43808. HS.

Organism-specific databases

HPAiHPA052708.
HPA060972.

Interactioni

Subunit structurei

Interacts (via N- and C-terminus peroxisomal targeting regions) with PEX19; the interaction occurs with the newly synthesized SLC25A17 in the cytosol.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PEX19P408554EBI-594912,EBI-594747

GO - Molecular functioni

  • chaperone binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi115741. 30 interactors.
IntActiO43808. 3 interactors.
STRINGi9606.ENSP00000390722.

Structurei

3D structure databases

ProteinModelPortaliO43808.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati7 – 92Solcar 1Add BLAST86
Repeati99 – 192Solcar 2Add BLAST94
Repeati200 – 294Solcar 3Add BLAST95

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 147Necessary for targeting to peroxisomes and interaction with PEX19Add BLAST147
Regioni244 – 307Necessary for targeting to peroxisomes and interaction with PEX19Add BLAST64

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi190 – 199Peroxisome localization signal10

Domaini

The N- and C-terminal portions are exposed to the cytoplasm. Lacks a typical peroxisomal sorting signal. A region between helical transmembrane domains (TM) 4 and 5 and TM1-TM3 or TM4-TM6 are necessary for the peroxisome-targeting activity.

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0769. Eukaryota.
ENOG410ZNC0. LUCA.
GeneTreeiENSGT00770000120566.
HOGENOMiHOG000159426.
HOVERGENiHBG003235.
InParanoidiO43808.
KOiK13354.
OMAiMGLKSAH.
OrthoDBiEOG091G0DMQ.
PhylomeDBiO43808.
TreeFamiTF324772.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43808-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVLSYESL VHAVAGAVGS VTAMTVFFPL DTARLRLQVD EKRKSKTTHM
60 70 80 90 100
VLLEIIKEEG LLAPYRGWFP VISSLCCSNF VYFYTFNSLK ALWVKGQHST
110 120 130 140 150
TGKDLVVGFV AGVVNVLLTT PLWVVNTRLK LQGAKFRNED IVPTNYKGII
160 170 180 190 200
DAFHQIIRDE GISALWNGTF PSLLLVFNPA IQFMFYEGLK RQLLKKRMKL
210 220 230 240 250
SSLDVFIIGA VAKAIATTVT YPLQTVQSIL RFGRHRLNPE NRTLGSLRNI
260 270 280 290 300
LYLLHQRVRR FGIMGLYKGL EAKLLQTVLT AALMFLVYEK LTAATFTVMG

LKRAHQH
Length:307
Mass (Da):34,567
Last modified:June 1, 1998 - v1
Checksum:iB7043D82966D47A5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05013998H → R.Corresponds to variant rs12159334dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12860 mRNA. Translation: CAA73367.1.
CR456577 mRNA. Translation: CAG30463.1.
AK292924 mRNA. Translation: BAF85613.1.
AL049764, Z98048 Genomic DNA. Translation: CAI20333.1.
Z98048, AL049764 Genomic DNA. Translation: CAI20491.1.
CH471095 Genomic DNA. Translation: EAW60390.1.
BC005957 mRNA. Translation: AAH05957.1.
BC012998 mRNA. Translation: AAH12998.1.
CCDSiCCDS14005.1.
RefSeqiNP_001269656.1. NM_001282727.1.
NP_006349.1. NM_006358.3.
UniGeneiHs.474938.

Genome annotation databases

EnsembliENST00000435456; ENSP00000390722; ENSG00000100372.
GeneIDi10478.
KEGGihsa:10478.
UCSCiuc003azc.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12860 mRNA. Translation: CAA73367.1.
CR456577 mRNA. Translation: CAG30463.1.
AK292924 mRNA. Translation: BAF85613.1.
AL049764, Z98048 Genomic DNA. Translation: CAI20333.1.
Z98048, AL049764 Genomic DNA. Translation: CAI20491.1.
CH471095 Genomic DNA. Translation: EAW60390.1.
BC005957 mRNA. Translation: AAH05957.1.
BC012998 mRNA. Translation: AAH12998.1.
CCDSiCCDS14005.1.
RefSeqiNP_001269656.1. NM_001282727.1.
NP_006349.1. NM_006358.3.
UniGeneiHs.474938.

3D structure databases

ProteinModelPortaliO43808.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115741. 30 interactors.
IntActiO43808. 3 interactors.
STRINGi9606.ENSP00000390722.

Protein family/group databases

TCDBi2.A.29.20.1. the mitochondrial carrier (mc) family.

PTM databases

iPTMnetiO43808.
PhosphoSitePlusiO43808.

Proteomic databases

EPDiO43808.
MaxQBiO43808.
PaxDbiO43808.
PeptideAtlasiO43808.
PRIDEiO43808.

Protocols and materials databases

DNASUi10478.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000435456; ENSP00000390722; ENSG00000100372.
GeneIDi10478.
KEGGihsa:10478.
UCSCiuc003azc.5. human.

Organism-specific databases

CTDi10478.
GeneCardsiSLC25A17.
HGNCiHGNC:10987. SLC25A17.
HPAiHPA052708.
HPA060972.
MIMi606795. gene.
neXtProtiNX_O43808.
OpenTargetsiENSG00000100372.
PharmGKBiPA35863.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0769. Eukaryota.
ENOG410ZNC0. LUCA.
GeneTreeiENSGT00770000120566.
HOGENOMiHOG000159426.
HOVERGENiHBG003235.
InParanoidiO43808.
KOiK13354.
OMAiMGLKSAH.
OrthoDBiEOG091G0DMQ.
PhylomeDBiO43808.
TreeFamiTF324772.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100372-MONOMER.
ReactomeiR-HSA-389599. Alpha-oxidation of phytanate.

Miscellaneous databases

GeneWikiiSLC25A17.
GenomeRNAii10478.
PROiO43808.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100372.
CleanExiHS_SLC25A17.
ExpressionAtlasiO43808. baseline and differential.
GenevisibleiO43808. HS.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPM34_HUMAN
AccessioniPrimary (citable) accession number: O43808
Secondary accession number(s): A8KA59
, Q5TFL0, Q9UGW8, Q9UGY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was first identified as a peroxisomal ATP transporter (PubMed:12445829). However, later experiments showed that it acts as a peroxisomal transporter for multiple cofactors (PubMed:22185573).2 Publications

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.