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O43692

- PI15_HUMAN

UniProt

O43692 - PI15_HUMAN

Protein

Peptidase inhibitor 15

Gene

PI15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Serine protease inhibitor which displays weak inhibitory activity against trypsin.1 Publication

    GO - Molecular functioni

    1. peptidase inhibitor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Protease inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidase inhibitor 15
    Short name:
    PI-15
    Alternative name(s):
    25 kDa trypsin inhibitor
    Short name:
    p25TI
    Cysteine-rich secretory protein 8
    Short name:
    CRISP-8
    SugarCrisp
    Gene namesi
    Name:PI15
    Synonyms:CRISP8, P25TI
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:8946. PI15.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33282.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Propeptidei20 – 60411 PublicationPRO_0000287622Add
    BLAST
    Chaini61 – 258198Peptidase inhibitor 15PRO_0000287623Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi26 – 261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi124 – 1241N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiO43692.
    PRIDEiO43692.

    PTM databases

    PhosphoSiteiO43692.

    Expressioni

    Tissue specificityi

    Weakly expressed. Expressed at low level in prostate, mammary gland, salivary gland and thyroid gland.2 Publications

    Gene expression databases

    BgeeiO43692.
    CleanExiHS_PI15.
    GenevestigatoriO43692.

    Organism-specific databases

    HPAiHPA006593.
    HPA030057.

    Structurei

    3D structure databases

    ProteinModelPortaliO43692.
    SMRiO43692. Positions 70-245.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini71 – 211141SCPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CRISP family.Curated
    Contains 1 SCP domain.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG331624.
    HOGENOMiHOG000111978.
    HOVERGENiHBG079090.
    InParanoidiO43692.
    OMAiMNVWGAV.
    OrthoDBiEOG7F7WB4.
    PhylomeDBiO43692.
    TreeFamiTF316148.

    Family and domain databases

    Gene3Di3.40.33.10. 1 hit.
    InterProiIPR001283. Allrgn_V5/Tpx1.
    IPR018244. Allrgn_V5/Tpx1_CS.
    IPR014044. CAP_domain.
    [Graphical view]
    PANTHERiPTHR10334. PTHR10334. 1 hit.
    PfamiPF00188. CAP. 1 hit.
    [Graphical view]
    PRINTSiPR00837. V5TPXLIKE.
    SMARTiSM00198. SCP. 1 hit.
    [Graphical view]
    SUPFAMiSSF55797. SSF55797. 1 hit.
    PROSITEiPS01010. CRISP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O43692-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIAISAVSSA LLFSLLCEAS TVVLLNSTDS SPPTNNFTDI EAALKAQLDS    50
    ADIPKARRKR YISQNDMIAI LDYHNQVRGK VFPPAANMEY MVWDENLAKS 100
    AEAWAATCIW DHGPSYLLRF LGQNLSVRTG RYRSILQLVK PWYDEVKDYA 150
    FPYPQDCNPR CPMRCFGPMC THYTQMVWAT SNRIGCAIHT CQNMNVWGSV 200
    WRRAVYLVCN YAPKGNWIGE APYKVGVPCS SCPPSYGGSC TDNLCFPGVT 250
    SNYLYWFK 258
    Length:258
    Mass (Da):29,065
    Last modified:June 1, 1998 - v1
    Checksum:i1915A5831637795F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D45027 mRNA. Translation: BAA25066.1.
    CR749657 mRNA. Translation: CAH18451.2.
    BC074931 mRNA. Translation: AAH74931.1.
    BC074932 mRNA. Translation: AAH74932.1.
    BC126290 mRNA. Translation: AAI26291.1.
    BC126292 mRNA. Translation: AAI26293.1.
    CCDSiCCDS6218.1.
    RefSeqiNP_056970.1. NM_015886.3.
    XP_006716516.1. XM_006716453.1.
    UniGeneiHs.98558.

    Genome annotation databases

    EnsembliENST00000260113; ENSP00000260113; ENSG00000137558.
    ENST00000523773; ENSP00000428567; ENSG00000137558.
    GeneIDi51050.
    KEGGihsa:51050.
    UCSCiuc003yal.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D45027 mRNA. Translation: BAA25066.1 .
    CR749657 mRNA. Translation: CAH18451.2 .
    BC074931 mRNA. Translation: AAH74931.1 .
    BC074932 mRNA. Translation: AAH74932.1 .
    BC126290 mRNA. Translation: AAI26291.1 .
    BC126292 mRNA. Translation: AAI26293.1 .
    CCDSi CCDS6218.1.
    RefSeqi NP_056970.1. NM_015886.3.
    XP_006716516.1. XM_006716453.1.
    UniGenei Hs.98558.

    3D structure databases

    ProteinModelPortali O43692.
    SMRi O43692. Positions 70-245.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei O43692.

    Proteomic databases

    PaxDbi O43692.
    PRIDEi O43692.

    Protocols and materials databases

    DNASUi 51050.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000260113 ; ENSP00000260113 ; ENSG00000137558 .
    ENST00000523773 ; ENSP00000428567 ; ENSG00000137558 .
    GeneIDi 51050.
    KEGGi hsa:51050.
    UCSCi uc003yal.3. human.

    Organism-specific databases

    CTDi 51050.
    GeneCardsi GC08P075773.
    HGNCi HGNC:8946. PI15.
    HPAi HPA006593.
    HPA030057.
    MIMi 607076. gene.
    neXtProti NX_O43692.
    PharmGKBi PA33282.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG331624.
    HOGENOMi HOG000111978.
    HOVERGENi HBG079090.
    InParanoidi O43692.
    OMAi MNVWGAV.
    OrthoDBi EOG7F7WB4.
    PhylomeDBi O43692.
    TreeFami TF316148.

    Miscellaneous databases

    GenomeRNAii 51050.
    NextBioi 53608.
    PROi O43692.
    SOURCEi Search...

    Gene expression databases

    Bgeei O43692.
    CleanExi HS_PI15.
    Genevestigatori O43692.

    Family and domain databases

    Gene3Di 3.40.33.10. 1 hit.
    InterProi IPR001283. Allrgn_V5/Tpx1.
    IPR018244. Allrgn_V5/Tpx1_CS.
    IPR014044. CAP_domain.
    [Graphical view ]
    PANTHERi PTHR10334. PTHR10334. 1 hit.
    Pfami PF00188. CAP. 1 hit.
    [Graphical view ]
    PRINTSi PR00837. V5TPXLIKE.
    SMARTi SM00198. SCP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55797. SSF55797. 1 hit.
    PROSITEi PS01010. CRISP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning of a novel trypsin inhibitor with similarity to pathogenesis-related proteins, and its frequent expression in human brain cancer cells."
      Yamakawa T., Miyata S., Ogawa N., Koshikawa N., Yasumitsu H., Kanamori T., Miyazaki K.
      Biochim. Biophys. Acta 1395:202-208(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, GLYCOSYLATION.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Endometrial adenocarcinoma.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. "Purification and identification of a novel and four known serine proteinase inhibitors secreted by human glioblastoma cells."
      Koshikawa N., Nakamura T., Tsuchiya N., Isaji M., Yasumitsu H., Umeda M., Miyazaki K.
      J. Biochem. 119:334-339(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 61-85, FUNCTION.
    5. "Cloning and expression of a novel cysteine-rich secreted protein family member expressed in thyroid and pancreatic mesoderm within the chicken embryo."
      Smith D.M., Collins-Racie L.A., Marigo V.A., Roberts D.J., Davis N.M., Hartmann C., Schweitzer R., LaVallie E.R., Gamer L., McCoy J., Tabin C.J.
      Mech. Dev. 102:223-226(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiPI15_HUMAN
    AccessioniPrimary (citable) accession number: O43692
    Secondary accession number(s): Q68CY1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3