Small glutamine-rich tetratricopeptide repeat-containing protein alpha

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Reviewed, UniProtKB/Swiss-Prot O43765 (SGTA_HUMAN)

Last modified November 25, 2008. Version 83. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Small glutamine-rich tetratricopeptide repeat-containing protein alpha
Alternative name(s):
    Alpha-SGT
    Vpu-binding protein
      Short name=UBP

Gene names

Name:	SGTA
Synonyms:	SGT

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	313 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.
Subunit structure	Homooligomerize By similarity. Interacts with NS1 from parvovirus H-1, with Vpu and Gag from HIV-1. Interacts with SARS-CoV accessory protein 7a.
Tissue specificity	Ubiquitous.
Domain	The second tetratricopeptide repeat (TPR 2) mediates the interaction with SARS-CoV accessory protein 7a.
Sequence similarities	Belongs to the SGT family. Contains 3 TPR repeats.

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Ontologies

Keywords
Biological process	Host-virus interaction
Domain	Repeat TPR repeat
Molecular function	Chaperone
PTM	Phosphoprotein
Technical term	3D-structure
Gene Ontology (GO)
Biological process	interspecies interaction between organisms Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from direct assay. Source: LIFEdb
Molecular function	protein binding Ref.1 Ref.2 Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct	Notes
BAT3	P46379	1	EBI-347996,EBI-347552

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 313

313

Small glutamine-rich tetratricopeptide repeat-containing protein alpha

PRO_0000106365

Regions

Repeat

91 – 124

TPR 1

Repeat

125 – 158

TPR 2

Repeat

159 – 192

TPR 3

Compositional bias

275 – 287

Gln-rich

Amino acid modifications

Modified residue

Phosphothreonine By similarity

Modified residue

301

Phosphoserine

Modified residue

303

Phosphothreonine

Modified residue

305

Phosphoserine

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Sequences

Sequence

Length

Mass (Da)

Tools

O43765-1 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 80B3C71B41F3CB55
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FASTA

313

34,063

        10         20         30         40         50         60 
MDNKKRLAYA IIQFLHDQLR HGGLSSDAQE SLEVAIQCLE TAFGVTVEDS DLALPQTLPE 

        70         80         90        100        110        120 
IFEAAATGKE MPQDLRSPAR TPPSEEDSAE AERLKTEGNE QMKVENFEAA VHFYGKAIEL 

       130        140        150        160        170        180 
NPANAVYFCN RAAAYSKLGN YAGAVQDCER AICIDPAYSK AYGRMGLALS SLNKHVEAVA 

       190        200        210        220        230        240 
YYKKALELDP DNETYKSNLK IAELKLREAP SPTGGVGSFD IAGLLNNPGF MSMASNLMNN 

       250        260        270        280        290        300 
PQIQQLMSGM ISGGNNPLGT PGTSPSQNDL ASLIQAGQQF AQQMQQQNPE LIEQLRSQIR 

       310 
SRTPSASNDD QQE

« Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of human SGT and identification of homologues in Saccharomyces cerevisiae and Caenorhabditis elegans." Kordes E., Savelyeva L., Schwab M., Rommelaere J., Jauniaux J.-C., Cziepluch C. Genomics 52:90-94(1998) [PubMed: 9740675] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Specific interaction of the 70-kDa heat shock cognate protein with the tetratricopeptide repeats." Liu F.H., Wu S.J., Hu S.M., Hsiao C.D., Wang C. J. Biol. Chem. 274:34425-34432(1999) [PubMed: 10567422] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Functional interaction of human immunodeficiency virus type 1 Vpu and Gag with a novel member of the tetratricopeptide repeat protein family." Callahan M.A., Handley M.A., Lee Y.H., Talbot K.J., Harper J.W., Panganiban A.T. J. Virol. 72:5189-5197(1998) [PubMed: 9573291] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. Poustka A. Genome Res. 11:422-435(2001) [PubMed: 11230166] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
[5]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung, Muscle and Uterus.
[7]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-303, MASS SPECTROMETRY. Tissue: Epithelium.
[8]	"Severe acute respiratory syndrome coronavirus protein 7a interacts with hSGT." Fielding B.C., Gunalan V., Tan T.H.P., Chou C.-F., Shen S., Khan S., Lim S.G., Hong W., Tan Y.-J. Biochem. Biophys. Res. Commun. 343:1201-1208(2006) [PubMed: 16580632] [Abstract] Cited for: INTERACTION WITH SARS-COV ACCESSORY PROTEIN 7A.
[9]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-301 AND SER-305, MASS SPECTROMETRY. Tissue: Epithelium.
[10]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-305, MASS SPECTROMETRY. Tissue: Epithelium.
+	Additional computationally mapped references.

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Cross-references

Sequence databases

AJ223828 mRNA. Translation: CAA11565.1.
AJ133129 mRNA. Translation: CAB39725.1.
AF408399 mRNA. Translation: AAL01051.1.
AL050156 mRNA. Translation: CAB43297.2.
AC006538 Genomic DNA. Translation: AAD13117.1.
BC000390 mRNA. Translation: AAH00390.1.
BC002989 mRNA. Translation: AAH02989.2.
BC005165 mRNA. Translation: AAH05165.1.
BC008885 mRNA. Translation: AAH08885.1.

RefSeq

NP_003012.1.

UniGene

Hs.203910

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2VYI	X-ray	2.40	A/B	84-210	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

O43765.

PTM databases

PhosphoSite

O43765.

Proteomic databases

PeptideAtlas

O43765.

Genome annotation databases

Ensembl

ENSG00000104969. Homo sapiens. [Contig view]

GeneID

6449.

KEGG

hsa:6449.

Organism-specific databases

H-InvDB

HIX0014624.

HGNC

HGNC:10819. SGTA.

MIM

603419. gene.

PharmGKB

PA35727.

GenAtlas

Search...

GeneCards

Search...

Phylogenomic databases

HOGENOM

O43765.

HOVERGEN

O43765.

Gene expression databases

ArrayExpress

O43765.

CleanEx

HS_SGTA.

GermOnline

ENSG00000104969. Homo sapiens.

Family and domain databases

InterPro

IPR001440. TPR-1.
IPR011990. TPR-like_helical.
IPR013026. TPR_region.
[Graphical view]

Gene3D

G3DSA:1.25.40.10. TPR-like_helical. 1 hit.

Pfam

PF00515. TPR_1. 3 hits.
[Graphical view]

SMART

SM00028. TPR. 3 hits.
[Graphical view]

PROSITE

PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

25065.

SOURCE

Search...

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Entry information

Entry name

SGTA_HUMAN

Accession

Primary (citable) accession number: O43765
Secondary accession number(s): Q9BTZ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	June 1, 1998
Last modified:	November 25, 2008
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Keywords

Gene Ontology (GO)

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents