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Protein

Syntaxin-6

Gene

STX6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in intracellular vesicle trafficking.

GO - Molecular functioni

  • SNAP receptor activity Source: GO_Central
  • syntaxin binding Source: UniProtKB

GO - Biological processi

  • endocytic recycling Source: MGI
  • endosome organization Source: Ensembl
  • Golgi ribbon formation Source: UniProtKB
  • Golgi vesicle transport Source: InterPro
  • intracellular protein transport Source: GO_Central
  • regulation of cellular protein localization Source: Ensembl
  • regulation of protein localization Source: UniProtKB
  • retrograde transport, endosome to Golgi Source: UniProtKB
  • vesicle docking Source: GO_Central
  • vesicle fusion Source: UniProtKB

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-6811438 Intra-Golgi traffic
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network

Protein family/group databases

TCDBi1.F.1.1.5 the synaptosomal vesicle fusion pore (svf-pore) family

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-6
Gene namesi
Name:STX6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000135823.13
HGNCiHGNC:11441 STX6
MIMi603944 gene
neXtProtiNX_O43752

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 234CytoplasmicSequence analysisAdd BLAST233
Transmembranei235 – 255Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10228
OpenTargetsiENSG00000135823
PharmGKBiPA36238

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002102082 – 255Syntaxin-6Add BLAST254

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineCombined sources1
Modified residuei129PhosphoserineCombined sources1
Modified residuei152PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO43752
MaxQBiO43752
PaxDbiO43752
PeptideAtlasiO43752
PRIDEiO43752

PTM databases

iPTMnetiO43752
PhosphoSitePlusiO43752
SwissPalmiO43752

Expressioni

Gene expression databases

BgeeiENSG00000135823
CleanExiHS_STX6
GenevisibleiO43752 HS

Organism-specific databases

HPAiHPA038557
HPA038558

Interactioni

Subunit structurei

Identified in a complex containing STX6, STX12, VAMP4 and VTI1A (PubMed:17159904). Binds EEA1 (By similarity). Interacts with VPS45A (By similarity). Interacts with MARCH2 and MARCH3 (By similarity). Interacts with GOPC (PubMed:11384996). Interacts with UHRF1BP1L (via C-terminal coiled-coil domain) (PubMed:20163565). Interacts with BAIAP3; this interaction is increased in the presence of calcium (PubMed:28626000).By similarity4 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • SNAP receptor activity Source: GO_Central
  • syntaxin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115522, 66 interactors
CORUMiO43752
DIPiDIP-44224N
IntActiO43752, 22 interactors
MINTiO43752
STRINGi9606.ENSP00000258301

Structurei

Secondary structure

1255
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 33Combined sources27
Turni35 – 37Combined sources3
Helixi40 – 73Combined sources34
Helixi75 – 78Combined sources4
Helixi82 – 107Combined sources26
Helixi173 – 229Combined sources57

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NPSX-ray2.50D169-234[»]
4J2CX-ray1.80A/C3-110[»]
ProteinModelPortaliO43752
SMRiO43752
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43752

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini163 – 225t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili41 – 74Sequence analysisAdd BLAST34

Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3202 Eukaryota
ENOG410ZZA3 LUCA
GeneTreeiENSGT00390000008991
HOGENOMiHOG000237350
HOVERGENiHBG007194
InParanoidiO43752
KOiK08498
OMAiWARNELK
OrthoDBiEOG091G0KE5
PhylomeDBiO43752
TreeFamiTF313254

Family and domain databases

InterProiView protein in InterPro
IPR010989 SNARE
IPR015260 Syntaxin-6_N
IPR006012 Syntaxin/epimorphin_CS
IPR000727 T_SNARE_dom
PfamiView protein in Pfam
PF05739 SNARE, 1 hit
PF09177 Syntaxin-6_N, 1 hit
SMARTiView protein in SMART
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS00914 SYNTAXIN, 1 hit
PS50192 T_SNARE, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O43752-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSMEDPFFVV KGEVQKAVNT AQGLFQRWTE LLQDPSTATR EEIDWTTNEL
60 70 80 90 100
RNNLRSIEWD LEDLDETISI VEANPRKFNL DATELSIRKA FITSTRQVVR
110 120 130 140 150
DMKDQMSTSS VQALAERKNR QALLGDSGSQ NWSTGTTDKY GRLDRELQRA
160 170 180 190 200
NSHFIEEQQA QQQLIVEQQD EQLELVSGSI GVLKNMSQRI GGELEEQAVM
210 220 230 240 250
LEDFSHELES TQSRLDNVMK KLAKVSHMTS DRRQWCAIAI LFAVLLVVLI

LFLVL
Length:255
Mass (Da):29,176
Last modified:June 1, 1998 - v1
Checksum:iCC05C025DE1FE89E
GO
Isoform 2 (identifier: O43752-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.

Show »
Length:154
Mass (Da):17,434
Checksum:i63C26276F286C7E9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti77K → R in CAG46654 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0547631 – 101Missing in isoform 2. 1 PublicationAdd BLAST101

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002078 mRNA Translation: CAA05177.1
CR541856 mRNA Translation: CAG46654.1
CR541873 mRNA Translation: CAG46671.1
AK299063 mRNA Translation: BAG61129.1
AK312440 mRNA Translation: BAG35349.1
AL356267 Genomic DNA No translation available.
AL162431 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91091.1
BC009944 mRNA Translation: AAH09944.1
CCDSiCCDS1341.1 [O43752-1]
CCDS65738.1 [O43752-2]
RefSeqiNP_001273139.1, NM_001286210.1 [O43752-2]
NP_005810.1, NM_005819.5 [O43752-1]
XP_016855496.1, XM_017000007.1 [O43752-2]
UniGeneiHs.518417
Hs.737037

Genome annotation databases

EnsembliENST00000258301; ENSP00000258301; ENSG00000135823 [O43752-1]
ENST00000542060; ENSP00000440188; ENSG00000135823 [O43752-2]
GeneIDi10228
KEGGihsa:10228
UCSCiuc010pnr.4 human [O43752-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSTX6_HUMAN
AccessioniPrimary (citable) accession number: O43752
Secondary accession number(s): B2R652
, B4DR17, Q5VY08, Q6FH83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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