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Protein

Adapter protein CIKS

Gene

TRAF3IP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Could be involved in the activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent mechanism and stress-activated protein kinase (SAPK)/JNK.

GO - Molecular functioni

GO - Biological processi

  • B cell apoptotic process Source: Ensembl
  • humoral immune response Source: Ensembl
  • immunoglobulin secretion Source: Ensembl
  • intracellular signal transduction Source: UniProtKB
  • positive regulation of defense response to virus by host Source: CACAO
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB

Enzyme and pathway databases

SignaLinkiO43734

Names & Taxonomyi

Protein namesi
Recommended name:
Adapter protein CIKS
Alternative name(s):
Connection to IKK and SAPK/JNK
Nuclear factor NF-kappa-B activator 1
Short name:
ACT1
TRAF3-interacting protein 2
Gene namesi
Name:TRAF3IP2
Synonyms:C6orf2, C6orf4, C6orf5, C6orf6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000056972.18
HGNCiHGNC:1343 TRAF3IP2
MIMi607043 gene
neXtProtiNX_O43734

Subcellular locationi

Pathology & Biotechi

Involvement in diseasei

Psoriasis 13 (PSORS13)2 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.
See also OMIM:614070
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04734919D → N in PSORS13; there is a reducing binding of this variant to TRAF6. 2 PublicationsCorresponds to variant dbSNP:rs33980500Ensembl.1
Candidiasis, familial, 8 (CANDF8)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.
See also OMIM:615527
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070904536T → I in CANDF8; abolishes homotypic interactions with the SEFIR domain of IL17RA, IL17RB and IL17RC; does not affect homodimerization; does not affect SEFIR-independent interactions with other proteins. 1 PublicationCorresponds to variant dbSNP:rs397518485Ensembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi10758
MalaCardsiTRAF3IP2
MIMi614070 phenotype
615527 phenotype
OpenTargetsiENSG00000056972
Orphaneti1334 Chronic mucocutaneous candidosis
PharmGKBiPA25938

Polymorphism and mutation databases

BioMutaiTRAF3IP2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000897511 – 574Adapter protein CIKSAdd BLAST574

Proteomic databases

EPDiO43734
MaxQBiO43734
PaxDbiO43734
PeptideAtlasiO43734
PRIDEiO43734
ProteomicsDBi49136
49137 [O43734-2]
49138 [O43734-3]
49139 [O43734-4]

PTM databases

iPTMnetiO43734
PhosphoSitePlusiO43734

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSG00000056972
CleanExiHS_TRAF3IP2
GenevisibleiO43734 HS

Organism-specific databases

HPAiHPA036352

Interactioni

Subunit structurei

Interacts with IKBKG/NF-kappa B essential modulator, with CHUK/IKK-alpha and with IKBKB/IKK-beta. Interacts with TRAF6.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115979, 39 interactors
IntActiO43734, 16 interactors
MINTiO43734
STRINGi9606.ENSP00000357750

Structurei

3D structure databases

ProteinModelPortaliO43734
SMRiO43734
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini409 – 550SEFIRPROSITE-ProRule annotationAdd BLAST142

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 256Mediates interaction with TRAF61 PublicationAdd BLAST256

Phylogenomic databases

eggNOGiENOG410IF9W Eukaryota
ENOG4111GTJ LUCA
GeneTreeiENSGT00390000007714
HOGENOMiHOG000126819
HOVERGENiHBG002060
InParanoidiO43734
KOiK21124
OMAiNYPSPWD
OrthoDBiEOG091G04TE
PhylomeDBiO43734
TreeFamiTF329063

Family and domain databases

InterProiView protein in InterPro
IPR013568 SEFIR_dom
PfamiView protein in Pfam
PF08357 SEFIR, 1 hit
PROSITEiView protein in PROSITE
PS51534 SEFIR, 1 hit

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O43734-1) [UniParc]FASTAAdd to basket
Also known as: C6ORF4

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPPQLQETRM NRSIPVEVDE SEPYPSQLLK PIPEYSPEEE SEPPAPNIRN
60 70 80 90 100
MAPNSLSAPT MLHNSSGDFS QAHSTLKLAN HQRPVSRQVT CLRTQVLEDS
110 120 130 140 150
EDSFCRRHPG LGKAFPSGCS AVSEPASESV VGALPAEHQF SFMEKRNQWL
160 170 180 190 200
VSQLSAASPD TGHDSDKSDQ SLPNASADSL GGSQEMVQRP QPHRNRAGLD
210 220 230 240 250
LPTIDTGYDS QPQDVLGIRQ LERPLPLTSV CYPQDLPRPL RSREFPQFEP
260 270 280 290 300
QRYPACAQML PPNLSPHAPW NYHYHCPGSP DHQVPYGHDY PRAAYQQVIQ
310 320 330 340 350
PALPGQPLPG ASVRGLHPVQ KVILNYPSPW DHEERPAQRD CSFPGLPRHQ
360 370 380 390 400
DQPHHQPPNR AGAPGESLEC PAELRPQVPQ PPSPAAVPRP PSNPPARGTL
410 420 430 440 450
KTSNLPEELR KVFITYSMDT AMEVVKFVNF LLVNGFQTAI DIFEDRIRGI
460 470 480 490 500
DIIKWMERYL RDKTVMIIVA ISPKYKQDVE GAESQLDEDE HGLHTKYIHR
510 520 530 540 550
MMQIEFIKQG SMNFRFIPVL FPNAKKEHVP TWLQNTHVYS WPKNKKNILL
560 570
RLLREEEYVA PPRGPLPTLQ VVPL
Length:574
Mass (Da):64,666
Last modified:January 11, 2011 - v3
Checksum:i4985795466D71422
GO
Isoform 2 (identifier: O43734-2) [UniParc]FASTAAdd to basket
Also known as: C6ORF5, C6ORF6

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: Missing.

Show »
Length:565
Mass (Da):63,585
Checksum:iD585DABB3FCA8B1D
GO
Isoform 3 (identifier: O43734-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-421: Missing.

Show »
Length:153
Mass (Da):18,118
Checksum:i7197AC2147A19690
GO
Isoform 4 (identifier: O43734-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-465: Missing.

Show »
Length:109
Mass (Da):12,803
Checksum:i32083D194A68478D
GO
Isoform 5 (identifier: O43734-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: Missing.
     463-463: Missing.

Note: No experimental confirmation available.
Show »
Length:564
Mass (Da):63,457
Checksum:iC2592D267AD39699
GO

Sequence cautioni

The sequence BAB15507 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti334E → D in AAG15407 (PubMed:10962033).Curated1
Sequence conflicti347P → S in AAF67447 (PubMed:10903453).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04734919D → N in PSORS13; there is a reducing binding of this variant to TRAF6. 2 PublicationsCorresponds to variant dbSNP:rs33980500Ensembl.1
Natural variantiVAR_03122783R → W. Corresponds to variant dbSNP:rs13190932Ensembl.1
Natural variantiVAR_024307332H → Q5 PublicationsCorresponds to variant dbSNP:rs1043730Ensembl.1
Natural variantiVAR_070904536T → I in CANDF8; abolishes homotypic interactions with the SEFIR domain of IL17RA, IL17RB and IL17RC; does not affect homodimerization; does not affect SEFIR-independent interactions with other proteins. 1 PublicationCorresponds to variant dbSNP:rs397518485Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0403741 – 465Missing in isoform 4. 1 PublicationAdd BLAST465
Alternative sequenceiVSP_0357331 – 421Missing in isoform 3. CuratedAdd BLAST421
Alternative sequenceiVSP_0041631 – 9Missing in isoform 2 and isoform 5. 4 Publications9
Alternative sequenceiVSP_047098463Missing in isoform 5. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF136405 mRNA Translation: AAF67445.1
AF136406 mRNA Translation: AAF67446.1
AF136407 mRNA Translation: AAF67447.1
AF274303 mRNA Translation: AAG15367.1
AF272151 mRNA Translation: AAG15407.1
AK025351 mRNA Translation: BAB15117.1
AK026602 mRNA Translation: BAB15507.1 Different initiation.
AK314415 mRNA Translation: BAG37036.1
AL050289 mRNA Translation: CAB43390.1
AL008730 Genomic DNA No translation available.
Z97989 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48285.1
CH471051 Genomic DNA Translation: EAW48287.1
BC002823 mRNA Translation: AAH02823.1
BI856094 mRNA No translation available.
CCDSiCCDS5092.1 [O43734-1]
CCDS5093.1 [O43734-2]
CCDS55049.1 [O43734-4]
CCDS55050.1 [O43734-5]
PIRiT08794
RefSeqiNP_001157753.1, NM_001164281.2 [O43734-5]
NP_001157755.1, NM_001164283.2 [O43734-4]
NP_671733.2, NM_147200.2 [O43734-1]
NP_679211.2, NM_147686.3 [O43734-2]
XP_006715382.1, XM_006715319.3 [O43734-4]
XP_011533688.1, XM_011535386.1 [O43734-1]
UniGeneiHs.561514
Hs.740602

Genome annotation databases

EnsembliENST00000340026; ENSP00000345984; ENSG00000056972 [O43734-1]
ENST00000359831; ENSP00000352889; ENSG00000056972 [O43734-5]
ENST00000368735; ENSP00000357724; ENSG00000056972 [O43734-4]
ENST00000368761; ENSP00000357750; ENSG00000056972 [O43734-2]
ENST00000392556; ENSP00000376339; ENSG00000056972 [O43734-1]
GeneIDi10758
KEGGihsa:10758
UCSCiuc003pvf.5 human [O43734-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCIKS_HUMAN
AccessioniPrimary (citable) accession number: O43734
Secondary accession number(s): B2RAY9
, E1P555, Q5R3A3, Q7Z6Q1, Q7Z6Q2, Q7Z6Q3, Q9H5W2, Q9H6Y3, Q9NS14, Q9UG72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 11, 2011
Last modified: June 20, 2018
This is version 162 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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