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Protein

Syntaxin-6

Gene

STX6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in intracellular vesicle trafficking.

GO - Molecular functioni

  • SNAP receptor activity Source: GO_Central
  • syntaxin binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-6811438. Intra-Golgi traffic.
R-HSA-6811440. Retrograde transport at the Trans-Golgi-Network.

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-6
Gene namesi
Name:STX6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000135823.13.
HGNCiHGNC:11441. STX6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 234CytoplasmicIEP:Add BLAST233
Transmembranei235 – 255Helical; Anchor for type IV membrane proteinIEP:Add BLAST21

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10228.
OpenTargetsiENSG00000135823.
PharmGKBiPA36238.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedND:
ChainiPRO_00002102082 – 255Syntaxin-6Add BLAST254

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineND:1
Modified residuei2PhosphoserineND:1
Modified residuei129PhosphoserineND:1
Modified residuei152PhosphoserineND:1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO43752.
MaxQBiO43752.
PaxDbiO43752.
PeptideAtlasiO43752.
PRIDEiO43752.

PTM databases

iPTMnetiO43752.
PhosphoSitePlusiO43752.
SwissPalmiO43752.

Expressioni

Gene expression databases

BgeeiENSG00000135823.
CleanExiHS_STX6.
GenevisibleiO43752. HS.

Organism-specific databases

HPAiHPA038557.
HPA038558.

Interactioni

Subunit structurei

Binds EEA1. Interacts with VPS45A. Interacts with MARCH2 and MARCH3 (By similarity). Interacts with GOPC. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A.HMP:2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • SNAP receptor activity Source: GO_Central
  • syntaxin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115522. 64 interactors.
CORUMiO43752.
DIPiDIP-44224N.
IntActiO43752. 20 interactors.
MINTiMINT-5002256.
STRINGi9606.ENSP00000258301.

Structurei

Secondary structure

1255
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 33ND:27
Turni35 – 37ND:3
Helixi40 – 73ND:34
Helixi75 – 78ND:4
Helixi82 – 107ND:26
Helixi173 – 229ND:57

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NPSX-ray2.50D169-234[»]
4J2CX-ray1.80A/C3-110[»]
ProteinModelPortaliO43752.
SMRiO43752.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43752.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini163 – 225t-SNARE coiled-coil homologyIEP:Add BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili41 – 74IEP:Add BLAST34

Sequence similaritiesi

Belongs to the syntaxin family.IKR:

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3202. Eukaryota.
ENOG410ZZA3. LUCA.
GeneTreeiENSGT00390000008991.
HOGENOMiHOG000237350.
HOVERGENiHBG007194.
InParanoidiO43752.
KOiK08498.
OMAiWARNELK.
OrthoDBiEOG091G0KE5.
PhylomeDBiO43752.
TreeFamiTF313254.

Family and domain databases

InterProiView protein in InterPro
IPR010989. SNARE.
IPR015260. Syntaxin-6_N.
IPR006012. Syntaxin/epimorphin_CS.
IPR000727. T_SNARE_dom.
PfamiView protein in Pfam
PF05739. SNARE. 1 hit.
PF09177. Syntaxin-6_N. 1 hit.
SMARTiView protein in SMART
SM00397. t_SNARE. 1 hit.
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiView protein in PROSITE
PS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O43752-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSMEDPFFVV KGEVQKAVNT AQGLFQRWTE LLQDPSTATR EEIDWTTNEL
60 70 80 90 100
RNNLRSIEWD LEDLDETISI VEANPRKFNL DATELSIRKA FITSTRQVVR
110 120 130 140 150
DMKDQMSTSS VQALAERKNR QALLGDSGSQ NWSTGTTDKY GRLDRELQRA
160 170 180 190 200
NSHFIEEQQA QQQLIVEQQD EQLELVSGSI GVLKNMSQRI GGELEEQAVM
210 220 230 240 250
LEDFSHELES TQSRLDNVMK KLAKVSHMTS DRRQWCAIAI LFAVLLVVLI

LFLVL
Length:255
Mass (Da):29,176
Last modified:June 1, 1998 - v1
Checksum:iCC05C025DE1FE89E
GO
Isoform 2 (identifier: O43752-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.

Show »
Length:154
Mass (Da):17,434
Checksum:i63C26276F286C7E9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti77K → R in CAG46654 (Ref. 2) IKR:1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0547631 – 101Missing in isoform 2. IBD:Add BLAST101

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002078 mRNA. Translation: CAA05177.1.
CR541856 mRNA. Translation: CAG46654.1.
CR541873 mRNA. Translation: CAG46671.1.
AK299063 mRNA. Translation: BAG61129.1.
AK312440 mRNA. Translation: BAG35349.1.
AL356267 Genomic DNA. No translation available.
AL162431 Genomic DNA. No translation available.
CH471067 Genomic DNA. Translation: EAW91091.1.
BC009944 mRNA. Translation: AAH09944.1.
CCDSiCCDS1341.1. [O43752-1]
CCDS65738.1. [O43752-2]
RefSeqiNP_001273139.1. NM_001286210.1. [O43752-2]
NP_005810.1. NM_005819.5. [O43752-1]
XP_016855496.1. XM_017000007.1. [O43752-2]
UniGeneiHs.518417.
Hs.737037.

Genome annotation databases

EnsembliENST00000258301; ENSP00000258301; ENSG00000135823. [O43752-1]
ENST00000542060; ENSP00000440188; ENSG00000135823. [O43752-2]
GeneIDi10228.
KEGGihsa:10228.
UCSCiuc010pnr.4. human. [O43752-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSTX6_HUMAN
AccessioniPrimary (citable) accession number: O43752
Secondary accession number(s): B2R652
, B4DR17, Q5VY08, Q6FH83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: November 22, 2017
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families