O43761 (SNG3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Synaptogyrin-3

Gene names

Name:

SYNGR3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	229 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in the positive regulation of dopamine transporter activity. Probably facilitates the physical and functional interactions of the transporter with the dopamine vesicular storage system, allowing a more efficient loading of the vesicles with extracellular dopamine after release By similarity.
Subunit structure	Interacts (via N-terminus) with SLC6A3 (via N-terminus) By similarity.
Subcellular location	Membrane; Multi-pass membrane protein. Cytoplasmic vesicle › secretory vesicle › synaptic vesicle By similarity. Cell junction › synapse. Note: Found at the neuromuscular synapses By similarity.
Tissue specificity	Expressed in brain and placenta.
Sequence similarities	Belongs to the synaptogyrin family. Contains 1 MARVEL domain.

Ontologies

Keywords
Cellular component	Cell junction Cytoplasmic vesicle Membrane Synapse
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	positive regulation of transporter activity Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW integral to plasma membrane Traceable author statement. Source: ProtInc synaptic vesicle Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 229	229	Synaptogyrin-3		PRO_0000183996
Regions
	Transmembrane	30 – 50	21	Helical; Potential
	Transmembrane	70 – 90	21	Helical; Potential
	Transmembrane	105 – 125	21	Helical; Potential
	Transmembrane	148 – 168	21	Helical; Potential
	Domain	20 – 172	153	MARVEL

Sequences

	Sequence		Length	Mass (Da)
	O43761 [UniParc]. Last modified July 11, 2001. Version 2. Checksum: 0755812EDD4AD4C5	FASTA	229	24,555
	10 20 30 40 50 60 MEGASFGAGR AGAALDPVSF ARRPQTLLRV ASWVFSIAVF GPIVNEGYVN TDSGPELRCV 70 80 90 100 110 120 FNGNAGACRF GVALGLGAFL ACAAFLLLDV RFQQISSVRD RRRAVLLDLG FSGLWSFLWF 130 140 150 160 170 180 VGFCFLTNQW QRTAPGPATT QAGDAARAAI AFSFFSILSW VALTVKALQR FRLGTDMSLF 190 200 210 220 ATEQLSTGAS QAYPGYPVGS GVEGTETYQS PPFTETLDTS PKGYQVPAY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the human synaptogyrin gene family." Kedra D., Pan H.-Q., Seroussi E., Fransson I., Guilbaud C., Collins J.E., Dunham I., Blennow E., Roe B.A., Piehl F., Dumanski J.P. Hum. Genet. 103:131-141(1998) [PubMed: 9760194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	Kedra D. Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain cortex.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: B-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ002309 mRNA. Translation: CAA05326.2. AK313894 mRNA. Translation: BAG36617.1. CH471112 Genomic DNA. Translation: EAW85577.1. BC014087 mRNA. Translation: AAH14087.1.
IPI	IPI00013947.
RefSeq	NP_004200.2. NM_004209.5.
UniGene	Hs.435277.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	O43761.
PTM databases
PhosphoSite	O43761.
Proteomic databases
PRIDE	O43761.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000248121; ENSP00000248121; ENSG00000127561.
GeneID	9143.
KEGG	hsa:9143.
UCSC	uc002cod.1. human.
Organism-specific databases
CTD	9143.
GeneCards	GC16P002046.
H-InvDB	HIX0012708.
HGNC	HGNC:11501. SYNGR3.
MIM	603927. gene.
neXtProt	NX_O43761.
PharmGKB	PA36283.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG20593.
GeneTree	ENSGT00510000046450.
HOGENOM	HBG446580.
HOVERGEN	HBG000896.
InParanoid	O43761.
OMA	LSWVALT.
OrthoDB	EOG43JC5R.
PhylomeDB	O43761.
Gene expression databases
ArrayExpress	O43761.
Bgee	O43761.
CleanEx	HS_SYNGR3.
Genevestigator	O43761.
GermOnline	ENSG00000127561. Homo sapiens.
Family and domain databases
InterPro	IPR008253. Marvel. IPR021128. MARVEL-like_dom. IPR016579. Synaptogyrin. [Graphical view]
Pfam	PF01284. MARVEL. 1 hit. [Graphical view]
PIRSF	PIRSF011282. Synaptogyrin. 1 hit.
PROSITE	PS51225. MARVEL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	34291.
SOURCE	Search...

Entry information

Entry name

SNG3_HUMAN

Accession

Primary (citable) accession number: O43761
Secondary accession number(s): B2R9S0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	July 11, 2001
Last modified:	January 25, 2012
This is version 81 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.