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O43711 (TLX3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
T-cell leukemia homeobox protein 3
Alternative name(s):
Homeobox protein Hox-11L2
Gene names
Name:TLX3
Synonyms:HOX11L2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length291 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Nucleus Probable.

Sequence similarities

Contains 1 homeobox DNA-binding domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Ets1P275772EBI-3939165,EBI-4289053From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 291291T-cell leukemia homeobox protein 3
PRO_0000049338

Regions

DNA binding166 – 22560Homeobox

Experimental info

Sequence conflict661L → P in CAA11550. Ref.1
Sequence conflict1221G → R in CAA11550. Ref.1
Sequence conflict232 – 2332ER → DG in CAA11550. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O43711 [UniParc].

Last modified October 3, 2006. Version 3.
Checksum: B5E3B910393EB4F3

FASTA29131,867
        10         20         30         40         50         60 
MEAPASAQTP HPHEPISFGI DQILNSPDQD SAPAPRGPDG ASYLGGPPGG RPGATYPSLP 

        70         80         90        100        110        120 
ASFAGLGAPF EDAGSYSVNL SLAPAGVIRV PAHRPLPGAV PPPLPSALPA MPSVPTVSSL 

       130        140        150        160        170        180 
GGLNFPWMES SRRFVKDRFT AAAALTPFTV TRRIGHPYQN RTPPKRKKPR TSFSRVQICE 

       190        200        210        220        230        240 
LEKRFHRQKY LASAERAALA KSLKMTDAQV KTWFQNRRTK WRRQTAEERE AERQQASRLM 

       250        260        270        280        290 
LQLQHDAFQK SLNDSIQPDP LCLHNSSLFA LQNLQPWEED SSKVPAVTSL V 

« Hide

References

« Hide 'large scale' references
[1]"Genomic characterization of the human and mouse HOX11L2 genes."
Delgado P., Rodriguez R., Gonzalez-Sarmiento R.
Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Muscle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ223798, AJ223799, AJ223800 Genomic DNA. Translation: CAA11550.1.
BC017291 mRNA. Translation: AAH17291.1.
RefSeqNP_066305.2. NM_021025.2.
UniGeneHs.249125.

3D structure databases

ProteinModelPortalO43711.
SMRO43711. Positions 152-228.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119030. 15 interactions.
IntActO43711. 3 interactions.
STRING9606.ENSP00000296921.

PTM databases

PhosphoSiteO43711.

Proteomic databases

PaxDbO43711.
PRIDEO43711.

Protocols and materials databases

DNASU30012.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000296921; ENSP00000296921; ENSG00000164438.
GeneID30012.
KEGGhsa:30012.
UCSCuc003mbf.3. human.

Organism-specific databases

CTD30012.
GeneCardsGC05P170736.
HGNCHGNC:13532. TLX3.
HPACAB017792.
MIM604640. gene.
neXtProtNX_O43711.
Orphanet99861. Precursor T-cell acute lymphoblastic leukemia.
PharmGKBPA37797.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG314631.
HOGENOMHOG000116280.
HOVERGENHBG036206.
InParanoidO43711.
KOK15607.
OMARPPRMEA.
OrthoDBEOG7Q5HFW.
PhylomeDBO43711.
TreeFamTF325347.

Enzyme and pathway databases

SignaLinkO43711.

Gene expression databases

BgeeO43711.
CleanExHS_TLX3.
GenevestigatorO43711.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiTLX3.
GenomeRNAi30012.
NextBio52838.
PROO43711.
SOURCESearch...

Entry information

Entry nameTLX3_HUMAN
AccessionPrimary (citable) accession number: O43711
Secondary accession number(s): Q96AD3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: October 3, 2006
Last modified: February 19, 2014
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM