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O43734

- CIKS_HUMAN

UniProt

O43734 - CIKS_HUMAN

Protein

Adapter protein CIKS

Gene

TRAF3IP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 3 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Could be involved in the activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent mechanism and stress-activated protein kinase (SAPK)/JNK.

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. B cell apoptotic process Source: Ensembl
    2. humoral immune response Source: Ensembl
    3. immunoglobulin secretion Source: Ensembl
    4. intracellular signal transduction Source: UniProtKB
    5. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB

    Enzyme and pathway databases

    SignaLinkiO43734.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adapter protein CIKS
    Alternative name(s):
    Connection to IKK and SAPK/JNK
    Nuclear factor NF-kappa-B activator 1
    Short name:
    ACT1
    TRAF3-interacting protein 2
    Gene namesi
    Name:TRAF3IP2
    Synonyms:C6orf2, C6orf4, C6orf5, C6orf6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:1343. TRAF3IP2.

    Pathology & Biotechi

    Involvement in diseasei

    Psoriasis 13 (PSORS13) [MIM:614070]: A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.2 Publications
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti19 – 191D → N in PSORS13; there is a reducing binding of this variant to TRAF6. 2 Publications
    Corresponds to variant rs33980500 [ dbSNP | Ensembl ].
    VAR_047349
    Candidiasis, familial, 8 (CANDF8) [MIM:615527]: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti536 – 5361T → I in CANDF8; abolishes homotypic interactions with the SEFIR domain of IL17RA, IL17RB and IL17RC; does not affect homodimerization; does not affect SEFIR-independent interactions with other proteins. 1 Publication
    VAR_070904

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi614070. phenotype.
    615527. phenotype.
    Orphaneti1334. Chronic mucocutaneous candidiasis.
    PharmGKBiPA25938.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 574574Adapter protein CIKSPRO_0000089751Add
    BLAST

    Proteomic databases

    MaxQBiO43734.
    PaxDbiO43734.
    PRIDEiO43734.

    PTM databases

    PhosphoSiteiO43734.

    Expressioni

    Tissue specificityi

    Widely expressed.

    Gene expression databases

    ArrayExpressiO43734.
    BgeeiO43734.
    CleanExiHS_TRAF3IP2.
    GenevestigatoriO43734.

    Organism-specific databases

    HPAiHPA036352.

    Interactioni

    Subunit structurei

    Interacts with IKBKG/NF-kappa B essential modulator, with CHUK/IKK-alpha and with IKBKB/IKK-beta. Interacts with TRAF6.1 Publication

    Protein-protein interaction databases

    BioGridi115979. 20 interactions.
    IntActiO43734. 7 interactions.
    MINTiMINT-143208.
    STRINGi9606.ENSP00000345984.

    Structurei

    3D structure databases

    ProteinModelPortaliO43734.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini409 – 550142SEFIRPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 256256Mediates interaction with TRAF6Add
    BLAST

    Sequence similaritiesi

    Contains 1 SEFIR domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG43147.
    HOVERGENiHBG002060.
    InParanoidiO43734.
    OMAiNYPSPWD.
    OrthoDBiEOG7DVD9N.
    PhylomeDBiO43734.
    TreeFamiTF329063.

    Family and domain databases

    InterProiIPR013568. SEFIR.
    [Graphical view]
    PfamiPF08357. SEFIR. 1 hit.
    [Graphical view]
    PROSITEiPS51534. SEFIR. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O43734-1) [UniParc]FASTAAdd to Basket

    Also known as: C6ORF4

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPPQLQETRM NRSIPVEVDE SEPYPSQLLK PIPEYSPEEE SEPPAPNIRN    50
    MAPNSLSAPT MLHNSSGDFS QAHSTLKLAN HQRPVSRQVT CLRTQVLEDS 100
    EDSFCRRHPG LGKAFPSGCS AVSEPASESV VGALPAEHQF SFMEKRNQWL 150
    VSQLSAASPD TGHDSDKSDQ SLPNASADSL GGSQEMVQRP QPHRNRAGLD 200
    LPTIDTGYDS QPQDVLGIRQ LERPLPLTSV CYPQDLPRPL RSREFPQFEP 250
    QRYPACAQML PPNLSPHAPW NYHYHCPGSP DHQVPYGHDY PRAAYQQVIQ 300
    PALPGQPLPG ASVRGLHPVQ KVILNYPSPW DHEERPAQRD CSFPGLPRHQ 350
    DQPHHQPPNR AGAPGESLEC PAELRPQVPQ PPSPAAVPRP PSNPPARGTL 400
    KTSNLPEELR KVFITYSMDT AMEVVKFVNF LLVNGFQTAI DIFEDRIRGI 450
    DIIKWMERYL RDKTVMIIVA ISPKYKQDVE GAESQLDEDE HGLHTKYIHR 500
    MMQIEFIKQG SMNFRFIPVL FPNAKKEHVP TWLQNTHVYS WPKNKKNILL 550
    RLLREEEYVA PPRGPLPTLQ VVPL 574
    Length:574
    Mass (Da):64,666
    Last modified:January 11, 2011 - v3
    Checksum:i4985795466D71422
    GO
    Isoform 2 (identifier: O43734-2) [UniParc]FASTAAdd to Basket

    Also known as: C6ORF5, C6ORF6

    The sequence of this isoform differs from the canonical sequence as follows:
         1-9: Missing.

    Show »
    Length:565
    Mass (Da):63,585
    Checksum:iD585DABB3FCA8B1D
    GO
    Isoform 3 (identifier: O43734-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-421: Missing.

    Show »
    Length:153
    Mass (Da):18,118
    Checksum:i7197AC2147A19690
    GO
    Isoform 4 (identifier: O43734-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-465: Missing.

    Show »
    Length:109
    Mass (Da):12,803
    Checksum:i32083D194A68478D
    GO
    Isoform 5 (identifier: O43734-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-9: Missing.
         463-463: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:564
    Mass (Da):63,457
    Checksum:iC2592D267AD39699
    GO

    Sequence cautioni

    The sequence BAB15507.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti334 – 3341E → D in AAG15407. (PubMed:10962033)Curated
    Sequence conflicti347 – 3471P → S in AAF67447. (PubMed:10903453)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti19 – 191D → N in PSORS13; there is a reducing binding of this variant to TRAF6. 2 Publications
    Corresponds to variant rs33980500 [ dbSNP | Ensembl ].
    VAR_047349
    Natural varianti83 – 831R → W.
    Corresponds to variant rs13190932 [ dbSNP | Ensembl ].
    VAR_031227
    Natural varianti332 – 3321H → Q.5 Publications
    Corresponds to variant rs1043730 [ dbSNP | Ensembl ].
    VAR_024307
    Natural varianti536 – 5361T → I in CANDF8; abolishes homotypic interactions with the SEFIR domain of IL17RA, IL17RB and IL17RC; does not affect homodimerization; does not affect SEFIR-independent interactions with other proteins. 1 Publication
    VAR_070904

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 465465Missing in isoform 4. 1 PublicationVSP_040374Add
    BLAST
    Alternative sequencei1 – 421421Missing in isoform 3. CuratedVSP_035733Add
    BLAST
    Alternative sequencei1 – 99Missing in isoform 2 and isoform 5. 4 PublicationsVSP_004163
    Alternative sequencei463 – 4631Missing in isoform 5. 1 PublicationVSP_047098

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF136405 mRNA. Translation: AAF67445.1.
    AF136406 mRNA. Translation: AAF67446.1.
    AF136407 mRNA. Translation: AAF67447.1.
    AF274303 mRNA. Translation: AAG15367.1.
    AF272151 mRNA. Translation: AAG15407.1.
    AK025351 mRNA. Translation: BAB15117.1.
    AK026602 mRNA. Translation: BAB15507.1. Different initiation.
    AK314415 mRNA. Translation: BAG37036.1.
    AL050289 mRNA. Translation: CAB43390.1.
    AL008730 Genomic DNA. Translation: CAA15506.1.
    AL008730 Genomic DNA. Translation: CAA15507.1.
    AL008730 Genomic DNA. Translation: CAD92596.1.
    AL008730, Z97989 Genomic DNA. Translation: CAD92597.1.
    Z97989, AL008730 Genomic DNA. Translation: CAI22298.1.
    Z97989, AL008730 Genomic DNA. Translation: CAI22297.1.
    CH471051 Genomic DNA. Translation: EAW48285.1.
    CH471051 Genomic DNA. Translation: EAW48287.1.
    BC002823 mRNA. Translation: AAH02823.1.
    BI856094 mRNA. No translation available.
    CCDSiCCDS5093.1. [O43734-2]
    CCDS55049.1. [O43734-4]
    CCDS55050.1. [O43734-5]
    PIRiT08794.
    RefSeqiNP_001157753.1. NM_001164281.2. [O43734-5]
    NP_001157755.1. NM_001164283.2. [O43734-4]
    NP_679211.2. NM_147686.3. [O43734-2]
    XP_006715382.1. XM_006715319.1. [O43734-4]
    UniGeneiHs.561514.
    Hs.740602.

    Genome annotation databases

    EnsembliENST00000340026; ENSP00000345984; ENSG00000056972. [O43734-1]
    ENST00000359831; ENSP00000352889; ENSG00000056972. [O43734-5]
    ENST00000368735; ENSP00000357724; ENSG00000056972. [O43734-4]
    ENST00000368761; ENSP00000357750; ENSG00000056972. [O43734-2]
    ENST00000392556; ENSP00000376339; ENSG00000056972. [O43734-3]
    GeneIDi10758.
    KEGGihsa:10758.
    UCSCiuc003pvf.4. human. [O43734-1]
    uc011ebb.3. human. [O43734-4]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF136405 mRNA. Translation: AAF67445.1 .
    AF136406 mRNA. Translation: AAF67446.1 .
    AF136407 mRNA. Translation: AAF67447.1 .
    AF274303 mRNA. Translation: AAG15367.1 .
    AF272151 mRNA. Translation: AAG15407.1 .
    AK025351 mRNA. Translation: BAB15117.1 .
    AK026602 mRNA. Translation: BAB15507.1 . Different initiation.
    AK314415 mRNA. Translation: BAG37036.1 .
    AL050289 mRNA. Translation: CAB43390.1 .
    AL008730 Genomic DNA. Translation: CAA15506.1 .
    AL008730 Genomic DNA. Translation: CAA15507.1 .
    AL008730 Genomic DNA. Translation: CAD92596.1 .
    AL008730 , Z97989 Genomic DNA. Translation: CAD92597.1 .
    Z97989 , AL008730 Genomic DNA. Translation: CAI22298.1 .
    Z97989 , AL008730 Genomic DNA. Translation: CAI22297.1 .
    CH471051 Genomic DNA. Translation: EAW48285.1 .
    CH471051 Genomic DNA. Translation: EAW48287.1 .
    BC002823 mRNA. Translation: AAH02823.1 .
    BI856094 mRNA. No translation available.
    CCDSi CCDS5093.1. [O43734-2 ]
    CCDS55049.1. [O43734-4 ]
    CCDS55050.1. [O43734-5 ]
    PIRi T08794.
    RefSeqi NP_001157753.1. NM_001164281.2. [O43734-5 ]
    NP_001157755.1. NM_001164283.2. [O43734-4 ]
    NP_679211.2. NM_147686.3. [O43734-2 ]
    XP_006715382.1. XM_006715319.1. [O43734-4 ]
    UniGenei Hs.561514.
    Hs.740602.

    3D structure databases

    ProteinModelPortali O43734.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115979. 20 interactions.
    IntActi O43734. 7 interactions.
    MINTi MINT-143208.
    STRINGi 9606.ENSP00000345984.

    PTM databases

    PhosphoSitei O43734.

    Proteomic databases

    MaxQBi O43734.
    PaxDbi O43734.
    PRIDEi O43734.

    Protocols and materials databases

    DNASUi 10758.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000340026 ; ENSP00000345984 ; ENSG00000056972 . [O43734-1 ]
    ENST00000359831 ; ENSP00000352889 ; ENSG00000056972 . [O43734-5 ]
    ENST00000368735 ; ENSP00000357724 ; ENSG00000056972 . [O43734-4 ]
    ENST00000368761 ; ENSP00000357750 ; ENSG00000056972 . [O43734-2 ]
    ENST00000392556 ; ENSP00000376339 ; ENSG00000056972 . [O43734-3 ]
    GeneIDi 10758.
    KEGGi hsa:10758.
    UCSCi uc003pvf.4. human. [O43734-1 ]
    uc011ebb.3. human. [O43734-4 ]

    Organism-specific databases

    CTDi 10758.
    GeneCardsi GC06M111877.
    HGNCi HGNC:1343. TRAF3IP2.
    HPAi HPA036352.
    MIMi 607043. gene.
    614070. phenotype.
    615527. phenotype.
    neXtProti NX_O43734.
    Orphaneti 1334. Chronic mucocutaneous candidiasis.
    PharmGKBi PA25938.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43147.
    HOVERGENi HBG002060.
    InParanoidi O43734.
    OMAi NYPSPWD.
    OrthoDBi EOG7DVD9N.
    PhylomeDBi O43734.
    TreeFami TF329063.

    Enzyme and pathway databases

    SignaLinki O43734.

    Miscellaneous databases

    GeneWikii TRAF3IP2.
    GenomeRNAii 10758.
    NextBioi 40857.
    PROi O43734.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O43734.
    Bgeei O43734.
    CleanExi HS_TRAF3IP2.
    Genevestigatori O43734.

    Family and domain databases

    InterProi IPR013568. SEFIR.
    [Graphical view ]
    Pfami PF08357. SEFIR. 1 hit.
    [Graphical view ]
    PROSITEi PS51534. SEFIR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of two overlapping genes in a subregion at 6q21 involved in replicative senescence and schizophrenia."
      Morelli C., Magnanini C., Mungall A.J., Negrini M., Barbanti-Brodano G.
      Gene 252:217-225(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT GLN-332.
      Tissue: Embryonic kidney.
    3. "CIKS, a connection to Ikappa B kinase and stress-activated protein kinase."
      Leonardi A., Chariot A., Claudio E., Cunningham K., Siebenlist U.
      Proc. Natl. Acad. Sci. U.S.A. 97:10494-10499(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Liver.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 5), VARIANT GLN-332.
      Tissue: Colon and Kidney.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT GLN-332.
      Tissue: Uterus.
    6. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLN-332.
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), VARIANT GLN-332.
      Tissue: Lymph.
    9. "NF-kappaB activator Act1 associates with IL-1/Toll pathway adaptor molecule TRAF6."
      Kanamori M., Kai C., Hayashizaki Y., Suzuki H.
      FEBS Lett. 532:241-246(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TRAF6.
    10. Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO PSORS13, VARIANT ASN-19, CHARACTERIZATION OF VARIANT ASN-19.
    11. Cited for: VARIANT PSORS13 ASN-19.
    12. "An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis."
      Boisson B., Wang C., Pedergnana V., Wu L., Cypowyj S., Rybojad M., Belkadi A., Picard C., Abel L., Fieschi C., Puel A., Li X., Casanova J.L.
      Immunity 39:676-686(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT CANDF8 ILE-536, CHARACTERIZATION OF VARIANT CANDF8 ILE-536.

    Entry informationi

    Entry nameiCIKS_HUMAN
    AccessioniPrimary (citable) accession number: O43734
    Secondary accession number(s): B2RAY9
    , E1P555, Q5R3A3, Q7Z6Q1, Q7Z6Q2, Q7Z6Q3, Q9H5W2, Q9H6Y3, Q9NS14, Q9UG72
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 129 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3