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Protein

Synaptogyrin-3

Gene

SYNGR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the positive regulation of dopamine transporter activity. Probably facilitates the physical and functional interactions of the transporter with the dopamine vesicular storage system, allowing a more efficient loading of the vesicles with extracellular dopamine after release (By similarity).By similarity

GO - Biological processi

  • positive regulation of transporter activity Source: UniProtKB
  • substantia nigra development Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptogyrin-3
Gene namesi
Name:SYNGR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:11501. SYNGR3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei30 – 5021HelicalSequence analysisAdd
BLAST
Transmembranei70 – 9021HelicalSequence analysisAdd
BLAST
Transmembranei105 – 12521HelicalSequence analysisAdd
BLAST
Transmembranei148 – 16821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36283.

Polymorphism and mutation databases

BioMutaiSYNGR3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229Synaptogyrin-3PRO_0000183996Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO43761.
MaxQBiO43761.
PaxDbiO43761.
PRIDEiO43761.

PTM databases

iPTMnetiO43761.
PhosphoSiteiO43761.

Expressioni

Tissue specificityi

Expressed in brain and placenta.

Gene expression databases

BgeeiO43761.
CleanExiHS_SYNGR3.
ExpressionAtlasiO43761. baseline and differential.
GenevisibleiO43761. HS.

Organism-specific databases

HPAiCAB034278.
HPA042842.

Interactioni

Subunit structurei

Interacts (via N-terminus) with SLC6A3 (via N-terminus).By similarity

Protein-protein interaction databases

BioGridi114590. 4 interactions.
IntActiO43761. 1 interaction.
STRINGi9606.ENSP00000248121.

Structurei

3D structure databases

ProteinModelPortaliO43761.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 172153MARVELPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the synaptogyrin family.Curated
Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4016. Eukaryota.
ENOG4111F8S. LUCA.
GeneTreeiENSGT00510000046450.
HOGENOMiHOG000220816.
HOVERGENiHBG000896.
InParanoidiO43761.
OMAiANQWQQT.
PhylomeDBiO43761.
TreeFamiTF320995.

Family and domain databases

InterProiIPR008253. Marvel.
IPR016579. Synaptogyrin.
[Graphical view]
PANTHERiPTHR10838. PTHR10838. 1 hit.
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PIRSFiPIRSF011282. Synaptogyrin. 1 hit.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43761-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGASFGAGR AGAALDPVSF ARRPQTLLRV ASWVFSIAVF GPIVNEGYVN
60 70 80 90 100
TDSGPELRCV FNGNAGACRF GVALGLGAFL ACAAFLLLDV RFQQISSVRD
110 120 130 140 150
RRRAVLLDLG FSGLWSFLWF VGFCFLTNQW QRTAPGPATT QAGDAARAAI
160 170 180 190 200
AFSFFSILSW VALTVKALQR FRLGTDMSLF ATEQLSTGAS QAYPGYPVGS
210 220
GVEGTETYQS PPFTETLDTS PKGYQVPAY
Length:229
Mass (Da):24,555
Last modified:July 11, 2001 - v2
Checksum:i0755812EDD4AD4C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002309 mRNA. Translation: CAA05326.2.
AK313894 mRNA. Translation: BAG36617.1.
CH471112 Genomic DNA. Translation: EAW85577.1.
BC014087 mRNA. Translation: AAH14087.1.
CCDSiCCDS10456.1.
RefSeqiNP_004200.2. NM_004209.5.
UniGeneiHs.435277.

Genome annotation databases

EnsembliENST00000248121; ENSP00000248121; ENSG00000127561.
GeneIDi9143.
KEGGihsa:9143.
UCSCiuc002cod.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002309 mRNA. Translation: CAA05326.2.
AK313894 mRNA. Translation: BAG36617.1.
CH471112 Genomic DNA. Translation: EAW85577.1.
BC014087 mRNA. Translation: AAH14087.1.
CCDSiCCDS10456.1.
RefSeqiNP_004200.2. NM_004209.5.
UniGeneiHs.435277.

3D structure databases

ProteinModelPortaliO43761.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114590. 4 interactions.
IntActiO43761. 1 interaction.
STRINGi9606.ENSP00000248121.

PTM databases

iPTMnetiO43761.
PhosphoSiteiO43761.

Polymorphism and mutation databases

BioMutaiSYNGR3.

Proteomic databases

EPDiO43761.
MaxQBiO43761.
PaxDbiO43761.
PRIDEiO43761.

Protocols and materials databases

DNASUi9143.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000248121; ENSP00000248121; ENSG00000127561.
GeneIDi9143.
KEGGihsa:9143.
UCSCiuc002cod.3. human.

Organism-specific databases

CTDi9143.
GeneCardsiSYNGR3.
HGNCiHGNC:11501. SYNGR3.
HPAiCAB034278.
HPA042842.
MIMi603927. gene.
neXtProtiNX_O43761.
PharmGKBiPA36283.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4016. Eukaryota.
ENOG4111F8S. LUCA.
GeneTreeiENSGT00510000046450.
HOGENOMiHOG000220816.
HOVERGENiHBG000896.
InParanoidiO43761.
OMAiANQWQQT.
PhylomeDBiO43761.
TreeFamiTF320995.

Miscellaneous databases

GenomeRNAii9143.
PROiO43761.
SOURCEiSearch...

Gene expression databases

BgeeiO43761.
CleanExiHS_SYNGR3.
ExpressionAtlasiO43761. baseline and differential.
GenevisibleiO43761. HS.

Family and domain databases

InterProiIPR008253. Marvel.
IPR016579. Synaptogyrin.
[Graphical view]
PANTHERiPTHR10838. PTHR10838. 1 hit.
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PIRSFiPIRSF011282. Synaptogyrin. 1 hit.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Kedra D.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain cortex.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: B-cell.
  6. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSNG3_HUMAN
AccessioniPrimary (citable) accession number: O43761
Secondary accession number(s): B2R9S0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 11, 2001
Last modified: June 8, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.