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Protein

T-cell leukemia homeobox protein 2

Gene

TLX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transcription activator that binds DNA elements with the consensus sequence 5'-CGGTAATTGG-3'. Binds DNA via its homeobox. Required for normal cell death of enteric neurons in the gastrointestinal tract. Required for normal development of the enteric nervous system, and for proper development of normal motility of the gastrointestinal tract (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi157 – 216HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115297-MONOMER.
SignaLinkiO43763.

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell leukemia homeobox protein 2
Alternative name(s):
Homeobox protein Hox-11L1
Neural crest homeobox protein
Gene namesi
Name:TLX2
Synonyms:HOX11L1, NCX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:5057. TLX2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3196.
OpenTargetsiENSG00000115297.
PharmGKBiPA35096.

Polymorphism and mutation databases

BioMutaiTLX2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000493361 – 284T-cell leukemia homeobox protein 2Add BLAST284

Proteomic databases

PaxDbiO43763.
PRIDEiO43763.

PTM databases

iPTMnetiO43763.
PhosphoSitePlusiO43763.

Expressioni

Gene expression databases

BgeeiENSG00000115297.
CleanExiHS_TLX2.
ExpressionAtlasiO43763. baseline and differential.
GenevisibleiO43763. HS.

Organism-specific databases

HPAiHPA040969.
HPA062254.

Interactioni

Protein-protein interaction databases

BioGridi109436. 9 interactors.
IntActiO43763. 1 interactor.
STRINGi9606.ENSP00000233638.

Structurei

Secondary structure

1284
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi166 – 178Combined sources13
Helixi184 – 194Combined sources11
Helixi198 – 215Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3A03X-ray1.54A162-216[»]
ProteinModelPortaliO43763.
SMRiO43763.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43763.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi27 – 115Gly-richAdd BLAST89

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0488. Eukaryota.
ENOG411188D. LUCA.
GeneTreeiENSGT00860000133665.
HOGENOMiHOG000116280.
HOVERGENiHBG036206.
InParanoidiO43763.
KOiK15606.
OMAiQGHGENG.
OrthoDBiEOG091G0RNV.
PhylomeDBiO43763.
TreeFamiTF325347.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43763-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPGMLGPHN LPHHEPISFG IDQILSGPET PGGGLGLGRG GQGHGENGAF
60 70 80 90 100
SGGYHGASGY GPAGSLAPLP GSSGVGPGGV IRVPAHRPLP VPPPAGGAPA
110 120 130 140 150
VPGPSGLGGA GGLAGLTFPW MDSGRRFAKD RLTAALSPFS GTRRIGHPYQ
160 170 180 190 200
NRTPPKRKKP RTSFSRSQVL ELERRFLRQK YLASAERAAL AKALRMTDAQ
210 220 230 240 250
VKTWFQNRRT KWRRQTAEER EAERHRAGRL LLHLQQDALP RPLRPPLPPD
260 270 280
PLCLHNSSLF ALQNLQPWAE DNKVASVSGL ASVV
Length:284
Mass (Da):30,251
Last modified:May 10, 2002 - v2
Checksum:i794B07A9E7817939
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16P → A in CAA05636 (Ref. 2) Curated1
Sequence conflicti30 – 32TPG → PR in CAA05636 (Ref. 2) Curated3
Sequence conflicti37 – 48LGRGG…HGENG → WVAGQVIGEWA in CAA05636 (Ref. 2) CuratedAdd BLAST12
Sequence conflicti100 – 102Missing in CAA05636 (Ref. 2) Curated3
Sequence conflicti131 – 136RLTAAL → PAV in CAA05636 (Ref. 2) Curated6
Sequence conflicti196M → T no nucleotide entry (PubMed:7518789).Curated1
Sequence conflicti219Missing in CAA05636 (Ref. 2) Curated1
Sequence conflicti241R → T in CAA05636 (Ref. 2) Curated1
Sequence conflicti274V → A in CAA05636 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008501 mRNA. Translation: BAA83463.1.
AJ002607, AJ002608, AJ002609 Genomic DNA. Translation: CAA05636.1.
AC005041 Genomic DNA. No translation available.
BC006356 mRNA. Translation: AAH06356.1.
CCDSiCCDS1947.1.
RefSeqiNP_057254.1. NM_016170.4.
UniGeneiHs.168586.

Genome annotation databases

EnsembliENST00000233638; ENSP00000233638; ENSG00000115297.
GeneIDi3196.
KEGGihsa:3196.
UCSCiuc002smb.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008501 mRNA. Translation: BAA83463.1.
AJ002607, AJ002608, AJ002609 Genomic DNA. Translation: CAA05636.1.
AC005041 Genomic DNA. No translation available.
BC006356 mRNA. Translation: AAH06356.1.
CCDSiCCDS1947.1.
RefSeqiNP_057254.1. NM_016170.4.
UniGeneiHs.168586.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3A03X-ray1.54A162-216[»]
ProteinModelPortaliO43763.
SMRiO43763.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109436. 9 interactors.
IntActiO43763. 1 interactor.
STRINGi9606.ENSP00000233638.

PTM databases

iPTMnetiO43763.
PhosphoSitePlusiO43763.

Polymorphism and mutation databases

BioMutaiTLX2.

Proteomic databases

PaxDbiO43763.
PRIDEiO43763.

Protocols and materials databases

DNASUi3196.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233638; ENSP00000233638; ENSG00000115297.
GeneIDi3196.
KEGGihsa:3196.
UCSCiuc002smb.3. human.

Organism-specific databases

CTDi3196.
DisGeNETi3196.
GeneCardsiTLX2.
HGNCiHGNC:5057. TLX2.
HPAiHPA040969.
HPA062254.
MIMi604240. gene.
neXtProtiNX_O43763.
OpenTargetsiENSG00000115297.
PharmGKBiPA35096.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0488. Eukaryota.
ENOG411188D. LUCA.
GeneTreeiENSGT00860000133665.
HOGENOMiHOG000116280.
HOVERGENiHBG036206.
InParanoidiO43763.
KOiK15606.
OMAiQGHGENG.
OrthoDBiEOG091G0RNV.
PhylomeDBiO43763.
TreeFamiTF325347.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115297-MONOMER.
SignaLinkiO43763.

Miscellaneous databases

EvolutionaryTraceiO43763.
GeneWikiiTLX2.
GenomeRNAii3196.
PROiO43763.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115297.
CleanExiHS_TLX2.
ExpressionAtlasiO43763. baseline and differential.
GenevisibleiO43763. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTLX2_HUMAN
AccessioniPrimary (citable) accession number: O43763
Secondary accession number(s): Q9UD56, Q9UQ48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 10, 2002
Last modified: November 30, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.