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O43763 (TLX2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
T-cell leukemia homeobox protein 2
Alternative name(s):
Homeobox protein Hox-11L1
Neural crest homeobox protein
Gene names
Name:TLX2
Synonyms:HOX11L1, NCX
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length284 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcription activator that binds DNA elements with the consensus sequence 5'-CGGTAATTGG-3'. Binds DNA via its homeobox. Required for normal cell death of enteric neurons in the gastrointestinal tract. Required for normal development of the enteric nervous system, and for proper development of normal motility of the gastrointestinal tract By similarity.

Subcellular location

Nucleus Probable.

Sequence similarities

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 284284T-cell leukemia homeobox protein 2
PRO_0000049336

Regions

DNA binding157 – 21660Homeobox Ref.6
Compositional bias27 – 11589Gly-rich

Experimental info

Sequence conflict161P → A in CAA05636. Ref.2
Sequence conflict30 – 323TPG → PR in CAA05636. Ref.2
Sequence conflict37 – 4812LGRGG…HGENG → WVAGQVIGEWA in CAA05636. Ref.2
Sequence conflict100 – 1023Missing in CAA05636. Ref.2
Sequence conflict131 – 1366RLTAAL → PAV in CAA05636. Ref.2
Sequence conflict1961M → T no nucleotide entry Ref.5
Sequence conflict2191Missing in CAA05636. Ref.2
Sequence conflict2411R → T in CAA05636. Ref.2
Sequence conflict2741V → A in CAA05636. Ref.2

Secondary structure

....... 284
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O43763 [UniParc].

Last modified May 10, 2002. Version 2.
Checksum: 794B07A9E7817939

FASTA28430,251
        10         20         30         40         50         60 
MEPGMLGPHN LPHHEPISFG IDQILSGPET PGGGLGLGRG GQGHGENGAF SGGYHGASGY 

        70         80         90        100        110        120 
GPAGSLAPLP GSSGVGPGGV IRVPAHRPLP VPPPAGGAPA VPGPSGLGGA GGLAGLTFPW 

       130        140        150        160        170        180 
MDSGRRFAKD RLTAALSPFS GTRRIGHPYQ NRTPPKRKKP RTSFSRSQVL ELERRFLRQK 

       190        200        210        220        230        240 
YLASAERAAL AKALRMTDAQ VKTWFQNRRT KWRRQTAEER EAERHRAGRL LLHLQQDALP 

       250        260        270        280 
RPLRPPLPPD PLCLHNSSLF ALQNLQPWAE DNKVASVSGL ASVV 

« Hide

References

« Hide 'large scale' references
[1]"An enhancer element for expression of the Ncx (Enx, Hox11L1) gene in neural crest-derived cells."
Iitsuka Y., Shimizu H., Kang M.M., Sasagawa K., Sekiya S., Tokuhisa T., Hatano M.
J. Biol. Chem. 274:24401-24407(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Genomic characterization and chromosomal location of the human homeobox gene HOX11L1."
Delgado P., Rodriguez R.E., Gonzalez-Sarmiento R.
Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[5]"Identification of homeobox genes expressed in human haemopoietic progenitor cells."
Moretti P., Simmons P., Thomas P., Haylock D., Rathjen P., Vadas M., D'Andrea R.
Gene 144:213-219(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 165-203.
Tissue: Bone marrow.
[6]"Cooperative DNA-binding and sequence-recognition mechanism of aristaless and clawless."
Miyazono K., Zhi Y., Takamura Y., Nagata K., Saigo K., Kojima T., Tanokura M.
EMBO J. 29:1613-1623(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.54 ANGSTROMS) OF 162-216, DNA-BINDING.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB008501 mRNA. Translation: BAA83463.1.
AJ002607, AJ002608, AJ002609 Genomic DNA. Translation: CAA05636.1.
AC005041 Genomic DNA. No translation available.
BC006356 mRNA. Translation: AAH06356.1.
RefSeqNP_057254.1. NM_016170.4.
UniGeneHs.168586.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3A03X-ray1.54A162-216[»]
ProteinModelPortalO43763.
SMRO43763. Positions 164-216.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109436. 9 interactions.
STRING9606.ENSP00000233638.

PTM databases

PhosphoSiteO43763.

Proteomic databases

PaxDbO43763.
PRIDEO43763.

Protocols and materials databases

DNASU3196.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000233638; ENSP00000233638; ENSG00000115297.
GeneID3196.
KEGGhsa:3196.
UCSCuc002smb.2. human.

Organism-specific databases

CTD3196.
GeneCardsGC02P074740.
HGNCHGNC:5057. TLX2.
HPAHPA040969.
MIM604240. gene.
neXtProtNX_O43763.
PharmGKBPA35096.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG329715.
HOGENOMHOG000116280.
HOVERGENHBG036206.
InParanoidO43763.
KOK15606.
OMAAGQGHGE.
OrthoDBEOG7Q5HFW.
PhylomeDBO43763.
TreeFamTF325347.

Enzyme and pathway databases

SignaLinkO43763.

Gene expression databases

BgeeO43763.
CleanExHS_TLX2.
GenevestigatorO43763.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceO43763.
GeneWikiTLX2.
GenomeRNAi3196.
NextBio12712.
PROO43763.
SOURCESearch...

Entry information

Entry nameTLX2_HUMAN
AccessionPrimary (citable) accession number: O43763
Secondary accession number(s): Q9UD56, Q9UQ48
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 10, 2002
Last modified: February 19, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM