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Protein

Peroxisomal membrane protein PMP34

Gene

SLC25A17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extent for nicotinamide adenine dinucleotide (NAD+), adenosine diphosphate (ADP) and adenosine 3',5'-diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD+ from the cytosol into the peroxisomal matrix by a counter-exchange mechanism. Inhibited by pyridoxal 5'-phosphate and bathophenanthroline in vitro.2 Publications

Caution

Was first identified as a peroxisomal ATP transporter (PubMed:12445829). However, later experiments showed that it acts as a peroxisomal transporter for multiple cofactors (PubMed:22185573).2 Publications

GO - Molecular functioni

  • adenine nucleotide transmembrane transporter activity Source: Reactome
  • ADP transmembrane transporter activity Source: UniProtKB
  • AMP transmembrane transporter activity Source: UniProtKB
  • ATP transmembrane transporter activity Source: BHF-UCL
  • chaperone binding Source: BHF-UCL
  • coenzyme A transmembrane transporter activity Source: UniProtKB
  • FAD transmembrane transporter activity Source: UniProtKB
  • FMN transmembrane transporter activity Source: UniProtKB
  • NAD transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  • ATP transport Source: BHF-UCL
  • fatty acid alpha-oxidation Source: Reactome
  • fatty acid beta-oxidation Source: BHF-UCL
  • fatty acid transport Source: BHF-UCL
  • mitochondrial transport Source: GO_Central

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-HSA-389599 Alpha-oxidation of phytanate

Protein family/group databases

TCDBi2.A.29.20.1 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein PMP34
Alternative name(s):
34 kDa peroxisomal membrane protein
Solute carrier family 25 member 17
Gene namesi
Name:SLC25A17
Synonyms:PMP34
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100372.14
HGNCiHGNC:10987 SLC25A17
MIMi606795 gene
neXtProtiNX_O43808

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9Cytoplasmic9
Transmembranei10 – 30Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini31 – 66LumenalSequence analysisAdd BLAST36
Transmembranei67 – 87Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini88 – 104CytoplasmicSequence analysisAdd BLAST17
Transmembranei105 – 125Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini126 – 160LumenalSequence analysisAdd BLAST35
Transmembranei161 – 181Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini182 – 202CytoplasmicSequence analysisAdd BLAST21
Transmembranei203 – 223Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini224 – 280LumenalSequence analysisAdd BLAST57
Transmembranei281 – 301Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini302 – 307Cytoplasmic6

Keywords - Cellular componenti

Cytoplasm, Membrane, Peroxisome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi190 – 199KRQLLKKRMK → AAQLLAAAMA: Localizes in the cytoplasm. 1 Publication10
Mutagenesisi283 – 285LMF → KKK: Impairs interaction with PEX19. 1 Publication3
Mutagenesisi289 – 290EK → LL: Impairs interaction with PEX19. 1 Publication2
Mutagenesisi302 – 303KR → EE: No effect on interaction with PEX19. 1 Publication2

Organism-specific databases

OpenTargetsiENSG00000100372
PharmGKBiPA35863

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000907051 – 307Peroxisomal membrane protein PMP34Add BLAST307

Proteomic databases

EPDiO43808
MaxQBiO43808
PaxDbiO43808
PeptideAtlasiO43808
PRIDEiO43808

PTM databases

iPTMnetiO43808
PhosphoSitePlusiO43808

Expressioni

Tissue specificityi

Ubiquitous. Expressed in liver.1 Publication

Gene expression databases

BgeeiENSG00000100372
CleanExiHS_SLC25A17
ExpressionAtlasiO43808 baseline and differential
GenevisibleiO43808 HS

Organism-specific databases

HPAiHPA052708
HPA060972

Interactioni

Subunit structurei

Interacts (via N- and C-terminus peroxisomal targeting regions) with PEX19; the interaction occurs with the newly synthesized SLC25A17 in the cytosol.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PEX19P408554EBI-594912,EBI-594747

GO - Molecular functioni

  • chaperone binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi115741, 33 interactors
IntActiO43808, 3 interactors
STRINGi9606.ENSP00000390722

Structurei

3D structure databases

ProteinModelPortaliO43808
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati7 – 92Solcar 1Add BLAST86
Repeati99 – 192Solcar 2Add BLAST94
Repeati200 – 294Solcar 3Add BLAST95

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 147Necessary for targeting to peroxisomes and interaction with PEX19Add BLAST147
Regioni244 – 307Necessary for targeting to peroxisomes and interaction with PEX19Add BLAST64

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi190 – 199Peroxisome localization signal10

Domaini

The N- and C-terminal portions are exposed to the cytoplasm. Lacks a typical peroxisomal sorting signal. A region between helical transmembrane domains (TM) 4 and 5 and TM1-TM3 or TM4-TM6 are necessary for the peroxisome-targeting activity.

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0769 Eukaryota
ENOG410ZNC0 LUCA
GeneTreeiENSGT00910000144149
HOGENOMiHOG000159426
HOVERGENiHBG003235
InParanoidiO43808
KOiK13354
OMAiYITVKSQ
OrthoDBiEOG091G0DMQ
PhylomeDBiO43808
TreeFamiTF324772

Family and domain databases

Gene3Di1.50.40.10, 2 hits
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

O43808-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVLSYESL VHAVAGAVGS VTAMTVFFPL DTARLRLQVD EKRKSKTTHM
60 70 80 90 100
VLLEIIKEEG LLAPYRGWFP VISSLCCSNF VYFYTFNSLK ALWVKGQHST
110 120 130 140 150
TGKDLVVGFV AGVVNVLLTT PLWVVNTRLK LQGAKFRNED IVPTNYKGII
160 170 180 190 200
DAFHQIIRDE GISALWNGTF PSLLLVFNPA IQFMFYEGLK RQLLKKRMKL
210 220 230 240 250
SSLDVFIIGA VAKAIATTVT YPLQTVQSIL RFGRHRLNPE NRTLGSLRNI
260 270 280 290 300
LYLLHQRVRR FGIMGLYKGL EAKLLQTVLT AALMFLVYEK LTAATFTVMG

LKRAHQH
Length:307
Mass (Da):34,567
Last modified:June 1, 1998 - v1
Checksum:iB7043D82966D47A5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05013998H → R. Corresponds to variant dbSNP:rs12159334Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12860 mRNA Translation: CAA73367.1
CR456577 mRNA Translation: CAG30463.1
AK292924 mRNA Translation: BAF85613.1
AL049764 Genomic DNA No translation available.
Z98048 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60390.1
BC005957 mRNA Translation: AAH05957.1
BC012998 mRNA Translation: AAH12998.1
CCDSiCCDS14005.1
RefSeqiNP_001269656.1, NM_001282727.1
NP_006349.1, NM_006358.3
UniGeneiHs.474938

Genome annotation databases

EnsembliENST00000435456; ENSP00000390722; ENSG00000100372
GeneIDi10478
KEGGihsa:10478
UCSCiuc003azc.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPM34_HUMAN
AccessioniPrimary (citable) accession number: O43808
Secondary accession number(s): A8KA59
, Q5TFL0, Q9UGW8, Q9UGY7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: June 1, 1998
Last modified: February 28, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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