##gff-version 3
O43734	UniProtKB	Chain	1	574	.	.	.	ID=PRO_0000089751;Note=E3 ubiquitin ligase TRAF3IP2	
O43734	UniProtKB	Domain	409	550	.	.	.	Note=SEFIR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00867	
O43734	UniProtKB	Region	1	256	.	.	.	Note=Mediates interaction with TRAF6;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12459498;Dbxref=PMID:12459498	
O43734	UniProtKB	Region	1	67	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O43734	UniProtKB	Region	155	211	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O43734	UniProtKB	Region	327	403	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O43734	UniProtKB	Compositional bias	48	67	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O43734	UniProtKB	Compositional bias	168	190	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O43734	UniProtKB	Compositional bias	375	395	.	.	.	Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O43734	UniProtKB	Alternative sequence	1	465	.	.	.	ID=VSP_040374;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334	
O43734	UniProtKB	Alternative sequence	1	421	.	.	.	ID=VSP_035733;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305	
O43734	UniProtKB	Alternative sequence	1	9	.	.	.	ID=VSP_004163;Note=In isoform 2 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10903453,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:10903453,PMID:14702039,PMID:15489334,PMID:17974005	
O43734	UniProtKB	Alternative sequence	463	463	.	.	.	ID=VSP_047098;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039	
O43734	UniProtKB	Natural variant	19	19	.	.	.	ID=VAR_047349;Note=Likely risk factor for PSORS13%3B there is a reducing binding of this variant to TRAF6. D->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20953186,ECO:0000269|PubMed:20953188;Dbxref=dbSNP:rs33980500,PMID:20953186,PMID:20953188	
O43734	UniProtKB	Natural variant	83	83	.	.	.	ID=VAR_031227;Note=R->W;Dbxref=dbSNP:rs13190932	
O43734	UniProtKB	Natural variant	332	332	.	.	.	ID=VAR_024307;Note=H->Q;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10962024,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:17974005,ECO:0000269|Ref.7;Dbxref=dbSNP:rs1043730,PMID:10962024,PMID:14702039,PMID:15489334,PMID:17974005	
O43734	UniProtKB	Natural variant	536	536	.	.	.	ID=VAR_070904;Note=In CANDF8%3B abolishes homotypic interactions with the SEFIR domain of IL17RA%2C IL17RB and IL17RC%3B does not affect homodimerization%3B does not affect SEFIR-independent interactions with other proteins. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24120361;Dbxref=dbSNP:rs397518485,PMID:24120361	
O43734	UniProtKB	Mutagenesis	303	303	.	.	.	Note=Loss of E3 ubiquitin ligase activity. L->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19825828;Dbxref=PMID:19825828	
O43734	UniProtKB	Mutagenesis	318	318	.	.	.	Note=Decreases E3 ubiquitin ligase activity. P->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19825828;Dbxref=PMID:19825828	
O43734	UniProtKB	Mutagenesis	319	319	.	.	.	Note=Loss of E3 ubiquitin ligase activity. V->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19825828;Dbxref=PMID:19825828	
O43734	UniProtKB	Mutagenesis	324	324	.	.	.	Note=Decreases E3 ubiquitin ligase activity. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19825828;Dbxref=PMID:19825828	
O43734	UniProtKB	Sequence conflict	334	334	.	.	.	Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305	
O43734	UniProtKB	Sequence conflict	347	347	.	.	.	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305