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Protein

TP53-regulated inhibitor of apoptosis 1

Gene

TRIAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane (PubMed:23931759). Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo) (PubMed:26071602). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis (PubMed:15735003).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei27Important for interaction with PRELID3A1 Publication1
Sitei41Important for interaction with PRELID3A1 Publication1

GO - Molecular functioni

  • p53 binding Source: BHF-UCL

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • cellular response to UV Source: BHF-UCL
  • DNA damage response, signal transduction by p53 class mediator Source: BHF-UCL
  • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: HGNC
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: BHF-UCL
  • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: BHF-UCL
  • negative regulation of release of cytochrome c from mitochondria Source: UniProtKB
  • phospholipid transport Source: UniProtKB
  • positive regulation of phospholipid transport Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • regulation of apoptotic process Source: Reactome
  • regulation of membrane lipid distribution Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Lipid transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170855-MONOMER.
ReactomeiR-HSA-6803204. TP53 Regulates Transcription of Genes Involved in Cytochrome C Release.

Protein family/group databases

TCDBi3.A.9.1.1. the chloroplast envelope protein translocase (cept or tic-toc) family.

Chemistry databases

SwissLipidsiSLP:000000338.

Names & Taxonomyi

Protein namesi
Recommended name:
TP53-regulated inhibitor of apoptosis 1
Alternative name(s):
Protein 15E1.1
WF-1
p53-inducible cell-survival factor
Short name:
p53CSV
Gene namesi
Name:TRIAP1
Synonyms:15E1.1
ORF Names:HSPC132
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:26937. TRIAP1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial intermembrane space Source: UniProtKB
  • mitochondrion Source: HGNC
  • perinuclear region of cytoplasm Source: UniProtKB-SubCell
  • protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi27F → A: Impairs interaction with PRELID3A. 1 Publication1

Organism-specific databases

DisGeNETi51499.
OpenTargetsiENSG00000170855.
PharmGKBiPA143485661.

Polymorphism and mutation databases

BioMutaiTRIAP1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002205231 – 76TP53-regulated inhibitor of apoptosis 1Add BLAST76

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Disulfide bondi8 ↔ 47PROSITE-ProRule annotationCombined sources1 Publication
Disulfide bondi18 ↔ 37PROSITE-ProRule annotationCombined sources1 Publication

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

EPDiO43715.
MaxQBiO43715.
PaxDbiO43715.
PeptideAtlasiO43715.
PRIDEiO43715.

PTM databases

iPTMnetiO43715.
PhosphoSitePlusiO43715.

Expressioni

Inductioni

In p53/TP53-dependent manner in response to low levels of DNA damage. Not induced when DNA damage is severe.1 Publication

Gene expression databases

BgeeiENSG00000170855.
CleanExiHS_TRIAP1.
GenevisibleiO43715. HS.

Organism-specific databases

HPAiHPA053640.

Interactioni

Subunit structurei

Monomer (PubMed:26071602). Interacts with APAF1 and HSP70 (PubMed:15735003). Forms a complex with PRELID1 in the mitochondrion intermembrane space (PubMed:23931759). Interacts with PRELID3A (PubMed:26071602).3 Publications

GO - Molecular functioni

  • p53 binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi119573. 13 interactors.
IntActiO43715. 2 interactors.
STRINGi9606.ENSP00000449795.

Structurei

Secondary structure

176
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 25Combined sources24
Helixi27 – 29Combined sources3
Helixi38 – 51Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XZSX-ray2.12A/B2-76[»]
4XZVX-ray3.58A/C/E/G2-76[»]
ProteinModelPortaliO43715.
SMRiO43715.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 55CHCHPROSITE-ProRule annotationAdd BLAST51

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 521 PublicationAdd BLAST52

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi8 – 18Cx9C motif 1PROSITE-ProRule annotationAdd BLAST11
Motifi37 – 47Cx9C motif 2PROSITE-ProRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the TRIAP1/MDM35 family.Curated
Contains 1 CHCH (coiled coil-helix-coiled coil-helix) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3481. Eukaryota.
ENOG4111YV1. LUCA.
GeneTreeiENSGT00390000010642.
HOGENOMiHOG000230782.
HOVERGENiHBG000004.
InParanoidiO43715.
KOiK17968.
OMAiFMGPNKD.
OrthoDBiEOG091G0Z43.
PhylomeDBiO43715.
TreeFamiTF326640.

Family and domain databases

InterProiIPR007918. MDM35_apoptosis.
[Graphical view]
PfamiPF05254. UPF0203. 1 hit.
[Graphical view]
PROSITEiPS51808. CHCH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43715-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSVGEACTD MKREYDQCFN RWFAEKFLKG DSSGDPCTDL FKRYQQCVQK
60 70
AIKEKEIPIE GLEFMGHGKE KPENSS
Length:76
Mass (Da):8,786
Last modified:June 1, 1998 - v1
Checksum:i00B41AC399D76590
GO

Sequence cautioni

The sequence AAR00584 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161481 mRNA. Translation: AAF29096.1.
AL021546 Genomic DNA. Translation: CAA16495.1.
AK312006 mRNA. Translation: BAG34944.1.
CH471054 Genomic DNA. Translation: EAW98192.1.
BC002638 mRNA. Translation: AAH02638.1.
BC055313 mRNA. Translation: AAH55313.1.
U75688 mRNA. Translation: AAR00584.1. Different initiation.
CCDSiCCDS9198.1.
PIRiT09476.
RefSeqiNP_057483.1. NM_016399.2.
UniGeneiHs.69499.

Genome annotation databases

EnsembliENST00000546954; ENSP00000449795; ENSG00000170855.
GeneIDi51499.
KEGGihsa:51499.
UCSCiuc001tyg.3. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161481 mRNA. Translation: AAF29096.1.
AL021546 Genomic DNA. Translation: CAA16495.1.
AK312006 mRNA. Translation: BAG34944.1.
CH471054 Genomic DNA. Translation: EAW98192.1.
BC002638 mRNA. Translation: AAH02638.1.
BC055313 mRNA. Translation: AAH55313.1.
U75688 mRNA. Translation: AAR00584.1. Different initiation.
CCDSiCCDS9198.1.
PIRiT09476.
RefSeqiNP_057483.1. NM_016399.2.
UniGeneiHs.69499.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XZSX-ray2.12A/B2-76[»]
4XZVX-ray3.58A/C/E/G2-76[»]
ProteinModelPortaliO43715.
SMRiO43715.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119573. 13 interactors.
IntActiO43715. 2 interactors.
STRINGi9606.ENSP00000449795.

Chemistry databases

SwissLipidsiSLP:000000338.

Protein family/group databases

TCDBi3.A.9.1.1. the chloroplast envelope protein translocase (cept or tic-toc) family.

PTM databases

iPTMnetiO43715.
PhosphoSitePlusiO43715.

Polymorphism and mutation databases

BioMutaiTRIAP1.

Proteomic databases

EPDiO43715.
MaxQBiO43715.
PaxDbiO43715.
PeptideAtlasiO43715.
PRIDEiO43715.

Protocols and materials databases

DNASUi51499.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000546954; ENSP00000449795; ENSG00000170855.
GeneIDi51499.
KEGGihsa:51499.
UCSCiuc001tyg.3. human.

Organism-specific databases

CTDi51499.
DisGeNETi51499.
GeneCardsiTRIAP1.
HGNCiHGNC:26937. TRIAP1.
HPAiHPA053640.
MIMi614943. gene.
neXtProtiNX_O43715.
OpenTargetsiENSG00000170855.
PharmGKBiPA143485661.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3481. Eukaryota.
ENOG4111YV1. LUCA.
GeneTreeiENSGT00390000010642.
HOGENOMiHOG000230782.
HOVERGENiHBG000004.
InParanoidiO43715.
KOiK17968.
OMAiFMGPNKD.
OrthoDBiEOG091G0Z43.
PhylomeDBiO43715.
TreeFamiTF326640.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170855-MONOMER.
ReactomeiR-HSA-6803204. TP53 Regulates Transcription of Genes Involved in Cytochrome C Release.

Miscellaneous databases

ChiTaRSiTRIAP1. human.
GenomeRNAii51499.
PROiO43715.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170855.
CleanExiHS_TRIAP1.
GenevisibleiO43715. HS.

Family and domain databases

InterProiIPR007918. MDM35_apoptosis.
[Graphical view]
PfamiPF05254. UPF0203. 1 hit.
[Graphical view]
PROSITEiPS51808. CHCH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRIA1_HUMAN
AccessioniPrimary (citable) accession number: O43715
Secondary accession number(s): B2R4Z7, Q5RKS5, Q6LCA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: November 2, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.