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Protein

Sulfotransferase family cytosolic 1B member 1

Gene

SULT1B1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei109Proton acceptorBy similarity1
Binding sitei131PAPS1
Binding sitei139PAPS1
Binding sitei194PAPS1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi48 – 53PAPS6
Nucleotide bindingi228 – 233PAPS6
Nucleotide bindingi258 – 260PAPS3

GO - Molecular functioni

  • aryl sulfotransferase activity Source: CAFA
  • sulfotransferase activity Source: UniProtKB

GO - Biological processi

  • 3'-phosphoadenosine 5'-phosphosulfate metabolic process Source: CAFA
  • cellular biogenic amine metabolic process Source: ProtInc
  • epithelial cell differentiation Source: UniProtKB
  • ethanol catabolic process Source: CAFA
  • flavonoid metabolic process Source: BHF-UCL
  • phenol-containing compound metabolic process Source: UniProtKB
  • steroid metabolic process Source: UniProtKB-KW
  • sulfation Source: BHF-UCL
  • thyroid hormone metabolic process Source: UniProtKB
  • xenobiotic metabolic process Source: BHF-UCL

Keywordsi

Molecular functionTransferase
Biological processLipid metabolism, Steroid metabolism

Enzyme and pathway databases

BRENDAi2.8.2.1. 2681.
ReactomeiR-HSA-156584. Cytosolic sulfonation of small molecules.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfotransferase family cytosolic 1B member 1 (EC:2.8.2.-)
Short name:
ST1B1
Short name:
Sulfotransferase 1B1
Alternative name(s):
Sulfotransferase 1B2
Short name:
ST1B2
Thyroid hormone sulfotransferase
Gene namesi
Name:SULT1B1
Synonyms:ST1B2, SULT1B2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000173597.8.
HGNCiHGNC:17845. SULT1B1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi27284.
OpenTargetsiENSG00000173597.
PharmGKBiPA415.

Chemistry databases

ChEMBLiCHEMBL1743294.
DrugBankiDB01812. Adenosine-3'-5'-Diphosphate.

Polymorphism and mutation databases

BioMutaiSULT1B1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000851611 – 296Sulfotransferase family cytosolic 1B member 1Add BLAST296

Proteomic databases

MaxQBiO43704.
PaxDbiO43704.
PeptideAtlasiO43704.
PRIDEiO43704.

PTM databases

iPTMnetiO43704.
PhosphoSitePlusiO43704.

Expressioni

Tissue specificityi

Highly expressed in the liver, peripheral blood leukocytes, colon (mucosal lining), small intestine (jejunum) and spleen. A lesser expression was observed in the lung, placenta and thymus.1 Publication

Gene expression databases

BgeeiENSG00000173597.
CleanExiHS_SULT1B1.
ExpressionAtlasiO43704. baseline and differential.
GenevisibleiO43704. HS.

Organism-specific databases

HPAiHPA002107.

Interactioni

Subunit structurei

Monomer.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi118108. 4 interactors.
IntActiO43704. 4 interactors.

Structurei

Secondary structure

1296
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni5 – 9Combined sources5
Beta strandi13 – 15Combined sources3
Beta strandi18 – 20Combined sources3
Helixi22 – 25Combined sources4
Helixi29 – 32Combined sources4
Beta strandi41 – 46Combined sources6
Helixi51 – 62Combined sources12
Turni63 – 65Combined sources3
Helixi67 – 70Combined sources4
Helixi75 – 78Combined sources4
Turni87 – 89Combined sources3
Helixi93 – 99Combined sources7
Beta strandi105 – 108Combined sources4
Turni112 – 114Combined sources3
Helixi117 – 121Combined sources5
Beta strandi125 – 130Combined sources6
Helixi133 – 146Combined sources14
Helixi156 – 165Combined sources10
Helixi173 – 182Combined sources10
Turni183 – 186Combined sources4
Beta strandi189 – 193Combined sources5
Helixi194 – 199Combined sources6
Helixi201 – 211Combined sources11
Helixi218 – 227Combined sources10
Helixi230 – 234Combined sources5
Turni237 – 239Combined sources3
Turni246 – 248Combined sources3
Turni251 – 253Combined sources3
Helixi264 – 267Combined sources4
Helixi271 – 285Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Z5FX-ray2.10A/B1-296[»]
3CKLX-ray2.00A/B1-296[»]
ProteinModelPortaliO43704.
SMRiO43704.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43704.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni107 – 109Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the sulfotransferase 1 family.Curated

Phylogenomic databases

eggNOGiKOG1584. Eukaryota.
ENOG4111H56. LUCA.
GeneTreeiENSGT00760000118932.
HOGENOMiHOG000037209.
HOVERGENiHBG001195.
InParanoidiO43704.
KOiK01025.
OMAiNLQPFPG.
OrthoDBiEOG091G0D5F.
PhylomeDBiO43704.
TreeFamiTF321745.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
IPR033289. SULT1B1.
PANTHERiPTHR11783:SF125. PTHR11783:SF125. 1 hit.
PfamiView protein in Pfam
PF00685. Sulfotransfer_1. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

O43704-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSPKDILRK DLKLVHGYPM TCAFASNWEK IEQFHSRPDD IVIATYPKSG
60 70 80 90 100
TTWVSEIIDM ILNDGDIEKC KRGFITEKVP MLEMTLPGLR TSGIEQLEKN
110 120 130 140 150
PSPRIVKTHL PTDLLPKSFW ENNCKMIYLA RNAKDVSVSY YHFDLMNNLQ
160 170 180 190 200
PFPGTWEEYL EKFLTGKVAY GSWFTHVKNW WKKKEEHPIL FLYYEDMKEN
210 220 230 240 250
PKEEIKKIIR FLEKNLNDEI LDRIIHHTSF EVMKDNPLVN YTHLPTTVMD
260 270 280 290
HSKSPFMRKG TAGDWKNYFT VAQNEKFDAI YETEMSKTAL QFRTEI
Length:296
Mass (Da):34,899
Last modified:January 4, 2005 - v2
Checksum:iAFEB61B21DBD782C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti183K → R in AAH10895 (PubMed:15489334).Curated1
Sequence conflicti186E → G in BAA24547 (PubMed:9443824).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89479 mRNA. Translation: BAA24547.1.
U95726 mRNA. Translation: AAB65154.1.
BC010895 mRNA. Translation: AAH10895.1.
AF184894 Genomic DNA. Translation: AAF05917.1.
CCDSiCCDS3530.1.
PIRiJC5885.
RefSeqiNP_055280.2. NM_014465.3.
XP_005265734.1. XM_005265677.3.
UniGeneiHs.129742.

Genome annotation databases

EnsembliENST00000310613; ENSP00000308770; ENSG00000173597.
GeneIDi27284.
KEGGihsa:27284.
UCSCiuc003hen.4. human.

Similar proteinsi

Entry informationi

Entry nameiST1B1_HUMAN
AccessioniPrimary (citable) accession number: O43704
Secondary accession number(s): O15497, Q96FI1, Q9UK34
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 4, 2005
Last modified: September 27, 2017
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families