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O43749 (OR1F1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 1F1
Alternative name(s):
Olfactory receptor 16-35
Short name=OR16-35
Olfactory receptor 1F10
Olfactory receptor 1F4
Olfactory receptor 1F5
Olfactory receptor 1F6
Olfactory receptor 1F7
Olfactory receptor 1F8
Olfactory receptor 1F9
Olfactory receptor OR16-4
Gene names
Name:OR1F1
Synonyms:OLFMF, OR1F10, OR1F4, OR1F5, OR1F6, OR1F7, OR1F8, OR1F9
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 312312Olfactory receptor 1F1
PRO_0000150431

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4924Helical; Name=1; Potential
Topological domain50 – 578Cytoplasmic Potential
Transmembrane58 – 7922Helical; Name=2; Potential
Topological domain80 – 10021Extracellular Potential
Transmembrane101 – 12020Helical; Name=3; Potential
Topological domain121 – 13919Cytoplasmic Potential
Transmembrane140 – 15819Helical; Name=4; Potential
Topological domain159 – 19638Extracellular Potential
Transmembrane197 – 21923Helical; Name=5; Potential
Topological domain220 – 23617Cytoplasmic Potential
Transmembrane237 – 25923Helical; Name=6; Potential
Topological domain260 – 27213Extracellular Potential
Transmembrane273 – 29220Helical; Name=7; Potential
Topological domain293 – 31220Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 189 By similarity

Natural variations

Natural variant751F → S.
Corresponds to variant rs1834026 [ dbSNP | Ensembl ].
VAR_024086
Natural variant1261V → M.
Corresponds to variant rs8045183 [ dbSNP | Ensembl ].
VAR_053121

Experimental info

Sequence conflict1911D → N in CAA74794. Ref.1
Sequence conflict3051V → I in CAA74794. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O43749 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 5C1E1708A18B10E4

FASTA31234,866
        10         20         30         40         50         60 
MSGTNQSSVS EFLLLGLSRQ PQQQHLLFVF FLSMYLATVL GNLLIILSVS IDSCLHTPMY 

        70         80         90        100        110        120 
FFLSNLSFVD ICFSFTTVPK MLANHILETQ TISFCGCLTQ MYFVFMFVDM DNFLLAVMAY 

       130        140        150        160        170        180 
DHFVAVCHPL HYTAKMTHQL CALLVAGLWV VANLNVLLHT LLMAPLSFCA DNAITHFFCD 

       190        200        210        220        230        240 
VTPLLKLSCS DTHLNEVIIL SEGALVMITP FLCILASYMH ITCTVLKVPS TKGRWKAFST 

       250        260        270        280        290        300 
CGSHLAVVLL FYSTIIAVYF NPLSSHSAEK DTMATVLYTV VTPMLNPFIY SLRNRYLKGA 

       310 
LKKVVGRVVF SV 

« Hide

References

« Hide 'large scale' references
[1]"A candidate gene for familial Mediterranean fever."
Bernot A., Clepet C., Dasilva C., Devaud C., Petit J.-L., Caloustian C., Cruaud C., Samson D., Pulcini F., Weissenbach J., Heilig R., Notanicola C., Domingo C., Rozenbaum M., Benchetrit E., Topaloglu R., Dewalle M., Dross C. expand/collapse author list , Hadjari P., Dupont M., Demaille J.G., Touitou I., Smaoui N., Nedelec B., Mery J.-P., Chaabouni H., Delpech M., Grateau G.
Nat. Genet. 17:25-31(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"A transcriptional map of the FMF region."
Bernot A., Heilig R., Clepet C., Smaoui N., Da Silva C., Petit J.-L., Devaud C., Chiannilkulchai N., Fizames C., Samson D., Cruaud C., Caloustian C., Gyapay G., Delpech M., Weissenbach J.
Genomics 50:147-160(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Distribution of olfactory receptor genes in the human genome."
Rouquier S., Taviaux S., Trask B.J., Brand-Arpon V., Van den Engh G., Demaille J.G., Giorgi D.
Nat. Genet. 18:243-250(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
[6]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
[7]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[8]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y14442 mRNA. Translation: CAA74794.1.
AJ003147 Genomic DNA. Translation: CAA05903.1.
AB065907 Genomic DNA. Translation: BAC06122.1.
BC069335 mRNA. Translation: AAH69335.1.
U86234 Genomic DNA. Translation: AAC39614.1.
AF399559 Genomic DNA. Translation: AAK95044.1.
BK004247 Genomic DNA. Translation: DAA04645.1.
CCDSCCDS10496.1.
RefSeqNP_036492.1. NM_012360.1.
UniGeneHs.664502.

3D structure databases

ProteinModelPortalO43749.
SMRO43749. Positions 32-305.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000305424.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteO43749.

Proteomic databases

PRIDEO43749.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000304646; ENSP00000305424; ENSG00000168124.
GeneID4992.
KEGGhsa:4992.
UCSCuc010uwu.2. human.

Organism-specific databases

CTD4992.
GeneCardsGC16P003260.
H-InvDBHIX0202335.
HGNCHGNC:8194. OR1F1.
MIM603232. gene.
neXtProtNX_O43749.
PharmGKBPA32070.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG150110.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidO43749.
KOK04257.
OMAYMHITCT.
OrthoDBEOG7JT6WV.
PhylomeDBO43749.
TreeFamTF337210.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeO43749.
CleanExHS_OR1F1.
GenevestigatorO43749.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR1F1.
GenomeRNAi4992.
NextBio19224.
PROO43749.
SOURCESearch...

Entry information

Entry nameOR1F1_HUMAN
AccessionPrimary (citable) accession number: O43749
Secondary accession number(s): O15246, Q6IFL5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: July 9, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries