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O43795 (MYO1B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Unconventional myosin-Ib
Alternative name(s):
MYH-1c
Myosin I alpha
Short name=MMI-alpha
Short name=MMIa
Gene names
Name:MYO1B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1136 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport By similarity.

Sequence similarities

Contains 6 IQ domains.

Contains 1 myosin head-like domain.

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
   LigandActin-binding
ATP-binding
Calmodulin-binding
Nucleotide-binding
   Molecular functionMotor protein
Myosin
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactin filament bundle assembly

Inferred from sequence or structural similarity. Source: UniProtKB

actin filament-based movement

Inferred from sequence or structural similarity. Source: UniProtKB

metabolic process

Inferred from sequence or structural similarity. Source: GOC

   Cellular_componentbrush border

Inferred from sequence or structural similarity. Source: UniProtKB

cell periphery

Inferred from sequence or structural similarity. Source: UniProtKB

cytoplasm

Inferred from sequence or structural similarity. Source: UniProtKB

extracellular vesicular exosome

Inferred from direct assay PubMed 19056867PubMed 19199708. Source: UniProt

filopodium

Inferred from sequence or structural similarity. Source: UniProtKB

myosin complex

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionATP binding

Inferred from sequence or structural similarity. Source: UniProtKB

microfilament motor activity

Inferred from sequence or structural similarity. Source: UniProtKB

phosphatidylinositol-3,4,5-trisphosphate binding

Inferred from sequence or structural similarity. Source: UniProtKB

phosphatidylinositol-4,5-bisphosphate binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O43795-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O43795-2)

The sequence of this isoform differs from the canonical sequence as follows:
     795-852: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11361136Unconventional myosin-Ib
PRO_0000123442

Regions

Domain17 – 688672Myosin head-like
Domain704 – 73330IQ 1
Domain728 – 74821IQ 2
Domain750 – 77930IQ 3
Domain779 – 80830IQ 4
Domain808 – 83730IQ 5
Domain837 – 86630IQ 6

Natural variations

Alternative sequence795 – 85258Missing in isoform 2.
VSP_012759
Natural variant3851V → G in a colorectal cancer sample; somatic mutation. Ref.4
VAR_036007
Natural variant3851V → I in a colorectal cancer sample; somatic mutation. Ref.4
VAR_036008
Natural variant9691E → K in a melanoma patient. Ref.2
VAR_014113

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 1, 2005. Version 3.
Checksum: 98B7F2357928218D

FASTA1,136131,985
        10         20         30         40         50         60 
MAKMEVKTSL LDNMIGVGDM VLLEPLNEET FINNLKKRFD HSEIYTYIGS VVISVNPYRS 

        70         80         90        100        110        120 
LPIYSPEKVE EYRNRNFYEL SPHIFALSDE AYRSLRDQDK DQCILITGES GAGKTEASKL 

       130        140        150        160        170        180 
VMSYVAAVCG KGAEVNQVKE QLLQSNPVLE AFGNAKTVRN DNSSRFGKYM DIEFDFKGDP 

       190        200        210        220        230        240 
LGGVISNYLL EKSRVVKQPR GERNFHVFYQ LLSGASEELL NKLKLERDFS RYNYLSLDSA 

       250        260        270        280        290        300 
KVNGVDDAAN FRTVRNAMQI VGFMDHEAES VLAVVAAVLK LGNIEFKPES RVNGLDESKI 

       310        320        330        340        350        360 
KDKNELKEIC ELTGIDQSVL ERAFSFRTVE AKQEKVSTTL NVAQAYYARD ALAKNLYSRL 

       370        380        390        400        410        420 
FSWLVNRINE SIKAQTKVRK KVMGVLDIYG FEIFEDNSFE QFIINYCNEK LQQIFIELTL 

       430        440        450        460        470        480 
KEEQEEYIRE DIEWTHIDYF NNAIICDLIE NNTNGILAML DEECLRPGTV TDETFLEKLN 

       490        500        510        520        530        540 
QVCATHQHFE SRMSKCSRFL NDTSLPHSCF RIQHYAGKVL YQVEGFVDKN NDLLYRDLSQ 

       550        560        570        580        590        600 
AMWKASHALI KSLFPEGNPA KINLKRPPTA GSQFKASVAT LMKNLQTKNP NYIRCIKPND 

       610        620        630        640        650        660 
KKAAHIFNEA LVCHQIRYLG LLENVRVRRA GYAFRQAYEP CLERYKMLCK QTWPHWKGPA 

       670        680        690        700        710        720 
RSGVEVLFNE LEIPVEEYSF GRSKIFIRNP RTLFKLEDLR KQRLEDLATL IQKIYRGWKC 

       730        740        750        760        770        780 
RTHFLLMKKS QIVIAAWYRR YAQQKRYQQT KSSALVIQSY IRGWKARKIL RELKHQKRCK 

       790        800        810        820        830        840 
EAVTTIAAYW HGTQARRELR RLKEEARNKH AIAVIWAYWL GSKARRELKR LKEEARRKHA 

       850        860        870        880        890        900 
VAVIWAYWLG LKVRREYRKF FRANAGKKIY EFTLQRIVQK YFLEMKNKMP SLSPIDKNWP 

       910        920        930        940        950        960 
SRPYLFLDST HKELKRIFHL WRCKKYRDQF TDQQKLIYEE KLEASELFKD KKALYPSSVG 

       970        980        990       1000       1010       1020 
QPFQGAYLEI NKNPKYKKLK DAIEEKIIIA EVVNKINRAN GKSTSRIFLL TNNNLLLADQ 

      1030       1040       1050       1060       1070       1080 
KSGQIKSEVP LVDVTKVSMS SQNDGFFAVH LKEGSEAASK GDFLFSSDHL IEMATKLYRT 

      1090       1100       1110       1120       1130 
TLSQTKQKLN IEISDEFLVQ FRQDKVCVKF IQGNQKNGSV PTCKRKNNRL LEVAVP 

« Hide

Isoform 2 [UniParc].

Checksum: D77952776D3EFDE5
Show »

FASTA1,078124,951

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Skin.
[2]"A mutated non conventional class I myosin peptide elicits a dominant CTL response in a regressive human primary melanoma lesion."
Zorn E., Hercend T.
Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 644-1136 (ISOFORM 2), VARIANT LYS-969.
[3]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[4]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLY-385 AND ILE-385.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC053558 mRNA. Translation: AAH53558.1.
AJ001381 mRNA. Translation: CAA04712.1.
AJ001382 mRNA. Translation: CAA04713.1.
RefSeqNP_001123630.1. NM_001130158.1.
NP_001155291.1. NM_001161819.1.
NP_036355.2. NM_012223.3.
XP_005246629.1. XM_005246572.1.
UniGeneHs.439620.

3D structure databases

ProteinModelPortalO43795.
SMRO43795. Positions 16-858.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110567. 16 interactions.
IntActO43795. 6 interactions.
MINTMINT-4998969.
STRING9606.ENSP00000306382.

PTM databases

PhosphoSiteO43795.

Proteomic databases

PaxDbO43795.
PRIDEO43795.

Protocols and materials databases

DNASU4430.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000304164; ENSP00000306382; ENSG00000128641. [O43795-1]
ENST00000339514; ENSP00000341903; ENSG00000128641. [O43795-2]
ENST00000392318; ENSP00000376132; ENSG00000128641. [O43795-1]
GeneID4430.
KEGGhsa:4430.
UCSCuc002usq.2. human. [O43795-2]
uc002usr.2. human. [O43795-1]

Organism-specific databases

CTD4430.
GeneCardsGC02P192091.
HGNCHGNC:7596. MYO1B.
HPAHPA013607.
MIM606537. gene.
neXtProtNX_O43795.
PharmGKBPA31398.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5022.
HOGENOMHOG000260264.
HOVERGENHBG062373.
InParanoidO43795.
KOK10356.
OMAGHERKTK.
OrthoDBEOG7V49XQ.
PhylomeDBO43795.
TreeFamTF312960.

Gene expression databases

ArrayExpressO43795.
BgeeO43795.
CleanExHS_MYO1B.
GenevestigatorO43795.

Family and domain databases

InterProIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_tail_2.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00612. IQ. 2 hits.
PF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
[Graphical view]
PRINTSPR00193. MYOSINHEAVY.
SMARTSM00015. IQ. 6 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 2 hits.
PROSITEPS50096. IQ. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMYO1B. human.
GeneWikiMYO1B.
GenomeRNAi4430.
NextBio17273.
PROO43795.
SOURCESearch...

Entry information

Entry nameMYO1B_HUMAN
AccessionPrimary (citable) accession number: O43795
Secondary accession number(s): O43794, Q7Z6L5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: February 1, 2005
Last modified: April 16, 2014
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM