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Protein

Peptidase inhibitor 15

Gene

PI15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Serine protease inhibitor which displays weak inhibitory activity against trypsin (PubMed:8882727). May play a role in facial patterning during embryonic development (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidase inhibitor 15
Short name:
PI-15
Alternative name(s):
25 kDa trypsin inhibitor
Short name:
p25TI
Cysteine-rich secretory protein 8
Short name:
CRISP-8
SugarCrisp
Gene namesi
Name:PI15
Synonyms:CRISP8, P25TI
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000137558.7.
HGNCiHGNC:8946. PI15.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi51050.
OpenTargetsiENSG00000137558.
PharmGKBiPA33282.

Polymorphism and mutation databases

BioMutaiPI15.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000028762220 – 601 PublicationAdd BLAST41
ChainiPRO_000028762361 – 258Peptidase inhibitor 15Add BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi26N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi36N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi124N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO43692.
PaxDbiO43692.
PeptideAtlasiO43692.
PRIDEiO43692.

PTM databases

iPTMnetiO43692.
PhosphoSitePlusiO43692.

Expressioni

Tissue specificityi

Weakly expressed. Expressed at low level in prostate, mammary gland, salivary gland and thyroid gland.2 Publications

Gene expression databases

BgeeiENSG00000137558.
CleanExiHS_PI15.
GenevisibleiO43692. HS.

Organism-specific databases

HPAiHPA006593.
HPA030057.

Interactioni

Protein-protein interaction databases

BioGridi119244. 13 interactors.
STRINGi9606.ENSP00000260113.

Structurei

3D structure databases

ProteinModelPortaliO43692.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini71 – 211SCPAdd BLAST141

Sequence similaritiesi

Belongs to the CRISP family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3017. Eukaryota.
COG2340. LUCA.
GeneTreeiENSGT00760000119004.
HOGENOMiHOG000111978.
HOVERGENiHBG079090.
InParanoidiO43692.
OMAiNMNVWGA.
OrthoDBiEOG091G048D.
PhylomeDBiO43692.
TreeFamiTF316148.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiView protein in InterPro
IPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR035940. CAP_sf.
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiView protein in Pfam
PF00188. CAP. 1 hit.
PRINTSiPR00837. V5TPXLIKE.
SMARTiView protein in SMART
SM00198. SCP. 1 hit.
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiView protein in PROSITE
PS01010. CRISP_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O43692-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIAISAVSSA LLFSLLCEAS TVVLLNSTDS SPPTNNFTDI EAALKAQLDS
60 70 80 90 100
ADIPKARRKR YISQNDMIAI LDYHNQVRGK VFPPAANMEY MVWDENLAKS
110 120 130 140 150
AEAWAATCIW DHGPSYLLRF LGQNLSVRTG RYRSILQLVK PWYDEVKDYA
160 170 180 190 200
FPYPQDCNPR CPMRCFGPMC THYTQMVWAT SNRIGCAIHT CQNMNVWGSV
210 220 230 240 250
WRRAVYLVCN YAPKGNWIGE APYKVGVPCS SCPPSYGGSC TDNLCFPGVT

SNYLYWFK
Length:258
Mass (Da):29,065
Last modified:June 1, 1998 - v1
Checksum:i1915A5831637795F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D45027 mRNA. Translation: BAA25066.1.
CR749657 mRNA. Translation: CAH18451.2.
BC074931 mRNA. Translation: AAH74931.1.
BC074932 mRNA. Translation: AAH74932.1.
BC126290 mRNA. Translation: AAI26291.1.
BC126292 mRNA. Translation: AAI26293.1.
CCDSiCCDS6218.1.
RefSeqiNP_001311332.1. NM_001324403.1.
NP_056970.1. NM_015886.4.
UniGeneiHs.98558.

Genome annotation databases

EnsembliENST00000260113; ENSP00000260113; ENSG00000137558.
ENST00000523773; ENSP00000428567; ENSG00000137558.
GeneIDi51050.
KEGGihsa:51050.
UCSCiuc003yal.3. human.

Similar proteinsi

Entry informationi

Entry nameiPI15_HUMAN
AccessioniPrimary (citable) accession number: O43692
Secondary accession number(s): Q68CY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: June 1, 1998
Last modified: October 25, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families