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Protein

Peptidase inhibitor 15

Gene

PI15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Serine protease inhibitor which displays weak inhibitory activity against trypsin.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidase inhibitor 15
Short name:
PI-15
Alternative name(s):
25 kDa trypsin inhibitor
Short name:
p25TI
Cysteine-rich secretory protein 8
Short name:
CRISP-8
SugarCrisp
Gene namesi
Name:PI15
Synonyms:CRISP8, P25TI
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:8946. PI15.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33282.

Polymorphism and mutation databases

BioMutaiPI15.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Propeptidei20 – 60411 PublicationPRO_0000287622Add
BLAST
Chaini61 – 258198Peptidase inhibitor 15PRO_0000287623Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi26 – 261N-linked (GlcNAc...)Sequence Analysis
Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi124 – 1241N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO43692.
PRIDEiO43692.

PTM databases

PhosphoSiteiO43692.

Expressioni

Tissue specificityi

Weakly expressed. Expressed at low level in prostate, mammary gland, salivary gland and thyroid gland.2 Publications

Gene expression databases

BgeeiO43692.
CleanExiHS_PI15.
GenevestigatoriO43692.

Organism-specific databases

HPAiHPA006593.
HPA030057.

Structurei

3D structure databases

ProteinModelPortaliO43692.
SMRiO43692. Positions 70-245.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini71 – 211141SCPAdd
BLAST

Sequence similaritiesi

Belongs to the CRISP family.Curated
Contains 1 SCP domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG331624.
GeneTreeiENSGT00760000119004.
HOGENOMiHOG000111978.
HOVERGENiHBG079090.
InParanoidiO43692.
OMAiNMNVWGA.
OrthoDBiEOG7F7WB4.
PhylomeDBiO43692.
TreeFamiTF316148.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
[Graphical view]
PRINTSiPR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01010. CRISP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O43692-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIAISAVSSA LLFSLLCEAS TVVLLNSTDS SPPTNNFTDI EAALKAQLDS
60 70 80 90 100
ADIPKARRKR YISQNDMIAI LDYHNQVRGK VFPPAANMEY MVWDENLAKS
110 120 130 140 150
AEAWAATCIW DHGPSYLLRF LGQNLSVRTG RYRSILQLVK PWYDEVKDYA
160 170 180 190 200
FPYPQDCNPR CPMRCFGPMC THYTQMVWAT SNRIGCAIHT CQNMNVWGSV
210 220 230 240 250
WRRAVYLVCN YAPKGNWIGE APYKVGVPCS SCPPSYGGSC TDNLCFPGVT

SNYLYWFK
Length:258
Mass (Da):29,065
Last modified:June 1, 1998 - v1
Checksum:i1915A5831637795F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D45027 mRNA. Translation: BAA25066.1.
CR749657 mRNA. Translation: CAH18451.2.
BC074931 mRNA. Translation: AAH74931.1.
BC074932 mRNA. Translation: AAH74932.1.
BC126290 mRNA. Translation: AAI26291.1.
BC126292 mRNA. Translation: AAI26293.1.
CCDSiCCDS6218.1.
RefSeqiNP_056970.1. NM_015886.3.
XP_006716516.1. XM_006716453.2.
UniGeneiHs.98558.

Genome annotation databases

EnsembliENST00000260113; ENSP00000260113; ENSG00000137558.
ENST00000523773; ENSP00000428567; ENSG00000137558.
GeneIDi51050.
KEGGihsa:51050.
UCSCiuc003yal.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D45027 mRNA. Translation: BAA25066.1.
CR749657 mRNA. Translation: CAH18451.2.
BC074931 mRNA. Translation: AAH74931.1.
BC074932 mRNA. Translation: AAH74932.1.
BC126290 mRNA. Translation: AAI26291.1.
BC126292 mRNA. Translation: AAI26293.1.
CCDSiCCDS6218.1.
RefSeqiNP_056970.1. NM_015886.3.
XP_006716516.1. XM_006716453.2.
UniGeneiHs.98558.

3D structure databases

ProteinModelPortaliO43692.
SMRiO43692. Positions 70-245.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiO43692.

Polymorphism and mutation databases

BioMutaiPI15.

Proteomic databases

PaxDbiO43692.
PRIDEiO43692.

Protocols and materials databases

DNASUi51050.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260113; ENSP00000260113; ENSG00000137558.
ENST00000523773; ENSP00000428567; ENSG00000137558.
GeneIDi51050.
KEGGihsa:51050.
UCSCiuc003yal.3. human.

Organism-specific databases

CTDi51050.
GeneCardsiGC08P075773.
HGNCiHGNC:8946. PI15.
HPAiHPA006593.
HPA030057.
MIMi607076. gene.
neXtProtiNX_O43692.
PharmGKBiPA33282.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG331624.
GeneTreeiENSGT00760000119004.
HOGENOMiHOG000111978.
HOVERGENiHBG079090.
InParanoidiO43692.
OMAiNMNVWGA.
OrthoDBiEOG7F7WB4.
PhylomeDBiO43692.
TreeFamiTF316148.

Miscellaneous databases

GenomeRNAii51050.
NextBioi53608.
PROiO43692.
SOURCEiSearch...

Gene expression databases

BgeeiO43692.
CleanExiHS_PI15.
GenevestigatoriO43692.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
[Graphical view]
PRINTSiPR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01010. CRISP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning of a novel trypsin inhibitor with similarity to pathogenesis-related proteins, and its frequent expression in human brain cancer cells."
    Yamakawa T., Miyata S., Ogawa N., Koshikawa N., Yasumitsu H., Kanamori T., Miyazaki K.
    Biochim. Biophys. Acta 1395:202-208(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, GLYCOSYLATION.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Endometrial adenocarcinoma.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Purification and identification of a novel and four known serine proteinase inhibitors secreted by human glioblastoma cells."
    Koshikawa N., Nakamura T., Tsuchiya N., Isaji M., Yasumitsu H., Umeda M., Miyazaki K.
    J. Biochem. 119:334-339(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 61-85, FUNCTION.
  5. "Cloning and expression of a novel cysteine-rich secreted protein family member expressed in thyroid and pancreatic mesoderm within the chicken embryo."
    Smith D.M., Collins-Racie L.A., Marigo V.A., Roberts D.J., Davis N.M., Hartmann C., Schweitzer R., LaVallie E.R., Gamer L., McCoy J., Tabin C.J.
    Mech. Dev. 102:223-226(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiPI15_HUMAN
AccessioniPrimary (citable) accession number: O43692
Secondary accession number(s): Q68CY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: June 1, 1998
Last modified: May 27, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.