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O43752

- STX6_HUMAN

UniProt

O43752 - STX6_HUMAN

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Protein

Syntaxin-6

Gene

STX6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in intracellular vesicle trafficking.

GO - Molecular functioni

  1. SNAP receptor activity Source: RefGenome

GO - Biological processi

  1. endosome organization Source: Ensembl
  2. Golgi vesicle transport Source: InterPro
  3. intracellular protein transport Source: RefGenome
  4. retrograde transport, endosome to Golgi Source: UniProtKB
  5. vesicle fusion Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-6
Gene namesi
Name:STX6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:11441. STX6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 234233CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei235 – 25521Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. clathrin-coated vesicle Source: UniProtKB
  2. early endosome Source: UniProtKB
  3. Golgi apparatus Source: UniProtKB
  4. integral component of membrane Source: RefGenome
  5. perinuclear region of cytoplasm Source: UniProtKB
  6. plasma membrane Source: UniProtKB
  7. SNARE complex Source: MGI
  8. trans-Golgi network membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36238.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 255254Syntaxin-6PRO_0000210208Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Modified residuei2 – 21Phosphoserine1 Publication
Modified residuei152 – 1521Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO43752.
PaxDbiO43752.
PeptideAtlasiO43752.
PRIDEiO43752.

PTM databases

PhosphoSiteiO43752.

Expressioni

Gene expression databases

BgeeiO43752.
CleanExiHS_STX6.
GenevestigatoriO43752.

Organism-specific databases

HPAiHPA038557.
HPA038558.

Interactioni

Subunit structurei

Binds EEA1. Interacts with VPS45A. Interacts with MARCH2 and MARCH3 (By similarity). Interacts with GOPC. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A.By similarity2 Publications

Protein-protein interaction databases

BioGridi115522. 40 interactions.
DIPiDIP-44224N.
IntActiO43752. 9 interactions.
MINTiMINT-5002256.
STRINGi9606.ENSP00000258301.

Structurei

Secondary structure

1
255
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi7 – 3327Combined sources
Turni35 – 373Combined sources
Helixi40 – 7334Combined sources
Helixi75 – 784Combined sources
Helixi82 – 10726Combined sources
Helixi173 – 22957Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2NPSX-ray2.50D169-234[»]
4J2CX-ray1.80A/C3-110[»]
ProteinModelPortaliO43752.
SMRiO43752. Positions 2-108, 170-232.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43752.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini163 – 22563t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili41 – 7434Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46901.
GeneTreeiENSGT00390000008991.
HOGENOMiHOG000237350.
HOVERGENiHBG007194.
InParanoidiO43752.
KOiK08498.
OMAiQVVREMK.
OrthoDBiEOG7JHM7F.
PhylomeDBiO43752.
TreeFamiTF313254.

Family and domain databases

InterProiIPR015260. Syntaxin-6_N.
IPR006012. Syntaxin/epimorphin_CS.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
PF09177. Syntaxin-6_N. 1 hit.
[Graphical view]
SMARTiSM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O43752-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSMEDPFFVV KGEVQKAVNT AQGLFQRWTE LLQDPSTATR EEIDWTTNEL
60 70 80 90 100
RNNLRSIEWD LEDLDETISI VEANPRKFNL DATELSIRKA FITSTRQVVR
110 120 130 140 150
DMKDQMSTSS VQALAERKNR QALLGDSGSQ NWSTGTTDKY GRLDRELQRA
160 170 180 190 200
NSHFIEEQQA QQQLIVEQQD EQLELVSGSI GVLKNMSQRI GGELEEQAVM
210 220 230 240 250
LEDFSHELES TQSRLDNVMK KLAKVSHMTS DRRQWCAIAI LFAVLLVVLI

LFLVL
Length:255
Mass (Da):29,176
Last modified:June 1, 1998 - v1
Checksum:iCC05C025DE1FE89E
GO
Isoform 2 (identifier: O43752-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.

Show »
Length:154
Mass (Da):17,434
Checksum:i63C26276F286C7E9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti77 – 771K → R in CAG46654. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 101101Missing in isoform 2. 1 PublicationVSP_054763Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002078 mRNA. Translation: CAA05177.1.
CR541856 mRNA. Translation: CAG46654.1.
CR541873 mRNA. Translation: CAG46671.1.
AK299063 mRNA. Translation: BAG61129.1.
AK312440 mRNA. Translation: BAG35349.1.
AL356267, AL162431 Genomic DNA. Translation: CAH72301.1.
AL162431, AL356267 Genomic DNA. Translation: CAH74088.1.
CH471067 Genomic DNA. Translation: EAW91091.1.
BC009944 mRNA. Translation: AAH09944.1.
CCDSiCCDS1341.1. [O43752-1]
CCDS65738.1. [O43752-2]
RefSeqiNP_001273139.1. NM_001286210.1. [O43752-2]
NP_005810.1. NM_005819.5. [O43752-1]
XP_005244881.1. XM_005244824.1. [O43752-2]
UniGeneiHs.518417.
Hs.737037.

Genome annotation databases

EnsembliENST00000258301; ENSP00000258301; ENSG00000135823. [O43752-1]
ENST00000542060; ENSP00000440188; ENSG00000135823. [O43752-2]
GeneIDi10228.
KEGGihsa:10228.
UCSCiuc010pnr.2. human. [O43752-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002078 mRNA. Translation: CAA05177.1 .
CR541856 mRNA. Translation: CAG46654.1 .
CR541873 mRNA. Translation: CAG46671.1 .
AK299063 mRNA. Translation: BAG61129.1 .
AK312440 mRNA. Translation: BAG35349.1 .
AL356267 , AL162431 Genomic DNA. Translation: CAH72301.1 .
AL162431 , AL356267 Genomic DNA. Translation: CAH74088.1 .
CH471067 Genomic DNA. Translation: EAW91091.1 .
BC009944 mRNA. Translation: AAH09944.1 .
CCDSi CCDS1341.1. [O43752-1 ]
CCDS65738.1. [O43752-2 ]
RefSeqi NP_001273139.1. NM_001286210.1. [O43752-2 ]
NP_005810.1. NM_005819.5. [O43752-1 ]
XP_005244881.1. XM_005244824.1. [O43752-2 ]
UniGenei Hs.518417.
Hs.737037.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2NPS X-ray 2.50 D 169-234 [» ]
4J2C X-ray 1.80 A/C 3-110 [» ]
ProteinModelPortali O43752.
SMRi O43752. Positions 2-108, 170-232.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115522. 40 interactions.
DIPi DIP-44224N.
IntActi O43752. 9 interactions.
MINTi MINT-5002256.
STRINGi 9606.ENSP00000258301.

PTM databases

PhosphoSitei O43752.

Proteomic databases

MaxQBi O43752.
PaxDbi O43752.
PeptideAtlasi O43752.
PRIDEi O43752.

Protocols and materials databases

DNASUi 10228.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000258301 ; ENSP00000258301 ; ENSG00000135823 . [O43752-1 ]
ENST00000542060 ; ENSP00000440188 ; ENSG00000135823 . [O43752-2 ]
GeneIDi 10228.
KEGGi hsa:10228.
UCSCi uc010pnr.2. human. [O43752-1 ]

Organism-specific databases

CTDi 10228.
GeneCardsi GC01M180941.
HGNCi HGNC:11441. STX6.
HPAi HPA038557.
HPA038558.
MIMi 603944. gene.
neXtProti NX_O43752.
PharmGKBi PA36238.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46901.
GeneTreei ENSGT00390000008991.
HOGENOMi HOG000237350.
HOVERGENi HBG007194.
InParanoidi O43752.
KOi K08498.
OMAi QVVREMK.
OrthoDBi EOG7JHM7F.
PhylomeDBi O43752.
TreeFami TF313254.

Miscellaneous databases

ChiTaRSi STX6. human.
EvolutionaryTracei O43752.
GeneWikii STX6.
GenomeRNAii 10228.
NextBioi 35474275.
PROi O43752.
SOURCEi Search...

Gene expression databases

Bgeei O43752.
CleanExi HS_STX6.
Genevestigatori O43752.

Family and domain databases

InterProi IPR015260. Syntaxin-6_N.
IPR006012. Syntaxin/epimorphin_CS.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view ]
Pfami PF05739. SNARE. 1 hit.
PF09177. Syntaxin-6_N. 1 hit.
[Graphical view ]
SMARTi SM00397. t_SNARE. 1 hit.
[Graphical view ]
SUPFAMi SSF47661. SSF47661. 1 hit.
PROSITEi PS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1."
    Martin-Martin B., Nabokina S.M., Lazo P.A., Mollinedo F.
    J. Leukoc. Biol. 65:397-406(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Muscle.
  7. "Association of a novel PDZ domain-containing peripheral Golgi protein with the Q-SNARE (Q-soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor) protein syntaxin 6."
    Charest A., Lane K., McMahon K., Housman D.E.
    J. Biol. Chem. 276:29456-29465(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH GOPC.
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-152, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Early endosomal SNAREs form a structurally conserved SNARE complex and fuse liposomes with multiple topologies."
    Zwilling D., Cypionka A., Pohl W.H., Fasshauer D., Walla P.J., Wahl M.C., Jahn R.
    EMBO J. 26:9-18(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 47-117 IN COMPLEX WITH STX12; VTI1A AND VAMP4, SUBUNIT.

Entry informationi

Entry nameiSTX6_HUMAN
AccessioniPrimary (citable) accession number: O43752
Secondary accession number(s): B2R652
, B4DR17, Q5VY08, Q6FH83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: November 26, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3