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O43734

- CIKS_HUMAN

UniProt

O43734 - CIKS_HUMAN

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Protein
Adapter protein CIKS
Gene
TRAF3IP2, C6orf2, C6orf4, C6orf5, C6orf6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Could be involved in the activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent mechanism and stress-activated protein kinase (SAPK)/JNK.

GO - Molecular functioni

  1. protein binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. B cell apoptotic process Source: Ensembl
  2. humoral immune response Source: Ensembl
  3. immunoglobulin secretion Source: Ensembl
  4. intracellular signal transduction Source: UniProtKB
  5. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiO43734.

Names & Taxonomyi

Protein namesi
Recommended name:
Adapter protein CIKS
Alternative name(s):
Connection to IKK and SAPK/JNK
Nuclear factor NF-kappa-B activator 1
Short name:
ACT1
TRAF3-interacting protein 2
Gene namesi
Synonyms:C6orf2, C6orf4, C6orf5, C6orf6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:1343. TRAF3IP2.

Pathology & Biotechi

Involvement in diseasei

Psoriasis 13 (PSORS13) [MIM:614070]: A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.2 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti19 – 191D → N in PSORS13; there is a reducing binding of this variant to TRAF6. 2 Publications
Corresponds to variant rs33980500 [ dbSNP | Ensembl ].
VAR_047349
Candidiasis, familial, 8 (CANDF8) [MIM:615527]: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti536 – 5361T → I in CANDF8; abolishes homotypic interactions with the SEFIR domain of IL17RA, IL17RB and IL17RC; does not affect homodimerization; does not affect SEFIR-independent interactions with other proteins. 1 Publication
VAR_070904

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi614070. phenotype.
615527. phenotype.
Orphaneti1334. Chronic mucocutaneous candidiasis.
PharmGKBiPA25938.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 574574Adapter protein CIKS
PRO_0000089751Add
BLAST

Proteomic databases

MaxQBiO43734.
PaxDbiO43734.
PRIDEiO43734.

PTM databases

PhosphoSiteiO43734.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

ArrayExpressiO43734.
BgeeiO43734.
CleanExiHS_TRAF3IP2.
GenevestigatoriO43734.

Organism-specific databases

HPAiHPA036352.

Interactioni

Subunit structurei

Interacts with IKBKG/NF-kappa B essential modulator, with CHUK/IKK-alpha and with IKBKB/IKK-beta. Interacts with TRAF6.1 Publication

Protein-protein interaction databases

BioGridi115979. 20 interactions.
IntActiO43734. 7 interactions.
MINTiMINT-143208.
STRINGi9606.ENSP00000345984.

Structurei

3D structure databases

ProteinModelPortaliO43734.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini409 – 550142SEFIR
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 256256Mediates interaction with TRAF6
Add
BLAST

Sequence similaritiesi

Contains 1 SEFIR domain.

Phylogenomic databases

eggNOGiNOG43147.
HOVERGENiHBG002060.
InParanoidiO43734.
OMAiNYPSPWD.
OrthoDBiEOG7DVD9N.
PhylomeDBiO43734.
TreeFamiTF329063.

Family and domain databases

InterProiIPR013568. SEFIR.
[Graphical view]
PfamiPF08357. SEFIR. 1 hit.
[Graphical view]
PROSITEiPS51534. SEFIR. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O43734-1) [UniParc]FASTAAdd to Basket

Also known as: C6ORF4

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPPQLQETRM NRSIPVEVDE SEPYPSQLLK PIPEYSPEEE SEPPAPNIRN    50
MAPNSLSAPT MLHNSSGDFS QAHSTLKLAN HQRPVSRQVT CLRTQVLEDS 100
EDSFCRRHPG LGKAFPSGCS AVSEPASESV VGALPAEHQF SFMEKRNQWL 150
VSQLSAASPD TGHDSDKSDQ SLPNASADSL GGSQEMVQRP QPHRNRAGLD 200
LPTIDTGYDS QPQDVLGIRQ LERPLPLTSV CYPQDLPRPL RSREFPQFEP 250
QRYPACAQML PPNLSPHAPW NYHYHCPGSP DHQVPYGHDY PRAAYQQVIQ 300
PALPGQPLPG ASVRGLHPVQ KVILNYPSPW DHEERPAQRD CSFPGLPRHQ 350
DQPHHQPPNR AGAPGESLEC PAELRPQVPQ PPSPAAVPRP PSNPPARGTL 400
KTSNLPEELR KVFITYSMDT AMEVVKFVNF LLVNGFQTAI DIFEDRIRGI 450
DIIKWMERYL RDKTVMIIVA ISPKYKQDVE GAESQLDEDE HGLHTKYIHR 500
MMQIEFIKQG SMNFRFIPVL FPNAKKEHVP TWLQNTHVYS WPKNKKNILL 550
RLLREEEYVA PPRGPLPTLQ VVPL 574
Length:574
Mass (Da):64,666
Last modified:January 11, 2011 - v3
Checksum:i4985795466D71422
GO
Isoform 2 (identifier: O43734-2) [UniParc]FASTAAdd to Basket

Also known as: C6ORF5, C6ORF6

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: Missing.

Show »
Length:565
Mass (Da):63,585
Checksum:iD585DABB3FCA8B1D
GO
Isoform 3 (identifier: O43734-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-421: Missing.

Show »
Length:153
Mass (Da):18,118
Checksum:i7197AC2147A19690
GO
Isoform 4 (identifier: O43734-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-465: Missing.

Show »
Length:109
Mass (Da):12,803
Checksum:i32083D194A68478D
GO
Isoform 5 (identifier: O43734-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: Missing.
     463-463: Missing.

Note: No experimental confirmation available.

Show »
Length:564
Mass (Da):63,457
Checksum:iC2592D267AD39699
GO

Sequence cautioni

The sequence BAB15507.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti19 – 191D → N in PSORS13; there is a reducing binding of this variant to TRAF6. 2 Publications
Corresponds to variant rs33980500 [ dbSNP | Ensembl ].
VAR_047349
Natural varianti83 – 831R → W.
Corresponds to variant rs13190932 [ dbSNP | Ensembl ].
VAR_031227
Natural varianti332 – 3321H → Q.5 Publications
Corresponds to variant rs1043730 [ dbSNP | Ensembl ].
VAR_024307
Natural varianti536 – 5361T → I in CANDF8; abolishes homotypic interactions with the SEFIR domain of IL17RA, IL17RB and IL17RC; does not affect homodimerization; does not affect SEFIR-independent interactions with other proteins. 1 Publication
VAR_070904

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 465465Missing in isoform 4.
VSP_040374Add
BLAST
Alternative sequencei1 – 421421Missing in isoform 3.
VSP_035733Add
BLAST
Alternative sequencei1 – 99Missing in isoform 2 and isoform 5.
VSP_004163
Alternative sequencei463 – 4631Missing in isoform 5.
VSP_047098

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti334 – 3341E → D in AAG15407. 1 Publication
Sequence conflicti347 – 3471P → S in AAF67447. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF136405 mRNA. Translation: AAF67445.1.
AF136406 mRNA. Translation: AAF67446.1.
AF136407 mRNA. Translation: AAF67447.1.
AF274303 mRNA. Translation: AAG15367.1.
AF272151 mRNA. Translation: AAG15407.1.
AK025351 mRNA. Translation: BAB15117.1.
AK026602 mRNA. Translation: BAB15507.1. Different initiation.
AK314415 mRNA. Translation: BAG37036.1.
AL050289 mRNA. Translation: CAB43390.1.
AL008730 Genomic DNA. Translation: CAA15506.1.
AL008730 Genomic DNA. Translation: CAA15507.1.
AL008730 Genomic DNA. Translation: CAD92596.1.
AL008730, Z97989 Genomic DNA. Translation: CAD92597.1.
Z97989, AL008730 Genomic DNA. Translation: CAI22298.1.
Z97989, AL008730 Genomic DNA. Translation: CAI22297.1.
CH471051 Genomic DNA. Translation: EAW48285.1.
CH471051 Genomic DNA. Translation: EAW48287.1.
BC002823 mRNA. Translation: AAH02823.1.
BI856094 mRNA. No translation available.
CCDSiCCDS5093.1. [O43734-2]
CCDS55049.1. [O43734-4]
CCDS55050.1. [O43734-5]
PIRiT08794.
RefSeqiNP_001157753.1. NM_001164281.2. [O43734-5]
NP_001157755.1. NM_001164283.2. [O43734-4]
NP_679211.2. NM_147686.3. [O43734-2]
XP_006715382.1. XM_006715319.1. [O43734-4]
UniGeneiHs.561514.
Hs.740602.

Genome annotation databases

EnsembliENST00000340026; ENSP00000345984; ENSG00000056972. [O43734-1]
ENST00000359831; ENSP00000352889; ENSG00000056972. [O43734-5]
ENST00000368735; ENSP00000357724; ENSG00000056972. [O43734-4]
ENST00000368761; ENSP00000357750; ENSG00000056972. [O43734-2]
ENST00000392556; ENSP00000376339; ENSG00000056972. [O43734-3]
GeneIDi10758.
KEGGihsa:10758.
UCSCiuc003pvf.4. human. [O43734-1]
uc011ebb.3. human. [O43734-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF136405 mRNA. Translation: AAF67445.1 .
AF136406 mRNA. Translation: AAF67446.1 .
AF136407 mRNA. Translation: AAF67447.1 .
AF274303 mRNA. Translation: AAG15367.1 .
AF272151 mRNA. Translation: AAG15407.1 .
AK025351 mRNA. Translation: BAB15117.1 .
AK026602 mRNA. Translation: BAB15507.1 . Different initiation.
AK314415 mRNA. Translation: BAG37036.1 .
AL050289 mRNA. Translation: CAB43390.1 .
AL008730 Genomic DNA. Translation: CAA15506.1 .
AL008730 Genomic DNA. Translation: CAA15507.1 .
AL008730 Genomic DNA. Translation: CAD92596.1 .
AL008730 , Z97989 Genomic DNA. Translation: CAD92597.1 .
Z97989 , AL008730 Genomic DNA. Translation: CAI22298.1 .
Z97989 , AL008730 Genomic DNA. Translation: CAI22297.1 .
CH471051 Genomic DNA. Translation: EAW48285.1 .
CH471051 Genomic DNA. Translation: EAW48287.1 .
BC002823 mRNA. Translation: AAH02823.1 .
BI856094 mRNA. No translation available.
CCDSi CCDS5093.1. [O43734-2 ]
CCDS55049.1. [O43734-4 ]
CCDS55050.1. [O43734-5 ]
PIRi T08794.
RefSeqi NP_001157753.1. NM_001164281.2. [O43734-5 ]
NP_001157755.1. NM_001164283.2. [O43734-4 ]
NP_679211.2. NM_147686.3. [O43734-2 ]
XP_006715382.1. XM_006715319.1. [O43734-4 ]
UniGenei Hs.561514.
Hs.740602.

3D structure databases

ProteinModelPortali O43734.
ModBasei Search...

Protein-protein interaction databases

BioGridi 115979. 20 interactions.
IntActi O43734. 7 interactions.
MINTi MINT-143208.
STRINGi 9606.ENSP00000345984.

PTM databases

PhosphoSitei O43734.

Proteomic databases

MaxQBi O43734.
PaxDbi O43734.
PRIDEi O43734.

Protocols and materials databases

DNASUi 10758.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000340026 ; ENSP00000345984 ; ENSG00000056972 . [O43734-1 ]
ENST00000359831 ; ENSP00000352889 ; ENSG00000056972 . [O43734-5 ]
ENST00000368735 ; ENSP00000357724 ; ENSG00000056972 . [O43734-4 ]
ENST00000368761 ; ENSP00000357750 ; ENSG00000056972 . [O43734-2 ]
ENST00000392556 ; ENSP00000376339 ; ENSG00000056972 . [O43734-3 ]
GeneIDi 10758.
KEGGi hsa:10758.
UCSCi uc003pvf.4. human. [O43734-1 ]
uc011ebb.3. human. [O43734-4 ]

Organism-specific databases

CTDi 10758.
GeneCardsi GC06M111877.
HGNCi HGNC:1343. TRAF3IP2.
HPAi HPA036352.
MIMi 607043. gene.
614070. phenotype.
615527. phenotype.
neXtProti NX_O43734.
Orphaneti 1334. Chronic mucocutaneous candidiasis.
PharmGKBi PA25938.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43147.
HOVERGENi HBG002060.
InParanoidi O43734.
OMAi NYPSPWD.
OrthoDBi EOG7DVD9N.
PhylomeDBi O43734.
TreeFami TF329063.

Enzyme and pathway databases

SignaLinki O43734.

Miscellaneous databases

GeneWikii TRAF3IP2.
GenomeRNAii 10758.
NextBioi 40857.
PROi O43734.
SOURCEi Search...

Gene expression databases

ArrayExpressi O43734.
Bgeei O43734.
CleanExi HS_TRAF3IP2.
Genevestigatori O43734.

Family and domain databases

InterProi IPR013568. SEFIR.
[Graphical view ]
Pfami PF08357. SEFIR. 1 hit.
[Graphical view ]
PROSITEi PS51534. SEFIR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of two overlapping genes in a subregion at 6q21 involved in replicative senescence and schizophrenia."
    Morelli C., Magnanini C., Mungall A.J., Negrini M., Barbanti-Brodano G.
    Gene 252:217-225(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT GLN-332.
    Tissue: Embryonic kidney.
  3. "CIKS, a connection to Ikappa B kinase and stress-activated protein kinase."
    Leonardi A., Chariot A., Claudio E., Cunningham K., Siebenlist U.
    Proc. Natl. Acad. Sci. U.S.A. 97:10494-10499(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Liver.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 5), VARIANT GLN-332.
    Tissue: Colon and Kidney.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT GLN-332.
    Tissue: Uterus.
  6. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLN-332.
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), VARIANT GLN-332.
    Tissue: Lymph.
  9. "NF-kappaB activator Act1 associates with IL-1/Toll pathway adaptor molecule TRAF6."
    Kanamori M., Kai C., Hayashizaki Y., Suzuki H.
    FEBS Lett. 532:241-246(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TRAF6.
  10. Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO PSORS13, VARIANT ASN-19, CHARACTERIZATION OF VARIANT ASN-19.
  11. Cited for: VARIANT PSORS13 ASN-19.
  12. "An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis."
    Boisson B., Wang C., Pedergnana V., Wu L., Cypowyj S., Rybojad M., Belkadi A., Picard C., Abel L., Fieschi C., Puel A., Li X., Casanova J.L.
    Immunity 39:676-686(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT CANDF8 ILE-536, CHARACTERIZATION OF VARIANT CANDF8 ILE-536.

Entry informationi

Entry nameiCIKS_HUMAN
AccessioniPrimary (citable) accession number: O43734
Secondary accession number(s): B2RAY9
, E1P555, Q5R3A3, Q7Z6Q1, Q7Z6Q2, Q7Z6Q3, Q9H5W2, Q9H6Y3, Q9NS14, Q9UG72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 11, 2011
Last modified: July 9, 2014
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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