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Protein

T-cell leukemia homeobox protein 2

Gene

TLX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transcription activator that binds DNA elements with the consensus sequence 5'-CGGTAATTGG-3'. Binds DNA via its homeobox. Required for normal cell death of enteric neurons in the gastrointestinal tract. Required for normal development of the enteric nervous system, and for proper development of normal motility of the gastrointestinal tract (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi157 – 21660HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiO43763.

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell leukemia homeobox protein 2
Alternative name(s):
Homeobox protein Hox-11L1
Neural crest homeobox protein
Gene namesi
Name:TLX2
Synonyms:HOX11L1, NCX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:5057. TLX2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35096.

Polymorphism and mutation databases

BioMutaiTLX2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284T-cell leukemia homeobox protein 2PRO_0000049336Add
BLAST

Proteomic databases

PaxDbiO43763.
PRIDEiO43763.

PTM databases

PhosphoSiteiO43763.

Expressioni

Gene expression databases

BgeeiO43763.
CleanExiHS_TLX2.
ExpressionAtlasiO43763. baseline and differential.
GenevisibleiO43763. HS.

Organism-specific databases

HPAiHPA040969.

Interactioni

Protein-protein interaction databases

BioGridi109436. 9 interactions.
STRINGi9606.ENSP00000233638.

Structurei

Secondary structure

1
284
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi166 – 17813Combined sources
Helixi184 – 19411Combined sources
Helixi198 – 21518Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3A03X-ray1.54A162-216[»]
ProteinModelPortaliO43763.
SMRiO43763. Positions 164-216.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43763.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi27 – 11589Gly-richAdd
BLAST

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG329715.
GeneTreeiENSGT00800000124015.
HOGENOMiHOG000116280.
HOVERGENiHBG036206.
InParanoidiO43763.
KOiK15606.
OMAiQGHGENG.
OrthoDBiEOG7Q5HFW.
PhylomeDBiO43763.
TreeFamiTF325347.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43763-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPGMLGPHN LPHHEPISFG IDQILSGPET PGGGLGLGRG GQGHGENGAF
60 70 80 90 100
SGGYHGASGY GPAGSLAPLP GSSGVGPGGV IRVPAHRPLP VPPPAGGAPA
110 120 130 140 150
VPGPSGLGGA GGLAGLTFPW MDSGRRFAKD RLTAALSPFS GTRRIGHPYQ
160 170 180 190 200
NRTPPKRKKP RTSFSRSQVL ELERRFLRQK YLASAERAAL AKALRMTDAQ
210 220 230 240 250
VKTWFQNRRT KWRRQTAEER EAERHRAGRL LLHLQQDALP RPLRPPLPPD
260 270 280
PLCLHNSSLF ALQNLQPWAE DNKVASVSGL ASVV
Length:284
Mass (Da):30,251
Last modified:May 10, 2002 - v2
Checksum:i794B07A9E7817939
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161P → A in CAA05636 (Ref. 2) Curated
Sequence conflicti30 – 323TPG → PR in CAA05636 (Ref. 2) Curated
Sequence conflicti37 – 4812LGRGG…HGENG → WVAGQVIGEWA in CAA05636 (Ref. 2) CuratedAdd
BLAST
Sequence conflicti100 – 1023Missing in CAA05636 (Ref. 2) Curated
Sequence conflicti131 – 1366RLTAAL → PAV in CAA05636 (Ref. 2) Curated
Sequence conflicti196 – 1961M → T no nucleotide entry (PubMed:7518789).Curated
Sequence conflicti219 – 2191Missing in CAA05636 (Ref. 2) Curated
Sequence conflicti241 – 2411R → T in CAA05636 (Ref. 2) Curated
Sequence conflicti274 – 2741V → A in CAA05636 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008501 mRNA. Translation: BAA83463.1.
AJ002607, AJ002608, AJ002609 Genomic DNA. Translation: CAA05636.1.
AC005041 Genomic DNA. No translation available.
BC006356 mRNA. Translation: AAH06356.1.
CCDSiCCDS1947.1.
RefSeqiNP_057254.1. NM_016170.4.
UniGeneiHs.168586.

Genome annotation databases

EnsembliENST00000233638; ENSP00000233638; ENSG00000115297.
GeneIDi3196.
KEGGihsa:3196.
UCSCiuc002smb.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008501 mRNA. Translation: BAA83463.1.
AJ002607, AJ002608, AJ002609 Genomic DNA. Translation: CAA05636.1.
AC005041 Genomic DNA. No translation available.
BC006356 mRNA. Translation: AAH06356.1.
CCDSiCCDS1947.1.
RefSeqiNP_057254.1. NM_016170.4.
UniGeneiHs.168586.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3A03X-ray1.54A162-216[»]
ProteinModelPortaliO43763.
SMRiO43763. Positions 164-216.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109436. 9 interactions.
STRINGi9606.ENSP00000233638.

PTM databases

PhosphoSiteiO43763.

Polymorphism and mutation databases

BioMutaiTLX2.

Proteomic databases

PaxDbiO43763.
PRIDEiO43763.

Protocols and materials databases

DNASUi3196.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233638; ENSP00000233638; ENSG00000115297.
GeneIDi3196.
KEGGihsa:3196.
UCSCiuc002smb.2. human.

Organism-specific databases

CTDi3196.
GeneCardsiGC02P074740.
HGNCiHGNC:5057. TLX2.
HPAiHPA040969.
MIMi604240. gene.
neXtProtiNX_O43763.
PharmGKBiPA35096.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG329715.
GeneTreeiENSGT00800000124015.
HOGENOMiHOG000116280.
HOVERGENiHBG036206.
InParanoidiO43763.
KOiK15606.
OMAiQGHGENG.
OrthoDBiEOG7Q5HFW.
PhylomeDBiO43763.
TreeFamiTF325347.

Enzyme and pathway databases

SignaLinkiO43763.

Miscellaneous databases

EvolutionaryTraceiO43763.
GeneWikiiTLX2.
GenomeRNAii3196.
NextBioi12712.
PROiO43763.
SOURCEiSearch...

Gene expression databases

BgeeiO43763.
CleanExiHS_TLX2.
ExpressionAtlasiO43763. baseline and differential.
GenevisibleiO43763. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "An enhancer element for expression of the Ncx (Enx, Hox11L1) gene in neural crest-derived cells."
    Iitsuka Y., Shimizu H., Kang M.M., Sasagawa K., Sekiya S., Tokuhisa T., Hatano M.
    J. Biol. Chem. 274:24401-24407(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genomic characterization and chromosomal location of the human homeobox gene HOX11L1."
    Delgado P., Rodriguez R.E., Gonzalez-Sarmiento R.
    Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "Identification of homeobox genes expressed in human haemopoietic progenitor cells."
    Moretti P., Simmons P., Thomas P., Haylock D., Rathjen P., Vadas M., D'Andrea R.
    Gene 144:213-219(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 165-203.
    Tissue: Bone marrow.
  6. "Cooperative DNA-binding and sequence-recognition mechanism of aristaless and clawless."
    Miyazono K., Zhi Y., Takamura Y., Nagata K., Saigo K., Kojima T., Tanokura M.
    EMBO J. 29:1613-1623(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.54 ANGSTROMS) OF 162-216, DNA-BINDING.

Entry informationi

Entry nameiTLX2_HUMAN
AccessioniPrimary (citable) accession number: O43763
Secondary accession number(s): Q9UD56, Q9UQ48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 10, 2002
Last modified: July 22, 2015
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.