O43711 (TLX3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
T-cell leukemia homeobox protein 3

Alternative name(s):
Homeobox protein Hox-11L2

Gene names

Name:	TLX3
Synonyms:	HOX11L2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	291 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Nucleus Probable.
Sequence similarities	Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	central nervous system development Inferred from electronic annotation. Source: Compara negative regulation of neuron differentiation Inferred from electronic annotation. Source: Compara neuron fate specification Inferred from electronic annotation. Source: Compara neuron migration Inferred from electronic annotation. Source: Compara regulation of respiratory gaseous exchange by neurological system process Inferred from electronic annotation. Source: Compara respiratory gaseous exchange Inferred from electronic annotation. Source: Compara
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Ets1	P27577	2	EBI-3939165,EBI-4289053	From a different organism.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 291	291	T-cell leukemia homeobox protein 3		PRO_0000049338
Regions
	DNA binding	166 – 225	60	Homeobox
Experimental info
	Sequence conflict	66	1	L → P in CAA11550. Ref.1
	Sequence conflict	122	1	G → R in CAA11550. Ref.1
	Sequence conflict	232 – 233	2	ER → DG in CAA11550. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O43711 [UniParc]. Last modified October 3, 2006. Version 3. Checksum: B5E3B910393EB4F3	FASTA	291	31,867
	10 20 30 40 50 60 MEAPASAQTP HPHEPISFGI DQILNSPDQD SAPAPRGPDG ASYLGGPPGG RPGATYPSLP 70 80 90 100 110 120 ASFAGLGAPF EDAGSYSVNL SLAPAGVIRV PAHRPLPGAV PPPLPSALPA MPSVPTVSSL 130 140 150 160 170 180 GGLNFPWMES SRRFVKDRFT AAAALTPFTV TRRIGHPYQN RTPPKRKKPR TSFSRVQICE 190 200 210 220 230 240 LEKRFHRQKY LASAERAALA KSLKMTDAQV KTWFQNRRTK WRRQTAEERE AERQQASRLM 250 260 270 280 290 LQLQHDAFQK SLNDSIQPDP LCLHNSSLFA LQNLQPWEED SSKVPAVTSL V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genomic characterization of the human and mouse HOX11L2 genes." Delgado P., Rodriguez R., Gonzalez-Sarmiento R. Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Muscle.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ223798, AJ223799, AJ223800 Genomic DNA. Translation: CAA11550.1. BC017291 mRNA. Translation: AAH17291.1.
IPI	IPI00306869.
RefSeq	NP_066305.2. NM_021025.2.
UniGene	Hs.249125.
3D structure databases
ProteinModelPortal	O43711.
ModBase	Search...
Protein-protein interaction databases
IntAct	O43711. 3 interactions.
STRING	9606.ENSP00000296921.
PTM databases
PhosphoSite	O43711.
Proteomic databases
PaxDb	O43711.
PRIDE	O43711.
Protocols and materials databases
DNASU	30012.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000296921; ENSP00000296921; ENSG00000164438.
GeneID	30012.
KEGG	hsa:30012.
UCSC	uc003mbf.3. human.
Organism-specific databases
CTD	30012.
GeneCards	GC05P170736.
HGNC	HGNC:13532. TLX3.
HPA	CAB017792.
MIM	604640. gene.
neXtProt	NX_O43711.
PharmGKB	PA37797.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG314631.
HOGENOM	HOG000116280.
HOVERGEN	HBG036206.
InParanoid	O43711.
KO	K15607.
OMA	SRPGATY.
OrthoDB	EOG4QJRP8.
PhylomeDB	O43711.
Gene expression databases
Bgee	O43711.
CleanEx	HS_TLX3.
Genevestigator	O43711.
GermOnline	ENSG00000164438. Homo sapiens.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	30012.
NextBio	52838.
SOURCE	Search...

Entry information

Entry name

TLX3_HUMAN

Accession

Primary (citable) accession number: O43711
Secondary accession number(s): Q96AD3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	October 3, 2006
Last modified:	May 1, 2013
This is version 113 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.