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Protein

Synaptogyrin-2

Gene

SYNGR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptogyrin-2
Alternative name(s):
Cellugyrin
Gene namesi
Name:SYNGR2
ORF Names:UNQ352/PRO615
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:11499. SYNGR2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei26 – 4621HelicalSequence analysisAdd
BLAST
Transmembranei73 – 9321HelicalSequence analysisAdd
BLAST
Transmembranei105 – 12521HelicalSequence analysisAdd
BLAST
Transmembranei147 – 16721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB
  • neuromuscular junction Source: GO_Central
  • synaptic vesicle membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36281.

Polymorphism and mutation databases

BioMutaiSYNGR2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224Synaptogyrin-2PRO_0000183993Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO43760.
MaxQBiO43760.
PaxDbiO43760.
PRIDEiO43760.
TopDownProteomicsiO43760-1. [O43760-1]

PTM databases

iPTMnetiO43760.
PhosphoSiteiO43760.
SwissPalmiO43760.

Expressioni

Tissue specificityi

Ubiquitous; low expression in brain.

Gene expression databases

BgeeiO43760.
CleanExiHS_SYNGR2.
ExpressionAtlasiO43760. baseline and differential.
GenevisibleiO43760. HS.

Organism-specific databases

HPAiHPA014742.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SCARA3Q6AZY73EBI-2826419,EBI-8657660

Protein-protein interaction databases

BioGridi114591. 22 interactions.
IntActiO43760. 4 interactions.
STRINGi9606.ENSP00000225777.

Structurei

3D structure databases

ProteinModelPortaliO43760.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 171152MARVELPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the synaptogyrin family.Curated
Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITZZ. Eukaryota.
ENOG4111G0F. LUCA.
GeneTreeiENSGT00510000046450.
HOGENOMiHOG000220816.
HOVERGENiHBG000896.
InParanoidiO43760.
PhylomeDBiO43760.
TreeFamiTF320995.

Family and domain databases

InterProiIPR008253. Marvel.
IPR016579. Synaptogyrin.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PIRSFiPIRSF011282. Synaptogyrin. 1 hit.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O43760-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESGAYGAAK AGGSFDLRRF LTQPQVVARA VCLVFALIVF SCIYGEGYSN
60 70 80 90 100
AHESKQMYCV FNRNEDACRY GSAIGVLAFL ASAFFLVVDA YFPQISNATD
110 120 130 140 150
RKYLVIGDLL FSALWTFLWF VGFCFLTNQW AVTNPKDVLV GADSVRAAIT
160 170 180 190 200
FSFFSIFSWG VLASLAYQRY KAGVDDFIQN YVDPTPDPNT AYASYPGASV
210 220
DNYQQPPFTQ NAETTEGYQP PPVY
Length:224
Mass (Da):24,810
Last modified:June 1, 1998 - v1
Checksum:iEC92C95CE9E5BD41
GO
Isoform 2 (identifier: O43760-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     160-224: GVLASLAYQR...TEGYQPPPVY → VGWPGAGSWV...GPSPLPWTFP

Note: No experimental confirmation available.
Show »
Length:275
Mass (Da):30,375
Checksum:iEA7DB173C9907C1D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti160 – 1623GVL → VGW in CAA05327 (PubMed:9760194).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei160 – 22465GVLAS…PPPVY → VGWPGAGSWVKGGGGWGPPP TCTLLCSPCRVCWPPWPTSA TRLAWTTSSRITLTPLRTPT LPTPPTQVHLWTTTNSHPSP RTRRPPRATSRPLCTERRLA WEGGQRGPSPLPWTFP in isoform 2. 1 PublicationVSP_056179Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002308 mRNA. Translation: CAA05325.1.
AJ002310, AJ002312 Genomic DNA. Translation: CAA05327.1.
AY358916 mRNA. Translation: AAQ89275.1.
AC021593 Genomic DNA. No translation available.
BC000407 mRNA. Translation: AAH00407.1.
BC029755 mRNA. Translation: AAH29755.1.
BC105992 mRNA. Translation: AAI05993.1.
AL833010 mRNA. Translation: CAH56291.1.
CCDSiCCDS11753.1. [O43760-1]
RefSeqiNP_001307452.1. NM_001320523.1.
NP_004701.1. NM_004710.4. [O43760-1]
XP_005257849.1. XM_005257792.3. [O43760-2]
UniGeneiHs.464210.
Hs.653473.
Hs.708616.

Genome annotation databases

EnsembliENST00000225777; ENSP00000225777; ENSG00000108639. [O43760-1]
ENST00000585591; ENSP00000465678; ENSG00000108639. [O43760-1]
ENST00000588282; ENSP00000467600; ENSG00000108639. [O43760-2]
GeneIDi9144.
KEGGihsa:9144.
UCSCiuc002jut.4. human. [O43760-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002308 mRNA. Translation: CAA05325.1.
AJ002310, AJ002312 Genomic DNA. Translation: CAA05327.1.
AY358916 mRNA. Translation: AAQ89275.1.
AC021593 Genomic DNA. No translation available.
BC000407 mRNA. Translation: AAH00407.1.
BC029755 mRNA. Translation: AAH29755.1.
BC105992 mRNA. Translation: AAI05993.1.
AL833010 mRNA. Translation: CAH56291.1.
CCDSiCCDS11753.1. [O43760-1]
RefSeqiNP_001307452.1. NM_001320523.1.
NP_004701.1. NM_004710.4. [O43760-1]
XP_005257849.1. XM_005257792.3. [O43760-2]
UniGeneiHs.464210.
Hs.653473.
Hs.708616.

3D structure databases

ProteinModelPortaliO43760.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114591. 22 interactions.
IntActiO43760. 4 interactions.
STRINGi9606.ENSP00000225777.

PTM databases

iPTMnetiO43760.
PhosphoSiteiO43760.
SwissPalmiO43760.

Polymorphism and mutation databases

BioMutaiSYNGR2.

Proteomic databases

EPDiO43760.
MaxQBiO43760.
PaxDbiO43760.
PRIDEiO43760.
TopDownProteomicsiO43760-1. [O43760-1]

Protocols and materials databases

DNASUi9144.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225777; ENSP00000225777; ENSG00000108639. [O43760-1]
ENST00000585591; ENSP00000465678; ENSG00000108639. [O43760-1]
ENST00000588282; ENSP00000467600; ENSG00000108639. [O43760-2]
GeneIDi9144.
KEGGihsa:9144.
UCSCiuc002jut.4. human. [O43760-1]

Organism-specific databases

CTDi9144.
GeneCardsiSYNGR2.
HGNCiHGNC:11499. SYNGR2.
HPAiHPA014742.
MIMi603926. gene.
neXtProtiNX_O43760.
PharmGKBiPA36281.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITZZ. Eukaryota.
ENOG4111G0F. LUCA.
GeneTreeiENSGT00510000046450.
HOGENOMiHOG000220816.
HOVERGENiHBG000896.
InParanoidiO43760.
PhylomeDBiO43760.
TreeFamiTF320995.

Miscellaneous databases

ChiTaRSiSYNGR2. human.
GenomeRNAii9144.
PROiO43760.
SOURCEiSearch...

Gene expression databases

BgeeiO43760.
CleanExiHS_SYNGR2.
ExpressionAtlasiO43760. baseline and differential.
GenevisibleiO43760. HS.

Family and domain databases

InterProiIPR008253. Marvel.
IPR016579. Synaptogyrin.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PIRSFiPIRSF011282. Synaptogyrin. 1 hit.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Lung, Lymph and Skin.
  5. Bienvenut W.V.
    Submitted (FEB-2005) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 1-18, ACETYLATION AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: B-cell lymphoma.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 34-224 (ISOFORM 1).
    Tissue: Stomach.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSNG2_HUMAN
AccessioniPrimary (citable) accession number: O43760
Secondary accession number(s): O43762, Q3KQZ2, Q658S7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: June 8, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.