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Protein

Keratin, type II cuticular Hb6

Gene

KRT86

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170442-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cuticular Hb6
Alternative name(s):
Hair keratin K2.11
Keratin-86
Short name:
K86
Type II hair keratin Hb6
Type-II keratin Kb26
Gene namesi
Name:KRT86
Synonyms:KRTHB6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:6463. KRT86.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
  • keratin filament Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Involvement in diseasei

Monilethrix (MNLIX)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder clinically characterized by alopecia and follicular papules. Affected hairs have uniform elliptical nodes of normal thickness and intermittent constrictions, internodes at which the hair easily breaks. Usually only the scalp is involved, but in severe forms, the secondary sexual hair, eyebrows, eyelashes, and nails may also be affected.
See also OMIM:158000
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_018125114N → D in MNLIX. 2 PublicationsCorresponds to variant rs61091894dbSNPEnsembl.1
Natural variantiVAR_023053114N → H in MNLIX. 1 PublicationCorresponds to variant rs61091894dbSNPEnsembl.1
Natural variantiVAR_018127402E → K in MNLIX. 2 PublicationsCorresponds to variant rs60687604dbSNPEnsembl.1
Natural variantiVAR_018126402E → Q in MNLIX. 1 PublicationCorresponds to variant rs28939669dbSNPEnsembl.1
Natural variantiVAR_073050409L → P in MNLIX. 1 Publication1
Natural variantiVAR_073051410L → P in MNLIX. 1 Publication1
Natural variantiVAR_018129413E → D in MNLIX. 1 PublicationCorresponds to variant rs121909130dbSNPEnsembl.1
Natural variantiVAR_018128413E → K in MNLIX. 2 PublicationsCorresponds to variant rs121909129dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi3892.
MalaCardsiKRT86.
MIMi158000. phenotype.
OpenTargetsiENSG00000170442.
Orphaneti573. Monilethrix.
PharmGKBiPA30252.

Polymorphism and mutation databases

BioMutaiKRT86.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000637041 – 486Keratin, type II cuticular Hb6Add BLAST486

Proteomic databases

PaxDbiO43790.
PeptideAtlasiO43790.
PRIDEiO43790.

PTM databases

iPTMnetiO43790.
PhosphoSitePlusiO43790.
SwissPalmiO43790.

Expressioni

Tissue specificityi

Synthesis begins slightly higher in the hair shaft than HB1 and HB3 and continues much farther up, ending in the keratogeneous zone.1 Publication

Gene expression databases

BgeeiENSG00000170442.
CleanExiHS_KRT86.
ExpressionAtlasiO43790. baseline and differential.
GenevisibleiO43790. HS.

Organism-specific databases

HPAiHPA039798.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT15P190125EBI-9996498,EBI-739566
MEOX2A4D1273EBI-9996498,EBI-10172134

Protein-protein interaction databases

BioGridi110090. 6 interactors.
IntActiO43790. 17 interactors.
STRINGi9606.ENSP00000452237.

Structurei

3D structure databases

ProteinModelPortaliO43790.
SMRiO43790.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 106HeadAdd BLAST106
Regioni107 – 413RodAdd BLAST307
Regioni107 – 141Coil 1AAdd BLAST35
Regioni142 – 151Linker 110
Regioni152 – 252Coil 1BAdd BLAST101
Regioni253 – 269Linker 12Add BLAST17
Regioni270 – 413Coil 2Add BLAST144
Regioni414 – 486TailAdd BLAST73

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IH1H. Eukaryota.
ENOG41113GZ. LUCA.
GeneTreeiENSGT00830000128228.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiO43790.
KOiK07605.
OMAiVCGGSCK.
OrthoDBiEOG091G06FG.
PhylomeDBiO43790.
TreeFamiTF317854.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43790-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTCGSYCGGR AFSCISACGP RPGRCCITAA PYRGISCYRG LTGGFGSHSV
60 70 80 90 100
CGGFRAGSCG RSFGYRSGGV CGPSPPCITT VSVNESLLTP LNLEIDPNAQ
110 120 130 140 150
CVKQEEKEQI KSLNSRFAAF IDKVRFLEQQ NKLLETKLQF YQNRECCQSN
160 170 180 190 200
LEPLFEGYIE TLRREAECVE ADSGRLASEL NHVQEVLEGY KKKYEEEVSL
210 220 230 240 250
RATAENEFVA LKKDVDCAYL RKSDLEANVE ALIQEIDFLR RLYEEEIRVL
260 270 280 290 300
QSHISDTSVV VKLDNSRDLN MDCIIAEIKA QYDDIVTRSR AEAESWYRSK
310 320 330 340 350
CEEMKATVIR HGETLRRTKE EINELNRMIQ RLTAEVENAK CQNSKLEAAV
360 370 380 390 400
AQSEQQGEAA LSDARCKLAE LEGALQKAKQ DMACLIREYQ EVMNSKLGLD
410 420 430 440 450
IEIATYRRLL EGEEQRLCEG VGSVNVCVSS SRGGVVCGDL CASTTAPVVS
460 470 480
TRVSSVPSNS NVVVGTTNAC APSARVGVCG GSCKRC
Length:486
Mass (Da):53,501
Last modified:June 1, 1998 - v1
Checksum:i5ED86FB4CCA62688
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62S → D in CAA67579 (PubMed:9084137).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_018125114N → D in MNLIX. 2 PublicationsCorresponds to variant rs61091894dbSNPEnsembl.1
Natural variantiVAR_023053114N → H in MNLIX. 1 PublicationCorresponds to variant rs61091894dbSNPEnsembl.1
Natural variantiVAR_018127402E → K in MNLIX. 2 PublicationsCorresponds to variant rs60687604dbSNPEnsembl.1
Natural variantiVAR_018126402E → Q in MNLIX. 1 PublicationCorresponds to variant rs28939669dbSNPEnsembl.1
Natural variantiVAR_073050409L → P in MNLIX. 1 Publication1
Natural variantiVAR_073051410L → P in MNLIX. 1 Publication1
Natural variantiVAR_018129413E → D in MNLIX. 1 PublicationCorresponds to variant rs121909130dbSNPEnsembl.1
Natural variantiVAR_018128413E → K in MNLIX. 2 PublicationsCorresponds to variant rs121909129dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000263 Genomic DNA. Translation: CAA03979.1.
BC069585 mRNA. Translation: AAH69585.1.
X99142 mRNA. Translation: CAA67579.1.
CCDSiCCDS41785.1.
RefSeqiNP_001307127.1. NM_001320198.1.
XP_016874785.1. XM_017019296.1.
UniGeneiHs.278658.
Hs.733602.

Genome annotation databases

EnsembliENST00000293525; ENSP00000293525; ENSG00000170442.
ENST00000423955; ENSP00000444533; ENSG00000170442.
GeneIDi3892.
KEGGihsa:3892.
UCSCiuc001sad.3. human.

Cross-referencesi

Web resourcesi

Human Intermediate Filament Mutation Database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000263 Genomic DNA. Translation: CAA03979.1.
BC069585 mRNA. Translation: AAH69585.1.
X99142 mRNA. Translation: CAA67579.1.
CCDSiCCDS41785.1.
RefSeqiNP_001307127.1. NM_001320198.1.
XP_016874785.1. XM_017019296.1.
UniGeneiHs.278658.
Hs.733602.

3D structure databases

ProteinModelPortaliO43790.
SMRiO43790.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110090. 6 interactors.
IntActiO43790. 17 interactors.
STRINGi9606.ENSP00000452237.

PTM databases

iPTMnetiO43790.
PhosphoSitePlusiO43790.
SwissPalmiO43790.

Polymorphism and mutation databases

BioMutaiKRT86.

Proteomic databases

PaxDbiO43790.
PeptideAtlasiO43790.
PRIDEiO43790.

Protocols and materials databases

DNASUi3892.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293525; ENSP00000293525; ENSG00000170442.
ENST00000423955; ENSP00000444533; ENSG00000170442.
GeneIDi3892.
KEGGihsa:3892.
UCSCiuc001sad.3. human.

Organism-specific databases

CTDi3892.
DisGeNETi3892.
GeneCardsiKRT86.
HGNCiHGNC:6463. KRT86.
HPAiHPA039798.
MalaCardsiKRT86.
MIMi158000. phenotype.
601928. gene.
neXtProtiNX_O43790.
OpenTargetsiENSG00000170442.
Orphaneti573. Monilethrix.
PharmGKBiPA30252.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH1H. Eukaryota.
ENOG41113GZ. LUCA.
GeneTreeiENSGT00830000128228.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiO43790.
KOiK07605.
OMAiVCGGSCK.
OrthoDBiEOG091G06FG.
PhylomeDBiO43790.
TreeFamiTF317854.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170442-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Miscellaneous databases

ChiTaRSiKRT86. human.
GeneWikiiKRT86.
GenomeRNAii3892.
PROiO43790.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170442.
CleanExiHS_KRT86.
ExpressionAtlasiO43790. baseline and differential.
GenevisibleiO43790. HS.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKRT86_HUMAN
AccessioniPrimary (citable) accession number: O43790
Secondary accession number(s): P78387
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.