Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O43692

- PI15_HUMAN

UniProt

O43692 - PI15_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Peptidase inhibitor 15

Gene

PI15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Serine protease inhibitor which displays weak inhibitory activity against trypsin.1 Publication

GO - Molecular functioni

  1. peptidase inhibitor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidase inhibitor 15
Short name:
PI-15
Alternative name(s):
25 kDa trypsin inhibitor
Short name:
p25TI
Cysteine-rich secretory protein 8
Short name:
CRISP-8
SugarCrisp
Gene namesi
Name:PI15
Synonyms:CRISP8, P25TI
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:8946. PI15.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33282.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Propeptidei20 – 60411 PublicationPRO_0000287622Add
BLAST
Chaini61 – 258198Peptidase inhibitor 15PRO_0000287623Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi26 – 261N-linked (GlcNAc...)Sequence Analysis
Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi124 – 1241N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO43692.
PRIDEiO43692.

PTM databases

PhosphoSiteiO43692.

Expressioni

Tissue specificityi

Weakly expressed. Expressed at low level in prostate, mammary gland, salivary gland and thyroid gland.2 Publications

Gene expression databases

BgeeiO43692.
CleanExiHS_PI15.
GenevestigatoriO43692.

Organism-specific databases

HPAiHPA006593.
HPA030057.

Structurei

3D structure databases

ProteinModelPortaliO43692.
SMRiO43692. Positions 70-245.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini71 – 211141SCPAdd
BLAST

Sequence similaritiesi

Belongs to the CRISP family.Curated
Contains 1 SCP domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG331624.
GeneTreeiENSGT00760000119004.
HOGENOMiHOG000111978.
HOVERGENiHBG079090.
InParanoidiO43692.
OMAiMNVWGAV.
OrthoDBiEOG7F7WB4.
PhylomeDBiO43692.
TreeFamiTF316148.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
[Graphical view]
PRINTSiPR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01010. CRISP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O43692-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIAISAVSSA LLFSLLCEAS TVVLLNSTDS SPPTNNFTDI EAALKAQLDS
60 70 80 90 100
ADIPKARRKR YISQNDMIAI LDYHNQVRGK VFPPAANMEY MVWDENLAKS
110 120 130 140 150
AEAWAATCIW DHGPSYLLRF LGQNLSVRTG RYRSILQLVK PWYDEVKDYA
160 170 180 190 200
FPYPQDCNPR CPMRCFGPMC THYTQMVWAT SNRIGCAIHT CQNMNVWGSV
210 220 230 240 250
WRRAVYLVCN YAPKGNWIGE APYKVGVPCS SCPPSYGGSC TDNLCFPGVT

SNYLYWFK
Length:258
Mass (Da):29,065
Last modified:June 1, 1998 - v1
Checksum:i1915A5831637795F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D45027 mRNA. Translation: BAA25066.1.
CR749657 mRNA. Translation: CAH18451.2.
BC074931 mRNA. Translation: AAH74931.1.
BC074932 mRNA. Translation: AAH74932.1.
BC126290 mRNA. Translation: AAI26291.1.
BC126292 mRNA. Translation: AAI26293.1.
CCDSiCCDS6218.1.
RefSeqiNP_056970.1. NM_015886.3.
XP_006716516.1. XM_006716453.1.
UniGeneiHs.98558.

Genome annotation databases

EnsembliENST00000260113; ENSP00000260113; ENSG00000137558.
ENST00000523773; ENSP00000428567; ENSG00000137558.
GeneIDi51050.
KEGGihsa:51050.
UCSCiuc003yal.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D45027 mRNA. Translation: BAA25066.1 .
CR749657 mRNA. Translation: CAH18451.2 .
BC074931 mRNA. Translation: AAH74931.1 .
BC074932 mRNA. Translation: AAH74932.1 .
BC126290 mRNA. Translation: AAI26291.1 .
BC126292 mRNA. Translation: AAI26293.1 .
CCDSi CCDS6218.1.
RefSeqi NP_056970.1. NM_015886.3.
XP_006716516.1. XM_006716453.1.
UniGenei Hs.98558.

3D structure databases

ProteinModelPortali O43692.
SMRi O43692. Positions 70-245.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei O43692.

Proteomic databases

PaxDbi O43692.
PRIDEi O43692.

Protocols and materials databases

DNASUi 51050.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000260113 ; ENSP00000260113 ; ENSG00000137558 .
ENST00000523773 ; ENSP00000428567 ; ENSG00000137558 .
GeneIDi 51050.
KEGGi hsa:51050.
UCSCi uc003yal.3. human.

Organism-specific databases

CTDi 51050.
GeneCardsi GC08P075773.
HGNCi HGNC:8946. PI15.
HPAi HPA006593.
HPA030057.
MIMi 607076. gene.
neXtProti NX_O43692.
PharmGKBi PA33282.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG331624.
GeneTreei ENSGT00760000119004.
HOGENOMi HOG000111978.
HOVERGENi HBG079090.
InParanoidi O43692.
OMAi MNVWGAV.
OrthoDBi EOG7F7WB4.
PhylomeDBi O43692.
TreeFami TF316148.

Miscellaneous databases

GenomeRNAii 51050.
NextBioi 53608.
PROi O43692.
SOURCEi Search...

Gene expression databases

Bgeei O43692.
CleanExi HS_PI15.
Genevestigatori O43692.

Family and domain databases

Gene3Di 3.40.33.10. 1 hit.
InterProi IPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
[Graphical view ]
PANTHERi PTHR10334. PTHR10334. 1 hit.
Pfami PF00188. CAP. 1 hit.
[Graphical view ]
PRINTSi PR00837. V5TPXLIKE.
SMARTi SM00198. SCP. 1 hit.
[Graphical view ]
SUPFAMi SSF55797. SSF55797. 1 hit.
PROSITEi PS01010. CRISP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning of a novel trypsin inhibitor with similarity to pathogenesis-related proteins, and its frequent expression in human brain cancer cells."
    Yamakawa T., Miyata S., Ogawa N., Koshikawa N., Yasumitsu H., Kanamori T., Miyazaki K.
    Biochim. Biophys. Acta 1395:202-208(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, GLYCOSYLATION.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Endometrial adenocarcinoma.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Purification and identification of a novel and four known serine proteinase inhibitors secreted by human glioblastoma cells."
    Koshikawa N., Nakamura T., Tsuchiya N., Isaji M., Yasumitsu H., Umeda M., Miyazaki K.
    J. Biochem. 119:334-339(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 61-85, FUNCTION.
  5. "Cloning and expression of a novel cysteine-rich secreted protein family member expressed in thyroid and pancreatic mesoderm within the chicken embryo."
    Smith D.M., Collins-Racie L.A., Marigo V.A., Roberts D.J., Davis N.M., Hartmann C., Schweitzer R., LaVallie E.R., Gamer L., McCoy J., Tabin C.J.
    Mech. Dev. 102:223-226(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiPI15_HUMAN
AccessioniPrimary (citable) accession number: O43692
Secondary accession number(s): Q68CY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: June 1, 1998
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3