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O43763

- TLX2_HUMAN

UniProt

O43763 - TLX2_HUMAN

Protein

T-cell leukemia homeobox protein 2

Gene

TLX2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (10 May 2002)
      Previous versions | rss
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    Functioni

    Transcription activator that binds DNA elements with the consensus sequence 5'-CGGTAATTGG-3'. Binds DNA via its homeobox. Required for normal cell death of enteric neurons in the gastrointestinal tract. Required for normal development of the enteric nervous system, and for proper development of normal motility of the gastrointestinal tract By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi157 – 21660HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. enteric nervous system development Source: Ensembl
    2. mesoderm formation Source: Ensembl
    3. negative regulation of dendrite morphogenesis Source: Ensembl
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    SignaLinkiO43763.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    T-cell leukemia homeobox protein 2
    Alternative name(s):
    Homeobox protein Hox-11L1
    Neural crest homeobox protein
    Gene namesi
    Name:TLX2
    Synonyms:HOX11L1, NCX
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:5057. TLX2.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35096.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 284284T-cell leukemia homeobox protein 2PRO_0000049336Add
    BLAST

    Proteomic databases

    PaxDbiO43763.
    PRIDEiO43763.

    PTM databases

    PhosphoSiteiO43763.

    Expressioni

    Gene expression databases

    BgeeiO43763.
    CleanExiHS_TLX2.
    GenevestigatoriO43763.

    Organism-specific databases

    HPAiHPA040969.

    Interactioni

    Protein-protein interaction databases

    BioGridi109436. 9 interactions.
    STRINGi9606.ENSP00000233638.

    Structurei

    Secondary structure

    1
    284
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi166 – 17813
    Helixi184 – 19411
    Helixi198 – 21518

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3A03X-ray1.54A162-216[»]
    ProteinModelPortaliO43763.
    SMRiO43763. Positions 164-216.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO43763.

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi27 – 11589Gly-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG329715.
    HOGENOMiHOG000116280.
    HOVERGENiHBG036206.
    InParanoidiO43763.
    KOiK15606.
    OMAiAGQGHGE.
    OrthoDBiEOG7Q5HFW.
    PhylomeDBiO43763.
    TreeFamiTF325347.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O43763-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPGMLGPHN LPHHEPISFG IDQILSGPET PGGGLGLGRG GQGHGENGAF    50
    SGGYHGASGY GPAGSLAPLP GSSGVGPGGV IRVPAHRPLP VPPPAGGAPA 100
    VPGPSGLGGA GGLAGLTFPW MDSGRRFAKD RLTAALSPFS GTRRIGHPYQ 150
    NRTPPKRKKP RTSFSRSQVL ELERRFLRQK YLASAERAAL AKALRMTDAQ 200
    VKTWFQNRRT KWRRQTAEER EAERHRAGRL LLHLQQDALP RPLRPPLPPD 250
    PLCLHNSSLF ALQNLQPWAE DNKVASVSGL ASVV 284
    Length:284
    Mass (Da):30,251
    Last modified:May 10, 2002 - v2
    Checksum:i794B07A9E7817939
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti16 – 161P → A in CAA05636. 1 PublicationCurated
    Sequence conflicti30 – 323TPG → PR in CAA05636. 1 PublicationCurated
    Sequence conflicti37 – 4812LGRGG…HGENG → WVAGQVIGEWA in CAA05636. 1 PublicationCuratedAdd
    BLAST
    Sequence conflicti100 – 1023Missing in CAA05636. 1 PublicationCurated
    Sequence conflicti131 – 1366RLTAAL → PAV in CAA05636. 1 PublicationCurated
    Sequence conflicti196 – 1961M → T no nucleotide entry (PubMed:7518789)Curated
    Sequence conflicti219 – 2191Missing in CAA05636. 1 PublicationCurated
    Sequence conflicti241 – 2411R → T in CAA05636. 1 PublicationCurated
    Sequence conflicti274 – 2741V → A in CAA05636. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB008501 mRNA. Translation: BAA83463.1.
    AJ002607, AJ002608, AJ002609 Genomic DNA. Translation: CAA05636.1.
    AC005041 Genomic DNA. No translation available.
    BC006356 mRNA. Translation: AAH06356.1.
    CCDSiCCDS1947.1.
    RefSeqiNP_057254.1. NM_016170.4.
    UniGeneiHs.168586.

    Genome annotation databases

    EnsembliENST00000233638; ENSP00000233638; ENSG00000115297.
    GeneIDi3196.
    KEGGihsa:3196.
    UCSCiuc002smb.2. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB008501 mRNA. Translation: BAA83463.1 .
    AJ002607 , AJ002608 , AJ002609 Genomic DNA. Translation: CAA05636.1 .
    AC005041 Genomic DNA. No translation available.
    BC006356 mRNA. Translation: AAH06356.1 .
    CCDSi CCDS1947.1.
    RefSeqi NP_057254.1. NM_016170.4.
    UniGenei Hs.168586.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3A03 X-ray 1.54 A 162-216 [» ]
    ProteinModelPortali O43763.
    SMRi O43763. Positions 164-216.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109436. 9 interactions.
    STRINGi 9606.ENSP00000233638.

    PTM databases

    PhosphoSitei O43763.

    Proteomic databases

    PaxDbi O43763.
    PRIDEi O43763.

    Protocols and materials databases

    DNASUi 3196.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000233638 ; ENSP00000233638 ; ENSG00000115297 .
    GeneIDi 3196.
    KEGGi hsa:3196.
    UCSCi uc002smb.2. human.

    Organism-specific databases

    CTDi 3196.
    GeneCardsi GC02P074740.
    HGNCi HGNC:5057. TLX2.
    HPAi HPA040969.
    MIMi 604240. gene.
    neXtProti NX_O43763.
    PharmGKBi PA35096.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG329715.
    HOGENOMi HOG000116280.
    HOVERGENi HBG036206.
    InParanoidi O43763.
    KOi K15606.
    OMAi AGQGHGE.
    OrthoDBi EOG7Q5HFW.
    PhylomeDBi O43763.
    TreeFami TF325347.

    Enzyme and pathway databases

    SignaLinki O43763.

    Miscellaneous databases

    EvolutionaryTracei O43763.
    GeneWikii TLX2.
    GenomeRNAii 3196.
    NextBioi 12712.
    PROi O43763.
    SOURCEi Search...

    Gene expression databases

    Bgeei O43763.
    CleanExi HS_TLX2.
    Genevestigatori O43763.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "An enhancer element for expression of the Ncx (Enx, Hox11L1) gene in neural crest-derived cells."
      Iitsuka Y., Shimizu H., Kang M.M., Sasagawa K., Sekiya S., Tokuhisa T., Hatano M.
      J. Biol. Chem. 274:24401-24407(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Genomic characterization and chromosomal location of the human homeobox gene HOX11L1."
      Delgado P., Rodriguez R.E., Gonzalez-Sarmiento R.
      Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. "Identification of homeobox genes expressed in human haemopoietic progenitor cells."
      Moretti P., Simmons P., Thomas P., Haylock D., Rathjen P., Vadas M., D'Andrea R.
      Gene 144:213-219(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 165-203.
      Tissue: Bone marrow.
    6. "Cooperative DNA-binding and sequence-recognition mechanism of aristaless and clawless."
      Miyazono K., Zhi Y., Takamura Y., Nagata K., Saigo K., Kojima T., Tanokura M.
      EMBO J. 29:1613-1623(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.54 ANGSTROMS) OF 162-216, DNA-BINDING.

    Entry informationi

    Entry nameiTLX2_HUMAN
    AccessioniPrimary (citable) accession number: O43763
    Secondary accession number(s): Q9UD56, Q9UQ48
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: May 10, 2002
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3