Olfactory receptor 1F1 - Homo sapiens (Human)

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O43749 (OR1F1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 119. History...

Clusters with 100%, 90%, 50% identity |

Documents (6) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Olfactory receptor 1F1

Alternative name(s):
Olfactory receptor 16-35
Short name=OR16-35
Olfactory receptor 1F10
Olfactory receptor 1F4
Olfactory receptor 1F5
Olfactory receptor 1F6
Olfactory receptor 1F7
Olfactory receptor 1F8
Olfactory receptor 1F9
Olfactory receptor OR16-4

Gene names

Name:	OR1F1
Synonyms:	OLFMF, OR1F10, OR1F4, OR1F5, OR1F6, OR1F7, OR1F8, OR1F9

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC signal transduction Non-traceable author statement Ref.5. Source: ProtInc
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 312

312

Olfactory receptor 1F1

PRO_0000150431

Regions

Topological domain

1 – 25

Extracellular Potential

Transmembrane

26 – 49

Helical; Name=1; Potential

Topological domain

50 – 57

Cytoplasmic Potential

Transmembrane

58 – 79

Helical; Name=2; Potential

Topological domain

80 – 100

Extracellular Potential

Transmembrane

101 – 120

Helical; Name=3; Potential

Topological domain

121 – 139

Cytoplasmic Potential

Transmembrane

140 – 158

Helical; Name=4; Potential

Topological domain

159 – 196

Extracellular Potential

Transmembrane

197 – 219

Helical; Name=5; Potential

Topological domain

220 – 236

Cytoplasmic Potential

Transmembrane

237 – 259

Helical; Name=6; Potential

Topological domain

260 – 272

Extracellular Potential

Transmembrane

273 – 292

Helical; Name=7; Potential

Topological domain

293 – 312

Cytoplasmic Potential

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Disulfide bond

97 ↔ 189

By similarity

Natural variations

Natural variant

F → S.
Corresponds to variant rs1834026 [ dbSNP | Ensembl ].

VAR_024086

Natural variant

126

V → M.
Corresponds to variant rs8045183 [ dbSNP | Ensembl ].

VAR_053121

Experimental info

Sequence conflict

191

D → N in CAA74794. Ref.1

Sequence conflict

305

V → I in CAA74794. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

O43749 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 5C1E1708A18B10E4
Show »

FASTA

312

34,866

        10         20         30         40         50         60 
MSGTNQSSVS EFLLLGLSRQ PQQQHLLFVF FLSMYLATVL GNLLIILSVS IDSCLHTPMY 

        70         80         90        100        110        120 
FFLSNLSFVD ICFSFTTVPK MLANHILETQ TISFCGCLTQ MYFVFMFVDM DNFLLAVMAY 

       130        140        150        160        170        180 
DHFVAVCHPL HYTAKMTHQL CALLVAGLWV VANLNVLLHT LLMAPLSFCA DNAITHFFCD 

       190        200        210        220        230        240 
VTPLLKLSCS DTHLNEVIIL SEGALVMITP FLCILASYMH ITCTVLKVPS TKGRWKAFST 

       250        260        270        280        290        300 
CGSHLAVVLL FYSTIIAVYF NPLSSHSAEK DTMATVLYTV VTPMLNPFIY SLRNRYLKGA 

       310 
LKKVVGRVVF SV

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A candidate gene for familial Mediterranean fever." Bernot A., Clepet C., Dasilva C., Devaud C., Petit J.-L., Caloustian C., Cruaud C., Samson D., Pulcini F., Weissenbach J., Heilig R., Notanicola C., Domingo C., Rozenbaum M., Benchetrit E., Topaloglu R., Dewalle M., Dross C. Grateau G. Nat. Genet. 17:25-31(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"A transcriptional map of the FMF region." Bernot A., Heilig R., Clepet C., Smaoui N., Da Silva C., Petit J.-L., Devaud C., Chiannilkulchai N., Fizames C., Samson D., Cruaud C., Caloustian C., Gyapay G., Delpech M., Weissenbach J. Genomics 50:147-160(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Distribution of olfactory receptor genes in the human genome." Rouquier S., Taviaux S., Trask B.J., Brand-Arpon V., Van den Engh G., Demaille J.G., Giorgi D. Nat. Genet. 18:243-250(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
[6]	"DEFOG: a practical scheme for deciphering families of genes." Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R. Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
[7]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[8]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y14442 mRNA. Translation: CAA74794.1. AJ003147 Genomic DNA. Translation: CAA05903.1. AB065907 Genomic DNA. Translation: BAC06122.1. BC069335 mRNA. Translation: AAH69335.1. U86234 Genomic DNA. Translation: AAC39614.1. AF399559 Genomic DNA. Translation: AAK95044.1. BK004247 Genomic DNA. Translation: DAA04645.1.
IPI	IPI00013916.
RefSeq	NP_036492.1. NM_012360.1.
UniGene	Hs.664502.
3D structure databases
ProteinModelPortal	O43749.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000305424.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	O43749.
Proteomic databases
PRIDE	O43749.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000304646; ENSP00000305424; ENSG00000168124.
GeneID	4992.
KEGG	hsa:4992.
UCSC	uc010uwu.2. human.
Organism-specific databases
CTD	4992.
GeneCards	GC16P003257.
H-InvDB	HIX0202335.
HGNC	HGNC:8194. OR1F1.
MIM	603232. gene.
neXtProt	NX_O43749.
PharmGKB	PA32070.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG150110.
HOGENOM	HOG000041364.
HOVERGEN	HBG017625.
InParanoid	O43749.
KO	K04257.
OMA	YMHITCT.
OrthoDB	EOG4MKNGZ.
PhylomeDB	O43749.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	O43749.
CleanEx	HS_OR1F1.
Genevestigator	O43749.
GermOnline	ENSG00000168124. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR24236. PTHR24236. 1 hit.
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	4992.
NextBio	19224.
SOURCE	Search...

Entry information

Entry name

OR1F1_HUMAN

Accession

Primary (citable) accession number: O43749
Secondary accession number(s): O15246, Q6IFL5

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	June 1, 1998
Last modified:	May 1, 2013
This is version 119 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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List of 7-transmembrane G-linked receptor entries

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Web resources

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents