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Protein

Syntaxin-6

Gene

STX6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in intracellular vesicle trafficking.

GO - Molecular functioni

  • SNAP receptor activity Source: GO_Central
  • syntaxin binding Source: UniProtKB

GO - Biological processi

  • endocytic recycling Source: MGI
  • endosome organization Source: Ensembl
  • Golgi ribbon formation Source: UniProtKB
  • Golgi vesicle transport Source: InterPro
  • intracellular protein transport Source: GO_Central
  • regulation of cellular protein localization Source: Ensembl
  • regulation of protein localization Source: UniProtKB
  • retrograde transport, endosome to Golgi Source: UniProtKB
  • vesicle docking Source: GO_Central
  • vesicle fusion Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135823-MONOMER.
ReactomeiR-HSA-6811438. Intra-Golgi traffic.
R-HSA-6811440. Retrograde transport at the Trans-Golgi-Network.

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-6
Gene namesi
Name:STX6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:11441. STX6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 234CytoplasmicSequence analysisAdd BLAST233
Transmembranei235 – 255Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21

GO - Cellular componenti

  • clathrin-coated vesicle Source: UniProtKB
  • cytosol Source: GOC
  • early endosome Source: UniProtKB
  • Golgi apparatus Source: UniProtKB
  • Golgi membrane Source: Reactome
  • integral component of membrane Source: GO_Central
  • perinuclear region of cytoplasm Source: UniProtKB
  • phagocytic vesicle Source: Ensembl
  • plasma membrane Source: UniProtKB
  • SNARE complex Source: MGI
  • terminal bouton Source: Ensembl
  • trans-Golgi network Source: UniProtKB
  • trans-Golgi network membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10228.
OpenTargetsiENSG00000135823.
PharmGKBiPA36238.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002102082 – 255Syntaxin-6Add BLAST254

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineCombined sources1
Modified residuei129PhosphoserineCombined sources1
Modified residuei152PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO43752.
MaxQBiO43752.
PaxDbiO43752.
PeptideAtlasiO43752.
PRIDEiO43752.

PTM databases

iPTMnetiO43752.
PhosphoSitePlusiO43752.
SwissPalmiO43752.

Expressioni

Gene expression databases

BgeeiENSG00000135823.
CleanExiHS_STX6.
GenevisibleiO43752. HS.

Organism-specific databases

HPAiHPA038557.
HPA038558.

Interactioni

Subunit structurei

Binds EEA1. Interacts with VPS45A. Interacts with MARCH2 and MARCH3 (By similarity). Interacts with GOPC. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GOSR2O146533EBI-2695795,EBI-4401517
NAPBQ9H1154EBI-2695795,EBI-3921185
PSMA3P257883EBI-2695795,EBI-348380
STX4Q128466EBI-2695795,EBI-744942

GO - Molecular functioni

  • SNAP receptor activity Source: GO_Central
  • syntaxin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115522. 57 interactors.
DIPiDIP-44224N.
IntActiO43752. 17 interactors.
MINTiMINT-5002256.
STRINGi9606.ENSP00000258301.

Structurei

Secondary structure

1255
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 33Combined sources27
Turni35 – 37Combined sources3
Helixi40 – 73Combined sources34
Helixi75 – 78Combined sources4
Helixi82 – 107Combined sources26
Helixi173 – 229Combined sources57

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NPSX-ray2.50D169-234[»]
4J2CX-ray1.80A/C3-110[»]
ProteinModelPortaliO43752.
SMRiO43752.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43752.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini163 – 225t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili41 – 74Sequence analysisAdd BLAST34

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3202. Eukaryota.
ENOG410ZZA3. LUCA.
GeneTreeiENSGT00390000008991.
HOGENOMiHOG000237350.
HOVERGENiHBG007194.
InParanoidiO43752.
KOiK08498.
OMAiQVVREMK.
OrthoDBiEOG091G0KE5.
PhylomeDBiO43752.
TreeFamiTF313254.

Family and domain databases

InterProiIPR015260. Syntaxin-6_N.
IPR006012. Syntaxin/epimorphin_CS.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
PF09177. Syntaxin-6_N. 1 hit.
[Graphical view]
SMARTiSM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O43752-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSMEDPFFVV KGEVQKAVNT AQGLFQRWTE LLQDPSTATR EEIDWTTNEL
60 70 80 90 100
RNNLRSIEWD LEDLDETISI VEANPRKFNL DATELSIRKA FITSTRQVVR
110 120 130 140 150
DMKDQMSTSS VQALAERKNR QALLGDSGSQ NWSTGTTDKY GRLDRELQRA
160 170 180 190 200
NSHFIEEQQA QQQLIVEQQD EQLELVSGSI GVLKNMSQRI GGELEEQAVM
210 220 230 240 250
LEDFSHELES TQSRLDNVMK KLAKVSHMTS DRRQWCAIAI LFAVLLVVLI

LFLVL
Length:255
Mass (Da):29,176
Last modified:June 1, 1998 - v1
Checksum:iCC05C025DE1FE89E
GO
Isoform 2 (identifier: O43752-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.

Show »
Length:154
Mass (Da):17,434
Checksum:i63C26276F286C7E9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti77K → R in CAG46654 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0547631 – 101Missing in isoform 2. 1 PublicationAdd BLAST101

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002078 mRNA. Translation: CAA05177.1.
CR541856 mRNA. Translation: CAG46654.1.
CR541873 mRNA. Translation: CAG46671.1.
AK299063 mRNA. Translation: BAG61129.1.
AK312440 mRNA. Translation: BAG35349.1.
AL356267, AL162431 Genomic DNA. Translation: CAH72301.1.
AL162431, AL356267 Genomic DNA. Translation: CAH74088.1.
CH471067 Genomic DNA. Translation: EAW91091.1.
BC009944 mRNA. Translation: AAH09944.1.
CCDSiCCDS1341.1. [O43752-1]
CCDS65738.1. [O43752-2]
RefSeqiNP_001273139.1. NM_001286210.1. [O43752-2]
NP_005810.1. NM_005819.5. [O43752-1]
XP_016855496.1. XM_017000007.1. [O43752-2]
UniGeneiHs.518417.
Hs.737037.

Genome annotation databases

EnsembliENST00000258301; ENSP00000258301; ENSG00000135823. [O43752-1]
ENST00000542060; ENSP00000440188; ENSG00000135823. [O43752-2]
GeneIDi10228.
KEGGihsa:10228.
UCSCiuc010pnr.4. human. [O43752-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002078 mRNA. Translation: CAA05177.1.
CR541856 mRNA. Translation: CAG46654.1.
CR541873 mRNA. Translation: CAG46671.1.
AK299063 mRNA. Translation: BAG61129.1.
AK312440 mRNA. Translation: BAG35349.1.
AL356267, AL162431 Genomic DNA. Translation: CAH72301.1.
AL162431, AL356267 Genomic DNA. Translation: CAH74088.1.
CH471067 Genomic DNA. Translation: EAW91091.1.
BC009944 mRNA. Translation: AAH09944.1.
CCDSiCCDS1341.1. [O43752-1]
CCDS65738.1. [O43752-2]
RefSeqiNP_001273139.1. NM_001286210.1. [O43752-2]
NP_005810.1. NM_005819.5. [O43752-1]
XP_016855496.1. XM_017000007.1. [O43752-2]
UniGeneiHs.518417.
Hs.737037.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NPSX-ray2.50D169-234[»]
4J2CX-ray1.80A/C3-110[»]
ProteinModelPortaliO43752.
SMRiO43752.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115522. 57 interactors.
DIPiDIP-44224N.
IntActiO43752. 17 interactors.
MINTiMINT-5002256.
STRINGi9606.ENSP00000258301.

PTM databases

iPTMnetiO43752.
PhosphoSitePlusiO43752.
SwissPalmiO43752.

Proteomic databases

EPDiO43752.
MaxQBiO43752.
PaxDbiO43752.
PeptideAtlasiO43752.
PRIDEiO43752.

Protocols and materials databases

DNASUi10228.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258301; ENSP00000258301; ENSG00000135823. [O43752-1]
ENST00000542060; ENSP00000440188; ENSG00000135823. [O43752-2]
GeneIDi10228.
KEGGihsa:10228.
UCSCiuc010pnr.4. human. [O43752-1]

Organism-specific databases

CTDi10228.
DisGeNETi10228.
GeneCardsiSTX6.
HGNCiHGNC:11441. STX6.
HPAiHPA038557.
HPA038558.
MIMi603944. gene.
neXtProtiNX_O43752.
OpenTargetsiENSG00000135823.
PharmGKBiPA36238.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3202. Eukaryota.
ENOG410ZZA3. LUCA.
GeneTreeiENSGT00390000008991.
HOGENOMiHOG000237350.
HOVERGENiHBG007194.
InParanoidiO43752.
KOiK08498.
OMAiQVVREMK.
OrthoDBiEOG091G0KE5.
PhylomeDBiO43752.
TreeFamiTF313254.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135823-MONOMER.
ReactomeiR-HSA-6811438. Intra-Golgi traffic.
R-HSA-6811440. Retrograde transport at the Trans-Golgi-Network.

Miscellaneous databases

ChiTaRSiSTX6. human.
EvolutionaryTraceiO43752.
GeneWikiiSTX6.
GenomeRNAii10228.
PROiO43752.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135823.
CleanExiHS_STX6.
GenevisibleiO43752. HS.

Family and domain databases

InterProiIPR015260. Syntaxin-6_N.
IPR006012. Syntaxin/epimorphin_CS.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
PF09177. Syntaxin-6_N. 1 hit.
[Graphical view]
SMARTiSM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTX6_HUMAN
AccessioniPrimary (citable) accession number: O43752
Secondary accession number(s): B2R652
, B4DR17, Q5VY08, Q6FH83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 151 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.