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O43708

- MAAI_HUMAN

UniProt

O43708 - MAAI_HUMAN

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Protein

Maleylacetoacetate isomerase

Gene

GSTZ1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid.1 Publication

Catalytic activityi

4-maleylacetoacetate = 4-fumarylacetoacetate.1 Publication
RX + glutathione = HX + R-S-glutathione.1 Publication

Cofactori

glutathioneNote: Glutathione is required for the MAAI activity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei45 – 451Glutathione1 Publication
Binding sitei59 – 591Glutathione; via amide nitrogen and carbonyl oxygen1 Publication
Binding sitei111 – 1111Glutathione1 Publication

GO - Molecular functioni

  1. glutathione peroxidase activity Source: ProtInc
  2. glutathione transferase activity Source: UniProtKB
  3. maleylacetoacetate isomerase activity Source: UniProtKB
  4. protein homodimerization activity Source: UniProtKB

GO - Biological processi

  1. cellular nitrogen compound metabolic process Source: Reactome
  2. glutathione derivative biosynthetic process Source: Reactome
  3. glutathione metabolic process Source: UniProtKB
  4. L-phenylalanine catabolic process Source: Reactome
  5. oxidation-reduction process Source: GOC
  6. small molecule metabolic process Source: Reactome
  7. tyrosine catabolic process Source: UniProtKB-KW
  8. xenobiotic metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Transferase

Keywords - Biological processi

Phenylalanine catabolism, Tyrosine catabolism

Enzyme and pathway databases

BioCyciMetaCyc:HS02114-MONOMER.
BRENDAi5.2.1.2. 2681.
ReactomeiREACT_1786. Phenylalanine and tyrosine catabolism.
REACT_6926. Glutathione conjugation.
UniPathwayiUPA00139; UER00340.

Names & Taxonomyi

Protein namesi
Recommended name:
Maleylacetoacetate isomerase (EC:5.2.1.2)
Short name:
MAAI
Alternative name(s):
GSTZ1-1
Glutathione S-transferase zeta 1 (EC:2.5.1.18)
Gene namesi
Name:GSTZ1
Synonyms:MAAI
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:4643. GSTZ1.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29031.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 216216Maleylacetoacetate isomerasePRO_0000186022Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei32 – 321N6-acetyllysine1 Publication
Modified residuei57 – 571N6-succinyllysineBy similarity
Modified residuei136 – 1361PhosphothreonineBy similarity
Modified residuei177 – 1771N6-succinyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO43708.
PaxDbiO43708.
PRIDEiO43708.

PTM databases

PhosphoSiteiO43708.

Expressioni

Tissue specificityi

Mostly expressed in liver followed by kidney, skeletal muscle and brain. Also expressed in melanocytes, synovium, placenta, breast and fetal liver and heart.

Gene expression databases

BgeeiO43708.
CleanExiHS_GSTZ1.
ExpressionAtlasiO43708. baseline and differential.
GenevestigatoriO43708.

Organism-specific databases

HPAiHPA004701.

Interactioni

Subunit structurei

Homodimer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK1P163332EBI-748043,EBI-389883

Protein-protein interaction databases

BioGridi109209. 6 interactions.
IntActiO43708. 5 interactions.
MINTiMINT-1444642.
STRINGi9606.ENSP00000216465.

Structurei

Secondary structure

1
216
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 104Combined sources
Helixi15 – 2612Combined sources
Beta strandi32 – 354Combined sources
Helixi44 – 463Combined sources
Helixi48 – 536Combined sources
Beta strandi61 – 644Combined sources
Beta strandi67 – 715Combined sources
Helixi72 – 8211Combined sources
Helixi93 – 10917Combined sources
Helixi111 – 1144Combined sources
Helixi116 – 1227Combined sources
Helixi124 – 14926Combined sources
Beta strandi150 – 1567Combined sources
Helixi161 – 17515Combined sources
Helixi184 – 19411Combined sources
Helixi197 – 1993Combined sources
Turni200 – 2023Combined sources
Helixi204 – 2063Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FW1X-ray1.90A1-216[»]
ProteinModelPortaliO43708.
SMRiO43708. Positions 5-212.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43708.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 8784GST N-terminalAdd
BLAST
Domaini92 – 212121GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni14 – 196Glutathione binding
Regioni71 – 722Glutathione binding
Regioni115 – 1173Glutathione binding

Sequence similaritiesi

Belongs to the GST superfamily. Zeta family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiCOG0625.
GeneTreeiENSGT00390000006580.
HOVERGENiHBG001501.
InParanoidiO43708.
KOiK01800.
OrthoDBiEOG7TF79P.
PhylomeDBiO43708.
TreeFamiTF105324.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR005955. Mal_ac_isom.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01262. maiA. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O43708-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQAGKPILYS YFRSSCSWRV RIALALKGID YKTVPINLIK DRGQQFSKDF
60 70 80 90 100
QALNPMKQVP TLKIDGITIH QSLAIIEYLE EMRPTPRLLP QDPKKRASVR
110 120 130 140 150
MISDLIAGGI QPLQNLSVLK QVGEEMQLTW AQNAITCGFN ALEQILQSTA
160 170 180 190 200
GIYCVGDEVT MADLCLVPQV ANAERFKVDL TPYPTISSIN KRLLVLEAFQ
210
VSHPCRQPDT PTELRA
Length:216
Mass (Da):24,212
Last modified:November 24, 2009 - v3
Checksum:i2B3112B8AE6B55E0
GO
Isoform 2 (identifier: O43708-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-55: Missing.

Show »
Length:161
Mass (Da):17,896
Checksum:i8EF7E58223F1C0E3
GO
Isoform 3 (identifier: O43708-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-114: Missing.

Note: Gene prediction based on EST data.

Show »
Length:174
Mass (Da):19,472
Checksum:i9C4636C87F67ADED
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti32 – 321K → E in allele GSTZ1*C. 6 Publications
Corresponds to variant rs7975 [ dbSNP | Ensembl ].
VAR_009705
Natural varianti42 – 421R → G in allele GSTZ1*B and allele GSTZ1*C. 9 Publications
Corresponds to variant rs7972 [ dbSNP | Ensembl ].
VAR_009706
Natural varianti82 – 821M → T.7 Publications
Corresponds to variant rs1046428 [ dbSNP | Ensembl ].
VAR_009707
Natural varianti133 – 1331N → H.1 Publication
Corresponds to variant rs2234955 [ dbSNP | Ensembl ].
VAR_014505

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5555Missing in isoform 2. 1 PublicationVSP_039862Add
BLAST
Alternative sequencei73 – 11442Missing in isoform 3. CuratedVSP_047392Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001838 mRNA. Translation: CAA05045.1.
U86529 mRNA. Translation: AAB96392.1.
AF053545
, AF053539, AF053540, AF053541, AF053542, AF053543, AF053544 Genomic DNA. Translation: AAC33591.1.
AF098318
, AF095582, AF098311, AF098312, AF098313, AF098314, AF098315, AF098316, AF098317 Genomic DNA. Translation: AAD43007.1.
AK315154 mRNA. Translation: BAG37600.1.
CR456987 mRNA. Translation: CAG33268.1.
AY316305 Genomic DNA. Translation: AAP69526.1.
AC007954 Genomic DNA. Translation: AAF62559.1.
CH471061 Genomic DNA. Translation: EAW81278.1.
CH471061 Genomic DNA. Translation: EAW81279.1.
BC001453 mRNA. Translation: AAH01453.1.
CCDSiCCDS9858.1. [O43708-1]
CCDS9859.1. [O43708-3]
CCDS9860.1. [O43708-2]
RefSeqiNP_001504.2. NM_001513.3. [O43708-2]
NP_665877.1. NM_145870.2.
NP_665878.2. NM_145871.2.
XP_005267616.1. XM_005267559.1. [O43708-2]
UniGeneiHs.655292.

Genome annotation databases

EnsembliENST00000216465; ENSP00000216465; ENSG00000100577.
ENST00000361389; ENSP00000354959; ENSG00000100577. [O43708-2]
ENST00000393734; ENSP00000377335; ENSG00000100577. [O43708-2]
ENST00000557639; ENSP00000451927; ENSG00000100577. [O43708-2]
GeneIDi2954.
KEGGihsa:2954.
UCSCiuc001xtk.3. human.
uc001xtm.3. human. [O43708-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001838 mRNA. Translation: CAA05045.1 .
U86529 mRNA. Translation: AAB96392.1 .
AF053545
, AF053539 , AF053540 , AF053541 , AF053542 , AF053543 , AF053544 Genomic DNA. Translation: AAC33591.1 .
AF098318
, AF095582 , AF098311 , AF098312 , AF098313 , AF098314 , AF098315 , AF098316 , AF098317 Genomic DNA. Translation: AAD43007.1 .
AK315154 mRNA. Translation: BAG37600.1 .
CR456987 mRNA. Translation: CAG33268.1 .
AY316305 Genomic DNA. Translation: AAP69526.1 .
AC007954 Genomic DNA. Translation: AAF62559.1 .
CH471061 Genomic DNA. Translation: EAW81278.1 .
CH471061 Genomic DNA. Translation: EAW81279.1 .
BC001453 mRNA. Translation: AAH01453.1 .
CCDSi CCDS9858.1. [O43708-1 ]
CCDS9859.1. [O43708-3 ]
CCDS9860.1. [O43708-2 ]
RefSeqi NP_001504.2. NM_001513.3. [O43708-2 ]
NP_665877.1. NM_145870.2.
NP_665878.2. NM_145871.2.
XP_005267616.1. XM_005267559.1. [O43708-2 ]
UniGenei Hs.655292.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1FW1 X-ray 1.90 A 1-216 [» ]
ProteinModelPortali O43708.
SMRi O43708. Positions 5-212.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109209. 6 interactions.
IntActi O43708. 5 interactions.
MINTi MINT-1444642.
STRINGi 9606.ENSP00000216465.

Chemistry

ChEMBLi CHEMBL4949.
DrugBanki DB00143. Glutathione.

PTM databases

PhosphoSitei O43708.

Proteomic databases

MaxQBi O43708.
PaxDbi O43708.
PRIDEi O43708.

Protocols and materials databases

DNASUi 2954.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000216465 ; ENSP00000216465 ; ENSG00000100577 .
ENST00000361389 ; ENSP00000354959 ; ENSG00000100577 . [O43708-2 ]
ENST00000393734 ; ENSP00000377335 ; ENSG00000100577 . [O43708-2 ]
ENST00000557639 ; ENSP00000451927 ; ENSG00000100577 . [O43708-2 ]
GeneIDi 2954.
KEGGi hsa:2954.
UCSCi uc001xtk.3. human.
uc001xtm.3. human. [O43708-1 ]

Organism-specific databases

CTDi 2954.
GeneCardsi GC14P077787.
HGNCi HGNC:4643. GSTZ1.
HPAi HPA004701.
MIMi 603758. gene.
neXtProti NX_O43708.
PharmGKBi PA29031.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0625.
GeneTreei ENSGT00390000006580.
HOVERGENi HBG001501.
InParanoidi O43708.
KOi K01800.
OrthoDBi EOG7TF79P.
PhylomeDBi O43708.
TreeFami TF105324.

Enzyme and pathway databases

UniPathwayi UPA00139 ; UER00340 .
BioCyci MetaCyc:HS02114-MONOMER.
BRENDAi 5.2.1.2. 2681.
Reactomei REACT_1786. Phenylalanine and tyrosine catabolism.
REACT_6926. Glutathione conjugation.

Miscellaneous databases

ChiTaRSi GSTZ1. human.
EvolutionaryTracei O43708.
GeneWikii GSTZ1.
GenomeRNAii 2954.
NextBioi 11706.
PROi O43708.
SOURCEi Search...

Gene expression databases

Bgeei O43708.
CleanExi HS_GSTZ1.
ExpressionAtlasi O43708. baseline and differential.
Genevestigatori O43708.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR005955. Mal_ac_isom.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
TIGRFAMsi TIGR01262. maiA. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a fungal maleylacetoacetate isomerase gene and identification of its human homologue."
    Fernandez-Canon J.M., Penalva M.A.
    J. Biol. Chem. 273:329-337(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION, VARIANTS GLY-42 AND THR-82.
  2. "Zeta, a novel class of glutathione transferases in a range of species from plants to humans."
    Board P.G., Baker R.T., Chelvanayagam G., Jermiin L.S.
    Biochem. J. 328:929-935(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), VARIANT THR-82, CHARACTERIZATION.
  3. "Characterization and chromosome location of the gene GSTZ1 encoding the human zeta class glutathione transferase and maleylacetoacetate isomerase."
    Blackburn A.C., Woollatt E., Sutherland G.R., Board P.G.
    Cytogenet. Cell Genet. 83:109-114(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANTS GLU-32; GLY-42 AND THR-82.
  4. "Gene structure, chromosomal location, and expression pattern of maleylacetoacetate isomerase."
    Fernandez-Canon J.M., Hejna J., Reifsteck C., Olson S., Grompe M.
    Genomics 58:263-269(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANTS GLY-42 AND THR-82.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT THR-82.
    Tissue: Skeletal muscle.
  6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLY-42 AND THR-82.
  7. NIEHS SNPs program
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANTS GLU-32; GLY-42; THR-82 AND HIS-133.
  8. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS GLU-32 AND GLY-42.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS GLU-32 AND GLY-42.
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLU-32 AND GLY-42.
    Tissue: Placenta.
  11. "Glutathione transferase zeta catalyses the oxygenation of the carcinogen dichloroacetic acid to glyoxylic acid."
    Tong Z., Board P.G., Anders M.W.
    Biochem. J. 331:371-374(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-32, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Discovery of a functional polymorphism in human glutathione transferase zeta by expressed sequence tag database analysis."
    Blackburn A.C., Tzeng H.F., Anders M.W., Board P.G.
    Pharmacogenetics 10:49-57(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS GLU-32 AND GLY-42, FUNCTION, CATALYTIC ACTIVITY.
  16. "Crystal structure of maleylacetoacetate isomerase/glutathione transferase zeta reveals the molecular basis for its remarkable catalytic promiscuity."
    Polekhina G., Board P.G., Blackburn A.C., Parker M.W.
    Biochemistry 40:1567-1576(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) IN COMPLEX WITH GLUTATHIONE, SUBUNIT.

Entry informationi

Entry nameiMAAI_HUMAN
AccessioniPrimary (citable) accession number: O43708
Secondary accession number(s): A6NED0
, A6NNB8, A8MWD7, B2RCK3, O15308, O75430, Q6IB17, Q7Z610, Q9BV63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 24, 2009
Last modified: November 26, 2014
This is version 162 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3