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O43749

- OR1F1_HUMAN

UniProt

O43749 - OR1F1_HUMAN

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Protein

Olfactory receptor 1F1

Gene

OR1F1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro

GO - Biological processi

  1. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1F1
Alternative name(s):
Olfactory receptor 16-35
Short name:
OR16-35
Olfactory receptor 1F10
Olfactory receptor 1F4
Olfactory receptor 1F5
Olfactory receptor 1F6
Olfactory receptor 1F7
Olfactory receptor 1F8
Olfactory receptor 1F9
Olfactory receptor OR16-4
Gene namesi
Name:OR1F1
Synonyms:OLFMF, OR1F10, OR1F4, OR1F5, OR1F6, OR1F7, OR1F8, OR1F9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:8194. OR1F1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini50 – 578CytoplasmicSequence Analysis
Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
BLAST
Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini159 – 19638ExtracellularSequence AnalysisAdd
BLAST
Transmembranei197 – 21923Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini220 – 23617CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei237 – 25923Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
BLAST
Transmembranei273 – 29220Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini293 – 31220CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32070.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Olfactory receptor 1F1PRO_0000150431Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiO43749.

PTM databases

PhosphoSiteiO43749.

Expressioni

Gene expression databases

BgeeiO43749.
CleanExiHS_OR1F1.
GenevestigatoriO43749.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000305424.

Structurei

3D structure databases

ProteinModelPortaliO43749.
SMRiO43749. Positions 32-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150110.
GeneTreeiENSGT00760000118845.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiO43749.
KOiK04257.
OMAiYMHITCT.
OrthoDBiEOG7JT6WV.
PhylomeDBiO43749.
TreeFamiTF337210.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43749-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGTNQSSVS EFLLLGLSRQ PQQQHLLFVF FLSMYLATVL GNLLIILSVS
60 70 80 90 100
IDSCLHTPMY FFLSNLSFVD ICFSFTTVPK MLANHILETQ TISFCGCLTQ
110 120 130 140 150
MYFVFMFVDM DNFLLAVMAY DHFVAVCHPL HYTAKMTHQL CALLVAGLWV
160 170 180 190 200
VANLNVLLHT LLMAPLSFCA DNAITHFFCD VTPLLKLSCS DTHLNEVIIL
210 220 230 240 250
SEGALVMITP FLCILASYMH ITCTVLKVPS TKGRWKAFST CGSHLAVVLL
260 270 280 290 300
FYSTIIAVYF NPLSSHSAEK DTMATVLYTV VTPMLNPFIY SLRNRYLKGA
310
LKKVVGRVVF SV
Length:312
Mass (Da):34,866
Last modified:June 1, 1998 - v1
Checksum:i5C1E1708A18B10E4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti191 – 1911D → N in CAA74794. (PubMed:9288094)Curated
Sequence conflicti305 – 3051V → I in CAA74794. (PubMed:9288094)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti75 – 751F → S.
Corresponds to variant rs1834026 [ dbSNP | Ensembl ].
VAR_024086
Natural varianti126 – 1261V → M.
Corresponds to variant rs8045183 [ dbSNP | Ensembl ].
VAR_053121

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14442 mRNA. Translation: CAA74794.1.
AJ003147 Genomic DNA. Translation: CAA05903.1.
AB065907 Genomic DNA. Translation: BAC06122.1.
BC069335 mRNA. Translation: AAH69335.1.
U86234 Genomic DNA. Translation: AAC39614.1.
AF399559 Genomic DNA. Translation: AAK95044.1.
BK004247 Genomic DNA. Translation: DAA04645.1.
CCDSiCCDS10496.1.
RefSeqiNP_036492.1. NM_012360.1.
UniGeneiHs.664502.

Genome annotation databases

EnsembliENST00000304646; ENSP00000305424; ENSG00000168124.
GeneIDi4992.
KEGGihsa:4992.
UCSCiuc010uwu.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14442 mRNA. Translation: CAA74794.1 .
AJ003147 Genomic DNA. Translation: CAA05903.1 .
AB065907 Genomic DNA. Translation: BAC06122.1 .
BC069335 mRNA. Translation: AAH69335.1 .
U86234 Genomic DNA. Translation: AAC39614.1 .
AF399559 Genomic DNA. Translation: AAK95044.1 .
BK004247 Genomic DNA. Translation: DAA04645.1 .
CCDSi CCDS10496.1.
RefSeqi NP_036492.1. NM_012360.1.
UniGenei Hs.664502.

3D structure databases

ProteinModelPortali O43749.
SMRi O43749. Positions 32-305.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000305424.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei O43749.

Proteomic databases

PRIDEi O43749.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000304646 ; ENSP00000305424 ; ENSG00000168124 .
GeneIDi 4992.
KEGGi hsa:4992.
UCSCi uc010uwu.2. human.

Organism-specific databases

CTDi 4992.
GeneCardsi GC16P003269.
H-InvDB HIX0202335.
HGNCi HGNC:8194. OR1F1.
MIMi 603232. gene.
neXtProti NX_O43749.
PharmGKBi PA32070.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG150110.
GeneTreei ENSGT00760000118845.
HOGENOMi HOG000041364.
HOVERGENi HBG017625.
InParanoidi O43749.
KOi K04257.
OMAi YMHITCT.
OrthoDBi EOG7JT6WV.
PhylomeDBi O43749.
TreeFami TF337210.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR1F1.
GenomeRNAii 4992.
NextBioi 19224.
PROi O43749.
SOURCEi Search...

Gene expression databases

Bgeei O43749.
CleanExi HS_OR1F1.
Genevestigatori O43749.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
  6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
  7. Cited for: IDENTIFICATION.
  8. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR1F1_HUMAN
AccessioniPrimary (citable) accession number: O43749
Secondary accession number(s): O15246, Q6IFL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: October 29, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3