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O43749

- OR1F1_HUMAN

UniProt

O43749 - OR1F1_HUMAN

Protein

Olfactory receptor 1F1

Gene

OR1F1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    GO - Biological processi

    1. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 1F1
    Alternative name(s):
    Olfactory receptor 16-35
    Short name:
    OR16-35
    Olfactory receptor 1F10
    Olfactory receptor 1F4
    Olfactory receptor 1F5
    Olfactory receptor 1F6
    Olfactory receptor 1F7
    Olfactory receptor 1F8
    Olfactory receptor 1F9
    Olfactory receptor OR16-4
    Gene namesi
    Name:OR1F1
    Synonyms:OLFMF, OR1F10, OR1F4, OR1F5, OR1F6, OR1F7, OR1F8, OR1F9
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:8194. OR1F1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32070.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 312312Olfactory receptor 1F1PRO_0000150431Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiO43749.

    PTM databases

    PhosphoSiteiO43749.

    Expressioni

    Gene expression databases

    BgeeiO43749.
    CleanExiHS_OR1F1.
    GenevestigatoriO43749.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000305424.

    Structurei

    3D structure databases

    ProteinModelPortaliO43749.
    SMRiO43749. Positions 32-305.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini50 – 578CytoplasmicSequence Analysis
    Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini159 – 19638ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini220 – 23617CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini293 – 31220CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei197 – 21923Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei237 – 25923Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei273 – 29220Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG150110.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiO43749.
    KOiK04257.
    OMAiYMHITCT.
    OrthoDBiEOG7JT6WV.
    PhylomeDBiO43749.
    TreeFamiTF337210.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O43749-1 [UniParc]FASTAAdd to Basket

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    MSGTNQSSVS EFLLLGLSRQ PQQQHLLFVF FLSMYLATVL GNLLIILSVS    50
    IDSCLHTPMY FFLSNLSFVD ICFSFTTVPK MLANHILETQ TISFCGCLTQ 100
    MYFVFMFVDM DNFLLAVMAY DHFVAVCHPL HYTAKMTHQL CALLVAGLWV 150
    VANLNVLLHT LLMAPLSFCA DNAITHFFCD VTPLLKLSCS DTHLNEVIIL 200
    SEGALVMITP FLCILASYMH ITCTVLKVPS TKGRWKAFST CGSHLAVVLL 250
    FYSTIIAVYF NPLSSHSAEK DTMATVLYTV VTPMLNPFIY SLRNRYLKGA 300
    LKKVVGRVVF SV 312
    Length:312
    Mass (Da):34,866
    Last modified:June 1, 1998 - v1
    Checksum:i5C1E1708A18B10E4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti191 – 1911D → N in CAA74794. (PubMed:9288094)Curated
    Sequence conflicti305 – 3051V → I in CAA74794. (PubMed:9288094)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti75 – 751F → S.
    Corresponds to variant rs1834026 [ dbSNP | Ensembl ].
    VAR_024086
    Natural varianti126 – 1261V → M.
    Corresponds to variant rs8045183 [ dbSNP | Ensembl ].
    VAR_053121

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y14442 mRNA. Translation: CAA74794.1.
    AJ003147 Genomic DNA. Translation: CAA05903.1.
    AB065907 Genomic DNA. Translation: BAC06122.1.
    BC069335 mRNA. Translation: AAH69335.1.
    U86234 Genomic DNA. Translation: AAC39614.1.
    AF399559 Genomic DNA. Translation: AAK95044.1.
    BK004247 Genomic DNA. Translation: DAA04645.1.
    CCDSiCCDS10496.1.
    RefSeqiNP_036492.1. NM_012360.1.
    UniGeneiHs.664502.

    Genome annotation databases

    EnsembliENST00000304646; ENSP00000305424; ENSG00000168124.
    GeneIDi4992.
    KEGGihsa:4992.
    UCSCiuc010uwu.2. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y14442 mRNA. Translation: CAA74794.1 .
    AJ003147 Genomic DNA. Translation: CAA05903.1 .
    AB065907 Genomic DNA. Translation: BAC06122.1 .
    BC069335 mRNA. Translation: AAH69335.1 .
    U86234 Genomic DNA. Translation: AAC39614.1 .
    AF399559 Genomic DNA. Translation: AAK95044.1 .
    BK004247 Genomic DNA. Translation: DAA04645.1 .
    CCDSi CCDS10496.1.
    RefSeqi NP_036492.1. NM_012360.1.
    UniGenei Hs.664502.

    3D structure databases

    ProteinModelPortali O43749.
    SMRi O43749. Positions 32-305.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000305424.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei O43749.

    Proteomic databases

    PRIDEi O43749.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000304646 ; ENSP00000305424 ; ENSG00000168124 .
    GeneIDi 4992.
    KEGGi hsa:4992.
    UCSCi uc010uwu.2. human.

    Organism-specific databases

    CTDi 4992.
    GeneCardsi GC16P003260.
    H-InvDB HIX0202335.
    HGNCi HGNC:8194. OR1F1.
    MIMi 603232. gene.
    neXtProti NX_O43749.
    PharmGKBi PA32070.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG150110.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi O43749.
    KOi K04257.
    OMAi YMHITCT.
    OrthoDBi EOG7JT6WV.
    PhylomeDBi O43749.
    TreeFami TF337210.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR1F1.
    GenomeRNAii 4992.
    NextBioi 19224.
    PROi O43749.
    SOURCEi Search...

    Gene expression databases

    Bgeei O43749.
    CleanExi HS_OR1F1.
    Genevestigatori O43749.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
    6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
    7. Cited for: IDENTIFICATION.
    8. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR1F1_HUMAN
    AccessioniPrimary (citable) accession number: O43749
    Secondary accession number(s): O15246, Q6IFL5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 130 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3