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Protein

Olfactory receptor 1F1

Gene

OR1F1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1F1
Alternative name(s):
Olfactory receptor 16-35
Short name:
OR16-35
Olfactory receptor 1F10
Olfactory receptor 1F4
Olfactory receptor 1F5
Olfactory receptor 1F6
Olfactory receptor 1F7
Olfactory receptor 1F8
Olfactory receptor 1F9
Olfactory receptor OR16-4
Gene namesi
Name:OR1F1
Synonyms:OLFMF, OR1F10, OR1F4, OR1F5, OR1F6, OR1F7, OR1F8, OR1F9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:8194. OR1F1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini50 – 578CytoplasmicSequence Analysis
Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
BLAST
Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini159 – 19638ExtracellularSequence AnalysisAdd
BLAST
Transmembranei197 – 21923Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini220 – 23617CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei237 – 25923Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
BLAST
Transmembranei273 – 29220Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini293 – 31220CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32070.

Polymorphism and mutation databases

BioMutaiOR1F1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Olfactory receptor 1F1PRO_0000150431Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiO43749.

PTM databases

PhosphoSiteiO43749.

Expressioni

Gene expression databases

BgeeiO43749.
CleanExiHS_OR1F1.
GenevisibleiO43749. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000305424.

Structurei

3D structure databases

ProteinModelPortaliO43749.
SMRiO43749. Positions 32-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150110.
GeneTreeiENSGT00800000124028.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiO43749.
KOiK04257.
OMAiNTHLNEV.
OrthoDBiEOG7JT6WV.
PhylomeDBiO43749.
TreeFamiTF337210.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43749-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGTNQSSVS EFLLLGLSRQ PQQQHLLFVF FLSMYLATVL GNLLIILSVS
60 70 80 90 100
IDSCLHTPMY FFLSNLSFVD ICFSFTTVPK MLANHILETQ TISFCGCLTQ
110 120 130 140 150
MYFVFMFVDM DNFLLAVMAY DHFVAVCHPL HYTAKMTHQL CALLVAGLWV
160 170 180 190 200
VANLNVLLHT LLMAPLSFCA DNAITHFFCD VTPLLKLSCS DTHLNEVIIL
210 220 230 240 250
SEGALVMITP FLCILASYMH ITCTVLKVPS TKGRWKAFST CGSHLAVVLL
260 270 280 290 300
FYSTIIAVYF NPLSSHSAEK DTMATVLYTV VTPMLNPFIY SLRNRYLKGA
310
LKKVVGRVVF SV
Length:312
Mass (Da):34,866
Last modified:June 1, 1998 - v1
Checksum:i5C1E1708A18B10E4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti191 – 1911D → N in CAA74794 (PubMed:9288094).Curated
Sequence conflicti305 – 3051V → I in CAA74794 (PubMed:9288094).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti75 – 751F → S.
Corresponds to variant rs1834026 [ dbSNP | Ensembl ].
VAR_024086
Natural varianti126 – 1261V → M.
Corresponds to variant rs8045183 [ dbSNP | Ensembl ].
VAR_053121

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14442 mRNA. Translation: CAA74794.1.
AJ003147 Genomic DNA. Translation: CAA05903.1.
AB065907 Genomic DNA. Translation: BAC06122.1.
BC069335 mRNA. Translation: AAH69335.1.
U86234 Genomic DNA. Translation: AAC39614.1.
AF399559 Genomic DNA. Translation: AAK95044.1.
BK004247 Genomic DNA. Translation: DAA04645.1.
CCDSiCCDS10496.1.
RefSeqiNP_036492.1. NM_012360.1.
XP_011520809.1. XM_011522507.1.
XP_011520810.1. XM_011522508.1.
XP_011520811.1. XM_011522509.1.
UniGeneiHs.664502.

Genome annotation databases

EnsembliENST00000304646; ENSP00000305424; ENSG00000168124.
GeneIDi4992.
KEGGihsa:4992.
UCSCiuc010uwu.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14442 mRNA. Translation: CAA74794.1.
AJ003147 Genomic DNA. Translation: CAA05903.1.
AB065907 Genomic DNA. Translation: BAC06122.1.
BC069335 mRNA. Translation: AAH69335.1.
U86234 Genomic DNA. Translation: AAC39614.1.
AF399559 Genomic DNA. Translation: AAK95044.1.
BK004247 Genomic DNA. Translation: DAA04645.1.
CCDSiCCDS10496.1.
RefSeqiNP_036492.1. NM_012360.1.
XP_011520809.1. XM_011522507.1.
XP_011520810.1. XM_011522508.1.
XP_011520811.1. XM_011522509.1.
UniGeneiHs.664502.

3D structure databases

ProteinModelPortaliO43749.
SMRiO43749. Positions 32-305.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000305424.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiO43749.

Polymorphism and mutation databases

BioMutaiOR1F1.

Proteomic databases

PRIDEiO43749.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304646; ENSP00000305424; ENSG00000168124.
GeneIDi4992.
KEGGihsa:4992.
UCSCiuc010uwu.2. human.

Organism-specific databases

CTDi4992.
GeneCardsiGC16P003269.
H-InvDBHIX0202335.
HGNCiHGNC:8194. OR1F1.
MIMi603232. gene.
neXtProtiNX_O43749.
PharmGKBiPA32070.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG150110.
GeneTreeiENSGT00800000124028.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiO43749.
KOiK04257.
OMAiNTHLNEV.
OrthoDBiEOG7JT6WV.
PhylomeDBiO43749.
TreeFamiTF337210.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR1F1.
GenomeRNAii4992.
NextBioi19224.
PROiO43749.
SOURCEiSearch...

Gene expression databases

BgeeiO43749.
CleanExiHS_OR1F1.
GenevisibleiO43749. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
  6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
  7. Cited for: IDENTIFICATION.
  8. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR1F1_HUMAN
AccessioniPrimary (citable) accession number: O43749
Secondary accession number(s): O15246, Q6IFL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: July 22, 2015
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.