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Protein

Olfactory receptor 1F1

Gene

OR1F1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: GO_Central
  • signal transduction Source: ProtInc

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1F1
Alternative name(s):
Olfactory receptor 16-35
Short name:
OR16-35
Olfactory receptor 1F10
Olfactory receptor 1F4
Olfactory receptor 1F5
Olfactory receptor 1F6
Olfactory receptor 1F7
Olfactory receptor 1F8
Olfactory receptor 1F9
Olfactory receptor OR16-4
Gene namesi
Name:OR1F1
Synonyms:OLFMF, OR1F10, OR1F4, OR1F5, OR1F6, OR1F7, OR1F8, OR1F9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000168124.2.
HGNCiHGNC:8194. OR1F1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 196ExtracellularSequence analysisAdd BLAST38
Transmembranei197 – 219Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini220 – 236CytoplasmicSequence analysisAdd BLAST17
Transmembranei237 – 259Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini260 – 272ExtracellularSequence analysisAdd BLAST13
Transmembranei273 – 292Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini293 – 312CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168124.
PharmGKBiPA32070.

Polymorphism and mutation databases

BioMutaiOR1F1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504311 – 312Olfactory receptor 1F1Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO43749.
PeptideAtlasiO43749.
PRIDEiO43749.

PTM databases

PhosphoSitePlusiO43749.

Expressioni

Gene expression databases

BgeeiENSG00000168124.
CleanExiHS_OR1F1.
GenevisibleiO43749. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000305424.

Structurei

3D structure databases

ProteinModelPortaliO43749.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVEZ. Eukaryota.
ENOG41113FS. LUCA.
GeneTreeiENSGT00860000133676.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiO43749.
KOiK04257.
OMAiTAKMTHQ.
OrthoDBiEOG091G0B53.
PhylomeDBiO43749.
TreeFamiTF337210.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
PfamiView protein in Pfam
PF13853. 7tm_4. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiView protein in PROSITE
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O43749-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGTNQSSVS EFLLLGLSRQ PQQQHLLFVF FLSMYLATVL GNLLIILSVS
60 70 80 90 100
IDSCLHTPMY FFLSNLSFVD ICFSFTTVPK MLANHILETQ TISFCGCLTQ
110 120 130 140 150
MYFVFMFVDM DNFLLAVMAY DHFVAVCHPL HYTAKMTHQL CALLVAGLWV
160 170 180 190 200
VANLNVLLHT LLMAPLSFCA DNAITHFFCD VTPLLKLSCS DTHLNEVIIL
210 220 230 240 250
SEGALVMITP FLCILASYMH ITCTVLKVPS TKGRWKAFST CGSHLAVVLL
260 270 280 290 300
FYSTIIAVYF NPLSSHSAEK DTMATVLYTV VTPMLNPFIY SLRNRYLKGA
310
LKKVVGRVVF SV
Length:312
Mass (Da):34,866
Last modified:June 1, 1998 - v1
Checksum:i5C1E1708A18B10E4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti191D → N in CAA74794 (PubMed:9288094).Curated1
Sequence conflicti305V → I in CAA74794 (PubMed:9288094).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02408675F → S. Corresponds to variant dbSNP:rs1834026Ensembl.1
Natural variantiVAR_053121126V → M. Corresponds to variant dbSNP:rs8045183Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14442 mRNA. Translation: CAA74794.1.
AJ003147 Genomic DNA. Translation: CAA05903.1.
AB065907 Genomic DNA. Translation: BAC06122.1.
BC069335 mRNA. Translation: AAH69335.1.
U86234 Genomic DNA. Translation: AAC39614.1.
AF399559 Genomic DNA. Translation: AAK95044.1.
BK004247 Genomic DNA. Translation: DAA04645.1.
CCDSiCCDS10496.1.
RefSeqiNP_036492.1. NM_012360.1.
XP_011520809.1. XM_011522507.2.
UniGeneiHs.664502.

Genome annotation databases

EnsembliENST00000304646; ENSP00000305424; ENSG00000168124.
GeneIDi4992.
KEGGihsa:4992.
UCSCiuc010uwu.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR1F1_HUMAN
AccessioniPrimary (citable) accession number: O43749
Secondary accession number(s): O15246, Q6IFL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: September 27, 2017
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families