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Protein

Sjoegren syndrome nuclear autoantigen 1

Gene

SSNA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-HSA-380259. Loss of Nlp from mitotic centrosomes.
R-HSA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-HSA-5620912. Anchoring of the basal body to the plasma membrane.
R-HSA-8854518. AURKA Activation by TPX2.

Names & Taxonomyi

Protein namesi
Recommended name:
Sjoegren syndrome nuclear autoantigen 1
Alternative name(s):
Nuclear autoantigen of 14 kDa
Gene namesi
Name:SSNA1
Synonyms:NA14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:11321. SSNA1.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • ciliary basal body Source: Ensembl
  • cytosol Source: Reactome
  • nucleus Source: ProtInc
  • plasma membrane Source: GOC
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36145.

Polymorphism and mutation databases

BioMutaiSSNA1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 119118Sjoegren syndrome nuclear autoantigen 1PRO_0000114483Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylthreonineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO43805.
MaxQBiO43805.
PaxDbiO43805.
PeptideAtlasiO43805.
PRIDEiO43805.

PTM databases

iPTMnetiO43805.
PhosphoSiteiO43805.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiO43805.
CleanExiHS_SSNA1.
ExpressionAtlasiO43805. baseline and differential.
GenevisibleiO43805. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EHHADHQ084263EBI-2515299,EBI-2339219
GOPCQ9HD263EBI-2515299,EBI-349832
LNX1Q8TBB13EBI-2515299,EBI-739832
SDCBPO005603EBI-2515299,EBI-727004
TBC1D7Q9P0N93EBI-2515299,EBI-3258000
TCEANCQ8N8B73EBI-2515299,EBI-954696
TXN2Q997573EBI-2515299,EBI-2932492

Protein-protein interaction databases

BioGridi114189. 19 interactions.
IntActiO43805. 8 interactions.
STRINGi9606.ENSP00000313752.

Structurei

3D structure databases

ProteinModelPortaliO43805.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili13 – 7058Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the SSNA1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IYU9. Eukaryota.
ENOG4111N70. LUCA.
GeneTreeiENSGT00390000012318.
HOGENOMiHOG000231490.
HOVERGENiHBG055234.
InParanoidiO43805.
KOiK16780.
OMAiHDIRVLT.
OrthoDBiEOG7KSXC9.
PhylomeDBiO43805.
TreeFamiTF328451.

Family and domain databases

InterProiIPR033362. SSNA1_fam.
[Graphical view]
PANTHERiPTHR28661. PTHR28661. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O43805-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQQGAALQN YNNELVKCIE ELCQKREELC RQIQEEEDEK QRLQNEVRQL
60 70 80 90 100
TEKLARVNEN LARKIASRNE FDRTIAETEA AYLKILESSQ TLLSVLKREA
110
GNLTKATAPD QKSSGGRDS
Length:119
Mass (Da):13,596
Last modified:September 13, 2004 - v2
Checksum:i6BB9BB96580DB807
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti57 – 571V → A in CAG47034 (Ref. 3) Curated
Sequence conflicti89 – 891S → F in CAB09660 (PubMed:9430706).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti17 – 171K → N in a breast cancer sample; somatic mutation. 1 Publication
VAR_036343

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z96932 mRNA. Translation: CAB09660.1.
BT006766 mRNA. Translation: AAP35412.1.
CR542238 mRNA. Translation: CAG47034.1.
AL929554 Genomic DNA. Translation: CAH72882.1.
CH471090 Genomic DNA. Translation: EAW88362.1.
BC000864 mRNA. Translation: AAH00864.1.
CCDSiCCDS7034.1.
RefSeqiNP_003722.2. NM_003731.2.
UniGeneiHs.530314.

Genome annotation databases

EnsembliENST00000322310; ENSP00000313752; ENSG00000176101.
GeneIDi8636.
KEGGihsa:8636.
UCSCiuc004cls.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z96932 mRNA. Translation: CAB09660.1.
BT006766 mRNA. Translation: AAP35412.1.
CR542238 mRNA. Translation: CAG47034.1.
AL929554 Genomic DNA. Translation: CAH72882.1.
CH471090 Genomic DNA. Translation: EAW88362.1.
BC000864 mRNA. Translation: AAH00864.1.
CCDSiCCDS7034.1.
RefSeqiNP_003722.2. NM_003731.2.
UniGeneiHs.530314.

3D structure databases

ProteinModelPortaliO43805.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114189. 19 interactions.
IntActiO43805. 8 interactions.
STRINGi9606.ENSP00000313752.

PTM databases

iPTMnetiO43805.
PhosphoSiteiO43805.

Polymorphism and mutation databases

BioMutaiSSNA1.

Proteomic databases

EPDiO43805.
MaxQBiO43805.
PaxDbiO43805.
PeptideAtlasiO43805.
PRIDEiO43805.

Protocols and materials databases

DNASUi8636.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322310; ENSP00000313752; ENSG00000176101.
GeneIDi8636.
KEGGihsa:8636.
UCSCiuc004cls.3. human.

Organism-specific databases

CTDi8636.
GeneCardsiSSNA1.
HGNCiHGNC:11321. SSNA1.
MIMi610882. gene.
neXtProtiNX_O43805.
PharmGKBiPA36145.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYU9. Eukaryota.
ENOG4111N70. LUCA.
GeneTreeiENSGT00390000012318.
HOGENOMiHOG000231490.
HOVERGENiHBG055234.
InParanoidiO43805.
KOiK16780.
OMAiHDIRVLT.
OrthoDBiEOG7KSXC9.
PhylomeDBiO43805.
TreeFamiTF328451.

Enzyme and pathway databases

ReactomeiR-HSA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-HSA-380259. Loss of Nlp from mitotic centrosomes.
R-HSA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-HSA-5620912. Anchoring of the basal body to the plasma membrane.
R-HSA-8854518. AURKA Activation by TPX2.

Miscellaneous databases

ChiTaRSiSSNA1. human.
GenomeRNAii8636.
PROiO43805.
SOURCEiSearch...

Gene expression databases

BgeeiO43805.
CleanExiHS_SSNA1.
ExpressionAtlasiO43805. baseline and differential.
GenevisibleiO43805. HS.

Family and domain databases

InterProiIPR033362. SSNA1_fam.
[Graphical view]
PANTHERiPTHR28661. PTHR28661. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "NA14 is a novel nuclear autoantigen with a coiled-coil domain."
    Ramos-Morales F., Infante C., Fedriani C., Bornens M., Rios R.M.
    J. Biol. Chem. 273:1634-1639(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Testis.
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix.
  7. "Proteomic characterization of the human centrosome by protein correlation profiling."
    Andersen J.S., Wilkinson C.J., Mayor T., Mortensen P., Nigg E.A., Mann M.
    Nature 426:570-574(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Lymphoblast.
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-17.

Entry informationi

Entry nameiSSNA1_HUMAN
AccessioniPrimary (citable) accession number: O43805
Secondary accession number(s): Q5VSG0, Q6FG70, Q9BVW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 13, 2004
Last modified: July 6, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.