Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O43711

- TLX3_HUMAN

UniProt

O43711 - TLX3_HUMAN

Protein

T-cell leukemia homeobox protein 3

Gene

TLX3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 3 (03 Oct 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi166 – 22560HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. central nervous system development Source: Ensembl
    2. negative regulation of neuron differentiation Source: Ensembl
    3. neuron fate specification Source: Ensembl
    4. neuron migration Source: Ensembl
    5. regulation of respiratory gaseous exchange by neurological system process Source: Ensembl
    6. respiratory gaseous exchange Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    SignaLinkiO43711.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    T-cell leukemia homeobox protein 3
    Alternative name(s):
    Homeobox protein Hox-11L2
    Gene namesi
    Name:TLX3
    Synonyms:HOX11L2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:13532. TLX3.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti99861. Precursor T-cell acute lymphoblastic leukemia.
    PharmGKBiPA37797.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 291291T-cell leukemia homeobox protein 3PRO_0000049338Add
    BLAST

    Proteomic databases

    PaxDbiO43711.
    PRIDEiO43711.

    PTM databases

    PhosphoSiteiO43711.

    Expressioni

    Gene expression databases

    BgeeiO43711.
    CleanExiHS_TLX3.
    GenevestigatoriO43711.

    Organism-specific databases

    HPAiCAB017792.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Ets1P275772EBI-3939165,EBI-4289053From a different organism.

    Protein-protein interaction databases

    BioGridi119030. 15 interactions.
    IntActiO43711. 3 interactions.
    STRINGi9606.ENSP00000296921.

    Structurei

    3D structure databases

    ProteinModelPortaliO43711.
    SMRiO43711. Positions 152-228.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG314631.
    HOGENOMiHOG000116280.
    HOVERGENiHBG036206.
    InParanoidiO43711.
    KOiK15607.
    OMAiRPPRMEA.
    OrthoDBiEOG7Q5HFW.
    PhylomeDBiO43711.
    TreeFamiTF325347.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O43711-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEAPASAQTP HPHEPISFGI DQILNSPDQD SAPAPRGPDG ASYLGGPPGG    50
    RPGATYPSLP ASFAGLGAPF EDAGSYSVNL SLAPAGVIRV PAHRPLPGAV 100
    PPPLPSALPA MPSVPTVSSL GGLNFPWMES SRRFVKDRFT AAAALTPFTV 150
    TRRIGHPYQN RTPPKRKKPR TSFSRVQICE LEKRFHRQKY LASAERAALA 200
    KSLKMTDAQV KTWFQNRRTK WRRQTAEERE AERQQASRLM LQLQHDAFQK 250
    SLNDSIQPDP LCLHNSSLFA LQNLQPWEED SSKVPAVTSL V 291
    Length:291
    Mass (Da):31,867
    Last modified:October 3, 2006 - v3
    Checksum:iB5E3B910393EB4F3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti66 – 661L → P in CAA11550. 1 PublicationCurated
    Sequence conflicti122 – 1221G → R in CAA11550. 1 PublicationCurated
    Sequence conflicti232 – 2332ER → DG in CAA11550. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ223798, AJ223799, AJ223800 Genomic DNA. Translation: CAA11550.1.
    BC017291 mRNA. Translation: AAH17291.1.
    CCDSiCCDS34288.1.
    RefSeqiNP_066305.2. NM_021025.2.
    UniGeneiHs.249125.

    Genome annotation databases

    EnsembliENST00000296921; ENSP00000296921; ENSG00000164438.
    GeneIDi30012.
    KEGGihsa:30012.
    UCSCiuc003mbf.3. human.

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ223798 , AJ223799 , AJ223800 Genomic DNA. Translation: CAA11550.1 .
    BC017291 mRNA. Translation: AAH17291.1 .
    CCDSi CCDS34288.1.
    RefSeqi NP_066305.2. NM_021025.2.
    UniGenei Hs.249125.

    3D structure databases

    ProteinModelPortali O43711.
    SMRi O43711. Positions 152-228.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119030. 15 interactions.
    IntActi O43711. 3 interactions.
    STRINGi 9606.ENSP00000296921.

    PTM databases

    PhosphoSitei O43711.

    Proteomic databases

    PaxDbi O43711.
    PRIDEi O43711.

    Protocols and materials databases

    DNASUi 30012.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000296921 ; ENSP00000296921 ; ENSG00000164438 .
    GeneIDi 30012.
    KEGGi hsa:30012.
    UCSCi uc003mbf.3. human.

    Organism-specific databases

    CTDi 30012.
    GeneCardsi GC05P170736.
    HGNCi HGNC:13532. TLX3.
    HPAi CAB017792.
    MIMi 604640. gene.
    neXtProti NX_O43711.
    Orphaneti 99861. Precursor T-cell acute lymphoblastic leukemia.
    PharmGKBi PA37797.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG314631.
    HOGENOMi HOG000116280.
    HOVERGENi HBG036206.
    InParanoidi O43711.
    KOi K15607.
    OMAi RPPRMEA.
    OrthoDBi EOG7Q5HFW.
    PhylomeDBi O43711.
    TreeFami TF325347.

    Enzyme and pathway databases

    SignaLinki O43711.

    Miscellaneous databases

    GeneWikii TLX3.
    GenomeRNAii 30012.
    NextBioi 52838.
    PROi O43711.
    SOURCEi Search...

    Gene expression databases

    Bgeei O43711.
    CleanExi HS_TLX3.
    Genevestigatori O43711.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic characterization of the human and mouse HOX11L2 genes."
      Delgado P., Rodriguez R., Gonzalez-Sarmiento R.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Muscle.

    Entry informationi

    Entry nameiTLX3_HUMAN
    AccessioniPrimary (citable) accession number: O43711
    Secondary accession number(s): Q96AD3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 123 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3