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O43781 (DYRK3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 138. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dual specificity tyrosine-phosphorylation-regulated kinase 3

EC=2.7.12.1
Alternative name(s):
Regulatory erythroid kinase
Short name=REDK
Gene names
Name:DYRK3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length588 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Negative regulator of EPO-dependent erythropoiesis, may place an upper limit on red cell production during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. May act by regulating CREB/CRE signaling. Ref.4

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Cofactor

Magnesium By similarity.

Enzyme regulation

Inhibited by harmine, leucettamine B and leucettine L41.

Subcellular location

Nucleus Ref.4.

Tissue specificity

Isoform 1 and isoform 2 are highly expressed in testis and in hematopoietic tissue such as fetal liver, and bone marrow. Isoform 2 is the predominant form in testis. Isoform 1 is the predominant form in fetal liver and bone marrow. Isoform 1 and isoform 2 are present at low levels in heart, pancreas, lymph node, and thymus. Ref.4

Induction

By EPO/erythropoietin. Ref.4

Post-translational modification

Autophosphorylated on tyrosine residues.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

Contains 1 protein kinase domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O43781-1)

Also known as: Long;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O43781-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.
     21-26: PPQQRR → MKWKEK

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 588588Dual specificity tyrosine-phosphorylation-regulated kinase 3
PRO_0000085938

Regions

Domain209 – 522314Protein kinase
Nucleotide binding215 – 2239ATP By similarity
Nucleotide binding288 – 2914ATP By similarity

Sites

Active site3351Proton acceptor By similarity
Binding site2381ATP By similarity

Amino acid modifications

Modified residue3691Phosphotyrosine By similarity

Natural variations

Alternative sequence1 – 2020Missing in isoform 2.
VSP_026178
Alternative sequence21 – 266PPQQRR → MKWKEK in isoform 2.
VSP_026179
Natural variant2391M → L. Ref.10
VAR_040464

Experimental info

Sequence conflict3131R → H in AAH15501. Ref.9
Sequence conflict3961G → R in CAA73266. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Long) [UniParc].

Last modified June 26, 2007. Version 3.
Checksum: 9950F51C39AFED82

FASTA58865,714
        10         20         30         40         50         60 
MGGTARGPGR KDAGPPGAGL PPQQRRLGDG VYDTFMMIDE TKCPPCSNVL CNPSEPPPPR 

        70         80         90        100        110        120 
RLNMTTEQFT GDHTQHFLDG GEMKVEQLFQ EFGNRKSNTI QSDGISDSEK CSPTVSQGKS 

       130        140        150        160        170        180 
SDCLNTVKSN SSSKAPKVVP LTPEQALKQY KHHLTAYEKL EIINYPEIYF VGPNAKKRHG 

       190        200        210        220        230        240 
VIGGPNNGGY DDADGAYIHV PRDHLAYRYE VLKIIGKGSF GQVARVYDHK LRQYVALKMV 

       250        260        270        280        290        300 
RNEKRFHRQA AEEIRILEHL KKQDKTGSMN VIHMLESFTF RNHVCMAFEL LSIDLYELIK 

       310        320        330        340        350        360 
KNKFQGFSVQ LVRKFAQSIL QSLDALHKNK IIHCDLKPEN ILLKHHGRSS TKVIDFGSSC 

       370        380        390        400        410        420 
FEYQKLYTYI QSRFYRAPEI ILGSRYSTPI DIWSFGCILA ELLTGQPLFP GEDEGDQLAC 

       430        440        450        460        470        480 
MMELLGMPPP KLLEQSKRAK YFINSKGIPR YCSVTTQADG RVVLVGGRSR RGKKRGPPGS 

       490        500        510        520        530        540 
KDWGTALKGC DDYLFIEFLK RCLHWDPSAR LTPAQALRHP WISKSVPRPL TTIDKVSGKR 

       550        560        570        580 
VVNPASAFQG LGSKLPPVVG IANKLKANLM SETNGSIPLC SVLPKLIS 

« Hide

Isoform 2 (Short) [UniParc].

Checksum: 9B710ECC413873F7
Show »

FASTA56863,977

References

« Hide 'large scale' references
[1]"Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases."
Becker W., Weber Y., Wetzel K., Eirmbter K., Tejedor F.J., Joost H.-G.
J. Biol. Chem. 273:25893-25902(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Fetal brain.
[2]Becker W.
Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO N-TERMINUS.
[3]"Molecular cloning and characterization of novel protein kinase gene DYRK3."
Xia J., Yang X., Ruan Q., Pan Q., Liu C., Xie W., Deng H.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 15:327-332(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]"REDK, a novel human regulatory erythroid kinase."
Lord K.A., Creasy C.L., King A.G., King C., Burns B.M., Lee J.C., Dillon S.B.
Blood 95:2838-2846(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
Tissue: Skeletal muscle.
[5]"Cloning of the human testis-specific dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 5 (DYRK5) gene."
Zhou Z.M.
Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Testis.
[6]Raya A., de la Luna S.
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[7]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Uterus.
[10]"Patterns of somatic mutation in human cancer genomes."
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. expand/collapse author list , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-239.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y12735 mRNA. Translation: CAA73266.2.
AF186773 mRNA. Translation: AAG17028.1.
AF186774 mRNA. Translation: AAG17029.1.
AF327561 mRNA. Translation: AAK16443.1.
AY590695 mRNA. Translation: AAT06103.1.
AL591846 Genomic DNA. Translation: CAI13539.1.
AL591846 Genomic DNA. Translation: CAI13541.1.
CH471100 Genomic DNA. Translation: EAW93533.1.
CH471100 Genomic DNA. Translation: EAW93534.1.
BC015501 mRNA. Translation: AAH15501.1.
RefSeqNP_001004023.1. NM_001004023.1.
NP_003573.2. NM_003582.2.
XP_005273372.1. XM_005273315.2.
XP_005273373.1. XM_005273316.2.
UniGeneHs.164267.

3D structure databases

ProteinModelPortalO43781.
SMRO43781. Positions 137-522.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114022. 5 interactions.
IntActO43781. 3 interactions.
STRING9606.ENSP00000356076.

Chemistry

BindingDBO43781.
ChEMBLCHEMBL4575.
GuidetoPHARMACOLOGY2012.

PTM databases

PhosphoSiteO43781.

Proteomic databases

PaxDbO43781.
PRIDEO43781.

Protocols and materials databases

DNASU8444.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000367106; ENSP00000356073; ENSG00000143479. [O43781-2]
ENST00000367108; ENSP00000356075; ENSG00000143479. [O43781-2]
ENST00000367109; ENSP00000356076; ENSG00000143479. [O43781-1]
ENST00000578483; ENSP00000463587; ENSG00000265184. [O43781-1]
ENST00000581534; ENSP00000462982; ENSG00000265184. [O43781-2]
ENST00000584909; ENSP00000463633; ENSG00000265184. [O43781-2]
GeneID8444.
KEGGhsa:8444.
UCSCuc001hei.3. human. [O43781-2]
uc001hej.3. human. [O43781-1]

Organism-specific databases

CTD8444.
GeneCardsGC01P206800.
HGNCHGNC:3094. DYRK3.
MIM603497. gene.
neXtProtNX_O43781.
PharmGKBPA27551.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000220863.
HOVERGENHBG051426.
InParanoidO43781.
KOK08825.
OMALKQYKHH.
PhylomeDBO43781.
TreeFamTF314624.

Enzyme and pathway databases

BRENDA2.7.12.1. 2681.
SignaLinkO43781.

Gene expression databases

ArrayExpressO43781.
BgeeO43781.
CleanExHS_DYRK3.
GenevestigatorO43781.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiDYRK3.
GenomeRNAi8444.
NextBio31590.
PROO43781.
SOURCESearch...

Entry information

Entry nameDYRK3_HUMAN
AccessionPrimary (citable) accession number: O43781
Secondary accession number(s): D3DT79 expand/collapse secondary AC list , Q7Z752, Q9HBY6, Q9HBY7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: June 26, 2007
Last modified: April 16, 2014
This is version 138 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM