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O43692 (PI15_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peptidase inhibitor 15

Short name=PI-15
Alternative name(s):
25 kDa trypsin inhibitor
Short name=p25TI
Cysteine-rich secretory protein 8
Short name=CRISP-8
SugarCrisp
Gene names
Name:PI15
Synonyms:CRISP8, P25TI
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Serine protease inhibitor which displays weak inhibitory activity against trypsin. Ref.4

Subcellular location

Secreted.

Tissue specificity

Weakly expressed. Expressed at low level in prostate, mammary gland, salivary gland and thyroid gland. Ref.1 Ref.5

Post-translational modification

N-glycosylated Probable. Ref.1

Sequence similarities

Belongs to the CRISP family.

Contains 1 SCP domain.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionProtease inhibitor
   PTMGlycoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionpeptidase inhibitor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Propeptide20 – 6041 Probable
PRO_0000287622
Chain61 – 258198Peptidase inhibitor 15
PRO_0000287623

Regions

Domain71 – 211141SCP

Amino acid modifications

Glycosylation261N-linked (GlcNAc...) Potential
Glycosylation361N-linked (GlcNAc...) Potential
Glycosylation1241N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O43692 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 1915A5831637795F

FASTA25829,065
        10         20         30         40         50         60 
MIAISAVSSA LLFSLLCEAS TVVLLNSTDS SPPTNNFTDI EAALKAQLDS ADIPKARRKR 

        70         80         90        100        110        120 
YISQNDMIAI LDYHNQVRGK VFPPAANMEY MVWDENLAKS AEAWAATCIW DHGPSYLLRF 

       130        140        150        160        170        180 
LGQNLSVRTG RYRSILQLVK PWYDEVKDYA FPYPQDCNPR CPMRCFGPMC THYTQMVWAT 

       190        200        210        220        230        240 
SNRIGCAIHT CQNMNVWGSV WRRAVYLVCN YAPKGNWIGE APYKVGVPCS SCPPSYGGSC 

       250 
TDNLCFPGVT SNYLYWFK 

« Hide

References

« Hide 'large scale' references
[1]"cDNA cloning of a novel trypsin inhibitor with similarity to pathogenesis-related proteins, and its frequent expression in human brain cancer cells."
Yamakawa T., Miyata S., Ogawa N., Koshikawa N., Yasumitsu H., Kanamori T., Miyazaki K.
Biochim. Biophys. Acta 1395:202-208(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, GLYCOSYLATION.
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Endometrial adenocarcinoma.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"Purification and identification of a novel and four known serine proteinase inhibitors secreted by human glioblastoma cells."
Koshikawa N., Nakamura T., Tsuchiya N., Isaji M., Yasumitsu H., Umeda M., Miyazaki K.
J. Biochem. 119:334-339(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 61-85, FUNCTION.
[5]"Cloning and expression of a novel cysteine-rich secreted protein family member expressed in thyroid and pancreatic mesoderm within the chicken embryo."
Smith D.M., Collins-Racie L.A., Marigo V.A., Roberts D.J., Davis N.M., Hartmann C., Schweitzer R., LaVallie E.R., Gamer L., McCoy J., Tabin C.J.
Mech. Dev. 102:223-226(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D45027 mRNA. Translation: BAA25066.1.
CR749657 mRNA. Translation: CAH18451.2.
BC074931 mRNA. Translation: AAH74931.1.
BC074932 mRNA. Translation: AAH74932.1.
BC126290 mRNA. Translation: AAI26291.1.
BC126292 mRNA. Translation: AAI26293.1.
CCDSCCDS6218.1.
RefSeqNP_056970.1. NM_015886.3.
XP_006716516.1. XM_006716453.1.
UniGeneHs.98558.

3D structure databases

ProteinModelPortalO43692.
SMRO43692. Positions 70-245.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteO43692.

Proteomic databases

PaxDbO43692.
PRIDEO43692.

Protocols and materials databases

DNASU51050.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000260113; ENSP00000260113; ENSG00000137558.
ENST00000523773; ENSP00000428567; ENSG00000137558.
GeneID51050.
KEGGhsa:51050.
UCSCuc003yal.3. human.

Organism-specific databases

CTD51050.
GeneCardsGC08P075773.
HGNCHGNC:8946. PI15.
HPAHPA006593.
HPA030057.
MIM607076. gene.
neXtProtNX_O43692.
PharmGKBPA33282.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG331624.
HOGENOMHOG000111978.
HOVERGENHBG079090.
InParanoidO43692.
OMAMNVWGAV.
OrthoDBEOG7F7WB4.
PhylomeDBO43692.
TreeFamTF316148.

Gene expression databases

BgeeO43692.
CleanExHS_PI15.
GenevestigatorO43692.

Family and domain databases

Gene3D3.40.33.10. 1 hit.
InterProIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
[Graphical view]
PANTHERPTHR10334. PTHR10334. 1 hit.
PfamPF00188. CAP. 1 hit.
[Graphical view]
PRINTSPR00837. V5TPXLIKE.
SMARTSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMSSF55797. SSF55797. 1 hit.
PROSITEPS01010. CRISP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi51050.
NextBio53608.
PROO43692.
SOURCESearch...

Entry information

Entry namePI15_HUMAN
AccessionPrimary (citable) accession number: O43692
Secondary accession number(s): Q68CY1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: June 1, 1998
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM