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Protein

Unconventional myosin-Ib

Gene

MYO1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport.By similarity

GO - Molecular functioni

  • actin-dependent ATPase activity Source: Ensembl
  • actin filament binding Source: UniProtKB
  • ATP binding Source: UniProtKB
  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • microfilament motor activity Source: UniProtKB
  • phosphatidylinositol-3,4,5-trisphosphate binding Source: UniProtKB
  • phosphatidylinositol-4,5-bisphosphate binding Source: UniProtKB

GO - Biological processi

  • actin filament-based movement Source: UniProtKB
  • actin filament bundle assembly Source: UniProtKB
  • actin filament organization Source: UniProtKB
  • post-Golgi vesicle-mediated transport Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000128641-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-Ib
Alternative name(s):
MYH-1c
Myosin I alpha
Short name:
MMI-alpha
Short name:
MMIa
Gene namesi
Name:MYO1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:7596. MYO1B.

Subcellular locationi

GO - Cellular componenti

  • actin filament Source: UniProtKB
  • brush border Source: UniProtKB
  • cell-cell adherens junction Source: BHF-UCL
  • cell periphery Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • early endosome Source: UniProtKB
  • endosome membrane Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • filopodium Source: UniProtKB
  • myosin complex Source: UniProtKB-KW
  • perinuclear region of cytoplasm Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi4430.
OpenTargetsiENSG00000128641.
PharmGKBiPA31398.

Polymorphism and mutation databases

BioMutaiMYO1B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001234421 – 1136Unconventional myosin-IbAdd BLAST1136

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60PhosphoserineCombined sources1
Cross-linki287Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki287Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO43795.
MaxQBiO43795.
PaxDbiO43795.
PeptideAtlasiO43795.
PRIDEiO43795.

PTM databases

iPTMnetiO43795.
PhosphoSitePlusiO43795.
SwissPalmiO43795.

Expressioni

Gene expression databases

BgeeiENSG00000128641.
CleanExiHS_MYO1B.
ExpressionAtlasiO43795. baseline and differential.
GenevisibleiO43795. HS.

Organism-specific databases

HPAiHPA013607.
HPA060144.

Interactioni

GO - Molecular functioni

  • actin filament binding Source: UniProtKB
  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

Protein-protein interaction databases

BioGridi110567. 59 interactors.
IntActiO43795. 40 interactors.
MINTiMINT-4998969.
STRINGi9606.ENSP00000306382.

Structurei

3D structure databases

ProteinModelPortaliO43795.
SMRiO43795.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 701Myosin motorAdd BLAST687
Domaini704 – 733IQ 1PROSITE-ProRule annotationAdd BLAST30
Domaini728 – 748IQ 2PROSITE-ProRule annotationAdd BLAST21
Domaini750 – 779IQ 3PROSITE-ProRule annotationAdd BLAST30
Domaini779 – 808IQ 4PROSITE-ProRule annotationAdd BLAST30
Domaini808 – 837IQ 5PROSITE-ProRule annotationAdd BLAST30
Domaini837 – 866IQ 6PROSITE-ProRule annotationAdd BLAST30
Domaini952 – 1136TH1PROSITE-ProRule annotationAdd BLAST185

Sequence similaritiesi

Contains 6 IQ domains.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated
Contains 1 TH1 (class I myosin tail homology) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0164. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00840000129697.
HOGENOMiHOG000260264.
HOVERGENiHBG062373.
InParanoidiO43795.
KOiK10356.
OMAiGHERKTK.
OrthoDBiEOG091G0136.
PhylomeDBiO43795.
TreeFamiTF312960.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_TH1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00612. IQ. 2 hits.
PF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 6 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS50096. IQ. 5 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
PS51757. TH1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O43795-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKMEVKTSL LDNMIGVGDM VLLEPLNEET FINNLKKRFD HSEIYTYIGS
60 70 80 90 100
VVISVNPYRS LPIYSPEKVE EYRNRNFYEL SPHIFALSDE AYRSLRDQDK
110 120 130 140 150
DQCILITGES GAGKTEASKL VMSYVAAVCG KGAEVNQVKE QLLQSNPVLE
160 170 180 190 200
AFGNAKTVRN DNSSRFGKYM DIEFDFKGDP LGGVISNYLL EKSRVVKQPR
210 220 230 240 250
GERNFHVFYQ LLSGASEELL NKLKLERDFS RYNYLSLDSA KVNGVDDAAN
260 270 280 290 300
FRTVRNAMQI VGFMDHEAES VLAVVAAVLK LGNIEFKPES RVNGLDESKI
310 320 330 340 350
KDKNELKEIC ELTGIDQSVL ERAFSFRTVE AKQEKVSTTL NVAQAYYARD
360 370 380 390 400
ALAKNLYSRL FSWLVNRINE SIKAQTKVRK KVMGVLDIYG FEIFEDNSFE
410 420 430 440 450
QFIINYCNEK LQQIFIELTL KEEQEEYIRE DIEWTHIDYF NNAIICDLIE
460 470 480 490 500
NNTNGILAML DEECLRPGTV TDETFLEKLN QVCATHQHFE SRMSKCSRFL
510 520 530 540 550
NDTSLPHSCF RIQHYAGKVL YQVEGFVDKN NDLLYRDLSQ AMWKASHALI
560 570 580 590 600
KSLFPEGNPA KINLKRPPTA GSQFKASVAT LMKNLQTKNP NYIRCIKPND
610 620 630 640 650
KKAAHIFNEA LVCHQIRYLG LLENVRVRRA GYAFRQAYEP CLERYKMLCK
660 670 680 690 700
QTWPHWKGPA RSGVEVLFNE LEIPVEEYSF GRSKIFIRNP RTLFKLEDLR
710 720 730 740 750
KQRLEDLATL IQKIYRGWKC RTHFLLMKKS QIVIAAWYRR YAQQKRYQQT
760 770 780 790 800
KSSALVIQSY IRGWKARKIL RELKHQKRCK EAVTTIAAYW HGTQARRELR
810 820 830 840 850
RLKEEARNKH AIAVIWAYWL GSKARRELKR LKEEARRKHA VAVIWAYWLG
860 870 880 890 900
LKVRREYRKF FRANAGKKIY EFTLQRIVQK YFLEMKNKMP SLSPIDKNWP
910 920 930 940 950
SRPYLFLDST HKELKRIFHL WRCKKYRDQF TDQQKLIYEE KLEASELFKD
960 970 980 990 1000
KKALYPSSVG QPFQGAYLEI NKNPKYKKLK DAIEEKIIIA EVVNKINRAN
1010 1020 1030 1040 1050
GKSTSRIFLL TNNNLLLADQ KSGQIKSEVP LVDVTKVSMS SQNDGFFAVH
1060 1070 1080 1090 1100
LKEGSEAASK GDFLFSSDHL IEMATKLYRT TLSQTKQKLN IEISDEFLVQ
1110 1120 1130
FRQDKVCVKF IQGNQKNGSV PTCKRKNNRL LEVAVP
Length:1,136
Mass (Da):131,985
Last modified:February 1, 2005 - v3
Checksum:i98B7F2357928218D
GO
Isoform 2 (identifier: O43795-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     795-852: Missing.

Show »
Length:1,078
Mass (Da):124,951
Checksum:iD77952776D3EFDE5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036007385V → G in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_036008385V → I in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_014113969E → K in a melanoma patient. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012759795 – 852Missing in isoform 2. 1 PublicationAdd BLAST58

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC053558 mRNA. Translation: AAH53558.1.
AJ001381 mRNA. Translation: CAA04712.1.
AJ001382 mRNA. Translation: CAA04713.1.
CCDSiCCDS2311.1. [O43795-2]
CCDS46477.1. [O43795-1]
RefSeqiNP_001123630.1. NM_001130158.2. [O43795-1]
NP_001155291.1. NM_001161819.2. [O43795-1]
NP_036355.2. NM_012223.4. [O43795-2]
XP_005246629.1. XM_005246572.1. [O43795-1]
UniGeneiHs.439620.

Genome annotation databases

EnsembliENST00000304164; ENSP00000306382; ENSG00000128641. [O43795-1]
ENST00000339514; ENSP00000341903; ENSG00000128641. [O43795-2]
ENST00000392318; ENSP00000376132; ENSG00000128641. [O43795-1]
GeneIDi4430.
KEGGihsa:4430.
UCSCiuc002usq.3. human. [O43795-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC053558 mRNA. Translation: AAH53558.1.
AJ001381 mRNA. Translation: CAA04712.1.
AJ001382 mRNA. Translation: CAA04713.1.
CCDSiCCDS2311.1. [O43795-2]
CCDS46477.1. [O43795-1]
RefSeqiNP_001123630.1. NM_001130158.2. [O43795-1]
NP_001155291.1. NM_001161819.2. [O43795-1]
NP_036355.2. NM_012223.4. [O43795-2]
XP_005246629.1. XM_005246572.1. [O43795-1]
UniGeneiHs.439620.

3D structure databases

ProteinModelPortaliO43795.
SMRiO43795.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110567. 59 interactors.
IntActiO43795. 40 interactors.
MINTiMINT-4998969.
STRINGi9606.ENSP00000306382.

PTM databases

iPTMnetiO43795.
PhosphoSitePlusiO43795.
SwissPalmiO43795.

Polymorphism and mutation databases

BioMutaiMYO1B.

Proteomic databases

EPDiO43795.
MaxQBiO43795.
PaxDbiO43795.
PeptideAtlasiO43795.
PRIDEiO43795.

Protocols and materials databases

DNASUi4430.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304164; ENSP00000306382; ENSG00000128641. [O43795-1]
ENST00000339514; ENSP00000341903; ENSG00000128641. [O43795-2]
ENST00000392318; ENSP00000376132; ENSG00000128641. [O43795-1]
GeneIDi4430.
KEGGihsa:4430.
UCSCiuc002usq.3. human. [O43795-1]

Organism-specific databases

CTDi4430.
DisGeNETi4430.
GeneCardsiMYO1B.
HGNCiHGNC:7596. MYO1B.
HPAiHPA013607.
HPA060144.
MIMi606537. gene.
neXtProtiNX_O43795.
OpenTargetsiENSG00000128641.
PharmGKBiPA31398.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0164. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00840000129697.
HOGENOMiHOG000260264.
HOVERGENiHBG062373.
InParanoidiO43795.
KOiK10356.
OMAiGHERKTK.
OrthoDBiEOG091G0136.
PhylomeDBiO43795.
TreeFamiTF312960.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000128641-MONOMER.

Miscellaneous databases

ChiTaRSiMYO1B. human.
GeneWikiiMYO1B.
GenomeRNAii4430.
PROiO43795.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128641.
CleanExiHS_MYO1B.
ExpressionAtlasiO43795. baseline and differential.
GenevisibleiO43795. HS.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_TH1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00612. IQ. 2 hits.
PF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 6 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS50096. IQ. 5 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
PS51757. TH1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYO1B_HUMAN
AccessioniPrimary (citable) accession number: O43795
Secondary accession number(s): O43794, Q7Z6L5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: February 1, 2005
Last modified: November 30, 2016
This is version 153 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.