Reviewed,
UniProtKB/Swiss-Prot O43739 (CYH3_HUMAN)
Last modified
November 4, 2008.
Version 74.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Cytohesin-3 Alternative name(s): PH, SEC7 and coiled-coil domain-containing protein 3 ARF nucleotide-binding site opener 3 Short name=Protein ARNO3 General receptor of phosphoinositides 1 Short name=Grp1 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 400 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Promotes guanine-nucleotide exchange on ARF1. Promotes the activation of ARF through replacement of GDP with GTP. |
| Subunit structure | Binds via its PH domain to the inositol head group of phosphotidylinositol 3,4,5-triphosphate with high affinity. Interacts with GRASP By similarity. |
| Tissue specificity | Almost absent from liver, thymus and peripheral blood lymphocytes. |
| Sequence similarities | Contains 1 PH domain. Contains 1 SEC7 domain. |
Ontologies
Keywords | |
|---|---|
| Coding sequence diversity | Alternative splicing |
| Domain | Coiled coil |
| Molecular function | Guanine-nucleotide releasing factor |
Gene Ontology (GO) | |
| Biological process | vesicle-mediated transport Ref.1 Traceable author statement. Source: ProtInc |
| Cellular component | membrane fraction Ref.2 Traceable author statement. Source: ProtInc plasma membrane Ref.2Traceable author statement. Source: ProtInc |
| Molecular function | ARF guanyl-nucleotide exchange factor activity Ref.1 Traceable author statement. Source: ProtInc inositol-1,4,5-triphosphate receptor activity Ref.2Traceable author statement. Source: ProtInc phosphatidylinositol binding Ref.2Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: O43739-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: O43739-2) The sequence of this isoform differs from the canonical sequence as follows: 277-277: Missing. |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "ARNO3, a Sec7-domain guanine nucleotide exchange factor for ADP ribosylation factor 1, is involved in the control of Golgi structure and function." Franco M., Boretto J., Robineau S., Monier S., Goud B., Chardin P., Chavrier P. Proc. Natl. Acad. Sci. U.S.A. 95:9926-9931(1998) [PubMed: 9707577] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Placenta. |
| [2] | "Nerve growth factor- and epidermal growth factor-stimulated translocation of the ADP-ribosylation factor-exchange factor GRP1 to the plasma membrane of PC12 cells requires activation of phosphatidylinositol 3-kinase and the GRP1 pleckstrin homology domain." Venkateswarlu K., Gunn-Moore F., Oatey P.B., Tavare J.M., Cullen P.J. Biochem. J. 335:139-146(1998) [PubMed: 9742223] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain. |
| [4] | "Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors." Ogasawara M., Kim S.C., Adamik R., Togawa A., Ferrans V.J., Takeda K., Kirby M., Moss J., Vaughan M. J. Biol. Chem. 275:3221-3230(2000) [PubMed: 10652308] [Abstract] Cited for: ALTERNATIVE SPLICING. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AJ223957 mRNA. Translation: CAA11686.1. AJ005197 mRNA. Translation: CAA06434.1. BC028717 mRNA. Translation: AAH28717.1. | |
| RefSeq | NP_004218.1. |
| UniGene | Hs.487479 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1FHW based on UniProtKB O08967. |
| SMR | O43739. Positions 59-251, 261-388. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | O43739. |
PTM databases | |
| PhosphoSite | O43739. |
Genome annotation databases | |
| Ensembl | ENSG00000008256. Homo sapiens. [Contig view] |
| GeneID | 9265. |
| KEGG | hsa:9265. |
Organism-specific databases | |
| H-InvDB | HIX0006463. |
| HGNC | HGNC:9504. PSCD3. |
| HPA | HPA013979. |
| MIM | 605081. gene. |
| PharmGKB | PA33851. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | O43739. |
| HOVERGEN | O43739. |
Gene expression databases | |
| ArrayExpress | O43739. |
| CleanEx | HS_PSCD3. |
| GermOnline | ENSG00000008256. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001849. PH. IPR011993. PH_type. IPR000904. Sec7. [Graphical view] |
| Gene3D | G3DSA:2.30.29.30. PH_type. 1 hit. |
| Pfam | PF00169. PH. 1 hit. PF01369. Sec7. 1 hit. [Graphical view] |
| SMART | SM00233. PH. 1 hit. SM00222. Sec7. 1 hit. [Graphical view] |
| PROSITE | PS50003. PH_DOMAIN. 1 hit. PS50190. SEC7. 1 hit. [Graphical view] |
| BLOCKS | Search... |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 34729. |
| SOURCE | Search... |
Entry information
| Entry name | CYH3_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O43739 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 7 Human chromosome 7: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


