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Protein

Sjoegren syndrome nuclear autoantigen 1

Gene

SSNA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176101-MONOMER.
ReactomeiR-HSA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-HSA-380259. Loss of Nlp from mitotic centrosomes.
R-HSA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-HSA-5620912. Anchoring of the basal body to the plasma membrane.
R-HSA-8854518. AURKA Activation by TPX2.

Names & Taxonomyi

Protein namesi
Recommended name:
Sjoegren syndrome nuclear autoantigen 1
Alternative name(s):
Nuclear autoantigen of 14 kDa
Gene namesi
Name:SSNA1
Synonyms:NA14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:11321. SSNA1.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • ciliary basal body Source: Ensembl
  • cytosol Source: Reactome
  • nucleus Source: ProtInc
  • plasma membrane Source: GOC
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8636.
OpenTargetsiENSG00000176101.
PharmGKBiPA36145.

Polymorphism and mutation databases

BioMutaiSSNA1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001144832 – 119Sjoegren syndrome nuclear autoantigen 1Add BLAST118

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO43805.
MaxQBiO43805.
PaxDbiO43805.
PeptideAtlasiO43805.
PRIDEiO43805.

PTM databases

iPTMnetiO43805.
PhosphoSitePlusiO43805.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000176101.
CleanExiHS_SSNA1.
ExpressionAtlasiO43805. baseline and differential.
GenevisibleiO43805. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself8EBI-2515299,EBI-2515299
EHHADHQ084263EBI-2515299,EBI-2339219
GOPCQ9HD263EBI-2515299,EBI-349832
LCA5Q86VQ02EBI-2515299,EBI-6658186
LNX1Q8TBB15EBI-2515299,EBI-739832
SDCBPO005605EBI-2515299,EBI-727004
TBC1D7Q9P0N95EBI-2515299,EBI-3258000
TCEANCQ8N8B73EBI-2515299,EBI-954696
TXN2Q997575EBI-2515299,EBI-2932492

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi114189. 19 interactors.
IntActiO43805. 14 interactors.
STRINGi9606.ENSP00000313752.

Structurei

3D structure databases

ProteinModelPortaliO43805.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili13 – 70Sequence analysisAdd BLAST58

Sequence similaritiesi

Belongs to the SSNA1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IYU9. Eukaryota.
ENOG4111N70. LUCA.
GeneTreeiENSGT00390000012318.
HOGENOMiHOG000231490.
HOVERGENiHBG055234.
InParanoidiO43805.
KOiK16780.
OMAiHDIRVLT.
OrthoDBiEOG091G11LK.
PhylomeDBiO43805.
TreeFamiTF328451.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR033362. SSNA1_fam.
[Graphical view]
PANTHERiPTHR28661. PTHR28661. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O43805-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQQGAALQN YNNELVKCIE ELCQKREELC RQIQEEEDEK QRLQNEVRQL
60 70 80 90 100
TEKLARVNEN LARKIASRNE FDRTIAETEA AYLKILESSQ TLLSVLKREA
110
GNLTKATAPD QKSSGGRDS
Length:119
Mass (Da):13,596
Last modified:September 13, 2004 - v2
Checksum:i6BB9BB96580DB807
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57V → A in CAG47034 (Ref. 3) Curated1
Sequence conflicti89S → F in CAB09660 (PubMed:9430706).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03634317K → N in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z96932 mRNA. Translation: CAB09660.1.
BT006766 mRNA. Translation: AAP35412.1.
CR542238 mRNA. Translation: CAG47034.1.
AL929554 Genomic DNA. Translation: CAH72882.1.
CH471090 Genomic DNA. Translation: EAW88362.1.
BC000864 mRNA. Translation: AAH00864.1.
CCDSiCCDS7034.1.
RefSeqiNP_003722.2. NM_003731.2.
UniGeneiHs.530314.

Genome annotation databases

EnsembliENST00000322310; ENSP00000313752; ENSG00000176101.
GeneIDi8636.
KEGGihsa:8636.
UCSCiuc004cls.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z96932 mRNA. Translation: CAB09660.1.
BT006766 mRNA. Translation: AAP35412.1.
CR542238 mRNA. Translation: CAG47034.1.
AL929554 Genomic DNA. Translation: CAH72882.1.
CH471090 Genomic DNA. Translation: EAW88362.1.
BC000864 mRNA. Translation: AAH00864.1.
CCDSiCCDS7034.1.
RefSeqiNP_003722.2. NM_003731.2.
UniGeneiHs.530314.

3D structure databases

ProteinModelPortaliO43805.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114189. 19 interactors.
IntActiO43805. 14 interactors.
STRINGi9606.ENSP00000313752.

PTM databases

iPTMnetiO43805.
PhosphoSitePlusiO43805.

Polymorphism and mutation databases

BioMutaiSSNA1.

Proteomic databases

EPDiO43805.
MaxQBiO43805.
PaxDbiO43805.
PeptideAtlasiO43805.
PRIDEiO43805.

Protocols and materials databases

DNASUi8636.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322310; ENSP00000313752; ENSG00000176101.
GeneIDi8636.
KEGGihsa:8636.
UCSCiuc004cls.3. human.

Organism-specific databases

CTDi8636.
DisGeNETi8636.
GeneCardsiSSNA1.
HGNCiHGNC:11321. SSNA1.
MIMi610882. gene.
neXtProtiNX_O43805.
OpenTargetsiENSG00000176101.
PharmGKBiPA36145.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYU9. Eukaryota.
ENOG4111N70. LUCA.
GeneTreeiENSGT00390000012318.
HOGENOMiHOG000231490.
HOVERGENiHBG055234.
InParanoidiO43805.
KOiK16780.
OMAiHDIRVLT.
OrthoDBiEOG091G11LK.
PhylomeDBiO43805.
TreeFamiTF328451.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176101-MONOMER.
ReactomeiR-HSA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-HSA-380259. Loss of Nlp from mitotic centrosomes.
R-HSA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-HSA-5620912. Anchoring of the basal body to the plasma membrane.
R-HSA-8854518. AURKA Activation by TPX2.

Miscellaneous databases

ChiTaRSiSSNA1. human.
GenomeRNAii8636.
PROiO43805.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000176101.
CleanExiHS_SSNA1.
ExpressionAtlasiO43805. baseline and differential.
GenevisibleiO43805. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR033362. SSNA1_fam.
[Graphical view]
PANTHERiPTHR28661. PTHR28661. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSSNA1_HUMAN
AccessioniPrimary (citable) accession number: O43805
Secondary accession number(s): Q5VSG0, Q6FG70, Q9BVW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 13, 2004
Last modified: November 30, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.