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O43795

- MYO1B_HUMAN

UniProt

O43795 - MYO1B_HUMAN

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Protein

Unconventional myosin-Ib

Gene

MYO1B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport.By similarity

GO - Molecular functioni

  1. actin filament binding Source: UniProt
  2. ATP binding Source: UniProtKB
  3. microfilament motor activity Source: UniProtKB
  4. phosphatidylinositol-3,4,5-trisphosphate binding Source: UniProtKB
  5. phosphatidylinositol-4,5-bisphosphate binding Source: UniProtKB

GO - Biological processi

  1. actin filament-based movement Source: UniProtKB
  2. actin filament bundle assembly Source: UniProtKB
  3. actin filament organization Source: UniProt
  4. metabolic process Source: GOC
  5. post-Golgi vesicle-mediated transport Source: UniProt
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-Ib
Alternative name(s):
MYH-1c
Myosin I alpha
Short name:
MMI-alpha
Short name:
MMIa
Gene namesi
Name:MYO1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:7596. MYO1B.

Subcellular locationi

GO - Cellular componenti

  1. actin filament Source: UniProt
  2. brush border Source: UniProtKB
  3. cell periphery Source: UniProtKB
  4. cytoplasm Source: UniProtKB
  5. early endosome Source: UniProt
  6. endosome membrane Source: UniProt
  7. extracellular vesicular exosome Source: UniProt
  8. filopodium Source: UniProtKB
  9. myosin complex Source: UniProtKB-KW
  10. perinuclear region of cytoplasm Source: UniProt
  11. plasma membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31398.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11361136Unconventional myosin-IbPRO_0000123442Add
BLAST

Proteomic databases

MaxQBiO43795.
PaxDbiO43795.
PRIDEiO43795.

PTM databases

PhosphoSiteiO43795.

Expressioni

Gene expression databases

BgeeiO43795.
CleanExiHS_MYO1B.
ExpressionAtlasiO43795. baseline and differential.
GenevestigatoriO43795.

Organism-specific databases

HPAiHPA013607.

Interactioni

Protein-protein interaction databases

BioGridi110567. 20 interactions.
IntActiO43795. 7 interactions.
MINTiMINT-4998969.
STRINGi9606.ENSP00000306382.

Structurei

3D structure databases

ProteinModelPortaliO43795.
SMRiO43795. Positions 5-764.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 701687Myosin motorAdd
BLAST
Domaini704 – 73330IQ 1PROSITE-ProRule annotationAdd
BLAST
Domaini728 – 74821IQ 2PROSITE-ProRule annotationAdd
BLAST
Domaini750 – 77930IQ 3PROSITE-ProRule annotationAdd
BLAST
Domaini779 – 80830IQ 4PROSITE-ProRule annotationAdd
BLAST
Domaini808 – 83730IQ 5PROSITE-ProRule annotationAdd
BLAST
Domaini837 – 86630IQ 6PROSITE-ProRule annotationAdd
BLAST
Domaini941 – 1131191Myosin tailSequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 6 IQ domains.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated
Contains 1 myosin tail domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5022.
GeneTreeiENSGT00760000118956.
HOGENOMiHOG000260264.
HOVERGENiHBG062373.
InParanoidiO43795.
KOiK10356.
OMAiGHERKTK.
OrthoDBiEOG7V49XQ.
PhylomeDBiO43795.
TreeFamiTF312960.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_tail_2.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00612. IQ. 2 hits.
PF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 6 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS50096. IQ. 5 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O43795-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKMEVKTSL LDNMIGVGDM VLLEPLNEET FINNLKKRFD HSEIYTYIGS
60 70 80 90 100
VVISVNPYRS LPIYSPEKVE EYRNRNFYEL SPHIFALSDE AYRSLRDQDK
110 120 130 140 150
DQCILITGES GAGKTEASKL VMSYVAAVCG KGAEVNQVKE QLLQSNPVLE
160 170 180 190 200
AFGNAKTVRN DNSSRFGKYM DIEFDFKGDP LGGVISNYLL EKSRVVKQPR
210 220 230 240 250
GERNFHVFYQ LLSGASEELL NKLKLERDFS RYNYLSLDSA KVNGVDDAAN
260 270 280 290 300
FRTVRNAMQI VGFMDHEAES VLAVVAAVLK LGNIEFKPES RVNGLDESKI
310 320 330 340 350
KDKNELKEIC ELTGIDQSVL ERAFSFRTVE AKQEKVSTTL NVAQAYYARD
360 370 380 390 400
ALAKNLYSRL FSWLVNRINE SIKAQTKVRK KVMGVLDIYG FEIFEDNSFE
410 420 430 440 450
QFIINYCNEK LQQIFIELTL KEEQEEYIRE DIEWTHIDYF NNAIICDLIE
460 470 480 490 500
NNTNGILAML DEECLRPGTV TDETFLEKLN QVCATHQHFE SRMSKCSRFL
510 520 530 540 550
NDTSLPHSCF RIQHYAGKVL YQVEGFVDKN NDLLYRDLSQ AMWKASHALI
560 570 580 590 600
KSLFPEGNPA KINLKRPPTA GSQFKASVAT LMKNLQTKNP NYIRCIKPND
610 620 630 640 650
KKAAHIFNEA LVCHQIRYLG LLENVRVRRA GYAFRQAYEP CLERYKMLCK
660 670 680 690 700
QTWPHWKGPA RSGVEVLFNE LEIPVEEYSF GRSKIFIRNP RTLFKLEDLR
710 720 730 740 750
KQRLEDLATL IQKIYRGWKC RTHFLLMKKS QIVIAAWYRR YAQQKRYQQT
760 770 780 790 800
KSSALVIQSY IRGWKARKIL RELKHQKRCK EAVTTIAAYW HGTQARRELR
810 820 830 840 850
RLKEEARNKH AIAVIWAYWL GSKARRELKR LKEEARRKHA VAVIWAYWLG
860 870 880 890 900
LKVRREYRKF FRANAGKKIY EFTLQRIVQK YFLEMKNKMP SLSPIDKNWP
910 920 930 940 950
SRPYLFLDST HKELKRIFHL WRCKKYRDQF TDQQKLIYEE KLEASELFKD
960 970 980 990 1000
KKALYPSSVG QPFQGAYLEI NKNPKYKKLK DAIEEKIIIA EVVNKINRAN
1010 1020 1030 1040 1050
GKSTSRIFLL TNNNLLLADQ KSGQIKSEVP LVDVTKVSMS SQNDGFFAVH
1060 1070 1080 1090 1100
LKEGSEAASK GDFLFSSDHL IEMATKLYRT TLSQTKQKLN IEISDEFLVQ
1110 1120 1130
FRQDKVCVKF IQGNQKNGSV PTCKRKNNRL LEVAVP
Length:1,136
Mass (Da):131,985
Last modified:February 1, 2005 - v3
Checksum:i98B7F2357928218D
GO
Isoform 2 (identifier: O43795-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     795-852: Missing.

Show »
Length:1,078
Mass (Da):124,951
Checksum:iD77952776D3EFDE5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti385 – 3851V → G in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036007
Natural varianti385 – 3851V → I in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036008
Natural varianti969 – 9691E → K in a melanoma patient. 1 Publication
VAR_014113

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei795 – 85258Missing in isoform 2. 1 PublicationVSP_012759Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC053558 mRNA. Translation: AAH53558.1.
AJ001381 mRNA. Translation: CAA04712.1.
AJ001382 mRNA. Translation: CAA04713.1.
CCDSiCCDS2311.1. [O43795-2]
CCDS46477.1. [O43795-1]
RefSeqiNP_001123630.1. NM_001130158.1. [O43795-1]
NP_001155291.1. NM_001161819.1. [O43795-1]
NP_036355.2. NM_012223.3. [O43795-2]
XP_005246629.1. XM_005246572.1. [O43795-1]
XP_006712599.1. XM_006712536.1. [O43795-1]
UniGeneiHs.439620.

Genome annotation databases

EnsembliENST00000304164; ENSP00000306382; ENSG00000128641. [O43795-1]
ENST00000339514; ENSP00000341903; ENSG00000128641. [O43795-2]
ENST00000392318; ENSP00000376132; ENSG00000128641. [O43795-1]
GeneIDi4430.
KEGGihsa:4430.
UCSCiuc002usq.2. human. [O43795-2]
uc002usr.2. human. [O43795-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC053558 mRNA. Translation: AAH53558.1 .
AJ001381 mRNA. Translation: CAA04712.1 .
AJ001382 mRNA. Translation: CAA04713.1 .
CCDSi CCDS2311.1. [O43795-2 ]
CCDS46477.1. [O43795-1 ]
RefSeqi NP_001123630.1. NM_001130158.1. [O43795-1 ]
NP_001155291.1. NM_001161819.1. [O43795-1 ]
NP_036355.2. NM_012223.3. [O43795-2 ]
XP_005246629.1. XM_005246572.1. [O43795-1 ]
XP_006712599.1. XM_006712536.1. [O43795-1 ]
UniGenei Hs.439620.

3D structure databases

ProteinModelPortali O43795.
SMRi O43795. Positions 5-764.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110567. 20 interactions.
IntActi O43795. 7 interactions.
MINTi MINT-4998969.
STRINGi 9606.ENSP00000306382.

PTM databases

PhosphoSitei O43795.

Proteomic databases

MaxQBi O43795.
PaxDbi O43795.
PRIDEi O43795.

Protocols and materials databases

DNASUi 4430.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000304164 ; ENSP00000306382 ; ENSG00000128641 . [O43795-1 ]
ENST00000339514 ; ENSP00000341903 ; ENSG00000128641 . [O43795-2 ]
ENST00000392318 ; ENSP00000376132 ; ENSG00000128641 . [O43795-1 ]
GeneIDi 4430.
KEGGi hsa:4430.
UCSCi uc002usq.2. human. [O43795-2 ]
uc002usr.2. human. [O43795-1 ]

Organism-specific databases

CTDi 4430.
GeneCardsi GC02P192091.
HGNCi HGNC:7596. MYO1B.
HPAi HPA013607.
MIMi 606537. gene.
neXtProti NX_O43795.
PharmGKBi PA31398.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5022.
GeneTreei ENSGT00760000118956.
HOGENOMi HOG000260264.
HOVERGENi HBG062373.
InParanoidi O43795.
KOi K10356.
OMAi GHERKTK.
OrthoDBi EOG7V49XQ.
PhylomeDBi O43795.
TreeFami TF312960.

Miscellaneous databases

ChiTaRSi MYO1B. human.
GeneWikii MYO1B.
GenomeRNAii 4430.
NextBioi 17273.
PROi O43795.
SOURCEi Search...

Gene expression databases

Bgeei O43795.
CleanExi HS_MYO1B.
ExpressionAtlasi O43795. baseline and differential.
Genevestigatori O43795.

Family and domain databases

InterProi IPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_tail_2.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00612. IQ. 2 hits.
PF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
[Graphical view ]
PRINTSi PR00193. MYOSINHEAVY.
SMARTi SM00015. IQ. 6 hits.
SM00242. MYSc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS50096. IQ. 5 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skin.
  2. "A mutated non conventional class I myosin peptide elicits a dominant CTL response in a regressive human primary melanoma lesion."
    Zorn E., Hercend T.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 644-1136 (ISOFORM 2), VARIANT LYS-969.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLY-385 AND ILE-385.

Entry informationi

Entry nameiMYO1B_HUMAN
AccessioniPrimary (citable) accession number: O43795
Secondary accession number(s): O43794, Q7Z6L5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: February 1, 2005
Last modified: November 26, 2014
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3