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O43709

- WBS22_HUMAN

UniProt

O43709 - WBS22_HUMAN

Protein

Probable 18S rRNA (guanine-N(7))-methyltransferase

Gene

WBSCR22

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 2 (10 Oct 2002)
      Previous versions | rss
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    Functioni

    S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N7 position of a guanine in 18S rRNA By similarity. Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity. Locus-specific steroid receptor coactivator. Potentiates transactivation by glucocorticoid (NR3C1), mineralocorticoid (NR3C2), androgen (AR) and progesterone (PGR) receptors. Required for the maintenance of open chromatin at the TSC22D3/GILZ locus to facilitate NR3C1 loading on the response elements. Required for maintenance of dimethylation on histone H3 'Lys-79' (H3K79me2), although direct histone methyltransferase activity is not observed in vitro (PubMed:24488492).By similarity2 Publications

    Catalytic activityi

    S-adenosyl-L-methionine + guanine in 18S rRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine in 18S rRNA.

    GO - Molecular functioni

    1. methyltransferase activity Source: UniProtKB
    2. poly(A) RNA binding Source: UniProtKB

    GO - Biological processi

    1. chromatin modification Source: UniProtKB-KW
    2. methylation Source: GOC
    3. regulation of transcription, DNA-templated Source: UniProtKB-KW
    4. rRNA processing Source: UniProtKB-KW
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Methyltransferase, Transferase

    Keywords - Biological processi

    Ribosome biogenesis, rRNA processing, Transcription, Transcription regulation

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable 18S rRNA (guanine-N(7))-methyltransferase (EC:2.1.1.-)
    Alternative name(s):
    Bud site selection protein 23 homolog
    Metastasis-related methyltransferase 1
    Williams-Beuren syndrome chromosomal region 22 protein
    Gene namesi
    Name:WBSCR22
    Synonyms:MERM1
    ORF Names:HUSSY-03, PP3381
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:16405. WBSCR22.

    Subcellular locationi

    Nucleus. Nucleusnucleolus By similarity. Cytoplasm
    Note: Localized diffusely throughout the nucleus and the cytoplasm. Localization is not affected by glucocorticoid treatment.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    WBSCR22 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of WBSCR22 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi180 – 1801K → R: Resistant to down-regulation in response to TNF and IFNG combined treatment and effective coactivator for NR3C1, even in the presence of TNF and IFNG; when associated R-196. 1 Publication
    Mutagenesisi196 – 1961K → R: Resistant to down-regulation in response to TNF and IFNG combined treatment and effective coactivator for NR3C1, even in the presence of TNF and IFNG; when associated R-180. 1 Publication

    Keywords - Diseasei

    Williams-Beuren syndrome

    Organism-specific databases

    MIMi194050. phenotype.
    Orphaneti904. Williams syndrome.
    PharmGKBiPA38133.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 281281Probable 18S rRNA (guanine-N(7))-methyltransferasePRO_0000204450Add
    BLAST

    Post-translational modificationi

    May be ubiquitinated and targeted to degradation in response to proinflammatory cytokine signaling.Curated

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    MaxQBiO43709.
    PaxDbiO43709.
    PRIDEiO43709.

    PTM databases

    PhosphoSiteiO43709.

    Expressioni

    Tissue specificityi

    Widely expressed, with high levels in heart, skeletal muscle and kidney. Detected at high levels in bronchial brushings and in normal lung (at protein level). In fetal lung tissue, expressed in the developing bronchial lumen lining cells (at protein level). Tends to be down-regulated in lungs affected by inflammatory diseases or neoplasia (at protein level). Expressed in immune cells, including B and T lymphocytes and macrophages.3 Publications

    Inductioni

    Up-regulated in CD8+ T lymphocytes by treatment with anti-CD3 and in B lymphocytes by treatment with CD40 ligand and anti-B cell receptor antibody. In macrophages, no induction following LPS treatment. Down-regulated by a combined treatment with TNF and IFNG (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiO43709.
    BgeeiO43709.
    CleanExiHS_WBSCR22.
    GenevestigatoriO43709.

    Organism-specific databases

    HPAiHPA052185.

    Interactioni

    Subunit structurei

    Interacts with GRIP1.1 Publication

    Protein-protein interaction databases

    BioGridi125277. 12 interactions.
    IntActiO43709. 5 interactions.
    MINTiMINT-2999647.
    STRINGi9606.ENSP00000265758.

    Structurei

    3D structure databases

    ProteinModelPortaliO43709.
    SMRiO43709. Positions 53-164.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0500.
    HOGENOMiHOG000111527.
    HOVERGENiHBG054765.
    InParanoidiO43709.
    KOiK00599.
    PhylomeDBiO43709.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR013216. Methyltransf_11.
    IPR029063. SAM-dependent_MTases-like.
    IPR022238. Unchr_MeTrfase_Williams-Beuren.
    [Graphical view]
    PfamiPF08241. Methyltransf_11. 1 hit.
    PF12589. WBS_methylT. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O43709-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASRGRRPEH GGPPELFYDE TEARKYVRNS RMIDIQTRMA GRALELLYLP    50
    ENKPCYLLDI GCGTGLSGSY LSDEGHYWVG LDISPAMLDE AVDREIEGDL 100
    LLGDMGQGIP FKPGTFDGCI SISAVQWLCN ANKKSENPAK RLYCFFASLF 150
    SVLVRGSRAV LQLYPENSEQ LELITTQATK AGFSGGMVVD YPNSAKAKKF 200
    YLCLFSGPST FIPEGLSENQ DEVEPRESVF TNERFPLRMS RRGMVRKSRA 250
    WVLEKKERHR RQGREVRPDT QYTGRKRKPR F 281
    Length:281
    Mass (Da):31,880
    Last modified:October 10, 2002 - v2
    Checksum:iB090B5F0A156B36A
    GO
    Isoform 2 (identifier: O43709-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         171-281: LELITTQATK...YTGRKRKPRF → VSPSATGCAG...VWPLMAHLMT

    Note: No experimental confirmation available.

    Show »
    Length:220
    Mass (Da):24,360
    Checksum:i834E91DBD30FA33A
    GO
    Isoform 3 (identifier: O43709-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         233-233: E → EREGGAFERRGIRGHQTR

    Note: No experimental confirmation available. Gene prediction based on EST data.

    Show »
    Length:298
    Mass (Da):33,846
    Checksum:iCAA524325DAE8F47
    GO

    Sequence cautioni

    The sequence AAG17249.1 differs from that shown. Reason: Frameshift at positions 194 and 203.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei171 – 281111LELIT…RKPRF → VSPSATGCAGELGDSTGKLS WGSDKESYADWREKEETCTL VWPLMAHLMT in isoform 2. 1 PublicationVSP_011511Add
    BLAST
    Alternative sequencei233 – 2331E → EREGGAFERRGIRGHQTR in isoform 3. CuratedVSP_054762

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF420248 mRNA. Translation: AAL16066.1.
    AJ224442 mRNA. Translation: CAA11944.1.
    AF412034 mRNA. Translation: AAM62316.1.
    AK291116 mRNA. Translation: BAF83805.1.
    AK315032 mRNA. Translation: BAG37517.1.
    AF218007 mRNA. Translation: AAG17249.1. Sequence problems.
    AC073846 Genomic DNA. Translation: AAS07473.1.
    CH471200 Genomic DNA. Translation: EAW69657.1.
    BC000169 mRNA. Translation: AAH00169.2.
    BC001780 mRNA. Translation: AAH01780.2.
    BC011696 mRNA. Translation: AAH11696.2.
    CCDSiCCDS5557.1. [O43709-1]
    CCDS56490.1. [O43709-3]
    RefSeqiNP_001189489.1. NM_001202560.2. [O43709-3]
    NP_059998.2. NM_017528.4. [O43709-1]
    UniGeneiHs.647063.

    Genome annotation databases

    EnsembliENST00000265758; ENSP00000265758; ENSG00000071462. [O43709-1]
    ENST00000423497; ENSP00000401191; ENSG00000071462. [O43709-3]
    GeneIDi114049.
    KEGGihsa:114049.
    UCSCiuc003tyt.3. human. [O43709-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF420248 mRNA. Translation: AAL16066.1 .
    AJ224442 mRNA. Translation: CAA11944.1 .
    AF412034 mRNA. Translation: AAM62316.1 .
    AK291116 mRNA. Translation: BAF83805.1 .
    AK315032 mRNA. Translation: BAG37517.1 .
    AF218007 mRNA. Translation: AAG17249.1 . Sequence problems.
    AC073846 Genomic DNA. Translation: AAS07473.1 .
    CH471200 Genomic DNA. Translation: EAW69657.1 .
    BC000169 mRNA. Translation: AAH00169.2 .
    BC001780 mRNA. Translation: AAH01780.2 .
    BC011696 mRNA. Translation: AAH11696.2 .
    CCDSi CCDS5557.1. [O43709-1 ]
    CCDS56490.1. [O43709-3 ]
    RefSeqi NP_001189489.1. NM_001202560.2. [O43709-3 ]
    NP_059998.2. NM_017528.4. [O43709-1 ]
    UniGenei Hs.647063.

    3D structure databases

    ProteinModelPortali O43709.
    SMRi O43709. Positions 53-164.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125277. 12 interactions.
    IntActi O43709. 5 interactions.
    MINTi MINT-2999647.
    STRINGi 9606.ENSP00000265758.

    PTM databases

    PhosphoSitei O43709.

    Proteomic databases

    MaxQBi O43709.
    PaxDbi O43709.
    PRIDEi O43709.

    Protocols and materials databases

    DNASUi 114049.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000265758 ; ENSP00000265758 ; ENSG00000071462 . [O43709-1 ]
    ENST00000423497 ; ENSP00000401191 ; ENSG00000071462 . [O43709-3 ]
    GeneIDi 114049.
    KEGGi hsa:114049.
    UCSCi uc003tyt.3. human. [O43709-1 ]

    Organism-specific databases

    CTDi 114049.
    GeneCardsi GC07P073097.
    H-InvDB HIX0006753.
    HGNCi HGNC:16405. WBSCR22.
    HPAi HPA052185.
    MIMi 194050. phenotype.
    615733. gene.
    neXtProti NX_O43709.
    Orphaneti 904. Williams syndrome.
    PharmGKBi PA38133.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0500.
    HOGENOMi HOG000111527.
    HOVERGENi HBG054765.
    InParanoidi O43709.
    KOi K00599.
    PhylomeDBi O43709.

    Miscellaneous databases

    ChiTaRSi WBSCR22. human.
    GeneWikii WBSCR22.
    GenomeRNAii 114049.
    NextBioi 78975.
    PROi O43709.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O43709.
    Bgeei O43709.
    CleanExi HS_WBSCR22.
    Genevestigatori O43709.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR013216. Methyltransf_11.
    IPR029063. SAM-dependent_MTases-like.
    IPR022238. Unchr_MeTrfase_Williams-Beuren.
    [Graphical view ]
    Pfami PF08241. Methyltransf_11. 1 hit.
    PF12589. WBS_methylT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of two novel genes, WBSCR20 and WBSCR22, deleted in Williams-Beuren syndrome."
      Doll A., Grzeschik K.-H.
      Cytogenet. Cell Genet. 95:20-27(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    2. "Characterization of 16 novel human genes showing high similarity to yeast sequences."
      Stanchi F., Bertocco E., Toppo S., Dioguardi R., Simionati B., Cannata N., Zimbello R., Lanfranchi G., Valle G.
      Yeast 18:69-80(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Brain.
    3. "Identification of additional transcripts in the Williams-Beuren syndrome critical region."
      Merla G., Ucla C., Guipponi M., Reymond A.
      Hum. Genet. 110:429-438(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Cervix, Lung and Skin.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "The human WBSCR22 protein is involved in the biogenesis of the 40S ribosomal subunits in mammalian cells."
      Ounap K., Kasper L., Kurg A., Kurg R.
      PLoS ONE 8:E75686-E75686(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN RIBOSOME BIOGENESIS, SUBCELLULAR LOCATION.
    11. "The methyltransferase WBSCR22/Merm1 enhances glucocorticoid receptor function and is regulated in lung inflammation and cancer."
      Jangani M., Poolman T.M., Matthews L., Yang N., Farrow S.N., Berry A., Hanley N., Williamson A.J., Whetton A.D., Donn R., Ray D.W.
      J. Biol. Chem. 289:8931-8946(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS NUCLEAR RECEPTOR COACTIVATOR, INTERACTION WITH GRIP1, PROBABLE UBIQUITINATION, INDUCTION BY TNF AND IFNG, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF LYS-180 AND LYS-196.

    Entry informationi

    Entry nameiWBS22_HUMAN
    AccessioniPrimary (citable) accession number: O43709
    Secondary accession number(s): A8K501
    , C9K060, Q96P12, Q9BQ58, Q9HBP9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: October 10, 2002
    Last modified: October 1, 2014
    This is version 127 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3