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Protein

Sulfotransferase family cytosolic 1B member 1

Gene

SULT1B1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei109 – 1091Proton acceptorBy similarity
Binding sitei131 – 1311PAPS
Binding sitei139 – 1391PAPS
Binding sitei194 – 1941PAPS

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi48 – 536PAPS
Nucleotide bindingi228 – 2336PAPS
Nucleotide bindingi258 – 2603PAPS

GO - Molecular functioni

  1. aryl sulfotransferase activity Source: Ensembl
  2. sulfotransferase activity Source: UniProtKB

GO - Biological processi

  1. 3'-phosphoadenosine 5'-phosphosulfate metabolic process Source: Reactome
  2. cellular biogenic amine metabolic process Source: ProtInc
  3. epithelial cell differentiation Source: UniProtKB
  4. flavonoid metabolic process Source: BHF-UCL
  5. phenol-containing compound metabolic process Source: UniProtKB
  6. small molecule metabolic process Source: Reactome
  7. steroid metabolic process Source: UniProtKB-KW
  8. sulfation Source: BHF-UCL
  9. thyroid hormone metabolic process Source: UniProtKB
  10. xenobiotic metabolic process Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid metabolism, Steroid metabolism

Enzyme and pathway databases

BRENDAi2.8.2.1. 2681.
ReactomeiREACT_6913. Cytosolic sulfonation of small molecules.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfotransferase family cytosolic 1B member 1 (EC:2.8.2.-)
Short name:
ST1B1
Short name:
Sulfotransferase 1B1
Alternative name(s):
Sulfotransferase 1B2
Short name:
ST1B2
Thyroid hormone sulfotransferase
Gene namesi
Name:SULT1B1
Synonyms:ST1B2, SULT1B2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:17845. SULT1B1.

Subcellular locationi

  1. Cytoplasm By similarity

GO - Cellular componenti

  1. cytosol Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA415.

Polymorphism and mutation databases

BioMutaiSULT1B1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 296296Sulfotransferase family cytosolic 1B member 1PRO_0000085161Add
BLAST

Proteomic databases

MaxQBiO43704.
PaxDbiO43704.
PRIDEiO43704.

PTM databases

PhosphoSiteiO43704.

Expressioni

Tissue specificityi

Highly expressed in the liver, peripheral blood leukocytes, colon (mucosal lining), small intestine (jejunum) and spleen. A lesser expression was observed in the lung, placenta and thymus.1 Publication

Gene expression databases

BgeeiO43704.
CleanExiHS_SULT1B1.
ExpressionAtlasiO43704. baseline and differential.
GenevestigatoriO43704.

Organism-specific databases

HPAiHPA002107.

Interactioni

Subunit structurei

Monomer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
SDCBPO005603EBI-10179062,EBI-727004
SULT2A1Q065203EBI-10179062,EBI-3921363
SULT2B1O002043EBI-10179062,EBI-749441

Protein-protein interaction databases

BioGridi118108. 4 interactions.
IntActiO43704. 3 interactions.

Structurei

Secondary structure

1
296
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni5 – 95Combined sources
Beta strandi13 – 153Combined sources
Beta strandi18 – 203Combined sources
Helixi22 – 254Combined sources
Helixi29 – 324Combined sources
Beta strandi41 – 466Combined sources
Helixi51 – 6212Combined sources
Turni63 – 653Combined sources
Helixi67 – 704Combined sources
Helixi75 – 784Combined sources
Turni87 – 893Combined sources
Helixi93 – 997Combined sources
Beta strandi105 – 1084Combined sources
Turni112 – 1143Combined sources
Helixi117 – 1215Combined sources
Beta strandi125 – 1306Combined sources
Helixi133 – 14614Combined sources
Helixi156 – 16510Combined sources
Helixi173 – 18210Combined sources
Turni183 – 1864Combined sources
Beta strandi189 – 1935Combined sources
Helixi194 – 1996Combined sources
Helixi201 – 21111Combined sources
Helixi218 – 22710Combined sources
Helixi230 – 2345Combined sources
Turni237 – 2393Combined sources
Turni246 – 2483Combined sources
Turni251 – 2533Combined sources
Helixi264 – 2674Combined sources
Helixi271 – 28515Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2Z5FX-ray2.10A/B1-296[»]
3CKLX-ray2.00A/B1-296[»]
ProteinModelPortaliO43704.
SMRiO43704. Positions 1-296.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43704.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni107 – 1093Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the sulfotransferase 1 family.Curated

Phylogenomic databases

eggNOGiNOG260792.
GeneTreeiENSGT00760000118932.
HOGENOMiHOG000037209.
HOVERGENiHBG001195.
InParanoidiO43704.
KOiK01025.
OMAiMKENPKQ.
OrthoDBiEOG7V49ZK.
PhylomeDBiO43704.
TreeFamiTF321745.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamiPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

O43704-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSPKDILRK DLKLVHGYPM TCAFASNWEK IEQFHSRPDD IVIATYPKSG
60 70 80 90 100
TTWVSEIIDM ILNDGDIEKC KRGFITEKVP MLEMTLPGLR TSGIEQLEKN
110 120 130 140 150
PSPRIVKTHL PTDLLPKSFW ENNCKMIYLA RNAKDVSVSY YHFDLMNNLQ
160 170 180 190 200
PFPGTWEEYL EKFLTGKVAY GSWFTHVKNW WKKKEEHPIL FLYYEDMKEN
210 220 230 240 250
PKEEIKKIIR FLEKNLNDEI LDRIIHHTSF EVMKDNPLVN YTHLPTTVMD
260 270 280 290
HSKSPFMRKG TAGDWKNYFT VAQNEKFDAI YETEMSKTAL QFRTEI
Length:296
Mass (Da):34,899
Last modified:January 4, 2005 - v2
Checksum:iAFEB61B21DBD782C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti183 – 1831K → R in AAH10895 (PubMed:15489334).Curated
Sequence conflicti186 – 1861E → G in BAA24547 (PubMed:9443824).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89479 mRNA. Translation: BAA24547.1.
U95726 mRNA. Translation: AAB65154.1.
BC010895 mRNA. Translation: AAH10895.1.
AF184894 Genomic DNA. Translation: AAF05917.1.
CCDSiCCDS3530.1.
PIRiJC5885.
RefSeqiNP_055280.2. NM_014465.3.
XP_005265734.1. XM_005265677.2.
UniGeneiHs.129742.

Genome annotation databases

EnsembliENST00000310613; ENSP00000308770; ENSG00000173597.
GeneIDi27284.
KEGGihsa:27284.
UCSCiuc003hen.3. human.

Polymorphism and mutation databases

BioMutaiSULT1B1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89479 mRNA. Translation: BAA24547.1.
U95726 mRNA. Translation: AAB65154.1.
BC010895 mRNA. Translation: AAH10895.1.
AF184894 Genomic DNA. Translation: AAF05917.1.
CCDSiCCDS3530.1.
PIRiJC5885.
RefSeqiNP_055280.2. NM_014465.3.
XP_005265734.1. XM_005265677.2.
UniGeneiHs.129742.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2Z5FX-ray2.10A/B1-296[»]
3CKLX-ray2.00A/B1-296[»]
ProteinModelPortaliO43704.
SMRiO43704. Positions 1-296.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118108. 4 interactions.
IntActiO43704. 3 interactions.

Chemistry

ChEMBLiCHEMBL1743294.

PTM databases

PhosphoSiteiO43704.

Polymorphism and mutation databases

BioMutaiSULT1B1.

Proteomic databases

MaxQBiO43704.
PaxDbiO43704.
PRIDEiO43704.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310613; ENSP00000308770; ENSG00000173597.
GeneIDi27284.
KEGGihsa:27284.
UCSCiuc003hen.3. human.

Organism-specific databases

CTDi27284.
GeneCardsiGC04M070586.
HGNCiHGNC:17845. SULT1B1.
HPAiHPA002107.
MIMi608436. gene.
neXtProtiNX_O43704.
PharmGKBiPA415.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG260792.
GeneTreeiENSGT00760000118932.
HOGENOMiHOG000037209.
HOVERGENiHBG001195.
InParanoidiO43704.
KOiK01025.
OMAiMKENPKQ.
OrthoDBiEOG7V49ZK.
PhylomeDBiO43704.
TreeFamiTF321745.

Enzyme and pathway databases

BRENDAi2.8.2.1. 2681.
ReactomeiREACT_6913. Cytosolic sulfonation of small molecules.

Miscellaneous databases

EvolutionaryTraceiO43704.
GeneWikiiSULT1B1.
GenomeRNAii27284.
NextBioi50216.
PROiO43704.
SOURCEiSearch...

Gene expression databases

BgeeiO43704.
CleanExiHS_SULT1B1.
ExpressionAtlasiO43704. baseline and differential.
GenevestigatoriO43704.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamiPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of rat ST1B1 and human ST1B2 cDNAs, encoding thyroid hormone sulfotransferases."
    Fujita K., Nagata K., Ozawa S., Sasano H., Yamazoe Y.
    J. Biochem. 122:1052-1061(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Tissue: Liver.
  2. "Expression and characterization of a novel thyroid hormone-sulfating form of cytosolic sulfotransferase from human liver."
    Wang J., Falany J.L., Falany C.N.
    Mol. Pharmacol. 53:274-282(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Liver.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow.
  4. "Mapping of the SULT1B2 gene to human chromosome 4q11-13."
    Falany C.N., Wang J.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-73.
  5. "Crystal structures of human sulfotransferases SULT1B1 and SULT1C1 complexed with the cofactor product adenosine-3'- 5'-diphosphate (PAP)."
    Dombrovski L., Dong A., Bochkarev A., Plotnikov A.N.
    Proteins 64:1091-1094(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) IN COMPLEX WITH ADENOSINE-3'-5'-DIPHOSPHATE.
  6. "Crystal structure of human cytosolic sulfotransferase SULT1B1 in complex with PAP and resveratrol."
    Structural genomics consortium (SGC)
    Submitted (APR-2008) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) IN COMPLEX WITH ADENOSINE-3'-5'-DIPHOSPHATE AND RESVERATROL.

Entry informationi

Entry nameiST1B1_HUMAN
AccessioniPrimary (citable) accession number: O43704
Secondary accession number(s): O15497, Q96FI1, Q9UK34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 4, 2005
Last modified: April 29, 2015
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.