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Protein

ER lumen protein-retaining receptor 3

Gene

KDELR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-381038. XBP1(S) activates chaperone genes.
R-HSA-6807878. COPI-mediated anterograde transport.
R-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
ER lumen protein-retaining receptor 3
Alternative name(s):
KDEL endoplasmic reticulum protein retention receptor 3
Short name:
KDEL receptor 3
Gene namesi
Name:KDELR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:6306. KDELR3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 22LumenalSequence analysis
Transmembranei3 – 2119HelicalSequence analysisAdd
BLAST
Topological domaini22 – 3514CytoplasmicSequence analysisAdd
BLAST
Transmembranei36 – 5318HelicalSequence analysisAdd
BLAST
Topological domaini54 – 618LumenalSequence analysis
Transmembranei62 – 8019HelicalSequence analysisAdd
BLAST
Topological domaini81 – 9616CytoplasmicSequence analysisAdd
BLAST
Transmembranei97 – 11014HelicalSequence analysisAdd
BLAST
Topological domaini111 – 1177LumenalSequence analysis
Transmembranei118 – 13720HelicalSequence analysisAdd
BLAST
Topological domaini138 – 14912CytoplasmicSequence analysisAdd
BLAST
Transmembranei150 – 16819HelicalSequence analysisAdd
BLAST
Topological domaini169 – 17810LumenalSequence analysis
Transmembranei179 – 19921HelicalSequence analysisAdd
BLAST
Topological domaini200 – 21415CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30085.

Polymorphism and mutation databases

BioMutaiKDELR3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 214214ER lumen protein-retaining receptor 3PRO_0000194158Add
BLAST

Proteomic databases

EPDiO43731.
MaxQBiO43731.
PaxDbiO43731.
PeptideAtlasiO43731.
PRIDEiO43731.

PTM databases

iPTMnetiO43731.
PhosphoSiteiO43731.

Expressioni

Gene expression databases

BgeeiENSG00000100196.
CleanExiHS_KDELR3.
ExpressionAtlasiO43731. baseline and differential.
GenevisibleiO43731. HS.

Organism-specific databases

HPAiHPA043477.

Interactioni

Protein-protein interaction databases

BioGridi116205. 18 interactions.
IntActiO43731. 1 interaction.
STRINGi9606.ENSP00000386918.

Structurei

3D structure databases

ProteinModelPortaliO43731.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ERD2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3106. Eukaryota.
COG5196. LUCA.
GeneTreeiENSGT00390000004010.
HOVERGENiHBG001398.
InParanoidiO43731.
KOiK10949.
OMAiHTEGFFD.
OrthoDBiEOG091G0Q1H.
PhylomeDBiO43731.
TreeFamiTF314792.

Family and domain databases

InterProiIPR000133. ER_ret_rcpt.
[Graphical view]
PANTHERiPTHR10585. PTHR10585. 1 hit.
PfamiPF00810. ER_lumen_recept. 1 hit.
[Graphical view]
PRINTSiPR00660. ERLUMENR.
PROSITEiPS00951. ER_LUMEN_RECEPTOR_1. 1 hit.
PS00952. ER_LUMEN_RECEPTOR_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O43731-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNVFRILGDL SHLLAMILLL GKIWRSKCCK GISGKSQILF ALVFTTRYLD
60 70 80 90 100
LFTNFISIYN TVMKVVFLLC AYVTVYMIYG KFRKTFDSEN DTFRLEFLLV
110 120 130 140 150
PVIGLSFLEN YSFTLLEILW TFSIYLESVA ILPQLFMISK TGEAETITTH
160 170 180 190 200
YLFFLGLYRA LYLANWIRRY QTENFYDQIA VVSGVVQTIF YCDFFYLYVT
210
KVLKGKKLSL PMPI
Length:214
Mass (Da):25,027
Last modified:June 1, 1998 - v1
Checksum:iED5F7D303390B314
GO
Isoform 2 (identifier: O43731-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     202-214: VLKGKKLSLPMPI → GRSWDDSNADTGLRSYSSI

Show »
Length:220
Mass (Da):25,690
Checksum:i4BCFEB17F3C6B5D7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti42 – 421L → P in BAD96650 (Ref. 4) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti199 – 1991V → G.2 Publications
Corresponds to variant rs12004 [ dbSNP | Ensembl ].
VAR_014506

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei202 – 21413VLKGK…LPMPI → GRSWDDSNADTGLRSYSSI in isoform 2. 2 PublicationsVSP_022856Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035081 mRNA. Translation: CAA22673.1.
AL035082 mRNA. Translation: CAA22674.1.
CR456509 mRNA. Translation: CAG30395.1.
AK292102 mRNA. Translation: BAF84791.1.
AK222930 mRNA. Translation: BAD96650.1.
AK223238 mRNA. Translation: BAD96958.1.
Z97056 Genomic DNA. Translation: CAX15124.1.
CH471095 Genomic DNA. Translation: EAW60237.1.
BC001277 mRNA. Translation: AAH01277.1.
BC096722 mRNA. Translation: AAH96722.1.
BC098131 mRNA. Translation: AAH98131.1.
BC098156 mRNA. Translation: AAH98156.1.
BC098336 mRNA. Translation: AAH98336.1.
CCDSiCCDS13972.1. [O43731-1]
CCDS46705.1. [O43731-2]
RefSeqiNP_006846.1. NM_006855.3. [O43731-1]
NP_057839.1. NM_016657.2. [O43731-2]
UniGeneiHs.745072.

Genome annotation databases

EnsembliENST00000216014; ENSP00000216014; ENSG00000100196. [O43731-1]
ENST00000409006; ENSP00000386918; ENSG00000100196. [O43731-2]
GeneIDi11015.
KEGGihsa:11015.
UCSCiuc003avu.5. human. [O43731-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035081 mRNA. Translation: CAA22673.1.
AL035082 mRNA. Translation: CAA22674.1.
CR456509 mRNA. Translation: CAG30395.1.
AK292102 mRNA. Translation: BAF84791.1.
AK222930 mRNA. Translation: BAD96650.1.
AK223238 mRNA. Translation: BAD96958.1.
Z97056 Genomic DNA. Translation: CAX15124.1.
CH471095 Genomic DNA. Translation: EAW60237.1.
BC001277 mRNA. Translation: AAH01277.1.
BC096722 mRNA. Translation: AAH96722.1.
BC098131 mRNA. Translation: AAH98131.1.
BC098156 mRNA. Translation: AAH98156.1.
BC098336 mRNA. Translation: AAH98336.1.
CCDSiCCDS13972.1. [O43731-1]
CCDS46705.1. [O43731-2]
RefSeqiNP_006846.1. NM_006855.3. [O43731-1]
NP_057839.1. NM_016657.2. [O43731-2]
UniGeneiHs.745072.

3D structure databases

ProteinModelPortaliO43731.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116205. 18 interactions.
IntActiO43731. 1 interaction.
STRINGi9606.ENSP00000386918.

PTM databases

iPTMnetiO43731.
PhosphoSiteiO43731.

Polymorphism and mutation databases

BioMutaiKDELR3.

Proteomic databases

EPDiO43731.
MaxQBiO43731.
PaxDbiO43731.
PeptideAtlasiO43731.
PRIDEiO43731.

Protocols and materials databases

DNASUi11015.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216014; ENSP00000216014; ENSG00000100196. [O43731-1]
ENST00000409006; ENSP00000386918; ENSG00000100196. [O43731-2]
GeneIDi11015.
KEGGihsa:11015.
UCSCiuc003avu.5. human. [O43731-1]

Organism-specific databases

CTDi11015.
GeneCardsiKDELR3.
HGNCiHGNC:6306. KDELR3.
HPAiHPA043477.
neXtProtiNX_O43731.
PharmGKBiPA30085.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3106. Eukaryota.
COG5196. LUCA.
GeneTreeiENSGT00390000004010.
HOVERGENiHBG001398.
InParanoidiO43731.
KOiK10949.
OMAiHTEGFFD.
OrthoDBiEOG091G0Q1H.
PhylomeDBiO43731.
TreeFamiTF314792.

Enzyme and pathway databases

ReactomeiR-HSA-381038. XBP1(S) activates chaperone genes.
R-HSA-6807878. COPI-mediated anterograde transport.
R-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Miscellaneous databases

ChiTaRSiKDELR3. human.
GeneWikiiKDELR3.
GenomeRNAii11015.
PROiO43731.

Gene expression databases

BgeeiENSG00000100196.
CleanExiHS_KDELR3.
ExpressionAtlasiO43731. baseline and differential.
GenevisibleiO43731. HS.

Family and domain databases

InterProiIPR000133. ER_ret_rcpt.
[Graphical view]
PANTHERiPTHR10585. PTHR10585. 1 hit.
PfamiPF00810. ER_lumen_recept. 1 hit.
[Graphical view]
PRINTSiPR00660. ERLUMENR.
PROSITEiPS00951. ER_LUMEN_RECEPTOR_1. 1 hit.
PS00952. ER_LUMEN_RECEPTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiERD23_HUMAN
AccessioniPrimary (citable) accession number: O43731
Secondary accession number(s): A8K7T7
, B8ZZ26, O95557, Q4V750, Q4V767, Q53FP4, Q53GK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: September 7, 2016
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.