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O43808

- PM34_HUMAN

UniProt

O43808 - PM34_HUMAN

Protein

Peroxisomal membrane protein PMP34

Gene

SLC25A17

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extend for nicotinamide adenine dinucleotide (NAD+), adenosine diphosphate (ADP) and adenosine 3',5'-diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD+ from the cytosol into the peroxisomal matrix by a counter-exchange mechanism. Inhibited by pyridoxal 5'-phosphate and bathophenanthroline in vitro.2 Publications

    GO - Molecular functioni

    1. ADP transmembrane transporter activity Source: UniProtKB
    2. AMP transmembrane transporter activity Source: UniProtKB
    3. ATP transmembrane transporter activity Source: BHF-UCL
    4. chaperone binding Source: BHF-UCL
    5. coenzyme A transmembrane transporter activity Source: UniProtKB
    6. FAD transmembrane transporter activity Source: UniProtKB
    7. FMN transmembrane transporter activity Source: UniProtKB
    8. NAD transporter activity Source: UniProtKB
    9. protein binding Source: UniProtKB

    GO - Biological processi

    1. ADP transport Source: GOC
    2. AMP transport Source: GOC
    3. ATP transport Source: BHF-UCL
    4. cellular lipid metabolic process Source: Reactome
    5. coenzyme A transmembrane transport Source: GOC
    6. FAD transmembrane transport Source: GOC
    7. fatty acid alpha-oxidation Source: Reactome
    8. fatty acid beta-oxidation Source: BHF-UCL
    9. fatty acid transport Source: BHF-UCL
    10. NAD transport Source: GOC
    11. nucleotide transmembrane transport Source: GOC
    12. small molecule metabolic process Source: Reactome

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    ReactomeiREACT_17003. Alpha-oxidation of phytanate.

    Protein family/group databases

    TCDBi2.A.29.20.1. the mitochondrial carrier (mc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peroxisomal membrane protein PMP34
    Alternative name(s):
    34 kDa peroxisomal membrane protein
    Solute carrier family 25 member 17
    Gene namesi
    Name:SLC25A17
    Synonyms:PMP34
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:10987. SLC25A17.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of peroxisomal membrane Source: UniProtKB
    2. intracellular membrane-bounded organelle Source: HPA
    3. membrane Source: UniProtKB
    4. mitochondrion Source: Ensembl
    5. peroxisomal membrane Source: UniProtKB
    6. peroxisome Source: BHF-UCL

    Keywords - Cellular componenti

    Cytoplasm, Membrane, Peroxisome

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi190 – 19910KRQLLKKRMK → AAQLLAAAMA: Localizes in the cytoplasm.
    Mutagenesisi283 – 2853LMF → KKK: Impairs interaction with PEX19.
    Mutagenesisi289 – 2902EK → LL: Impairs interaction with PEX19.
    Mutagenesisi302 – 3032KR → EE: No effect on interaction with PEX19.

    Organism-specific databases

    PharmGKBiPA35863.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 307307Peroxisomal membrane protein PMP34PRO_0000090705Add
    BLAST

    Proteomic databases

    MaxQBiO43808.
    PaxDbiO43808.
    PRIDEiO43808.

    PTM databases

    PhosphoSiteiO43808.

    Expressioni

    Tissue specificityi

    Ubiquitous. Expressed in liver.1 Publication

    Gene expression databases

    ArrayExpressiO43808.
    BgeeiO43808.
    CleanExiHS_SLC25A17.
    GenevestigatoriO43808.

    Organism-specific databases

    HPAiHPA052708.

    Interactioni

    Subunit structurei

    Interacts (via N- and C-terminus peroxisomal targeting regions) with PEX19; the interaction occurs with the newly synthesized SLC25A17 in the cytosol.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PEX19P408554EBI-594912,EBI-594747

    Protein-protein interaction databases

    BioGridi115741. 11 interactions.
    IntActiO43808. 1 interaction.
    STRINGi9606.ENSP00000390722.

    Structurei

    3D structure databases

    ProteinModelPortaliO43808.
    SMRiO43808. Positions 9-297.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 99Cytoplasmic
    Topological domaini31 – 6636LumenalSequence AnalysisAdd
    BLAST
    Topological domaini88 – 10417CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini126 – 16035LumenalSequence AnalysisAdd
    BLAST
    Topological domaini182 – 20221CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini224 – 28057LumenalSequence AnalysisAdd
    BLAST
    Topological domaini302 – 3076Cytoplasmic

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei67 – 8721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei105 – 12521Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei161 – 18121Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei203 – 22321Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei281 – 30121Helical; Name=6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati7 – 9286Solcar 1Add
    BLAST
    Repeati99 – 19294Solcar 2Add
    BLAST
    Repeati200 – 29495Solcar 3Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 147147Necessary for targeting to peroxisomes and interaction with PEX19Add
    BLAST
    Regioni244 – 30764Necessary for targeting to peroxisomes and interaction with PEX19Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi190 – 19910Peroxisome localization signal

    Domaini

    The N- and C-terminal portions are exposed to the cytoplasm. Lacks a typical peroxisomal sorting signal. A region between helical transmembrane domains (TM) 4 and 5 and TM1-TM3 or TM4-TM6 are necessary for the peroxisome-targeting activity.

    Sequence similaritiesi

    Contains 3 Solcar repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG258628.
    HOGENOMiHOG000159426.
    HOVERGENiHBG003235.
    InParanoidiO43808.
    KOiK13354.
    OMAiVGMLSWL.
    PhylomeDBiO43808.
    TreeFamiTF324772.

    Family and domain databases

    Gene3Di1.50.40.10. 1 hit.
    InterProiIPR002067. Mit_carrier.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view]
    PfamiPF00153. Mito_carr. 3 hits.
    [Graphical view]
    PRINTSiPR00926. MITOCARRIER.
    SUPFAMiSSF103506. SSF103506. 1 hit.
    PROSITEiPS50920. SOLCAR. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O43808-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASVLSYESL VHAVAGAVGS VTAMTVFFPL DTARLRLQVD EKRKSKTTHM    50
    VLLEIIKEEG LLAPYRGWFP VISSLCCSNF VYFYTFNSLK ALWVKGQHST 100
    TGKDLVVGFV AGVVNVLLTT PLWVVNTRLK LQGAKFRNED IVPTNYKGII 150
    DAFHQIIRDE GISALWNGTF PSLLLVFNPA IQFMFYEGLK RQLLKKRMKL 200
    SSLDVFIIGA VAKAIATTVT YPLQTVQSIL RFGRHRLNPE NRTLGSLRNI 250
    LYLLHQRVRR FGIMGLYKGL EAKLLQTVLT AALMFLVYEK LTAATFTVMG 300
    LKRAHQH 307
    Length:307
    Mass (Da):34,567
    Last modified:June 1, 1998 - v1
    Checksum:iB7043D82966D47A5
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti98 – 981H → R.
    Corresponds to variant rs12159334 [ dbSNP | Ensembl ].
    VAR_050139

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y12860 mRNA. Translation: CAA73367.1.
    CR456577 mRNA. Translation: CAG30463.1.
    AK292924 mRNA. Translation: BAF85613.1.
    AL049764, Z98048 Genomic DNA. Translation: CAI20333.1.
    Z98048, AL049764 Genomic DNA. Translation: CAI20491.1.
    CH471095 Genomic DNA. Translation: EAW60390.1.
    BC005957 mRNA. Translation: AAH05957.1.
    BC012998 mRNA. Translation: AAH12998.1.
    CCDSiCCDS14005.1.
    RefSeqiNP_001269656.1. NM_001282727.1.
    NP_006349.1. NM_006358.3.
    UniGeneiHs.474938.

    Genome annotation databases

    EnsembliENST00000435456; ENSP00000390722; ENSG00000100372.
    GeneIDi10478.
    KEGGihsa:10478.
    UCSCiuc003azc.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y12860 mRNA. Translation: CAA73367.1 .
    CR456577 mRNA. Translation: CAG30463.1 .
    AK292924 mRNA. Translation: BAF85613.1 .
    AL049764 , Z98048 Genomic DNA. Translation: CAI20333.1 .
    Z98048 , AL049764 Genomic DNA. Translation: CAI20491.1 .
    CH471095 Genomic DNA. Translation: EAW60390.1 .
    BC005957 mRNA. Translation: AAH05957.1 .
    BC012998 mRNA. Translation: AAH12998.1 .
    CCDSi CCDS14005.1.
    RefSeqi NP_001269656.1. NM_001282727.1.
    NP_006349.1. NM_006358.3.
    UniGenei Hs.474938.

    3D structure databases

    ProteinModelPortali O43808.
    SMRi O43808. Positions 9-297.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115741. 11 interactions.
    IntActi O43808. 1 interaction.
    STRINGi 9606.ENSP00000390722.

    Protein family/group databases

    TCDBi 2.A.29.20.1. the mitochondrial carrier (mc) family.

    PTM databases

    PhosphoSitei O43808.

    Proteomic databases

    MaxQBi O43808.
    PaxDbi O43808.
    PRIDEi O43808.

    Protocols and materials databases

    DNASUi 10478.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000435456 ; ENSP00000390722 ; ENSG00000100372 .
    GeneIDi 10478.
    KEGGi hsa:10478.
    UCSCi uc003azc.3. human.

    Organism-specific databases

    CTDi 10478.
    GeneCardsi GC22M041165.
    HGNCi HGNC:10987. SLC25A17.
    HPAi HPA052708.
    MIMi 606795. gene.
    neXtProti NX_O43808.
    PharmGKBi PA35863.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG258628.
    HOGENOMi HOG000159426.
    HOVERGENi HBG003235.
    InParanoidi O43808.
    KOi K13354.
    OMAi VGMLSWL.
    PhylomeDBi O43808.
    TreeFami TF324772.

    Enzyme and pathway databases

    Reactomei REACT_17003. Alpha-oxidation of phytanate.

    Miscellaneous databases

    GeneWikii SLC25A17.
    GenomeRNAii 10478.
    NextBioi 39748.
    PROi O43808.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O43808.
    Bgeei O43808.
    CleanExi HS_SLC25A17.
    Genevestigatori O43808.

    Family and domain databases

    Gene3Di 1.50.40.10. 1 hit.
    InterProi IPR002067. Mit_carrier.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view ]
    Pfami PF00153. Mito_carr. 3 hits.
    [Graphical view ]
    PRINTSi PR00926. MITOCARRIER.
    SUPFAMi SSF103506. SSF103506. 1 hit.
    PROSITEi PS50920. SOLCAR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of human PMP34, a protein closely related to the peroxisomal integral membrane protein PMP47 of Candida boidinii."
      Wylin T., Baes M., Brees C., Mannaerts G.P., Fransen M., Van Veldhoven P.P.
      Eur. J. Biochem. 258:332-338(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Trachea.
    4. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin and Uterus.
    7. "PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis."
      Sacksteder K.A., Jones J.M., South S.T., Li X., Liu Y., Gould S.J.
      J. Cell Biol. 148:931-944(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PEX19.
    8. "Topogenesis of peroxisomal membrane protein requires a short, positively charged intervening-loop sequence and flanking hydrophobic segments: study using human membrane protein PMP34."
      Honsho M., Fujiki Y.
      J. Biol. Chem. 276:9375-9382(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TOPOLOGY, MUTAGENESIS OF 190-LYS--LYS-199.
    9. "Multiple distinct targeting signals in integral peroxisomal membrane proteins."
      Jones J.M., Morrell J.C., Gould S.J.
      J. Cell Biol. 153:1141-1150(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PEX19, TOPOLOGY, SUBCELLULAR LOCATION, PEROXISOMAL TARGETING.
    10. Cited for: FUNCTION.
    11. "PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins."
      Jones J.M., Morrell J.C., Gould S.J.
      J. Cell Biol. 164:57-67(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PEX19, SUBCELLULAR LOCATION, MUTAGENESIS OF 283-LEU--PHE-285; 289-GLU-LYS-290 AND 302-LYS-GLU-303.
    12. "The human gene SLC25A17 encodes a peroxisomal transporter of coenzyme A, FAD and NAD+."
      Agrimi G., Russo A., Scarcia P., Palmieri F.
      Biochem. J. 443:241-247(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiPM34_HUMAN
    AccessioniPrimary (citable) accession number: O43808
    Secondary accession number(s): A8KA59
    , Q5TFL0, Q9UGW8, Q9UGY7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Was first identified as a peroxisomal ATP transporter (PubMed:12445829). However, later experiments showed that it acts as a peroxisomal transporter for multiple cofactors (PubMed:22185573).2 Publications

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3