Reviewed,
UniProtKB/Swiss-Prot O43765 (SGTA_HUMAN)
Last modified
November 25, 2008.
Version 83.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Small glutamine-rich tetratricopeptide repeat-containing protein alpha Alternative name(s): Alpha-SGT Vpu-binding protein Short name=UBP | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 313 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity. |
| Subunit structure | Homooligomerize By similarity. Interacts with NS1 from parvovirus H-1, with Vpu and Gag from HIV-1. Interacts with SARS-CoV accessory protein 7a. |
| Tissue specificity | Ubiquitous. |
| Domain | The second tetratricopeptide repeat (TPR 2) mediates the interaction with SARS-CoV accessory protein 7a. |
| Sequence similarities | Belongs to the SGT family. Contains 3 TPR repeats. |
Ontologies
Keywords | |
|---|---|
| Biological process | Host-virus interaction |
| Domain | Repeat TPR repeat |
| Molecular function | Chaperone |
| PTM | Phosphoprotein |
| Technical term | 3D-structure |
Gene Ontology (GO) | |
| Biological process | interspecies interaction between organisms Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from direct assay. Source: LIFEdb |
| Molecular function | protein binding Ref.1 Ref.2 Non-traceable author statement. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 313 | 313 | Small glutamine-rich tetratricopeptide repeat-containing protein alpha | PRO_0000106365 | |||||
Regions | |||||||||
| Repeat | 91 – 124 | 34 | TPR 1 | ||||||
| Repeat | 125 – 158 | 34 | TPR 2 | ||||||
| Repeat | 159 – 192 | 34 | TPR 3 | ||||||
| Compositional bias | 275 – 287 | 13 | Gln-rich | ||||||
Amino acid modifications | |||||||||
| Modified residue | 81 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 301 | 1 | Phosphoserine | ||||||
| Modified residue | 303 | 1 | Phosphothreonine | ||||||
| Modified residue | 305 | 1 | Phosphoserine | ||||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "Isolation and characterization of human SGT and identification of homologues in Saccharomyces cerevisiae and Caenorhabditis elegans." Kordes E., Savelyeva L., Schwab M., Rommelaere J., Jauniaux J.-C., Cziepluch C. Genomics 52:90-94(1998) [PubMed: 9740675] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Specific interaction of the 70-kDa heat shock cognate protein with the tetratricopeptide repeats." Liu F.H., Wu S.J., Hu S.M., Hsiao C.D., Wang C. J. Biol. Chem. 274:34425-34432(1999) [PubMed: 10567422] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "Functional interaction of human immunodeficiency virus type 1 Vpu and Gag with a novel member of the tetratricopeptide repeat protein family." Callahan M.A., Handley M.A., Lee Y.H., Talbot K.J., Harper J.W., Panganiban A.T. J. Virol. 72:5189-5197(1998) [PubMed: 9573291] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [4] | "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. Poustka A.Genome Res. 11:422-435(2001) [PubMed: 11230166] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus. |
| [5] | "The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. Lucas S.M.Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung, Muscle and Uterus. |
| [7] | "Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-303, MASS SPECTROMETRY. Tissue: Epithelium. |
| [8] | "Severe acute respiratory syndrome coronavirus protein 7a interacts with hSGT." Fielding B.C., Gunalan V., Tan T.H.P., Chou C.-F., Shen S., Khan S., Lim S.G., Hong W., Tan Y.-J. Biochem. Biophys. Res. Commun. 343:1201-1208(2006) [PubMed: 16580632] [Abstract] Cited for: INTERACTION WITH SARS-COV ACCESSORY PROTEIN 7A. |
| [9] | "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-301 AND SER-305, MASS SPECTROMETRY. Tissue: Epithelium. |
| [10] | "A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-305, MASS SPECTROMETRY. Tissue: Epithelium. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AJ223828 mRNA. Translation: CAA11565.1. AJ133129 mRNA. Translation: CAB39725.1. AF408399 mRNA. Translation: AAL01051.1. AL050156 mRNA. Translation: CAB43297.2. AC006538 Genomic DNA. Translation: AAD13117.1. BC000390 mRNA. Translation: AAH00390.1. BC002989 mRNA. Translation: AAH02989.2. BC005165 mRNA. Translation: AAH05165.1. BC008885 mRNA. Translation: AAH08885.1. | |||||||||||||
| RefSeq | NP_003012.1. | ||||||||||||
| UniGene | Hs.203910 | ||||||||||||
3D structure databases | |||||||||||||
| |||||||||||||
| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| IntAct | O43765. | ||||||||||||
PTM databases | |||||||||||||
| PhosphoSite | O43765. | ||||||||||||
Proteomic databases | |||||||||||||
| PeptideAtlas | O43765. | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENSG00000104969. Homo sapiens. [Contig view] | ||||||||||||
| GeneID | 6449. | ||||||||||||
| KEGG | hsa:6449. | ||||||||||||
Organism-specific databases | |||||||||||||
| H-InvDB | HIX0014624. | ||||||||||||
| HGNC | HGNC:10819. SGTA. | ||||||||||||
| MIM | 603419. gene. | ||||||||||||
| PharmGKB | PA35727. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
| GeneCards | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| HOGENOM | O43765. | ||||||||||||
| HOVERGEN | O43765. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | O43765. | ||||||||||||
| CleanEx | HS_SGTA. | ||||||||||||
| GermOnline | ENSG00000104969. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR001440. TPR-1. IPR011990. TPR-like_helical. IPR013026. TPR_region. [Graphical view] | ||||||||||||
| Gene3D | G3DSA:1.25.40.10. TPR-like_helical. 1 hit. | ||||||||||||
| Pfam | PF00515. TPR_1. 3 hits. [Graphical view] | ||||||||||||
| SMART | SM00028. TPR. 3 hits. [Graphical view] | ||||||||||||
| PROSITE | PS50005. TPR. 3 hits. PS50293. TPR_REGION. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other Resources | |||||||||||||
| NextBio | 25065. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | SGTA_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O43765 Secondary accession number(s): Q9BTZ9 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 19 Human chromosome 19: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


