Reviewed, UniProtKB/Swiss-Prot O43711 (TLX3_HUMAN)

Names and origin

Protein names

Recommended name:
    T-cell leukemia homeobox protein 3
Alternative name(s):
    Homeobox protein Hox-11L2

Gene names

Name:	TLX3
Synonyms:	HOX11L2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	291 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Nucleus Probable.
Sequence similarities	Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 291	291	T-cell leukemia homeobox protein 3		PRO_0000049338
Regions
	DNA binding	166 – 225	60	Homeobox
Experimental info
	Sequence conflict	66	1	L → P in CAA11550. Ref.1
	Sequence conflict	122	1	G → R in CAA11550. Ref.1
	Sequence conflict	232 – 233	2	ER → DG in CAA11550. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O43711-1 [UniParc]. Last modified October 3, 2006. Version 3. Checksum: B5E3B910393EB4F3	FASTA	291	31,867
	10 20 30 40 50 60 MEAPASAQTP HPHEPISFGI DQILNSPDQD SAPAPRGPDG ASYLGGPPGG RPGATYPSLP 70 80 90 100 110 120 ASFAGLGAPF EDAGSYSVNL SLAPAGVIRV PAHRPLPGAV PPPLPSALPA MPSVPTVSSL 130 140 150 160 170 180 GGLNFPWMES SRRFVKDRFT AAAALTPFTV TRRIGHPYQN RTPPKRKKPR TSFSRVQICE 190 200 210 220 230 240 LEKRFHRQKY LASAERAALA KSLKMTDAQV KTWFQNRRTK WRRQTAEERE AERQQASRLM 250 260 270 280 290 LQLQHDAFQK SLNDSIQPDP LCLHNSSLFA LQNLQPWEED SSKVPAVTSL V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genomic characterization of the human and mouse HOX11L2 genes." Delgado P., Rodriguez R., Gonzalez-Sarmiento R. Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Muscle.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ223798, AJ223799, AJ223800 Genomic DNA. Translation: CAA11550.1. BC017291 mRNA. Translation: AAH17291.1.
IPI	IPI00306869.
RefSeq	NP_066305.2.
UniGene	Hs.249125
3D structure databases
HSSP	HSSP built from PDB template 1IG7 based on UniProtKB P13297.
ModBase	Search...
Proteomic databases
PRIDE	O43711.
Genome annotation databases
Ensembl	ENSG00000164438. Homo sapiens. [Contig view]
GeneID	30012.
KEGG	hsa:30012.
Organism-specific databases
GeneCards	GC05P170668.
HGNC	HGNC:13532. TLX3.
HPA	CAB017792.
MIM	604640. gene.
PharmGKB	PA37797.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	O43711.
HOVERGEN	O43711.
OMA	O43711. FTXRQTA.
Gene expression databases
ArrayExpress	O43711.
Bgee	O43711.
CleanEx	HS_TLX3.
GermOnline	ENSG00000164438. Homo sapiens.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
ProDom	PD000010. Homeobox. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	52838.
SOURCE	Search...

Entry information

Entry name

TLX3_HUMAN

Accession

Primary (citable) accession number: O43711
Secondary accession number(s): Q96AD3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	October 3, 2006
Last modified:	June 16, 2009
This is version 75 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)