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Protein

Small glutamine-rich tetratricopeptide repeat-containing protein alpha

Gene

SGTA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892). Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892). Probably functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:28104892). It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605). Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484). Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:18759457).5 Publications
(Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection via interaction with DNAJB12, DNAJB14 and HSPA8/Hsc70 (PubMed:24675744).1 Publication

GO - Molecular functioni

  • BAT3 complex binding Source: ParkinsonsUK-UCL
  • protein self-association Source: UniProtKB

GO - Biological processi

  • negative regulation of ER-associated ubiquitin-dependent protein catabolic process Source: UniProtKB
  • negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: UniProtKB
  • positive regulation of ER-associated ubiquitin-dependent protein catabolic process Source: ParkinsonsUK-UCL
  • ubiquitin-dependent ERAD pathway Source: UniProtKB
  • viral process Source: UniProtKB-KW

Keywordsi

Molecular functionChaperone
Biological processHost-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
Small glutamine-rich tetratricopeptide repeat-containing protein alpha
Alternative name(s):
Alpha-SGT
Vpu-binding protein
Short name:
UBP
Gene namesi
Name:SGTA
Synonyms:SGT, SGT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000104969.9.
HGNCiHGNC:10819. SGTA.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6449.
OpenTargetsiENSG00000104969.
PharmGKBiPA35727.

Polymorphism and mutation databases

BioMutaiSGTA.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001063651 – 313Small glutamine-rich tetratricopeptide repeat-containing protein alphaAdd BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei77PhosphoserineCombined sources1
Modified residuei81PhosphothreonineCombined sources1
Modified residuei84PhosphoserineBy similarity1
Modified residuei137N6-acetyllysineCombined sources1
Modified residuei301PhosphoserineCombined sources1
Modified residuei303PhosphothreonineCombined sources1
Modified residuei305PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO43765.
MaxQBiO43765.
PaxDbiO43765.
PeptideAtlasiO43765.
PRIDEiO43765.
TopDownProteomicsiO43765.

PTM databases

iPTMnetiO43765.
PhosphoSitePlusiO43765.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000104969.
CleanExiHS_SGTA.
ExpressionAtlasiO43765. baseline and differential.
GenevisibleiO43765. HS.

Organism-specific databases

HPAiHPA056309.

Interactioni

Subunit structurei

Homodimer (PubMed:15708368). Homooligomer (By similarity). Interacts with DNAJC5 and DNAJC5B. Interacts (via TPR repeats) with HSP90AA1 (PubMed:15708368). Interacts (via Gln-rich region) with SLC2A1 (PubMed:15708368). Interacts with HSP90AB1 (PubMed:16580629). Interacts (via TPR repeats) with HSPA8/Hsc70; the interaction is direct (PubMed:24675744). Interacts with BAG6 (via ubiquitin-like domain); interaction prevents interaction between BAG6 and RNF126 (PubMed:23129660, PubMed:25179605, PubMed:27193484). Forms a multiprotein complex, at least composed of DNAJB12, DNAJB14, HSPA8/Hsc70 and SGTA; interaction with DNAJB14 and HSPA8/Hsc70 is direct (PubMed:24675744).By similarity8 Publications
(Microbial infection) Interacts with NS1 from parvovirus H-1, with Vpu and Gag from HIV-1. Interacts with SARS-CoV accessory protein 7a.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ADIPOQA8K6603EBI-347996,EBI-10174479
ADIPOQQ158485EBI-347996,EBI-10827839
AGR3Q8TD065EBI-347996,EBI-3925742
BAG2O958162EBI-347996,EBI-355275
BAG6P463795EBI-347996,EBI-347552
BTCP350705EBI-347996,EBI-6590057
C1QTNF1Q9BXJ14EBI-347996,EBI-750200
C1QTNF6Q9BXI93EBI-347996,EBI-10301084
CCDC155Q8N6L09EBI-347996,EBI-749265
CD79BP402596EBI-347996,EBI-2873732
CDH15P552915EBI-347996,EBI-10215061
COL1A2P081235EBI-347996,EBI-983038
COL8A2Q4VAQ03EBI-347996,EBI-10241815
CSF1P096035EBI-347996,EBI-2872294
CST1P010373EBI-347996,EBI-1056240
CTAG1BP783584EBI-347996,EBI-1188472
CTSLP077113EBI-347996,EBI-1220160
EFEMP1Q128059EBI-347996,EBI-536772
EFEMP2O959676EBI-347996,EBI-743414
ERP27Q96DN05EBI-347996,EBI-953772
EVA1BQ9NVM15EBI-347996,EBI-10314666
F11RQ9Y6249EBI-347996,EBI-742600
FERD3LQ96RJ63EBI-347996,EBI-10183007
FKBP7Q9Y6803EBI-347996,EBI-3918971
FXYD7P585497EBI-347996,EBI-10216171
GALP224663EBI-347996,EBI-6624768
GIPP096817EBI-347996,EBI-8588553
GPErikQ144403EBI-347996,EBI-10232920
GPX7Q96SL45EBI-347996,EBI-749411
GRNP287996EBI-347996,EBI-747754
GUCA2AQ027474EBI-347996,EBI-12244272
GYPAA0A0C4DFT73EBI-347996,EBI-12044847
GYPAB8Q1834EBI-347996,EBI-10176190
HSPA13P487235EBI-347996,EBI-750892
IER3P466954EBI-347996,EBI-1748945
IGL@Q6PIQ73EBI-347996,EBI-6677651
IGL@Q8N3554EBI-347996,EBI-748681
IRF3Q146533EBI-347996,EBI-2650369
IRF5Q135683EBI-347996,EBI-3931258
ITPRIPL1Q6GPH63EBI-347996,EBI-953819
KRT6AP025383EBI-347996,EBI-702198
KTN1Q86UP23EBI-347996,EBI-359761
LAIR2Q6ISS45EBI-347996,EBI-10250491
LATO435613EBI-347996,EBI-1222766
LCN2P801884EBI-347996,EBI-11911016
MSMBP081183EBI-347996,EBI-10195681
MYDGFQ969H85EBI-347996,EBI-718622
NAXDQ8IW456EBI-347996,EBI-8650724
NME3Q132328EBI-347996,EBI-713684
PAUFC3PTT63EBI-347996,EBI-3505892
PBXIP1Q96AQ63EBI-347996,EBI-740845
PCDHA4Q9UN743EBI-347996,EBI-712273
PPIBP232845EBI-347996,EBI-359252
PPICP458775EBI-347996,EBI-953909
PRAP1Q96NZ95EBI-347996,EBI-2116102
RARRES3Q9UL193EBI-347996,EBI-10323452
RNF170Q96K19-54EBI-347996,EBI-12055631
RPN1P048435EBI-347996,EBI-355963
SDC4P314315EBI-347996,EBI-3913237
SERPINE1P051215EBI-347996,EBI-953978
SGCAQ165869EBI-347996,EBI-5663553
SLPIP039733EBI-347996,EBI-355293
SMAGPQ0VAQ43EBI-347996,EBI-10226799
SMIM5Q71RC94EBI-347996,EBI-12334905
SOD3P082943EBI-347996,EBI-10195782
SPP1P104518EBI-347996,EBI-723648
SPPL2AQ8TCT86EBI-347996,EBI-750784
SRGNP101248EBI-347996,EBI-744915
SYT11Q9BT886EBI-347996,EBI-751770
SYT4Q9H2B26EBI-347996,EBI-751132
TFF3Q076543EBI-347996,EBI-10224676
TFRCP027865EBI-347996,EBI-355727
TGFAP011353EBI-347996,EBI-1034374
TMEM174Q8WUU85EBI-347996,EBI-10276729
TMEM31Q5JXX73EBI-347996,EBI-10244617
TMUB2Q71RG43EBI-347996,EBI-2820477
TNFRSF13BO148363EBI-347996,EBI-519160
TNFRSF13BO14836-25EBI-347996,EBI-12023110
TTMPQ5BVD15EBI-347996,EBI-10243654
TWSG1Q9GZX93EBI-347996,EBI-10304067
TXNDC12O958813EBI-347996,EBI-2564581
UBL4AP114414EBI-347996,EBI-356983
UPK3AO756313EBI-347996,EBI-10188907
VIPP012823EBI-347996,EBI-751454
WBP1LQ9NX943EBI-347996,EBI-10316321
ZG16O608448EBI-347996,EBI-746479

GO - Molecular functioni

  • BAT3 complex binding Source: ParkinsonsUK-UCL
  • protein self-association Source: UniProtKB

Protein-protein interaction databases

BioGridi112347. 139 interactors.
IntActiO43765. 186 interactors.
MINTiMINT-1035135.
STRINGi9606.ENSP00000221566.

Structurei

Secondary structure

1313
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 21Combined sources17
Helixi26 – 43Combined sources18
Helixi48 – 51Combined sources4
Helixi58 – 65Combined sources8
Helixi87 – 103Combined sources17
Helixi107 – 120Combined sources14
Helixi125 – 137Combined sources13
Helixi141 – 154Combined sources14
Helixi159 – 171Combined sources13
Helixi175 – 188Combined sources14
Helixi193 – 206Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VYIX-ray2.40A/B84-210[»]
4CPGNMR-A/B1-69[»]
4GODX-ray1.40A/B4-54[»]
4GOEX-ray1.45A/B4-54[»]
4GOFX-ray1.35A/B4-54[»]
ProteinModelPortaliO43765.
SMRiO43765.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43765.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati91 – 124TPR 1Add BLAST34
Repeati125 – 158TPR 2Add BLAST34
Repeati159 – 192TPR 3Add BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi275 – 287Gln-richAdd BLAST13

Domaini

The second tetratricopeptide repeat (TPR 2) mediates the interaction with SARS-CoV accessory protein 7a.

Sequence similaritiesi

Belongs to the SGT family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0553. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00730000110724.
HOGENOMiHOG000208193.
HOVERGENiHBG000885.
InParanoidiO43765.
KOiK16365.
OMAiEAVVYYK.
OrthoDBiEOG091G0C0Q.
PhylomeDBiO43765.
TreeFamiTF313092.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiView protein in InterPro
IPR032374. SGTA_dimer.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
PfamiView protein in Pfam
PF16546. SGTA_dimer. 1 hit.
PF00515. TPR_1. 2 hits.
PF13181. TPR_8. 1 hit.
SMARTiView protein in SMART
SM00028. TPR. 3 hits.
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiView protein in PROSITE
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

O43765-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNKKRLAYA IIQFLHDQLR HGGLSSDAQE SLEVAIQCLE TAFGVTVEDS
60 70 80 90 100
DLALPQTLPE IFEAAATGKE MPQDLRSPAR TPPSEEDSAE AERLKTEGNE
110 120 130 140 150
QMKVENFEAA VHFYGKAIEL NPANAVYFCN RAAAYSKLGN YAGAVQDCER
160 170 180 190 200
AICIDPAYSK AYGRMGLALS SLNKHVEAVA YYKKALELDP DNETYKSNLK
210 220 230 240 250
IAELKLREAP SPTGGVGSFD IAGLLNNPGF MSMASNLMNN PQIQQLMSGM
260 270 280 290 300
ISGGNNPLGT PGTSPSQNDL ASLIQAGQQF AQQMQQQNPE LIEQLRSQIR
310
SRTPSASNDD QQE
Length:313
Mass (Da):34,063
Last modified:June 1, 1998 - v1
Checksum:i80B3C71B41F3CB55
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223828 mRNA. Translation: CAA11565.1.
AJ133129 mRNA. Translation: CAB39725.1.
AF408399 mRNA. Translation: AAL01051.1.
AF368279 mRNA. Translation: AAP29457.1.
AL050156 mRNA. Translation: CAB43297.2.
CR533517 mRNA. Translation: CAG38548.1.
CR542282 mRNA. Translation: CAG47077.1.
AC006538 Genomic DNA. Translation: AAD13117.1.
CH471139 Genomic DNA. Translation: EAW69366.1.
CH471139 Genomic DNA. Translation: EAW69367.1.
CH471139 Genomic DNA. Translation: EAW69368.1.
BC000390 mRNA. Translation: AAH00390.1.
BC002989 mRNA. Translation: AAH02989.2.
BC005165 mRNA. Translation: AAH05165.1.
BC008885 mRNA. Translation: AAH08885.1.
CCDSiCCDS12094.1.
RefSeqiNP_003012.1. NM_003021.3.
XP_011526480.1. XM_011528178.2.
UniGeneiHs.203910.

Genome annotation databases

EnsembliENST00000221566; ENSP00000221566; ENSG00000104969.
GeneIDi6449.
KEGGihsa:6449.
UCSCiuc002lwi.2. human.

Similar proteinsi

Entry informationi

Entry nameiSGTA_HUMAN
AccessioniPrimary (citable) accession number: O43765
Secondary accession number(s): D6W610, Q6FIA9, Q9BTZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: October 25, 2017
This is version 174 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families