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O43768

- ENSA_HUMAN

UniProt

O43768 - ENSA_HUMAN

Protein

Alpha-endosulfine

Gene

ENSA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase By similarity. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents.By similarity1 Publication

    GO - Molecular functioni

    1. ion channel inhibitor activity Source: ProtInc
    2. phosphatase inhibitor activity Source: UniProtKB
    3. potassium channel inhibitor activity Source: MGI
    4. protein phosphatase 2A binding Source: UniProtKB
    5. protein phosphatase inhibitor activity Source: UniProtKB-KW
    6. protein phosphatase type 2A regulator activity Source: UniProtKB
    7. receptor binding Source: MGI

    GO - Biological processi

    1. G2/M transition of mitotic cell cycle Source: UniProtKB
    2. mitotic cell cycle Source: Reactome
    3. mitotic nuclear division Source: UniProtKB
    4. negative regulation of catalytic activity Source: GOC
    5. regulation of catalytic activity Source: GOC
    6. regulation of insulin secretion Source: MGI
    7. response to glucose Source: Ensembl
    8. response to nutrient Source: ProtInc
    9. transport Source: ProtInc

    Keywords - Molecular functioni

    Protein phosphatase inhibitor

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Enzyme and pathway databases

    ReactomeiREACT_150182. MASTL Facilitates Mitotic Progression.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-endosulfine
    Alternative name(s):
    ARPP-19e
    Gene namesi
    Name:ENSA
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:3360. ENSA.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleoplasm Source: Reactome

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi109 – 1091S → E: Mimicks a phosphorylated state and impairs interaction with SNCA. 1 Publication

    Organism-specific databases

    PharmGKBiPA27796.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 121120Alpha-endosulfinePRO_0000146758Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine2 Publications
    Modified residuei2 – 21Phosphoserine4 Publications
    Modified residuei67 – 671Phosphoserine; by GWL1 Publication
    Modified residuei109 – 1091Phosphoserine; by PKA4 Publications

    Post-translational modificationi

    Phosphorylation at Ser-67 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A By similarity. Phosphorylated by PKA.By similarity5 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiO43768.
    PaxDbiO43768.
    PRIDEiO43768.

    PTM databases

    PhosphoSiteiO43768.

    Expressioni

    Tissue specificityi

    Widely expressed with high levels in skeletal muscle and brain and lower levels in the pancreas.2 Publications

    Gene expression databases

    ArrayExpressiO43768.
    BgeeiO43768.
    CleanExiHS_ENSA.
    GenevestigatoriO43768.

    Organism-specific databases

    HPAiHPA051294.

    Interactioni

    Subunit structurei

    Interacts (when phosphorylated at Ser-67) with PPP2R2D By similarity. Interacts with ABCC8. Interacts with SNCA; interaction is disrupted when phosphorylated at Ser-109.By similarity2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MCM3P252051EBI-714511,EBI-355153

    Protein-protein interaction databases

    BioGridi108343. 10 interactions.
    IntActiO43768. 5 interactions.
    MINTiMINT-1431607.

    Structurei

    3D structure databases

    ProteinModelPortaliO43768.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the endosulfine family.Curated

    Phylogenomic databases

    eggNOGiNOG312450.
    HOVERGENiHBG000297.
    PhylomeDBiO43768.
    TreeFamiTF314718.

    Family and domain databases

    InterProiIPR006760. Endosulphine.
    [Graphical view]
    PfamiPF04667. Endosulfine. 1 hit.
    [Graphical view]

    Sequences (9)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 9 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O43768-1) [UniParc]FASTAAdd to Basket

    Also known as: Alpha

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSQKQEEENP AEETGEEKQD TQEKEGILPE RAEEAKLKAK YPSLGQKPGG    50
    SDFLMKRLQK GQKYFDSGDY NMAKAKMKNK QLPSAGPDKN LVTGDHIPTP 100
    QDLPQRKSSL VTSKLAGGQV E 121
    Length:121
    Mass (Da):13,389
    Last modified:June 1, 1998 - v1
    Checksum:i7C76315AA17E7542
    GO
    Isoform 2 (identifier: O43768-2) [UniParc]FASTAAdd to Basket

    Also known as: Beta

    The sequence of this isoform differs from the canonical sequence as follows:
         118-121: Missing.

    Show »
    Length:117
    Mass (Da):12,976
    Checksum:iD17E754219767472
    GO
    Isoform 3 (identifier: O43768-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         61-61: G → GDYKSLHWSVLLCADEM

    Show »
    Length:137
    Mass (Da):15,281
    Checksum:iE9CF169C48A1FC1B
    GO
    Isoform 4 (identifier: O43768-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         61-61: G → GVWGIASYPLSLGLKEVLRMKSVE
         118-121: Missing.

    Show »
    Length:140
    Mass (Da):15,534
    Checksum:i2AB6570AFD91E54D
    GO
    Isoform 5 (identifier: O43768-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-4: Missing.
         5-19: QEEENPAEETGEEKQ → MAGGLGCDVCYWFVE

    Show »
    Length:117
    Mass (Da):12,818
    Checksum:iEEE3B2739FD70FC2
    GO
    Isoform 6 (identifier: O43768-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-4: Missing.
         5-19: QEEENPAEETGEEKQ → MAGGLGCDVCYWFVE
         118-121: Missing.

    Show »
    Length:113
    Mass (Da):12,404
    Checksum:iCFD70FC2E5FE760C
    GO
    Isoform 7 (identifier: O43768-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-4: Missing.
         5-19: QEEENPAEETGEEKQ → MAGGLGCDVCYWFVE
         61-61: G → GDYKSLHWSVLLCADEM

    Show »
    Length:133
    Mass (Da):14,710
    Checksum:i852736F0B466D4AB
    GO
    Isoform 8 (identifier: O43768-8) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         62-121: QKYFDSGDYN...TSKLAGGQVE → VWGIVSYPLS...LNRSRGEFEI

    Show »
    Length:105
    Mass (Da):11,990
    Checksum:iE6306F60528ECCA4
    GO
    Isoform 9 (identifier: O43768-9) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         61-61: G → GDYKSLHWSVLLCADEM
         118-121: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:133
    Mass (Da):14,868
    Checksum:i28A1FC1BE09A3895
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti5 – 51Q → R in CAG38815. 1 PublicationCurated
    Sequence conflicti21 – 211T → M in BAF82753. (PubMed:14702039)Curated
    Sequence conflicti22 – 221Q → L in AAH68544. (PubMed:15489334)Curated
    Sequence conflicti114 – 1141K → Q in CAG33411. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 44Missing in isoform 5, isoform 6 and isoform 7. 1 PublicationVSP_037063
    Alternative sequencei5 – 1915QEEEN…GEEKQ → MAGGLGCDVCYWFVE in isoform 5, isoform 6 and isoform 7. 1 PublicationVSP_037064Add
    BLAST
    Alternative sequencei61 – 611G → GDYKSLHWSVLLCADEM in isoform 3, isoform 7 and isoform 9. 1 PublicationVSP_037065
    Alternative sequencei61 – 611G → GVWGIASYPLSLGLKEVLRM KSVE in isoform 4. 1 PublicationVSP_037066
    Alternative sequencei62 – 12160QKYFD…GGQVE → VWGIVSYPLSLELKEVLRMK SVEVLLDPFLEVLLLNRSRG EFEI in isoform 8. CuratedVSP_037067Add
    BLAST
    Alternative sequencei118 – 1214Missing in isoform 2, isoform 4, isoform 6 and isoform 9. 5 PublicationsVSP_001443

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X99906 mRNA. Translation: CAA68180.1.
    AJ010966 Genomic DNA. Translation: CAB65125.1.
    AY326403
    , AY326400, AY326401, AY326402 Genomic DNA. Translation: AAQ73827.1.
    AY326403
    , AY326400, AY326401, AY326402 Genomic DNA. Translation: AAQ73828.1.
    AY326402, AY326400, AY326401 Genomic DNA. Translation: AAQ73829.1.
    AY326401, AY326400 Genomic DNA. Translation: AAQ73830.1.
    AY326403
    , AY326400, AY326401, AY326402 Genomic DNA. Translation: AAQ73831.1.
    AY326403
    , AY326400, AY326401, AY326402 Genomic DNA. Translation: AAQ73832.1.
    AF067170 mRNA. Translation: AAD32454.1.
    AF157509 mRNA. Translation: AAF80340.1.
    AF157510 mRNA. Translation: AAF80341.1.
    AK001981 mRNA. Translation: BAG50998.1.
    AK290064 mRNA. Translation: BAF82753.1.
    DA888224 mRNA. No translation available.
    CR749580 mRNA. Translation: CAH18372.1.
    CR457130 mRNA. Translation: CAG33411.1.
    CR536578 mRNA. Translation: CAG38815.1.
    AL356356 Genomic DNA. Translation: CAI15505.1.
    AL356356 Genomic DNA. Translation: CAI15506.1.
    AL356356 Genomic DNA. Translation: CAI15507.1.
    AL356356 Genomic DNA. Translation: CAI15509.1.
    AL356356 Genomic DNA. Translation: CAI15510.1.
    AL356356 Genomic DNA. Translation: CAI15511.1.
    AL356356 Genomic DNA. Translation: CAI15512.1.
    CH471121 Genomic DNA. Translation: EAW53528.1.
    CH471121 Genomic DNA. Translation: EAW53529.1.
    CH471121 Genomic DNA. Translation: EAW53530.1.
    CH471121 Genomic DNA. Translation: EAW53532.1.
    CH471121 Genomic DNA. Translation: EAW53533.1.
    BC000436 mRNA. Translation: AAH00436.1.
    BC004461 mRNA. Translation: AAH04461.1.
    BC068544 mRNA. Translation: AAH68544.1.
    BC069208 mRNA. Translation: AAH69208.1.
    CCDSiCCDS958.1. [O43768-1]
    CCDS959.1. [O43768-3]
    CCDS960.1. [O43768-7]
    CCDS961.1. [O43768-5]
    CCDS962.1. [O43768-9]
    CCDS963.1. [O43768-2]
    CCDS964.1. [O43768-6]
    CCDS965.1. [O43768-8]
    RefSeqiNP_004427.1. NM_004436.2. [O43768-1]
    NP_996925.1. NM_207042.1. [O43768-3]
    NP_996926.1. NM_207043.1. [O43768-9]
    NP_996927.1. NM_207044.1. [O43768-2]
    NP_996928.1. NM_207045.1. [O43768-7]
    NP_996929.1. NM_207046.1. [O43768-5]
    NP_996930.1. NM_207047.1. [O43768-6]
    NP_997051.1. NM_207168.1. [O43768-8]
    UniGeneiHs.632456.

    Genome annotation databases

    EnsembliENST00000271690; ENSP00000271690; ENSG00000143420. [O43768-2]
    ENST00000339643; ENSP00000341743; ENSG00000143420. [O43768-3]
    ENST00000361532; ENSP00000354835; ENSG00000143420. [O43768-5]
    ENST00000361631; ENSP00000355239; ENSG00000143420. [O43768-7]
    ENST00000362052; ENSP00000355220; ENSG00000143420. [O43768-8]
    ENST00000369014; ENSP00000358010; ENSG00000143420. [O43768-1]
    ENST00000503241; ENSP00000424242; ENSG00000143420. [O43768-9]
    ENST00000503345; ENSP00000421458; ENSG00000143420. [O43768-8]
    ENST00000509582; ENSP00000426110; ENSG00000143420. [O43768-8]
    ENST00000513281; ENSP00000422343; ENSG00000143420. [O43768-6]
    GeneIDi2029.
    KEGGihsa:2029.
    UCSCiuc001evb.3. human. [O43768-7]
    uc001evc.3. human. [O43768-5]
    uc001evd.3. human. [O43768-3]
    uc001eve.3. human. [O43768-1]
    uc001evf.3. human. [O43768-6]
    uc001evi.3. human. [O43768-8]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X99906 mRNA. Translation: CAA68180.1 .
    AJ010966 Genomic DNA. Translation: CAB65125.1 .
    AY326403
    , AY326400 , AY326401 , AY326402 Genomic DNA. Translation: AAQ73827.1 .
    AY326403
    , AY326400 , AY326401 , AY326402 Genomic DNA. Translation: AAQ73828.1 .
    AY326402 , AY326400 , AY326401 Genomic DNA. Translation: AAQ73829.1 .
    AY326401 , AY326400 Genomic DNA. Translation: AAQ73830.1 .
    AY326403
    , AY326400 , AY326401 , AY326402 Genomic DNA. Translation: AAQ73831.1 .
    AY326403
    , AY326400 , AY326401 , AY326402 Genomic DNA. Translation: AAQ73832.1 .
    AF067170 mRNA. Translation: AAD32454.1 .
    AF157509 mRNA. Translation: AAF80340.1 .
    AF157510 mRNA. Translation: AAF80341.1 .
    AK001981 mRNA. Translation: BAG50998.1 .
    AK290064 mRNA. Translation: BAF82753.1 .
    DA888224 mRNA. No translation available.
    CR749580 mRNA. Translation: CAH18372.1 .
    CR457130 mRNA. Translation: CAG33411.1 .
    CR536578 mRNA. Translation: CAG38815.1 .
    AL356356 Genomic DNA. Translation: CAI15505.1 .
    AL356356 Genomic DNA. Translation: CAI15506.1 .
    AL356356 Genomic DNA. Translation: CAI15507.1 .
    AL356356 Genomic DNA. Translation: CAI15509.1 .
    AL356356 Genomic DNA. Translation: CAI15510.1 .
    AL356356 Genomic DNA. Translation: CAI15511.1 .
    AL356356 Genomic DNA. Translation: CAI15512.1 .
    CH471121 Genomic DNA. Translation: EAW53528.1 .
    CH471121 Genomic DNA. Translation: EAW53529.1 .
    CH471121 Genomic DNA. Translation: EAW53530.1 .
    CH471121 Genomic DNA. Translation: EAW53532.1 .
    CH471121 Genomic DNA. Translation: EAW53533.1 .
    BC000436 mRNA. Translation: AAH00436.1 .
    BC004461 mRNA. Translation: AAH04461.1 .
    BC068544 mRNA. Translation: AAH68544.1 .
    BC069208 mRNA. Translation: AAH69208.1 .
    CCDSi CCDS958.1. [O43768-1 ]
    CCDS959.1. [O43768-3 ]
    CCDS960.1. [O43768-7 ]
    CCDS961.1. [O43768-5 ]
    CCDS962.1. [O43768-9 ]
    CCDS963.1. [O43768-2 ]
    CCDS964.1. [O43768-6 ]
    CCDS965.1. [O43768-8 ]
    RefSeqi NP_004427.1. NM_004436.2. [O43768-1 ]
    NP_996925.1. NM_207042.1. [O43768-3 ]
    NP_996926.1. NM_207043.1. [O43768-9 ]
    NP_996927.1. NM_207044.1. [O43768-2 ]
    NP_996928.1. NM_207045.1. [O43768-7 ]
    NP_996929.1. NM_207046.1. [O43768-5 ]
    NP_996930.1. NM_207047.1. [O43768-6 ]
    NP_997051.1. NM_207168.1. [O43768-8 ]
    UniGenei Hs.632456.

    3D structure databases

    ProteinModelPortali O43768.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108343. 10 interactions.
    IntActi O43768. 5 interactions.
    MINTi MINT-1431607.

    PTM databases

    PhosphoSitei O43768.

    Proteomic databases

    MaxQBi O43768.
    PaxDbi O43768.
    PRIDEi O43768.

    Protocols and materials databases

    DNASUi 2029.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000271690 ; ENSP00000271690 ; ENSG00000143420 . [O43768-2 ]
    ENST00000339643 ; ENSP00000341743 ; ENSG00000143420 . [O43768-3 ]
    ENST00000361532 ; ENSP00000354835 ; ENSG00000143420 . [O43768-5 ]
    ENST00000361631 ; ENSP00000355239 ; ENSG00000143420 . [O43768-7 ]
    ENST00000362052 ; ENSP00000355220 ; ENSG00000143420 . [O43768-8 ]
    ENST00000369014 ; ENSP00000358010 ; ENSG00000143420 . [O43768-1 ]
    ENST00000503241 ; ENSP00000424242 ; ENSG00000143420 . [O43768-9 ]
    ENST00000503345 ; ENSP00000421458 ; ENSG00000143420 . [O43768-8 ]
    ENST00000509582 ; ENSP00000426110 ; ENSG00000143420 . [O43768-8 ]
    ENST00000513281 ; ENSP00000422343 ; ENSG00000143420 . [O43768-6 ]
    GeneIDi 2029.
    KEGGi hsa:2029.
    UCSCi uc001evb.3. human. [O43768-7 ]
    uc001evc.3. human. [O43768-5 ]
    uc001evd.3. human. [O43768-3 ]
    uc001eve.3. human. [O43768-1 ]
    uc001evf.3. human. [O43768-6 ]
    uc001evi.3. human. [O43768-8 ]

    Organism-specific databases

    CTDi 2029.
    GeneCardsi GC01M150577.
    HGNCi HGNC:3360. ENSA.
    HPAi HPA051294.
    MIMi 603061. gene.
    neXtProti NX_O43768.
    PharmGKBi PA27796.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG312450.
    HOVERGENi HBG000297.
    PhylomeDBi O43768.
    TreeFami TF314718.

    Enzyme and pathway databases

    Reactomei REACT_150182. MASTL Facilitates Mitotic Progression.

    Miscellaneous databases

    ChiTaRSi ENSA. human.
    GeneWikii ENSA_(gene).
    GenomeRNAii 2029.
    NextBioi 8217.
    PROi O43768.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O43768.
    Bgeei O43768.
    CleanExi HS_ENSA.
    Genevestigatori O43768.

    Family and domain databases

    InterProi IPR006760. Endosulphine.
    [Graphical view ]
    Pfami PF04667. Endosulfine. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human alpha-endosulfine, a possible regulator of sulfonylurea-sensitive K(ATP) channel: molecular cloning, expression and biological properties."
      Heron L., Virsolvy A., Peyrollier K., Gribble F.M., Le Cam A., Ashcroft F.M., Bataille D.
      Proc. Natl. Acad. Sci. U.S.A. 95:8387-8391(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, PHOSPHORYLATION.
      Tissue: Brain.
    2. "Isolation, characterization, and chromosomal localization of the human ENSA gene that encodes alpha-endosulfine, a regulator of beta-cell K(ATP) channels."
      Heron L., Virsolvy A., Apiou F., Le Cam A., Bataille D.
      Diabetes 48:1873-1876(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "The transcribed endosulfine alpha gene is located within a type 2 diabetes-linked region on 1q: sequence and expression analysis in Pima Indians."
      Thameem F., Farook V.S., Yang X., Lee Y.-H., Permana P.A., Bogardus C., Prochazka M.
      Mol. Genet. Metab. 81:16-21(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORMS 1; 2; 3; 5; 7 AND 8), TISSUE SPECIFICITY.
    4. "Human alpha endosulfine gene."
      Zhang Q., Fu G., Wu J., Zhou J., Ye M., Shen Y., Kan L., He K., Gu B., Chen S., Mao M., Chen Z.
      Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    5. "Cloning and molecular characterization of two isoforms of human endosulfine."
      Scott V.E.S., Roch J.-M., Davis-Taber R.A., Molinari E.J., Whiteaker K.L., Gopalakrishnan M., Idler K., Sullivan J.P.
      Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 6 AND 9).
      Tissue: Placenta and Pulmonary artery.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Liver.
    8. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    9. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: B-cell, Lung and Testis.
    12. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. "Conformation-specific binding of alpha-synuclein to novel protein partners detected by phage display and NMR spectroscopy."
      Woods W.S., Boettcher J.M., Zhou D.H., Kloepper K.D., Hartman K.L., Ladror D.T., Qi Z., Rienstra C.M., George J.M.
      J. Biol. Chem. 282:34555-34567(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SNCA.
    14. "Membrane-induced folding of the cAMP-regulated phosphoprotein endosulfine-alpha."
      Boettcher J.M., Hartman K.L., Ladror D.T., Qi Z., Woods W.S., George J.M., Rienstra C.M.
      Biochemistry 47:12357-12364(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SNCA, PHOSPHORYLATION AT SER-109, MUTAGENESIS OF SER-109.
    15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2 AND SER-109, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2 AND SER-109, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiENSA_HUMAN
    AccessioniPrimary (citable) accession number: O43768
    Secondary accession number(s): A8K1Z9
    , E9PB69, Q5T5H2, Q68D48, Q6FHW0, Q6IAM4, Q6NUL2, Q6VUC6, Q6VUC7, Q6VUC8, Q6VUC9, Q6VUD0, Q6VUD1, Q9NRZ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 28, 2003
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3