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Protein

TP53-regulated inhibitor of apoptosis 1

Gene

TRIAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane (PubMed:23931759). Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo) (PubMed:26071602). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis (PubMed:15735003).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei27Important for interaction with PRELID3A1 Publication1
Sitei41Important for interaction with PRELID3A1 Publication1

GO - Molecular functioni

  • p53 binding Source: BHF-UCL

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • cellular response to UV Source: BHF-UCL
  • DNA damage response, signal transduction by p53 class mediator Source: BHF-UCL
  • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: HGNC
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: BHF-UCL
  • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: BHF-UCL
  • negative regulation of release of cytochrome c from mitochondria Source: UniProtKB
  • phospholipid transport Source: UniProtKB
  • positive regulation of phospholipid transport Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: BHF-UCL
  • regulation of apoptotic process Source: Reactome
  • regulation of membrane lipid distribution Source: UniProtKB

Keywordsi

Biological processApoptosis, Lipid transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release

Protein family/group databases

TCDBi3.A.9.1.1 the chloroplast envelope protein translocase (cept or tic-toc) family

Chemistry databases

SwissLipidsiSLP:000000338

Names & Taxonomyi

Protein namesi
Recommended name:
TP53-regulated inhibitor of apoptosis 1
Alternative name(s):
Protein 15E1.1
WF-1
p53-inducible cell-survival factor
Short name:
p53CSV
Gene namesi
Name:TRIAP1
Synonyms:15E1.1
ORF Names:HSPC132
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000170855.3
HGNCiHGNC:26937 TRIAP1
MIMi614943 gene
neXtProtiNX_O43715

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi27F → A: Impairs interaction with PRELID3A. 1 Publication1

Organism-specific databases

DisGeNETi51499
OpenTargetsiENSG00000170855
PharmGKBiPA143485661

Polymorphism and mutation databases

BioMutaiTRIAP1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002205231 – 76TP53-regulated inhibitor of apoptosis 1Add BLAST76

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Disulfide bondi8 ↔ 47PROSITE-ProRule annotationCombined sources1 Publication
Disulfide bondi18 ↔ 37PROSITE-ProRule annotationCombined sources1 Publication

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

EPDiO43715
MaxQBiO43715
PaxDbiO43715
PeptideAtlasiO43715
PRIDEiO43715

PTM databases

iPTMnetiO43715
PhosphoSitePlusiO43715

Expressioni

Inductioni

In p53/TP53-dependent manner in response to low levels of DNA damage. Not induced when DNA damage is severe.1 Publication

Gene expression databases

BgeeiENSG00000170855
CleanExiHS_TRIAP1
GenevisibleiO43715 HS

Organism-specific databases

HPAiHPA053640

Interactioni

Subunit structurei

Monomer (PubMed:26071602). Interacts with APAF1 and HSP70 (PubMed:15735003). Forms a complex with PRELID1 in the mitochondrion intermembrane space (PubMed:23931759). Interacts with PRELID3A (PubMed:26071602).3 Publications

GO - Molecular functioni

  • p53 binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi119573, 14 interactors
IntActiO43715, 9 interactors
STRINGi9606.ENSP00000449795

Structurei

Secondary structure

176
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 25Combined sources24
Helixi27 – 29Combined sources3
Helixi38 – 51Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XZSX-ray2.12A/B2-76[»]
4XZVX-ray3.58A/C/E/G2-76[»]
ProteinModelPortaliO43715
SMRiO43715
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 55CHCHPROSITE-ProRule annotationAdd BLAST51

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 521 PublicationAdd BLAST52

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi8 – 18Cx9C motif 1PROSITE-ProRule annotationAdd BLAST11
Motifi37 – 47Cx9C motif 2PROSITE-ProRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the TRIAP1/MDM35 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3481 Eukaryota
ENOG4111YV1 LUCA
GeneTreeiENSGT00390000010642
HOGENOMiHOG000230782
HOVERGENiHBG000004
InParanoidiO43715
KOiK17968
OMAiFMGPNKD
OrthoDBiEOG091G0Z43
PhylomeDBiO43715
TreeFamiTF326640

Family and domain databases

InterProiView protein in InterPro
IPR007918 MDM35_apoptosis
PfamiView protein in Pfam
PF05254 UPF0203, 1 hit
PROSITEiView protein in PROSITE
PS51808 CHCH, 1 hit

Sequencei

Sequence statusi: Complete.

O43715-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSVGEACTD MKREYDQCFN RWFAEKFLKG DSSGDPCTDL FKRYQQCVQK
60 70
AIKEKEIPIE GLEFMGHGKE KPENSS
Length:76
Mass (Da):8,786
Last modified:June 1, 1998 - v1
Checksum:i00B41AC399D76590
GO

Sequence cautioni

The sequence AAR00584 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161481 mRNA Translation: AAF29096.1
AL021546 Genomic DNA No translation available.
AK312006 mRNA Translation: BAG34944.1
CH471054 Genomic DNA Translation: EAW98192.1
BC002638 mRNA Translation: AAH02638.1
BC055313 mRNA Translation: AAH55313.1
U75688 mRNA Translation: AAR00584.1 Different initiation.
CCDSiCCDS9198.1
PIRiT09476
RefSeqiNP_057483.1, NM_016399.2
UniGeneiHs.69499

Genome annotation databases

EnsembliENST00000546954; ENSP00000449795; ENSG00000170855
GeneIDi51499
KEGGihsa:51499
UCSCiuc001tyg.3 human

Similar proteinsi

Entry informationi

Entry nameiTRIA1_HUMAN
AccessioniPrimary (citable) accession number: O43715
Secondary accession number(s): B2R4Z7, Q5RKS5, Q6LCA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

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