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O43711

- TLX3_HUMAN

UniProt

O43711 - TLX3_HUMAN

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Protein
T-cell leukemia homeobox protein 3
Gene
TLX3, HOX11L2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi166 – 22560Homeobox
Add
BLAST

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. sequence-specific DNA binding Source: InterPro
  3. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. central nervous system development Source: Ensembl
  2. negative regulation of neuron differentiation Source: Ensembl
  3. neuron fate specification Source: Ensembl
  4. neuron migration Source: Ensembl
  5. regulation of respiratory gaseous exchange by neurological system process Source: Ensembl
  6. respiratory gaseous exchange Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiO43711.

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell leukemia homeobox protein 3
Alternative name(s):
Homeobox protein Hox-11L2
Gene namesi
Name:TLX3
Synonyms:HOX11L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:13532. TLX3.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

Orphaneti99861. Precursor T-cell acute lymphoblastic leukemia.
PharmGKBiPA37797.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 291291T-cell leukemia homeobox protein 3
PRO_0000049338Add
BLAST

Proteomic databases

PaxDbiO43711.
PRIDEiO43711.

PTM databases

PhosphoSiteiO43711.

Expressioni

Gene expression databases

BgeeiO43711.
CleanExiHS_TLX3.
GenevestigatoriO43711.

Organism-specific databases

HPAiCAB017792.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Ets1P275772EBI-3939165,EBI-4289053From a different organism.

Protein-protein interaction databases

BioGridi119030. 15 interactions.
IntActiO43711. 3 interactions.
STRINGi9606.ENSP00000296921.

Structurei

3D structure databases

ProteinModelPortaliO43711.
SMRiO43711. Positions 152-228.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG314631.
HOGENOMiHOG000116280.
HOVERGENiHBG036206.
InParanoidiO43711.
KOiK15607.
OMAiRPPRMEA.
OrthoDBiEOG7Q5HFW.
PhylomeDBiO43711.
TreeFamiTF325347.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43711-1 [UniParc]FASTAAdd to Basket

« Hide

MEAPASAQTP HPHEPISFGI DQILNSPDQD SAPAPRGPDG ASYLGGPPGG    50
RPGATYPSLP ASFAGLGAPF EDAGSYSVNL SLAPAGVIRV PAHRPLPGAV 100
PPPLPSALPA MPSVPTVSSL GGLNFPWMES SRRFVKDRFT AAAALTPFTV 150
TRRIGHPYQN RTPPKRKKPR TSFSRVQICE LEKRFHRQKY LASAERAALA 200
KSLKMTDAQV KTWFQNRRTK WRRQTAEERE AERQQASRLM LQLQHDAFQK 250
SLNDSIQPDP LCLHNSSLFA LQNLQPWEED SSKVPAVTSL V 291
Length:291
Mass (Da):31,867
Last modified:October 3, 2006 - v3
Checksum:iB5E3B910393EB4F3
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti66 – 661L → P in CAA11550. 1 Publication
Sequence conflicti122 – 1221G → R in CAA11550. 1 Publication
Sequence conflicti232 – 2332ER → DG in CAA11550. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ223798, AJ223799, AJ223800 Genomic DNA. Translation: CAA11550.1.
BC017291 mRNA. Translation: AAH17291.1.
CCDSiCCDS34288.1.
RefSeqiNP_066305.2. NM_021025.2.
UniGeneiHs.249125.

Genome annotation databases

EnsembliENST00000296921; ENSP00000296921; ENSG00000164438.
GeneIDi30012.
KEGGihsa:30012.
UCSCiuc003mbf.3. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ223798 , AJ223799 , AJ223800 Genomic DNA. Translation: CAA11550.1 .
BC017291 mRNA. Translation: AAH17291.1 .
CCDSi CCDS34288.1.
RefSeqi NP_066305.2. NM_021025.2.
UniGenei Hs.249125.

3D structure databases

ProteinModelPortali O43711.
SMRi O43711. Positions 152-228.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119030. 15 interactions.
IntActi O43711. 3 interactions.
STRINGi 9606.ENSP00000296921.

PTM databases

PhosphoSitei O43711.

Proteomic databases

PaxDbi O43711.
PRIDEi O43711.

Protocols and materials databases

DNASUi 30012.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000296921 ; ENSP00000296921 ; ENSG00000164438 .
GeneIDi 30012.
KEGGi hsa:30012.
UCSCi uc003mbf.3. human.

Organism-specific databases

CTDi 30012.
GeneCardsi GC05P170736.
HGNCi HGNC:13532. TLX3.
HPAi CAB017792.
MIMi 604640. gene.
neXtProti NX_O43711.
Orphaneti 99861. Precursor T-cell acute lymphoblastic leukemia.
PharmGKBi PA37797.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG314631.
HOGENOMi HOG000116280.
HOVERGENi HBG036206.
InParanoidi O43711.
KOi K15607.
OMAi RPPRMEA.
OrthoDBi EOG7Q5HFW.
PhylomeDBi O43711.
TreeFami TF325347.

Enzyme and pathway databases

SignaLinki O43711.

Miscellaneous databases

GeneWikii TLX3.
GenomeRNAii 30012.
NextBioi 52838.
PROi O43711.
SOURCEi Search...

Gene expression databases

Bgeei O43711.
CleanExi HS_TLX3.
Genevestigatori O43711.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic characterization of the human and mouse HOX11L2 genes."
    Delgado P., Rodriguez R., Gonzalez-Sarmiento R.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.

Entry informationi

Entry nameiTLX3_HUMAN
AccessioniPrimary (citable) accession number: O43711
Secondary accession number(s): Q96AD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: October 3, 2006
Last modified: July 9, 2014
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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