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Protein

T-cell leukemia homeobox protein 3

Gene

TLX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi166 – 225HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164438-MONOMER.
SignaLinkiO43711.

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell leukemia homeobox protein 3
Alternative name(s):
Homeobox protein Hox-11L2
Gene namesi
Name:TLX3
Synonyms:HOX11L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:13532. TLX3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi30012.
MalaCardsiTLX3.
OpenTargetsiENSG00000164438.
Orphaneti99861. Precursor T-cell acute lymphoblastic leukemia.
PharmGKBiPA37797.

Polymorphism and mutation databases

BioMutaiTLX3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000493381 – 291T-cell leukemia homeobox protein 3Add BLAST291

Proteomic databases

PaxDbiO43711.
PRIDEiO43711.

PTM databases

iPTMnetiO43711.
PhosphoSitePlusiO43711.

Expressioni

Gene expression databases

BgeeiENSG00000164438.
CleanExiHS_TLX3.
GenevisibleiO43711. HS.

Organism-specific databases

HPAiCAB017792.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Ets1P275772EBI-3939165,EBI-4289053From a different organism.

Protein-protein interaction databases

BioGridi119030. 15 interactors.
IntActiO43711. 11 interactors.
STRINGi9606.ENSP00000296921.

Structurei

3D structure databases

ProteinModelPortaliO43711.
SMRiO43711.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0488. Eukaryota.
ENOG411188D. LUCA.
GeneTreeiENSGT00860000133665.
HOGENOMiHOG000116280.
HOVERGENiHBG036206.
InParanoidiO43711.
KOiK15607.
OMAiXRQTAEE.
OrthoDBiEOG091G0RNV.
PhylomeDBiO43711.
TreeFamiTF325347.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43711-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAPASAQTP HPHEPISFGI DQILNSPDQD SAPAPRGPDG ASYLGGPPGG
60 70 80 90 100
RPGATYPSLP ASFAGLGAPF EDAGSYSVNL SLAPAGVIRV PAHRPLPGAV
110 120 130 140 150
PPPLPSALPA MPSVPTVSSL GGLNFPWMES SRRFVKDRFT AAAALTPFTV
160 170 180 190 200
TRRIGHPYQN RTPPKRKKPR TSFSRVQICE LEKRFHRQKY LASAERAALA
210 220 230 240 250
KSLKMTDAQV KTWFQNRRTK WRRQTAEERE AERQQASRLM LQLQHDAFQK
260 270 280 290
SLNDSIQPDP LCLHNSSLFA LQNLQPWEED SSKVPAVTSL V
Length:291
Mass (Da):31,867
Last modified:October 3, 2006 - v3
Checksum:iB5E3B910393EB4F3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66L → P in CAA11550 (Ref. 1) Curated1
Sequence conflicti122G → R in CAA11550 (Ref. 1) Curated1
Sequence conflicti232 – 233ER → DG in CAA11550 (Ref. 1) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223798, AJ223799, AJ223800 Genomic DNA. Translation: CAA11550.1.
BC017291 mRNA. Translation: AAH17291.1.
CCDSiCCDS34288.1.
RefSeqiNP_066305.2. NM_021025.3.
UniGeneiHs.249125.

Genome annotation databases

EnsembliENST00000296921; ENSP00000296921; ENSG00000164438.
GeneIDi30012.
KEGGihsa:30012.
UCSCiuc003mbf.3. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223798, AJ223799, AJ223800 Genomic DNA. Translation: CAA11550.1.
BC017291 mRNA. Translation: AAH17291.1.
CCDSiCCDS34288.1.
RefSeqiNP_066305.2. NM_021025.3.
UniGeneiHs.249125.

3D structure databases

ProteinModelPortaliO43711.
SMRiO43711.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119030. 15 interactors.
IntActiO43711. 11 interactors.
STRINGi9606.ENSP00000296921.

PTM databases

iPTMnetiO43711.
PhosphoSitePlusiO43711.

Polymorphism and mutation databases

BioMutaiTLX3.

Proteomic databases

PaxDbiO43711.
PRIDEiO43711.

Protocols and materials databases

DNASUi30012.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296921; ENSP00000296921; ENSG00000164438.
GeneIDi30012.
KEGGihsa:30012.
UCSCiuc003mbf.3. human.

Organism-specific databases

CTDi30012.
DisGeNETi30012.
GeneCardsiTLX3.
HGNCiHGNC:13532. TLX3.
HPAiCAB017792.
MalaCardsiTLX3.
MIMi604640. gene.
neXtProtiNX_O43711.
OpenTargetsiENSG00000164438.
Orphaneti99861. Precursor T-cell acute lymphoblastic leukemia.
PharmGKBiPA37797.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0488. Eukaryota.
ENOG411188D. LUCA.
GeneTreeiENSGT00860000133665.
HOGENOMiHOG000116280.
HOVERGENiHBG036206.
InParanoidiO43711.
KOiK15607.
OMAiXRQTAEE.
OrthoDBiEOG091G0RNV.
PhylomeDBiO43711.
TreeFamiTF325347.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164438-MONOMER.
SignaLinkiO43711.

Miscellaneous databases

GeneWikiiTLX3.
GenomeRNAii30012.
PROiO43711.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164438.
CleanExiHS_TLX3.
GenevisibleiO43711. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTLX3_HUMAN
AccessioniPrimary (citable) accession number: O43711
Secondary accession number(s): Q96AD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: October 3, 2006
Last modified: November 30, 2016
This is version 141 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.