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O43747

- AP1G1_HUMAN

UniProt

O43747 - AP1G1_HUMAN

Protein

AP-1 complex subunit gamma-1

Gene

AP1G1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 5 (01 May 2007)
      Previous versions | rss
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    Functioni

    Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

    GO - Molecular functioni

    1. GTP-dependent protein binding Source: BHF-UCL
    2. kinesin binding Source: UniProtKB
    3. protein binding Source: UniProtKB
    4. protein transporter activity Source: InterPro
    5. Rab GTPase binding Source: BHF-UCL
    6. transporter activity Source: ProtInc

    GO - Biological processi

    1. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
    2. endosome to melanosome transport Source: BHF-UCL
    3. Golgi to lysosome transport Source: UniProt
    4. intracellular protein transport Source: ProtInc
    5. melanosome organization Source: BHF-UCL
    6. membrane organization Source: Reactome
    7. positive regulation of natural killer cell degranulation Source: UniProt
    8. positive regulation of natural killer cell mediated cytotoxicity Source: UniProt
    9. post-Golgi vesicle-mediated transport Source: Reactome
    10. regulation of defense response to virus by virus Source: Reactome
    11. viral process Source: Reactome

    Keywords - Biological processi

    Protein transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_11103. Nef mediated downregulation of MHC class I complex cell surface expression.
    REACT_121399. MHC class II antigen presentation.
    REACT_19287. Lysosome Vesicle Biogenesis.
    REACT_19400. Golgi Associated Vesicle Biogenesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AP-1 complex subunit gamma-1
    Alternative name(s):
    Adaptor protein complex AP-1 subunit gamma-1
    Adaptor-related protein complex 1 subunit gamma-1
    Clathrin assembly protein complex 1 gamma-1 large chain
    Gamma1-adaptin
    Golgi adaptor HA1/AP1 adaptin subunit gamma-1
    Gene namesi
    Name:AP1G1
    Synonyms:ADTG, CLAPG1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:555. AP1G1.

    Subcellular locationi

    Golgi apparatus 1 Publication. Cytoplasmic vesicleclathrin-coated vesicle membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
    Note: Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.

    GO - Cellular componenti

    1. AP-type membrane coat adaptor complex Source: ProtInc
    2. clathrin adaptor complex Source: InterPro
    3. clathrin-coated vesicle Source: MGI
    4. clathrin-coated vesicle membrane Source: BHF-UCL
    5. cytoplasm Source: HPA
    6. cytoplasmic vesicle membrane Source: Reactome
    7. cytosol Source: Reactome
    8. Golgi apparatus Source: UniProtKB
    9. Golgi membrane Source: Reactome
    10. intracellular membrane-bounded organelle Source: HPA
    11. lysosomal membrane Source: Reactome
    12. membrane Source: UniProtKB
    13. perinuclear region of cytoplasm Source: Ensembl
    14. recycling endosome Source: UniProtKB
    15. trans-Golgi network membrane Source: Reactome

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24845.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 822821AP-1 complex subunit gamma-1PRO_0000193758Add
    BLAST

    Proteomic databases

    MaxQBiO43747.
    PaxDbiO43747.
    PRIDEiO43747.

    PTM databases

    PhosphoSiteiO43747.

    Miscellaneous databases

    PMAP-CutDBO43747.

    Expressioni

    Tissue specificityi

    Widely expressed.

    Gene expression databases

    ArrayExpressiO43747.
    BgeeiO43747.
    CleanExiHS_AP1G1.
    GenevestigatoriO43747.

    Organism-specific databases

    HPAiCAB009049.
    HPA041224.

    Interactioni

    Subunit structurei

    Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3). Binds RABEP1 and SYNRG. Interacts (via GAE domain) with AP1AR (via coiled-coil domain).3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    RABEP1Q152762EBI-447609,EBI-447043

    Protein-protein interaction databases

    BioGridi106673. 30 interactions.
    IntActiO43747. 20 interactions.
    MINTiMINT-3369703.
    STRINGi9606.ENSP00000377148.

    Structurei

    Secondary structure

    1
    822
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi707 – 7126
    Beta strandi715 – 7239
    Beta strandi730 – 73910
    Beta strandi741 – 7433
    Beta strandi745 – 7539
    Beta strandi758 – 7625
    Helixi772 – 7743
    Beta strandi778 – 7858
    Beta strandi795 – 8028
    Beta strandi805 – 8128
    Helixi818 – 8203

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1IU1X-ray1.80A/B677-822[»]
    ProteinModelPortaliO43747.
    SMRiO43747. Positions 1-589, 700-822.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO43747.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini702 – 817116GAEPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 GAE domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG303101.
    HOGENOMiHOG000210271.
    HOVERGENiHBG067473.
    KOiK12391.
    OrthoDBiEOG7S7SD7.
    PhylomeDBiO43747.
    TreeFamiTF300367.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    2.60.40.1230. 2 hits.
    InterProiIPR017107. AP1_complex_gsu.
    IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR002553. Clathrin/coatomer_adapt-like_N.
    IPR008152. Clathrin_a/b/g-adaptin_app_Ig.
    IPR008153. Clathrin_g-adaptin_app.
    IPR013041. Coatomer/clathrin_app_Ig-like.
    [Graphical view]
    PfamiPF01602. Adaptin_N. 1 hit.
    PF02883. Alpha_adaptinC2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037094. AP1_complex_gamma. 1 hit.
    SMARTiSM00809. Alpha_adaptinC2. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    SSF49348. SSF49348. 1 hit.
    PROSITEiPS50180. GAE. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O43747-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPAPIRLREL IRTIRTARTQ AEEREMIQKE CAAIRSSFRE EDNTYRCRNV    50
    AKLLYMHMLG YPAHFGQLEC LKLIASQKFT DKRIGYLGAM LLLDERQDVH 100
    LLMTNCIKND LNHSTQFVQG LALCTLGCMG SSEMCRDLAG EVEKLLKTSN 150
    SYLRKKAALC AVHVIRKVPE LMEMFLPATK NLLNEKNHGV LHTSVVLLTE 200
    MCERSPDMLA HFRKLVPQLV RILKNLIMSG YSPEHDVSGI SDPFLQVRIL 250
    RLLRILGRND DDSSEAMNDI LAQVATNTET SKNVGNAILY ETVLTIMDIK 300
    SESGLRVLAI NILGRFLLNN DKNIRYVALT SLLKTVQTDH NAVQRHRSTI 350
    VDCLKDLDVS IKRRAMELSF ALVNGNNIRG MMKELLYFLD SCEPEFKADC 400
    ASGIFLAAEK YAPSKRWHID TIMRVLTTAG SYVRDDAVPN LIQLITNSVE 450
    MHAYTVQRLY KAILGDYSQQ PLVQVAAWCI GEYGDLLVSG QCEEEEPIQV 500
    TEDEVLDILE SVLISNMSTS VTRGYALTAI MKLSTRFTCT VNRIKKVVSI 550
    YGSSIDVELQ QRAVEYNALF KKYDHMRSAL LERMPVMEKV TTNGPTEIVQ 600
    TNGETEPAPL ETKPPPSGPQ PTSQANDLLD LLGGNDITPV IPTAPTSKPS 650
    SAGGELLDLL GDINLTGAPA AAPAPASVPQ ISQPPFLLDG LSSQPLFNDI 700
    AAGIPSITAY SKNGLKIEFT FERSNTNPSV TVITIQASNS TELDMTDFVF 750
    QAAVPKTFQL QLLSPSSSIV PAFNTGTITQ VIKVLNPQKQ QLRMRIKLTY 800
    NHKGSAMQDL AEVNNFPPQS WQ 822
    Length:822
    Mass (Da):91,351
    Last modified:May 1, 2007 - v5
    Checksum:i42EF40223DFBA5E9
    GO
    Isoform 2 (identifier: O43747-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         213-213: R → RKNE

    Show »
    Length:825
    Mass (Da):91,723
    Checksum:i1F5EA713F104978C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti61 – 611Y → N in CAA11832. (PubMed:9653655)Curated
    Sequence conflicti141 – 1411E → K in CAA11832. (PubMed:9653655)Curated
    Sequence conflicti154 – 1541R → K in CAA11832. (PubMed:9653655)Curated
    Sequence conflicti174 – 1752MF → NV in CAA11832. (PubMed:9653655)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti195 – 1951V → G.
    Corresponds to variant rs36037071 [ dbSNP | Ensembl ].
    VAR_048194
    Natural varianti685 – 6851P → H.1 Publication
    Corresponds to variant rs904763 [ dbSNP | Ensembl ].
    VAR_013572

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei213 – 2131R → RKNE in isoform 2. 1 PublicationVSP_040133

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y12226 mRNA. Translation: CAA72902.1.
    AJ224112, AJ224113, AJ224114 Genomic DNA. Translation: CAA11832.1.
    AB015317 mRNA. Translation: BAA33389.1.
    AC009097 Genomic DNA. No translation available.
    AC010653 Genomic DNA. No translation available.
    AL050025 mRNA. No translation available.
    AL110198 mRNA. Translation: CAB53673.1.
    CCDSiCCDS32480.1. [O43747-1]
    CCDS45522.1. [O43747-2]
    RefSeqiNP_001025178.1. NM_001030007.1. [O43747-2]
    NP_001119.3. NM_001128.5. [O43747-1]
    UniGeneiHs.461253.

    Genome annotation databases

    EnsembliENST00000299980; ENSP00000299980; ENSG00000166747. [O43747-1]
    ENST00000393512; ENSP00000377148; ENSG00000166747. [O43747-2]
    ENST00000569748; ENSP00000454523; ENSG00000166747. [O43747-1]
    GeneIDi164.
    KEGGihsa:164.
    UCSCiuc010cgg.3. human. [O43747-1]
    uc021tky.1. human. [O43747-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y12226 mRNA. Translation: CAA72902.1 .
    AJ224112 , AJ224113 , AJ224114 Genomic DNA. Translation: CAA11832.1 .
    AB015317 mRNA. Translation: BAA33389.1 .
    AC009097 Genomic DNA. No translation available.
    AC010653 Genomic DNA. No translation available.
    AL050025 mRNA. No translation available.
    AL110198 mRNA. Translation: CAB53673.1 .
    CCDSi CCDS32480.1. [O43747-1 ]
    CCDS45522.1. [O43747-2 ]
    RefSeqi NP_001025178.1. NM_001030007.1. [O43747-2 ]
    NP_001119.3. NM_001128.5. [O43747-1 ]
    UniGenei Hs.461253.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1IU1 X-ray 1.80 A/B 677-822 [» ]
    ProteinModelPortali O43747.
    SMRi O43747. Positions 1-589, 700-822.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106673. 30 interactions.
    IntActi O43747. 20 interactions.
    MINTi MINT-3369703.
    STRINGi 9606.ENSP00000377148.

    PTM databases

    PhosphoSitei O43747.

    Proteomic databases

    MaxQBi O43747.
    PaxDbi O43747.
    PRIDEi O43747.

    Protocols and materials databases

    DNASUi 164.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000299980 ; ENSP00000299980 ; ENSG00000166747 . [O43747-1 ]
    ENST00000393512 ; ENSP00000377148 ; ENSG00000166747 . [O43747-2 ]
    ENST00000569748 ; ENSP00000454523 ; ENSG00000166747 . [O43747-1 ]
    GeneIDi 164.
    KEGGi hsa:164.
    UCSCi uc010cgg.3. human. [O43747-1 ]
    uc021tky.1. human. [O43747-2 ]

    Organism-specific databases

    CTDi 164.
    GeneCardsi GC16M071762.
    HGNCi HGNC:555. AP1G1.
    HPAi CAB009049.
    HPA041224.
    MIMi 603533. gene.
    neXtProti NX_O43747.
    PharmGKBi PA24845.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG303101.
    HOGENOMi HOG000210271.
    HOVERGENi HBG067473.
    KOi K12391.
    OrthoDBi EOG7S7SD7.
    PhylomeDBi O43747.
    TreeFami TF300367.

    Enzyme and pathway databases

    Reactomei REACT_11103. Nef mediated downregulation of MHC class I complex cell surface expression.
    REACT_121399. MHC class II antigen presentation.
    REACT_19287. Lysosome Vesicle Biogenesis.
    REACT_19400. Golgi Associated Vesicle Biogenesis.

    Miscellaneous databases

    ChiTaRSi AP1G1. human.
    EvolutionaryTracei O43747.
    GeneWikii AP1G1.
    GenomeRNAii 164.
    NextBioi 659.
    PMAP-CutDB O43747.
    PROi O43747.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O43747.
    Bgeei O43747.
    CleanExi HS_AP1G1.
    Genevestigatori O43747.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    2.60.40.1230. 2 hits.
    InterProi IPR017107. AP1_complex_gsu.
    IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR002553. Clathrin/coatomer_adapt-like_N.
    IPR008152. Clathrin_a/b/g-adaptin_app_Ig.
    IPR008153. Clathrin_g-adaptin_app.
    IPR013041. Coatomer/clathrin_app_Ig-like.
    [Graphical view ]
    Pfami PF01602. Adaptin_N. 1 hit.
    PF02883. Alpha_adaptinC2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037094. AP1_complex_gamma. 1 hit.
    SMARTi SM00809. Alpha_adaptinC2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    SSF49348. SSF49348. 1 hit.
    PROSITEi PS50180. GAE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, expression pattern, and chromosomal assignment to 16q23 of the human gamma-adaptin gene (ADTG)."
      Peyrard M., Parveneh S., Lagerkrantz S., Ekman M., Fransson I., Sahlen S., Dumanski J.P.
      Genomics 50:275-280(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2).
    2. "Identification and characterization of novel clathrin adaptor-related proteins."
      Takatsu H., Sakurai M., Shin H.-W., Murakami K., Nakayama K.
      J. Biol. Chem. 273:24693-24700(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT HIS-685.
    3. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 539-822.
      Tissue: Fetal brain and Uterus.
    5. "Rabaptin-5alpha/rabaptin-4 serves as a linker between rab4 and gamma(1)-adaptin in membrane recycling from endosomes."
      Deneka M., Neeft M., Popa I., van Oort M., Sprong H., Oorschot V., Klumperman J., Schu P., van der Sluijs P.
      EMBO J. 22:2645-2657(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RABEP1, SUBCELLULAR LOCATION.
    6. "Gamma-BAR, a novel AP-1-interacting protein involved in post-Golgi trafficking."
      Neubrand V.E., Will R.D., Moebius W., Poustka A., Wiemann S., Schu P., Dotti C.G., Pepperkok R., Simpson J.C.
      EMBO J. 24:1122-1133(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH AP1AR.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain."
      Nogi T., Shiba Y., Kawasaki M., Shiba T., Matsugaki N., Igarashi N., Suzuki M., Kato R., Takatsu H., Nakayama K., Wakatsuki S.
      Nat. Struct. Biol. 9:527-531(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 703-822, INTERACTION WITH RABPT5 AND SYNRG.

    Entry informationi

    Entry nameiAP1G1_HUMAN
    AccessioniPrimary (citable) accession number: O43747
    Secondary accession number(s): O75709
    , O75842, Q9UG09, Q9Y3U4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 142 of the entry and version 5 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3