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Protein

ER lumen protein-retaining receptor 3

Gene

KDELR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-381038 XBP1(S) activates chaperone genes
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
ER lumen protein-retaining receptor 3
Alternative name(s):
KDEL endoplasmic reticulum protein retention receptor 3
Short name:
KDEL receptor 3
Gene namesi
Name:KDELR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100196.10
HGNCiHGNC:6306 KDELR3
neXtProtiNX_O43731

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 2LumenalSequence analysis2
Transmembranei3 – 21HelicalSequence analysisAdd BLAST19
Topological domaini22 – 35CytoplasmicSequence analysisAdd BLAST14
Transmembranei36 – 53HelicalSequence analysisAdd BLAST18
Topological domaini54 – 61LumenalSequence analysis8
Transmembranei62 – 80HelicalSequence analysisAdd BLAST19
Topological domaini81 – 96CytoplasmicSequence analysisAdd BLAST16
Transmembranei97 – 110HelicalSequence analysisAdd BLAST14
Topological domaini111 – 117LumenalSequence analysis7
Transmembranei118 – 137HelicalSequence analysisAdd BLAST20
Topological domaini138 – 149CytoplasmicSequence analysisAdd BLAST12
Transmembranei150 – 168HelicalSequence analysisAdd BLAST19
Topological domaini169 – 178LumenalSequence analysis10
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Topological domaini200 – 214CytoplasmicSequence analysisAdd BLAST15

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000100196
PharmGKBiPA30085

Polymorphism and mutation databases

BioMutaiKDELR3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001941581 – 214ER lumen protein-retaining receptor 3Add BLAST214

Proteomic databases

EPDiO43731
MaxQBiO43731
PaxDbiO43731
PeptideAtlasiO43731
PRIDEiO43731

PTM databases

iPTMnetiO43731
PhosphoSitePlusiO43731

Expressioni

Gene expression databases

BgeeiENSG00000100196
CleanExiHS_KDELR3
ExpressionAtlasiO43731 baseline and differential
GenevisibleiO43731 HS

Organism-specific databases

HPAiHPA043477
HPA076405

Interactioni

Protein-protein interaction databases

BioGridi116205, 19 interactors
IntActiO43731, 1 interactor
MINTiO43731
STRINGi9606.ENSP00000386918

Structurei

3D structure databases

ProteinModelPortaliO43731
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ERD2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3106 Eukaryota
COG5196 LUCA
GeneTreeiENSGT00390000004010
HOVERGENiHBG001398
InParanoidiO43731
KOiK10949
OMAiIWRSKSC
OrthoDBiEOG091G0Q1H
PhylomeDBiO43731
TreeFamiTF314792

Family and domain databases

InterProiView protein in InterPro
IPR000133 ER_ret_rcpt
PANTHERiPTHR10585 PTHR10585, 1 hit
PfamiView protein in Pfam
PF00810 ER_lumen_recept, 1 hit
PRINTSiPR00660 ERLUMENR
PROSITEiView protein in PROSITE
PS00951 ER_LUMEN_RECEPTOR_1, 1 hit
PS00952 ER_LUMEN_RECEPTOR_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O43731-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNVFRILGDL SHLLAMILLL GKIWRSKCCK GISGKSQILF ALVFTTRYLD
60 70 80 90 100
LFTNFISIYN TVMKVVFLLC AYVTVYMIYG KFRKTFDSEN DTFRLEFLLV
110 120 130 140 150
PVIGLSFLEN YSFTLLEILW TFSIYLESVA ILPQLFMISK TGEAETITTH
160 170 180 190 200
YLFFLGLYRA LYLANWIRRY QTENFYDQIA VVSGVVQTIF YCDFFYLYVT
210
KVLKGKKLSL PMPI
Length:214
Mass (Da):25,027
Last modified:June 1, 1998 - v1
Checksum:iED5F7D303390B314
GO
Isoform 2 (identifier: O43731-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     202-214: VLKGKKLSLPMPI → GRSWDDSNADTGLRSYSSI

Show »
Length:220
Mass (Da):25,690
Checksum:i4BCFEB17F3C6B5D7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42L → P in BAD96650 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014506199V → G2 PublicationsCorresponds to variant dbSNP:rs12004Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_022856202 – 214VLKGK…LPMPI → GRSWDDSNADTGLRSYSSI in isoform 2. 2 PublicationsAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035081 mRNA Translation: CAA22673.1
AL035082 mRNA Translation: CAA22674.1
CR456509 mRNA Translation: CAG30395.1
AK292102 mRNA Translation: BAF84791.1
AK222930 mRNA Translation: BAD96650.1
AK223238 mRNA Translation: BAD96958.1
Z97056 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60237.1
BC001277 mRNA Translation: AAH01277.1
BC096722 mRNA Translation: AAH96722.1
BC098131 mRNA Translation: AAH98131.1
BC098156 mRNA Translation: AAH98156.1
BC098336 mRNA Translation: AAH98336.1
CCDSiCCDS13972.1 [O43731-1]
CCDS46705.1 [O43731-2]
RefSeqiNP_006846.1, NM_006855.3 [O43731-1]
NP_057839.1, NM_016657.2 [O43731-2]
UniGeneiHs.745072

Genome annotation databases

EnsembliENST00000216014; ENSP00000216014; ENSG00000100196 [O43731-1]
ENST00000409006; ENSP00000386918; ENSG00000100196 [O43731-2]
GeneIDi11015
KEGGihsa:11015
UCSCiuc003avu.5 human [O43731-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiERD23_HUMAN
AccessioniPrimary (citable) accession number: O43731
Secondary accession number(s): A8K7T7
, B8ZZ26, O95557, Q4V750, Q4V767, Q53FP4, Q53GK1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: February 28, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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