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O43795

- MYO1B_HUMAN

UniProt

O43795 - MYO1B_HUMAN

Protein

Unconventional myosin-Ib

Gene

MYO1B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 3 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport.By similarity

    GO - Molecular functioni

    1. actin filament binding Source: UniProt
    2. ATP binding Source: UniProtKB
    3. microfilament motor activity Source: UniProtKB
    4. phosphatidylinositol-3,4,5-trisphosphate binding Source: UniProtKB
    5. phosphatidylinositol-4,5-bisphosphate binding Source: UniProtKB

    GO - Biological processi

    1. actin filament-based movement Source: UniProtKB
    2. actin filament bundle assembly Source: UniProtKB
    3. actin filament organization Source: UniProt
    4. metabolic process Source: GOC
    5. post-Golgi vesicle-mediated transport Source: UniProt

    Keywords - Molecular functioni

    Motor protein, Myosin

    Keywords - Ligandi

    Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Unconventional myosin-Ib
    Alternative name(s):
    MYH-1c
    Myosin I alpha
    Short name:
    MMI-alpha
    Short name:
    MMIa
    Gene namesi
    Name:MYO1B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:7596. MYO1B.

    Subcellular locationi

    GO - Cellular componenti

    1. actin filament Source: UniProt
    2. brush border Source: UniProtKB
    3. cell periphery Source: UniProtKB
    4. cytoplasm Source: UniProtKB
    5. early endosome Source: UniProt
    6. endosome membrane Source: UniProt
    7. extracellular vesicular exosome Source: UniProt
    8. filopodium Source: UniProtKB
    9. myosin complex Source: UniProtKB-KW
    10. perinuclear region of cytoplasm Source: UniProt
    11. plasma membrane Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31398.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11361136Unconventional myosin-IbPRO_0000123442Add
    BLAST

    Proteomic databases

    MaxQBiO43795.
    PaxDbiO43795.
    PRIDEiO43795.

    PTM databases

    PhosphoSiteiO43795.

    Expressioni

    Gene expression databases

    ArrayExpressiO43795.
    BgeeiO43795.
    CleanExiHS_MYO1B.
    GenevestigatoriO43795.

    Organism-specific databases

    HPAiHPA013607.

    Interactioni

    Protein-protein interaction databases

    BioGridi110567. 19 interactions.
    IntActiO43795. 7 interactions.
    MINTiMINT-4998969.
    STRINGi9606.ENSP00000306382.

    Structurei

    3D structure databases

    ProteinModelPortaliO43795.
    SMRiO43795. Positions 5-764.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini15 – 701687Myosin motorAdd
    BLAST
    Domaini704 – 73330IQ 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini728 – 74821IQ 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini750 – 77930IQ 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini779 – 80830IQ 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini808 – 83730IQ 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini837 – 86630IQ 6PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 6 IQ domains.PROSITE-ProRule annotation
    Contains 1 myosin motor domain.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5022.
    HOGENOMiHOG000260264.
    HOVERGENiHBG062373.
    InParanoidiO43795.
    KOiK10356.
    OMAiGHERKTK.
    OrthoDBiEOG7V49XQ.
    PhylomeDBiO43795.
    TreeFamiTF312960.

    Family and domain databases

    InterProiIPR000048. IQ_motif_EF-hand-BS.
    IPR001609. Myosin_head_motor_dom.
    IPR010926. Myosin_tail_2.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00612. IQ. 2 hits.
    PF00063. Myosin_head. 1 hit.
    PF06017. Myosin_TH1. 1 hit.
    [Graphical view]
    PRINTSiPR00193. MYOSINHEAVY.
    SMARTiSM00015. IQ. 6 hits.
    SM00242. MYSc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    PROSITEiPS50096. IQ. 5 hits.
    PS51456. MYOSIN_MOTOR. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O43795-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAKMEVKTSL LDNMIGVGDM VLLEPLNEET FINNLKKRFD HSEIYTYIGS     50
    VVISVNPYRS LPIYSPEKVE EYRNRNFYEL SPHIFALSDE AYRSLRDQDK 100
    DQCILITGES GAGKTEASKL VMSYVAAVCG KGAEVNQVKE QLLQSNPVLE 150
    AFGNAKTVRN DNSSRFGKYM DIEFDFKGDP LGGVISNYLL EKSRVVKQPR 200
    GERNFHVFYQ LLSGASEELL NKLKLERDFS RYNYLSLDSA KVNGVDDAAN 250
    FRTVRNAMQI VGFMDHEAES VLAVVAAVLK LGNIEFKPES RVNGLDESKI 300
    KDKNELKEIC ELTGIDQSVL ERAFSFRTVE AKQEKVSTTL NVAQAYYARD 350
    ALAKNLYSRL FSWLVNRINE SIKAQTKVRK KVMGVLDIYG FEIFEDNSFE 400
    QFIINYCNEK LQQIFIELTL KEEQEEYIRE DIEWTHIDYF NNAIICDLIE 450
    NNTNGILAML DEECLRPGTV TDETFLEKLN QVCATHQHFE SRMSKCSRFL 500
    NDTSLPHSCF RIQHYAGKVL YQVEGFVDKN NDLLYRDLSQ AMWKASHALI 550
    KSLFPEGNPA KINLKRPPTA GSQFKASVAT LMKNLQTKNP NYIRCIKPND 600
    KKAAHIFNEA LVCHQIRYLG LLENVRVRRA GYAFRQAYEP CLERYKMLCK 650
    QTWPHWKGPA RSGVEVLFNE LEIPVEEYSF GRSKIFIRNP RTLFKLEDLR 700
    KQRLEDLATL IQKIYRGWKC RTHFLLMKKS QIVIAAWYRR YAQQKRYQQT 750
    KSSALVIQSY IRGWKARKIL RELKHQKRCK EAVTTIAAYW HGTQARRELR 800
    RLKEEARNKH AIAVIWAYWL GSKARRELKR LKEEARRKHA VAVIWAYWLG 850
    LKVRREYRKF FRANAGKKIY EFTLQRIVQK YFLEMKNKMP SLSPIDKNWP 900
    SRPYLFLDST HKELKRIFHL WRCKKYRDQF TDQQKLIYEE KLEASELFKD 950
    KKALYPSSVG QPFQGAYLEI NKNPKYKKLK DAIEEKIIIA EVVNKINRAN 1000
    GKSTSRIFLL TNNNLLLADQ KSGQIKSEVP LVDVTKVSMS SQNDGFFAVH 1050
    LKEGSEAASK GDFLFSSDHL IEMATKLYRT TLSQTKQKLN IEISDEFLVQ 1100
    FRQDKVCVKF IQGNQKNGSV PTCKRKNNRL LEVAVP 1136
    Length:1,136
    Mass (Da):131,985
    Last modified:February 1, 2005 - v3
    Checksum:i98B7F2357928218D
    GO
    Isoform 2 (identifier: O43795-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         795-852: Missing.

    Show »
    Length:1,078
    Mass (Da):124,951
    Checksum:iD77952776D3EFDE5
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti385 – 3851V → G in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036007
    Natural varianti385 – 3851V → I in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036008
    Natural varianti969 – 9691E → K in a melanoma patient. 1 Publication
    VAR_014113

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei795 – 85258Missing in isoform 2. 1 PublicationVSP_012759Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC053558 mRNA. Translation: AAH53558.1.
    AJ001381 mRNA. Translation: CAA04712.1.
    AJ001382 mRNA. Translation: CAA04713.1.
    CCDSiCCDS2311.1. [O43795-2]
    CCDS46477.1. [O43795-1]
    RefSeqiNP_001123630.1. NM_001130158.1. [O43795-1]
    NP_001155291.1. NM_001161819.1. [O43795-1]
    NP_036355.2. NM_012223.3. [O43795-2]
    XP_005246629.1. XM_005246572.1. [O43795-1]
    XP_006712599.1. XM_006712536.1. [O43795-1]
    UniGeneiHs.439620.

    Genome annotation databases

    EnsembliENST00000304164; ENSP00000306382; ENSG00000128641. [O43795-1]
    ENST00000339514; ENSP00000341903; ENSG00000128641. [O43795-2]
    ENST00000392318; ENSP00000376132; ENSG00000128641. [O43795-1]
    GeneIDi4430.
    KEGGihsa:4430.
    UCSCiuc002usq.2. human. [O43795-2]
    uc002usr.2. human. [O43795-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC053558 mRNA. Translation: AAH53558.1 .
    AJ001381 mRNA. Translation: CAA04712.1 .
    AJ001382 mRNA. Translation: CAA04713.1 .
    CCDSi CCDS2311.1. [O43795-2 ]
    CCDS46477.1. [O43795-1 ]
    RefSeqi NP_001123630.1. NM_001130158.1. [O43795-1 ]
    NP_001155291.1. NM_001161819.1. [O43795-1 ]
    NP_036355.2. NM_012223.3. [O43795-2 ]
    XP_005246629.1. XM_005246572.1. [O43795-1 ]
    XP_006712599.1. XM_006712536.1. [O43795-1 ]
    UniGenei Hs.439620.

    3D structure databases

    ProteinModelPortali O43795.
    SMRi O43795. Positions 5-764.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110567. 19 interactions.
    IntActi O43795. 7 interactions.
    MINTi MINT-4998969.
    STRINGi 9606.ENSP00000306382.

    PTM databases

    PhosphoSitei O43795.

    Proteomic databases

    MaxQBi O43795.
    PaxDbi O43795.
    PRIDEi O43795.

    Protocols and materials databases

    DNASUi 4430.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000304164 ; ENSP00000306382 ; ENSG00000128641 . [O43795-1 ]
    ENST00000339514 ; ENSP00000341903 ; ENSG00000128641 . [O43795-2 ]
    ENST00000392318 ; ENSP00000376132 ; ENSG00000128641 . [O43795-1 ]
    GeneIDi 4430.
    KEGGi hsa:4430.
    UCSCi uc002usq.2. human. [O43795-2 ]
    uc002usr.2. human. [O43795-1 ]

    Organism-specific databases

    CTDi 4430.
    GeneCardsi GC02P192091.
    HGNCi HGNC:7596. MYO1B.
    HPAi HPA013607.
    MIMi 606537. gene.
    neXtProti NX_O43795.
    PharmGKBi PA31398.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5022.
    HOGENOMi HOG000260264.
    HOVERGENi HBG062373.
    InParanoidi O43795.
    KOi K10356.
    OMAi GHERKTK.
    OrthoDBi EOG7V49XQ.
    PhylomeDBi O43795.
    TreeFami TF312960.

    Miscellaneous databases

    ChiTaRSi MYO1B. human.
    GeneWikii MYO1B.
    GenomeRNAii 4430.
    NextBioi 17273.
    PROi O43795.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O43795.
    Bgeei O43795.
    CleanExi HS_MYO1B.
    Genevestigatori O43795.

    Family and domain databases

    InterProi IPR000048. IQ_motif_EF-hand-BS.
    IPR001609. Myosin_head_motor_dom.
    IPR010926. Myosin_tail_2.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00612. IQ. 2 hits.
    PF00063. Myosin_head. 1 hit.
    PF06017. Myosin_TH1. 1 hit.
    [Graphical view ]
    PRINTSi PR00193. MYOSINHEAVY.
    SMARTi SM00015. IQ. 6 hits.
    SM00242. MYSc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    PROSITEi PS50096. IQ. 5 hits.
    PS51456. MYOSIN_MOTOR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skin.
    2. "A mutated non conventional class I myosin peptide elicits a dominant CTL response in a regressive human primary melanoma lesion."
      Zorn E., Hercend T.
      Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 644-1136 (ISOFORM 2), VARIANT LYS-969.
    3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    4. Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLY-385 AND ILE-385.

    Entry informationi

    Entry nameiMYO1B_HUMAN
    AccessioniPrimary (citable) accession number: O43795
    Secondary accession number(s): O43794, Q7Z6L5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 130 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3